Highly specific, membrane-permeant peptide blockers of cGMP-dependent protein kinase Iα inhibit NO-induced cerebral dilation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 26, 2000, Pages 14772-14777

  Dostmann, Wolfgang R G ^a   Taylor, Mark S ^a   Nickl, Christian K ^a   Brayden, Joseph E ^a   Frank, Ronald ^b   Tegge, Werner J ^b  

^a UNIVERSITY OF VERMONT   (United States)

^b HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

Combinatorial libraries; Membrane translocation signal; Protein kinase inhibitor; Smooth muscle; SPOT method

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; CYCLIC GMP DEPENDENT PROTEIN KINASE; CYCLIC GMP DEPENDENT PROTEIN KINASE INHIBITOR; NITRIC OXIDE; PEPTIDE LIBRARY; TRANSACTIVATOR PROTEIN;

ANIMAL TISSUE; ARTERY DILATATION; ARTICLE; BINDING AFFINITY; BRAIN ARTERY; CONTROLLED STUDY; DROSOPHILA; ENZYME ASSAY; ENZYME BINDING; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; INHIBITION KINETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN SECRETION; RAT; SMOOTH MUSCLE CONTRACTILITY; VASCULAR SMOOTH MUSCLE;

ANIMALS; ARTERIES; CELL LINE; CELLS, CULTURED; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLIC GMP-DEPENDENT PROTEIN KINASES; ENZYME INHIBITORS; HUMANS; KINETICS; MUSCLE, SMOOTH, VASCULAR; NITRIC OXIDE; PEPTIDE LIBRARY; PEPTIDES; SPODOPTERA; TELENCEPHALON; VASODILATION;

EID: 0034687854     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.97.26.14772     Document Type: Article

References (28)

1. Lincoln, T. M., Komalavilas, P., Boerth, N. J., Mac-Millan-Crow, L. A. & Cornwell T. L. (1995) Adv. Pharmacol. (San Diego) 34, 305-322.
2. Pfeifer, A., Ruth, P., Dostmann, W., Sausbier, M., Klatt, P. & Hofmann, F. (1999) Rev. Physiol. Biochem. Pharmacol. 135, 105-149.
3. Surks, H. K., Mochizuki, N., Kasai, Y., Georgescu, S. P., Tang, K. M., Ito, M., Lincoln, T. M. & Mendelsohn, M. E. (1999) Science 286, 1583-1587.
4. Schlossmann, J., Ammendola, A., Ashman, K., Zong, X., Huber, A., Neubauer, G., Wang, G.-X., Allescher, H. D., Korth, M., Wilm, M., et al. (2000) Nature (London) 404, 197-201.
5. Pfeifer, A., Aszodi, A., Seidler, U., Ruth, P., Hofmann, F. & Fassler, R. (1996) Science 274, 2082-2086.
6. Pfeifer, A., Klatt, P., Massberg, S., Ny, L., Sausbier, M., Hirneiss, C., Wang, G. X., Korth, M., Aszodi, A., Andersson, K. E., et al. (1998) EMBO J. 17, 3045-3051.
7. Kennelly, P. J. & Krebs, E. G. (1991) J. Biol. Chem. 266, 15555-15558.
8. Glass, D. B., Cheng, H. C., Mende-Mueller, L., Reed, J. & Walsh, D. A. (1989) J. Biol. Chem. 264, 8802-8810.
9. Mitchell, R. D., Glass, D. B., Wong, C. W., Angelos, K. L. & Walsh, D. A. (1995) Biochemistry 34, 528-534.
10. Butt, E., Abel, K., Krieger, M., Palm, D., Hoppe, V., Hoppe, J. & Walter, U. (1994) J. Biol. Chem. 269, 14509-14517.
11. Yan, X., Corbin, J. D., Francis, S. H. & Lawrence, D. S. (1996) J. Biol. Chem. 271, 1845-1848.
12. Tegge, W., Frank, R., Hofmann, F. & Dostmann, W. R. (1995) Biochemistry 34, 10569-10577.
13. Dostmann, W. R., Nickl, C., Thiel, S., Tsigelny, I., Frank, R. & Tegge, W. (1999) J. Pharmacol. Ther. 82, 373-387.
14. Wood, J. S., Yan, X., Mendelow, M., Corbin, J. D., Francis, S. H. & Lawrence, D. S. (1996) J. Biol. Chem. 271, 174-179.
15. Lev-Ram, V., Jiang, T., Wood, J., Lawrence, D. S. & Tsien, R. Y. (1997) Neuron 18, 1025-1038.
16. Slice, L. W. & Taylor, S. S. (1989) J. Biol. Chem. 264, 20940-20946.
17. Dostmann, W. R. G., Koep, N. & Endres, R. (1996) FEBS Lett. 398, 206-210.
18. Frank, R. (1992) Tetrahedron 48, 9217-9232.
19. Ruth, P., Landgraf, W., Keilbach, A., May, B., Egleme, C. & Hofmann, F. (1991) Eur. J. Biochem. 202, 1339-1344.
20. Brayden, J. E. & Nelson, M. T. (1992) Science 256, 532-535.
21. Conway, M. A., Nelson, M. T. & Brayden, J. E. (1994) Am. J. Physiol. 266, H1322-H1326.
22. Hofmann, F., Gensheimer, H. P. & Gobel, C. (1985) Eur. J. Biochem. 147, 361-365.
23. Keilbach, A., Ruth, P. & Hofmann, F. (1992) Eur. J. Biochem. 208, 467-473.
24. Fawell, S., Seery, J., Daikh, Y., Moore, C., Chen, L. L., Pepinsky, B. & Barsoum, J. (1994) Proc. Natl. Acad. Sci. USA 91, 664-668.
25. Vivès, E., Brodin, P. & Lebleu, B. (1997) J. Biol. Chem. 272, 16010-16017.
26. Derossi, D., Chassaing, G. & Prochiantz, A. (1998) Trends Cell Biol. 8, 84-87.
27. Tegge, W. J. & Frank, R. (1998) Methods Mol. Biol. 87, 99-106.
28. Toomik, R. & Ek, P. (1997) Biochem. J. 322, 455-460.