-
1
-
-
0032100706
-
Affinity dependence of the B cell response to antigen: A threshold, a ceiling, and the importance of off-rate
-
Batista F.D. and Neuberger M.S. 1998. Affinity dependence of the B cell response to antigen: A threshold, a ceiling, and the importance of off-rate. Immunity 8: 751.
-
(1998)
Immunity
, vol.8
, pp. 751
-
-
Batista, F.D.1
Neuberger, M.S.2
-
2
-
-
0027499308
-
Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: Clustering, polarity, and specific hot spots
-
Betz A.G., Rada C., Pannell R., Milstein C, and Neuberger M.S. 1993. Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: Clustering, polarity, and specific hot spots. Proc. Natl. Acad. Sci. 90: 2385.
-
(1993)
Proc. Natl. Acad. Sci.
, vol.90
, pp. 2385
-
-
Betz, A.G.1
Rada, C.2
Pannell, R.3
Milstein, C.4
Neuberger, M.S.5
-
3
-
-
0032525007
-
Enhanced B-1 cell development, but impaired IgG antibody responses in mice deficient in secreted IgM
-
Boes M., Esau C., Fischer M.B., Schmidt T., Carroll M., and Chen J. 1998. Enhanced B-1 cell development, but impaired IgG antibody responses in mice deficient in secreted IgM. J. Immunol. 160: 4776.
-
(1998)
J. Immunol.
, vol.160
, pp. 4776
-
-
Boes, M.1
Esau, C.2
Fischer, M.B.3
Schmidt, T.4
Carroll, M.5
Chen, J.6
-
4
-
-
0026587743
-
CD19: Lowering the threshold for antigen receptor stimulation of B lymphocytes
-
Carter R.H. and Fearon D.T. 1992. CD19: Lowering the threshold for antigen receptor stimulation of B lymphocytes. Science 256: 105.
-
(1992)
Science
, vol.256
, pp. 105
-
-
Carter, R.H.1
Fearon, D.T.2
-
5
-
-
0032522564
-
Ku80 is required for immunoglobulin isotype switching
-
Casellas R., Nussenzweig A., Wuerffel R., Pelanda R., Reichlin A., Suh H., Qin X.F., Besmer E., Kenter A., Rajewsky K., and Nussenzweig M.C. 1998. Ku80 is required for immunoglobulin isotype switching. EMBO J. 17: 2404.
-
(1998)
EMBO J.
, vol.17
, pp. 2404
-
-
Casellas, R.1
Nussenzweig, A.2
Wuerffel, R.3
Pelanda, R.4
Reichlin, A.5
Suh, H.6
Qin, X.F.7
Besmer, E.8
Kenter, A.9
Rajewsky, K.10
Nussenzweig, M.C.11
-
6
-
-
0030740148
-
Characterisation of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation
-
Chan V.W.F., Meng F., Soriano P., DeFranco A.L., and Lowell C.A.. 1997. Characterisation of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation. Immunity 7: 69.
-
(1997)
Immunity
, vol.7
, pp. 69
-
-
Chan, V.W.F.1
Meng, F.2
Soriano, P.3
DeFranco, A.L.4
Lowell, C.A.5
-
7
-
-
0343417077
-
Induction of somatic mutation in a human B cell line in vitro
-
Dénépoux S., Razanajaona D., Blanchard D., Meffre G., Capra J.D., Banchereau J., and Lebecque S. 1997. Induction of somatic mutation in a human B cell line in vitro. Immunity 6: 35.
-
(1997)
Immunity
, vol.6
, pp. 35
-
-
Dénépoux, S.1
Razanajaona, D.2
Blanchard, D.3
Meffre, G.4
Capra, J.D.5
Banchereau, J.6
Lebecque, S.7
-
8
-
-
0033564878
-
Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: Parallels with somatic hypermutation
-
Ehrenstein M.R. and Neuberger M.S. 1999. Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: Parallels with somatic hypermutation. EMBO J. 18: 3484.
-
(1999)
EMBO J.
, vol.18
, pp. 3484
-
-
Ehrenstein, M.R.1
Neuberger, M.S.2
-
9
-
-
0032544110
-
Targeted gene disruption reveals a role for natural secretory IgM in the maturation of the primary immune response
-
Ehrenstein M.R., O'Keefe T.L., Davies S.L., and Neuberger M.S. 1998. Targeted gene disruption reveals a role for natural secretory IgM in the maturation of the primary immune response. Proc. Natl. Acad. Sci. 95: 10089.
-
(1998)
Proc. Natl. Acad. Sci.
, vol.95
, pp. 10089
-
-
Ehrenstein, M.R.1
O'Keefe, T.L.2
Davies, S.L.3
Neuberger, M.S.4
-
10
-
-
0011647956
-
Regulation by membrane sialic acid of β1H-dependent decay-dissociation of amplification C3 convertase of the alternative pathway
-
Fearon D.T. 1978. Regulation by membrane sialic acid of β1H-dependent decay-dissociation of amplification C3 convertase of the alternative pathway. Proc. Natl. Acad. Sci. 75: 1971.
-
(1978)
Proc. Natl. Acad. Sci.
