PI3K/Akt Is Required for Heat Shock Proteins to Protect Hypoxia-inducible Factor 1α from pVHL-independent Degradation

Journal of Biological Chemistry

Volumn 279, Issue 14, 2004, Pages 13506-13513

  Zhou, Jie ^a   Schmid, Tobias ^a   Frank, Ronald ^b   Brüne, Bernhard ^a  

^a Rheinland Pfälzische Technische Universität Kaiserslautern Landau   (Germany)

^b HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; COMPOSITION; DEGRADATION; ENZYME INHIBITION; RNA; TUMORS;

HETERODIMERIC TRANSCRIPTION; HYPOXIA;

ENZYMES;

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 1BETA; MESSENGER RNA; OXYGEN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEASOME; PROTEIN KINASE B; UNCLASSIFIED DRUG; VON HIPPEL LINDAU PROTEIN; WORTMANNIN;

ADAPTATION; ARTICLE; CONTROLLED STUDY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYPOXIA; IMMUNOPRECIPITATION; KIDNEY CARCINOMA; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STABILITY; RNA TRANSLATION; STEADY STATE; UBIQUITINATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMINO ACID SEQUENCE; CELL HYPOXIA; CELL LINE; ENZYME INHIBITORS; GENE EXPRESSION; HSP70 HEAT-SHOCK PROTEINS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; KIDNEY; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN-PROTEIN LIGASES; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 1842691021     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M310164200     Document Type: Article

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