A broad-spectrum peptide inhibitor of β-lactamase identified using phage display and peptide arrays

Protein Engineering

Volumn 16, Issue 11, 2003, Pages 853-860

  Huang, Wanzhi ^a   Beharry, Zanna ^a   Zhang, Zhen ^a   Palzkill, Timothy ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Antibiotics; Bacteriophage; Inhibitors; Peptide arrays

Indexed keywords

AMINO ACID; ARGINYLARGINYLGLYCYLHISTIDYLTYROSYLTYROSINE; BACTERIAL PROTEIN; BETA LACTAM ANTIBIOTIC; BETA LACTAMASE; BETA LACTAMASE CLASS A; BETA LACTAMASE INHIBITOR; CLASS A BACILLUS ANTHRACIS BLA1 BETA LACTAMASE; CLASS C BETA LACTAMASE; CLAVULANIC ACID; P99 PROTEIN; TEM 1 PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIBIOTIC RESISTANCE; ARTICLE; BACILLUS ANTHRACIS; BACTERIOPHAGE; BINDING AFFINITY; DNA MICROARRAY; ENZYME INHIBITION; ENZYME KINETICS; ENZYME MECHANISM; HYDROLYSIS; PEPTIDE ARRAY; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; SPOT SYNTHESIS;

AMINO ACID SEQUENCE; BASE SEQUENCE; BETA-LACTAMASES; BINDING SITES; CLONING, MOLECULAR; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDE LIBRARY; PEPTIDES; PROTEIN ARRAY ANALYSIS; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

BACILLUS ANTHRACIS; BACTERIA (MICROORGANISMS);