, vol.75
, pp. 1971
-
-
Fearon, D.T.1
-
11
-
-
0032127811
-
Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process
-
Frey S., Bertocci B., Delbos F., Quint L., Weill J.C., and Reynaud C.A. 1998. Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process. Immunity 9: 127.
-
(1998)
Immunity
, vol.9
, pp. 127
-
-
Frey, S.1
Bertocci, B.2
Delbos, F.3
Quint, L.4
Weill, J.C.5
Reynaud, C.A.6
-
12
-
-
0028177588
-
Cytokine-induced β-galactoside α-2,6-sialyltransferase in human endothelial cells mediates α-2,6-sialylation of adhesion molecules and CD22 ligands
-
Hanasaki K., Varki A., Stamenkovic I., and Bevilacqua M.P. 1994. Cytokine-induced β-galactoside α-2,6-sialyltransferase in human endothelial cells mediates α-2,6-sialylation of adhesion molecules and CD22 ligands. J. Biol. Chem. 269: 10637.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 10637
-
-
Hanasaki, K.1
Varki, A.2
Stamenkovic, I.3
Bevilacqua, M.P.4
-
13
-
-
0028784215
-
Multiple defects in the immune system of Lyn-deficient mice culminating in autoimmune disease
-
Hibbs M.L., Tarlinton D.M., Armes J., Grail D., Hodgson G., Maglitto R., Stacker S.A., and Dunn A.R. 1995. Multiple defects in the immune system of Lyn-deficient mice culminating in autoimmune disease. Cell 83: 301.
-
(1995)
Cell
, vol.83
, pp. 301
-
-
Hibbs, M.L.1
Tarlinton, D.M.2
Armes, J.3
Grail, D.4
Hodgson, G.5
Maglitto, R.6
Stacker, S.A.7
Dunn, A.R.8
-
14
-
-
0018317786
-
Human alternative complement pathway: Membrane-associated sialic acid regulates the competition between B and β1H for cell-bound C3b
-
Kazatchkine M.D., Fearon D.T., and Austen K.F. 1979. Human alternative complement pathway: Membrane-associated sialic acid regulates the competition between B and β1H for cell-bound C3b. J. Immunol. 122: 75.
-
(1979)
J. Immunol.
, vol.122
, pp. 75
-
-
Kazatchkine, M.D.1
Fearon, D.T.2
Austen, K.F.3
-
15
-
-
0032526290
-
Ku70 is required for late B cell development and immunoglobulin heavy chain class switching
-
Manis J.P., Gu Y., Lansford R., Sonoda E., Ferrini R., Davidson L., Rajewsky K., and Alt F.W. 1998. Ku70 is required for late B cell development and immunoglobulin heavy chain class switching. J. Exp. Med. 187: 2081.
-
(1998)
J. Exp. Med.
, vol.187
, pp. 2081
-
-
Manis, J.P.1
Gu, Y.2
Lansford, R.3
Sonoda, E.4
Ferrini, R.5
Davidson, L.6
Rajewsky, K.7
Alt, F.W.8
-
17
-
-
0028806216
-
Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice
-
Nishizumi H., Taniuchi I., Yamanashi Y., Kitamura D., Ilic D., Mon S., Watanabe T., and Yamamoto T. 1995. Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice. Immunity 3: 549.
-
(1995)
Immunity
, vol.3
, pp. 549
-
-
Nishizumi, H.1
Taniuchi, I.2
Yamanashi, Y.3
Kitamura, D.4
Ilic, D.5
Mon, S.6
Watanabe, T.7
Yamamoto, T.8
-
18
-
-
0031080328
-
CD22 is a negative regulator of B-cell receptor signalling
-
Nitschke L., Carsetti R., Ocker B., Köhler G., and Lamers M.C. 1997. CD22 is a negative regulator of B-cell receptor signalling. Curr. Biol. 7: 133.
-
(1997)
Curr. Biol.
, vol.7
, pp. 133
-
-
Nitschke, L.1
Carsetti, R.2
Ocker, B.3
Köhler, G.4
Lamers, M.C.5
-
19
-
-
0033583479
-
Deficiency in CD22, a B cell-specific inhibitory receptor, is sufficient to predispose to development of high affinity autoantibodies
-
O'Keefe T.L., Williams G.T., Batista F.D., and Neuberger M.S. 1999. Deficiency in CD22, a B cell-specific inhibitory receptor, is sufficient to predispose to development of high affinity autoantibodies. J. Exp. Med. 189: 1307.
-
(1999)
J. Exp. Med.
, vol.189
, pp. 1307
-
-
O'Keefe, T.L.1
Williams, G.T.2
Batista, F.D.3
Neuberger, M.S.4
-
21
-
-
0030467610
-
CD22 regulates thymus-independent responses and the lifespan of B cells
-
Otipoby K.L., Andersson K.B., Draves K.E., Klaus S.J., Farr A.G., Kerner J.D., Perlmutter R.M., Law C.-L., and Clark E.A. 1996. CD22 regulates thymus-independent responses and the lifespan of B cells. Nature 384: 634.
