Multipin peptide libraries for antibody and receptor epitope screening and characterization

Journal of Immunological Methods

Volumn 267, Issue 1, 2002, Pages 27-35

  Tribbick, Gordon ^a  

^a Mimotopes Pty Ltd   (Australia)

Author keywords

Antibody; Antipeptide; B cell; Epitope mapping; Mimotopes; Synthetic peptide

Indexed keywords

ANTIBODY; EPITOPE; MONOCLONAL ANTIBODY; PEPTIDE LIBRARY; POLYCLONAL ANTIBODY; SYNTHETIC PEPTIDE; T LYMPHOCYTE RECEPTOR;

ANALYTIC METHOD; ANTIBODY COMBINING SITE; ANTIGENICITY; ARTICLE; BIOTINYLATION; COMBINATORIAL CHEMISTRY; EPITOPE MAPPING; METHODOLOGY; MOLECULAR BIOLOGY; MONONUCLEAR CELL; NONHUMAN; PRIORITY JOURNAL; SCREENING; T LYMPHOCYTE; TECHNOLOGY;

COMBINATORIAL CHEMISTRY TECHNIQUES; EPITOPE MAPPING; PEPTIDE BIOSYNTHESIS; PEPTIDE LIBRARY; PEPTIDES;

EID: 0036721765     PISSN: 00221759     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-1759(02)00138-2     Document Type: Article

References (67)