EID: 0345600210     PISSN: 02692139     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Bush, K. (1998) Clin. Infect. Dis., 27, S48-S53.
2. Bush, K. (2002) Curr. Opin. Invest. Drugs, 3, 1284-1290.
3. Cantu, C., III, Huang, W. and Palzkill, T. (1996) J. Biol. Chem., 271, 22538-22545.
4. Carfi, A., Pares, S., Duee, E., Galleni, M., Duez, C., Frere, J.M. and Dideberg, O. (1995) EMBO J., 14, 4914-4921.
5. Cavallo, J.D., Ramisse, F., Girardet, M., Vaissaire, J., Mock, M. and Hernandez, E. (2002) Antimicrob. Agents Chemother., 46, 2307-2309.
6. Charnas, R. and Knowles, J. (1981) Biochemistry, 20, 2732-2737.
7. Chen, Y., Succi, J., Tenover, F.C. and Koehler, T.M. (2003) J. Bacteriol., 185, 823-830.
8. Cheng, Y. and Prusoff, W.H. (1973) Biochem. Pharmacol., 22, 3099-3108.
9. Clackson, T. and Wells, J. (1994) Trends Biotechnol., 12, 173-184.
10. Cochran, A.G. (2001) Curr. Opin. Chem. Biol., 5, 654-659.
11. Dostmann, W.R.G., Nickl, C., Thiel, S., Tsigelny, I., Frank, R. and Tegge, W.J. (1999) Pharmacol. Ther., 82, 373-387.
12. Dubus, A., Lendent, P., Lamotte-Brasseur, J. and Frere, J.-M. (1996) Proteins, 25, 473-485.
13. Frank, R. (1992) Tetrahedron, 48, 9217-9232.
14. Frere, J.M., Dubus, A., Galleni, M., Matagne, A. and Amicosante, G. (1999) Biochem. Soc. Trans., 27, 58-63.
15. Ghuysen, J.-M. (1991) Annu. Rev. Microbiol., 45, 37-67.
16. Henquell, C., Chanal, C., Sirot, D., Labia, R. and Sirot, J. (1995) Antimicrob. Agents Chemother., 39, 427-430.
17. Huang, W., Petrosino, J. and Palzkill, T. (1998) Antimicrob. Agents Chemother., 42, 2893-2897.
18. Imtiaz, U., Manavathu, E., Mobashery, S. and Lerner, S. (1994) Antimicrob. Agents Chemother., 38, 1134-1139.
19. Kemp, B.E., Graves, D.J., Benjamini, E. and Krebs, E.G. (1977) J. Biol. Chem., 252, 4888-4894.
20. Knoblauch, N.T.M., Rudiger, S., Schonfeld, H.J., Driessen, A.J.M., Schneider-Mergener, J. and Bukau, B. (1999) J. Biol. Chem., 274, 34219-34225.
21. Kramer, A., Volkmer-Engert, R., Malin, R., Reineke, U. and Schneider-Mergener, J. (1993) Pept. Res., 6, 314-319.
22. Kramer, A., Keitel, T., Winkler, K., Stocklein, W., Hohne, W. and Schneider-Mergener, J. (1997) Cell, 91, 799-809.
23. Kramer, A., Reineke, U., Dong, L., Hoffmann, B., Winkler, D., Volkmer-Engert, R. and Schneider-Mergener, J. (1999) J. Pept. Res., 54, 319-327.
24. Livermore, D.M. (1995) Clin. Microbiol. Rev., 8, 557-584.
25. Lobkovsky, E., Moews, P.C., Liu, H., Zhao, H., Frere, J.-M. and Knox, J.R. (1993) Proc. Natl Acad. Sci. USA, 90, 11257-11261.
26. Massova, I. and Mobashery, S. (1998) Antimicrob. Agents Chemother., 42, 1-17.
27. Materon, I.C. and Palzkill, T. (2001) Protein Sci., 10, 2556-2565.
28. Materon, I.C., Queenan, A.M., Koehler, T.M., Bush, K. and Palzkill, T. (2003) Antimicrob. Agents Chemother., 47, 2040-2042.
29. Nieto, M. and Perkins, H.R. (1971) Biochem. J., 123, 773-787.
30. Petrosino, J., Cantu, C., III, and Palzkill, T. (1998) Trends Microbiol., 6, 323-327.
31. Petrosino, J., Rudgers, G., Gilbert, H. and Palzkill, T. (1999) J. Biol. Chem., 274, 2394-2400.
32. Pomerantz, A.H., Allfrey, V.G., Merrifield, R.B. and Johnson, E.M. (1977) Proc. Natl Acad. Sci. USA, 74, 4261-4265.
33. Rasched, I. and Oberer, E. (1986) Microbiol. Rev., 50, 401-427.
34. Reimer, U., Reinke, U. and Schneider-Mergener, J. (2002) Curr. Opin. Biotechnol., 13, 315-320.
35. Reineke, U., Volkmer-Engert, R. and Schneider-Mergener, J. (2001) Curr. Opin. Biotechnol., 12, 59-64.
36. Ren, J., Nichols, C., Bird, L.E., Fujiwara, T., Sugimoto, H., Stuart, D.I. and Stammers, D.K. (2000) J. Biol. Chem., 275, 14316-14320.
37. Rudgers, G.W., Huang, W. and Palzkill, T. (2001) Antimicrob. Agents Chemother., 45, 3279-3286.
38. Smith, G.P. (1985) Science, 228, 1315-1317.
39. Smith, G.P. and Petrenko, V.A. (1997) Chem. Rev., 97, 391-410.
40. Strynadka, N.C.J., Jensen, S.E., Johns, K., Blanchard, H., Page, M., Matagne, A., Frere, J.-M. and James, M.N.G. (1994) Nature, 368, 657-660.
41. Strynadka, N.C.J., Jensen, S.E., Alzari, P.M. and James, M.N.G. (1996) Nat. Struct. Biol., 3, 290-297.
42. Wang, Z., Fast, W., Valentine, A.M. and Benkovic, S.J. (1999) Curr. Opin. Chem. Biol., 3, 614-622.
43. Wenschuh, H. et al. (2000) In Fenniri, H. (ed.), Combinatorial Chemistry: a Practical Approach. Oxford University Press, New York, pp. 95-116.
44. Wrighton, N.C., Farrell, F.X., Chang, R., Kashyap, A.K., Barbone, F.P., Mulcahy, L.S., Johnson, D.L., Barrett, R.W., Jolliffe, L.K. and Dower, W.J. (1996) Science, 273, 458-463.
45. Zhang, Z., Yu, Y., Musser, J.M. and Palzkill, T. (2001) J. Biol. Chem., 276, 46568-46574.