-
(1996)
Nature
, vol.384
, pp. 634
-
-
Otipoby, K.L.1
Andersson, K.B.2
Draves, K.E.3
Klaus, S.J.4
Farr, A.G.5
Kerner, J.D.6
Perlmutter, R.M.7
Law, C.-L.8
Clark, E.A.9
-
22
-
-
0032101611
-
Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein
-
Phung Q.H., Winter D.B., Cranston A., Tarone R.E., Bohr V.A., Fishel R., and Gearhart P.J. 1998. Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein. J. Exp. Med. 187: 1745.
-
(1998)
J. Exp. Med.
, vol.187
, pp. 1745
-
-
Phung, Q.H.1
Winter, D.B.2
Cranston, A.3
Tarone, R.E.4
Bohr, V.A.5
Fishel, R.6
Gearhart, P.J.7
-
23
-
-
0027511875
-
Natural ligands of the B cell adhesion molecule CD22 beta carry N-linked oligosaccharides with α-2,6-linked sialic acids that are required for recognition
-
Powell L.D., Sgroi D., Sjoberg E.R., Stamenkovic I., and Varki A. 1993. Natural ligands of the B cell adhesion molecule CD22 beta carry N-linked oligosaccharides with α-2,6-linked sialic acids that are required for recognition. J. Biol. Chem. 268: 7019.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 7019
-
-
Powell, L.D.1
Sgroi, D.2
Sjoberg, E.R.3
Stamenkovic, I.4
Varki, A.5
-
24
-
-
0032127804
-
Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting
-
Rada C., Ehrenstein M.R., Neuberger M.S., and Milstein C. 1998. Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting. Immunity 9: 135.
-
(1998)
Immunity
, vol.9
, pp. 135
-
-
Rada, C.1
Ehrenstein, M.R.2
Neuberger, M.S.3
Milstein, C.4
-
25
-
-
0032473556
-
A novel sialic acid binding site on factor H mediates serum resistance of sialylated Neisseria gonorrhoeae
-
Ram S., Sharma A.K., Simpson S.D., Gulati S., McQuillen D.P., Pangburn M.K., and Rice P.A. 1998. A novel sialic acid binding site on factor H mediates serum resistance of sialylated Neisseria gonorrhoeae J. Exp. Med. 187: 743.
-
(1998)
J. Exp. Med.
, vol.187
, pp. 743
-
-
Ram, S.1
Sharma, A.K.2
Simpson, S.D.3
Gulati, S.4
McQuillen, D.P.5
Pangburn, M.K.6
Rice, P.A.7
-
26
-
-
0030273141
-
The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching
-
Rolink A., Melchers F., and Andersson J. 1996. The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching. Immunity 5: 319.
-
(1996)
Immunity
, vol.5
, pp. 319
-
-
Rolink, A.1
Melchers, F.2
Andersson, J.3
-
27
-
-
0032435650
-
TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line
-
Sale J.E. and Neuberger M.S. 1998. TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line. Immunity 9: 859.
-
(1998)
Immunity
, vol.9
, pp. 859
-
-
Sale, J.E.1
Neuberger, M.S.2
-
28
-
-
0030499431
-
CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: Altered signaling in CD22-deficient mice
-
Sato S., Miller A.S., Inaoki M., Bock C.B., Jansen P.J., Tang M.L.K., and Tedder T.F. 1996. CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: Altered signaling in CD22-deficient mice. Immunity 5: 551.
-
(1996)
Immunity
, vol.5
, pp. 551
-
-
Sato, S.1
Miller, A.S.2
Inaoki, M.3
Bock, C.B.4
Jansen, P.J.5
Tang, M.L.K.6
Tedder, T.F.7
-
29
-
-
0017105510
-
Motheaten, an immunodeficient mutant of the mouse. II. Depressed immune competence and elevated serum immunoglobulins
-
Shultz L.D. and Green M.C. 1976. Motheaten, an immunodeficient mutant of the mouse. II. Depressed immune competence and elevated serum immunoglobulins. J. Immunol. 116: 936.
-
(1976)
J. Immunol.
, vol.116
, pp. 936
-
-
Shultz, L.D.1
Green, M.C.2
-
30
-
-
0030022218
-
Antibody class switching
-
Stavnezer J. 1996. Antibody class switching. Adv. Immunol. 61: 79.
-
(1996)
Adv. Immunol.
, vol.61
, pp. 79
-
-
Stavnezer, J.1
-
31
-
-
0028109655
-
The diversity of antigen-specific monoclonal antibodies from transgenic mice bearing human immunoglobulin gene miniloci
-
Wagner S.D., Popov A.V., Davies S.L., Xian J., Neuberger M.S., and Brüggemann M. 1994. The diversity of antigen-specific monoclonal antibodies from transgenic mice bearing human immunoglobulin gene miniloci. Eur. J. Immunol. 24: 2672.
-
(1994)
Eur. J. Immunol.
, vol.24
, pp. 2672
-
-
Wagner, S.D.1
Popov, A.V.2
Davies, S.L.3
Xian, J.4
Neuberger, M.S.5
Brüggemann, M.6
|