1. Specific cleavage of tryptophyl peptide bonds with periodate in sperm whale myoglobin
2. Antigenic structure of myoglobin: The complete immunochemical anatomy of a protein and conclusions relating to antigenic structures of proteins
3. Precise determination of the entire antigenic structure of lysozyme: Molecular features of protein antigenic structures and potential of "surface-simulation" synthesis - A powerful new concept for protein binding sites
4. The precise and entire antigenic structure of native lysozyme
5. Immunochemistry of sperm whale myoglobin: I. The specific interaction of some tryptic peptides and of peptides containing all the reactive regions of the antigen
6. Immunochemistry of sperm whale myoglobin: 8. Specific interaction of peptides obtained by cleavage at proline peptide bonds
7. Immunochemistry of sperm whale myoglobin: VII. Correlation of immunochemical cross-reaction of eight myoglobins with structural similarity and its dependence on conformation
8. Conformational studies on modified proteins and peptides: IV. Conformation of lysozyme derivatives modified at tyrosine or at tryptophan residues
9. A mild procedure for solid phase peptide synthesis: Use of fluorenylmethoxycarbonylamino-acids
10. Analysis of the minimal amyloid-forming fragment of the islet amyloid polypeptide. An experimental support for the key role of the phenylalanine residue in amyloid formation
11. Intrinsic and extrinsic factors in protein antigenic structure
12. The simultaneous multiple production of solution phase peptides; Assessment of the Geysen method of simultaneous peptide synthesis
13. Gas phase cleavage of peptides from a solid support with ammonia vapour. Application in simultaneous multiple peptide synthesis
14. Binding of peptides to proteins; An exercise in molecular design
15. Principles and pitfalls in designing site-directed peptide ligands
16. Binding of synthetic peptides by a human monoclonal IgM with an unusual combining site structure
17. Light-directed, spatially addressable parallel chemical synthesis
18. SPOT synthesis: An easy technique for the positionally addressable, parallel chemical synthesis on a membrane support
19. Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid
20. Small peptides induce antibodies with a sequence and structural requirement for binding antigen comparable to antibodies raised against the native protein
21. A priori delineation of a peptide which mimics a discontinuous antigenic determinant
22. Peptides which mimic carbohydrate antigens. Towards Better Carbohydrate Vaccines
23. Strategies for epitope analysis using peptide synthesis
24. Chemistry of antibody binding to a protein
25. Cognitive features of continuous antigenic determinants
26. Antigenicity of myohemerythrin
27. Minimization of chronic plasma viremia in rhesus macaques immunized with synthetic HIV-1 Tat peptides and infected with a chimeric simian/human immunodeficiency virus (SHIV33)
28. Two B cell epitopes of HIV-1 Tat protein have limited antigenic polymorphism in geographically diverse HIV-1 strains
29. Delineation of a conserved B cell epitope on bonnet monkey (Macaca radiata) and human zona pellucida glycoprotein-B by monoclonal antibodies demonstrating inhibition of sperm-egg binding
30. 2 or COOH as C-terminus groups on the antigenic characters of immunogenic peptides
31. Avidin and streptavidin
32. Immunogenic structure of the influenza virus hemagglutinin
33. Selection of an immunogenic peptide mimic of the capsular polysaccharide of Neisseria meningitidis serogroup A using a peptide display library
34. Enzymic and immunochemical properties of lysozyme: V. Derivatives modified at lysine residues by guanidination, acetylation, succinylation or maleylation
35. Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery
36. Vaccination with carbohydrate peptide mimotopes promotes anti-tumor responses
37. A new type of synthetic peptide library for identifying ligand-binding activity
38. Epitope analysis of the murine p53 tumor suppressor protein
39. A method for preparing β-hCG COOH peptide-carrier conjugates of predictable composition
40. Immunocytochemical detection and mapping of a cytokeratin 18 neo-epitope exposed during early apoptosis
41. Analysis of p53 antibodies in patients with various cancers define B-cell epitopes of human p53: Distribution on primary structure and exposure on protein surface
42. Multi-pin peptide synthesis strategy for T cell determinant analysis
43. Simultaneous multiple synthesis of peptide-carrier conjugates
44. Solid phase peptide synthesis: 1. The synthesis of a tetrapeptide
45. Identification of sperm antigen targets for immunocontraception: B-cell epitope analysis of Sp17
46. Polysaccharides, mimotopes and vaccines for fungal and encapsulated pathogens
47. T-cell epitope mapping with synthetic peptides and peripheral blood mononuclear cells
48. The antibody response to myoglobin - I. Systematic synthesis of myoglobin peptides reveals location and substructure of species dependent continuous antigenic determinants
49. Searching for peptide ligands with an epitope library
50. Localization of virus-specific and group-specific epitopes of plant polyviruses by systematic immunochemical analysis of overlapping peptide fragments
51. Peptoids: A modular approach to drug discovery
52. A novel method for delineating antigenic determinants: Peptide synthesis and radioimmunoassay using the same solid support
53. Use of the multipin peptide synthesis technique for the generation of antipeptide sera
54. Developments in ELISA: The use of biotinylated peptides in the assessment of antipeptide sera
55. Antibody epitope mapping with Multipin peptides
56. Similar binding properties of peptide ligands for a human immunoglobulin and its light chain dimer
57. Systematic fractionation of serum antibodies using multiple antigen homologous peptides as affinity ligands
58. The antibody response to myoglobin is independent of the immunized species. Analysis in terms of replacements in the antigenic sites and in environmental residues of the cross-reactions of fifteen myoglobins with sperm-whale myoglobin antisera raised in different species
59. Inadequacy of traditional ELISA for screening hybridoma supernatants for murine monoclonal antibodies
60. Synthesis of peptide analogues using the multipin peptide synthesis method
61. Multipin peptide synthesis at the micromole scale using 2-hydroxyethyl methacrylate grafted polyethylene supports
62. Multiple peptide synthesis on acid-labile handle derivatized polyethylene supports
63. B-Cell epitope mapping of the VapA protein of Rhodococcus equi: Implications for early detection of R. equi disease in foals
64. Predicting antigenic determinants in proteins: Looking for unidimensional solutions to a three-dimensional problem?
65. Identification of continuous B-cell epitopes on the protein moiety of the 58-kiloDalton cell wall mannoprotein of Candida albicans belonging to a family of immunodominant fungal antigens
66. Systematic mapping of potential binding sites for Shc and Grb2 SH2 domains on insulin receptor substrate-1 and the receptors for insulin, epidermal growth factor, platelet-derived growth factor, and fibroblast growth factor
67. Natural antibodies that react with V-region peptide epitopes of DNA-binding antibodies are made by mice with systemic lupus erythematosus as disease develops