-
1
-
-
0034268780
-
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
-
Muramatsu, M., K. Kinoshita, S. Fagarasan, S. Yamada, Y. Shinkai, and T. Honjo. 2000. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell. 102:553-563.
-
(2000)
Cell
, vol.102
, pp. 553-563
-
-
Muramatsu, M.1
Kinoshita, K.2
Fagarasan, S.3
Yamada, S.4
Shinkai, Y.5
Honjo, T.6
-
2
-
-
12744259733
-
Activation-induced deaminase: Controversies and open questions
-
Barreto, V.M., A.R. Ramiro, and M.C. Nussenzweig. 2005. Activation-induced deaminase: controversies and open questions. Trends Immunol. 26:90-96.
-
(2005)
Trends Immunol.
, vol.26
, pp. 90-96
-
-
Barreto, V.M.1
Ramiro, A.R.2
Nussenzweig, M.C.3
-
3
-
-
0037076967
-
AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts
-
Yoshikawa, K., I.M. Okazaki, T. Eto, K. Kinoshita, M. Muramatsu, H. Nagaoka, and T. Honjo. 2002, AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts. Science. 296:2033-2036.
-
(2002)
Science
, vol.296
, pp. 2033-2036
-
-
Yoshikawa, K.1
Okazaki, I.M.2
Eto, T.3
Kinoshita, K.4
Muramatsu, M.5
Nagaoka, H.6
Honjo, T.7
-
4
-
-
0037625159
-
What role for AID: Mutator, or assembler of the immunoglobulin mutasome?
-
Reynaud, C.-A., S. Aoufouchi, A. Faili, and J.-C. Weill. 2003. What role for AID: mutator, or assembler of the immunoglobulin mutasome? Nat. Immunol. 4:631-638.
-
(2003)
Nat. Immunol.
, vol.4
, pp. 631-638
-
-
Reynaud, C.-A.1
Aoufouchi, S.2
Faili, A.3
Weill, J.-C.4
-
5
-
-
6344256944
-
Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T focused phase of somatic mutation
-
Rada, C., J.M. Di Noia, and M.S. Neuberger. 2004. Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T focused phase of somatic mutation. Mol. Cell. 16:163-171.
-
(2004)
Mol. Cell
, vol.16
, pp. 163-171
-
-
Rada, C.1
Di Noia, J.M.2
Neuberger, M.S.3
-
6
-
-
0037108463
-
Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice
-
Rada, C., G.T. Williams, H. Nilsen, D.E. Barnes, T. Lindahl, and M.S. Neuberger. 2002. Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice. Curr. Biol. 12:1748-1755.
-
(2002)
Curr. Biol.
, vol.12
, pp. 1748-1755
-
-
Rada, C.1
Williams, G.T.2
Nilsen, H.3
Barnes, D.E.4
Lindahl, T.5
Neuberger, M.S.6
-
7
-
-
0032127804
-
Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting
-
Rada, C., M.R. Ehrenstein, M.S. Neuberger, and C. Milstein. 1998. Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting. Immunity. 9:135-141.
-
(1998)
Immunity
, vol.9
, pp. 135-141
-
-
Rada, C.1
Ehrenstein, M.R.2
Neuberger, M.S.3
Milstein, C.4
-
8
-
-
0032127811
-
Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process
-
Frey, S., B. Bertocci, F. Delbos, L. Quint, J.C. Weill, and C.A. Reynaud. 1998. Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process. Immunity. 9:127-134.
-
(1998)
Immunity
, vol.9
, pp. 127-134
-
-
Frey, S.1
Bertocci, B.2
Delbos, F.3
Quint, L.4
Weill, J.C.5
Reynaud, C.A.6
-
9
-
-
0032101611
-
Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein
-
Phung, Q.H., D.B. Winter, A. Cranston, R.E. Tarone, V.A. Bohr, R. Fishel, and P.J. Gearhart. 1998. Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein. J. Exp. Med. 187:1745-1751.
-
(1998)
J. Exp. Med.
, vol.187
, pp. 1745-1751
-
-
Phung, Q.H.1
Winter, D.B.2
Cranston, A.3
Tarone, R.E.4
Bohr, V.A.5
Fishel, R.6
Gearhart, P.J.7
-
10
-
-
0034614916
-
Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern
-
Wiesendanger, M., B. Kneitz, W. Edelmann, and M.D. Scharff. 2000. Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern. J. Exp. Med. 191:579-584.
-
(2000)
J. Exp. Med.
, vol.191
, pp. 579-584
-
-
Wiesendanger, M.1
Kneitz, B.2
Edelmann, W.3
Scharff, M.D.4
-
11
-
-
0142250270
-
Msh2 ATPase activity is essential for somatic hypermutation at A-T base pairs and for efficient class switching
-
Martin, A., Z. Li, D.P. Lin, P.D. Bardwell, M.D. Iglesias-Ussel, W. Edelman, and M.D. Scharff. 2003. Msh2 ATPase activity is essential for somatic hypermutation at A-T base pairs and for efficient class switching. J. Exp. Med. 198:1171-1178.
-
(2003)
J. Exp. Med.
, vol.198
, pp. 1171-1178
-
-
Martin, A.1
Li, Z.2
Lin, D.P.3
Bardwell, P.D.4
Iglesias-Ussel, M.D.5
Edelman, W.6
Scharff, M.D.7
-
12
-
-
1142299546
-
Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice
-
Bardwell, P.D., C.J. Woo, K. Wei, Z. Li, A. Martin, S.Z. Sack, T. Parris, W. Edelman, and M.D. Scharff. 2004. Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice. Nat. Immunol. 5:224-229.
-
(2004)
Nat. Immunol.
, vol.5
, pp. 224-229
-
-
Bardwell, P.D.1
Woo, C.J.2
Wei, K.3
Li, Z.4
Martin, A.5
Sack, S.Z.6
Parris, T.7
Edelman, W.8
Scharff, M.D.9
-
13
-
-
3142663166
-
A role for Msh6 but not Msh3 in somatic hypermutation and class switch recombination
-
Martomo, S.A., W.W. Yang, and P.J. Gearhart. 2004. A role for Msh6 but not Msh3 in somatic hypermutation and class switch recombination. J. Exp. Med. 200:61-68.
-
(2004)
J. Exp. Med.
, vol.200
, pp. 61-68
-
-
Martomo, S.A.1
Yang, W.W.2
Gearhart, P.J.3
-
14
-
-
0037415391
-
Functions of human DNA polymerases eta, kappa and iota suggested by their properties, including fidelity with undamaged DNA templates
-
Kunkel, T.A., Y.I. Pavlov, and K. Bebenek. 2003. Functions of human DNA polymerases eta, kappa and iota suggested by their properties, including fidelity with undamaged DNA templates. DNA Repair (Amst.). 2:135-149.
-
(2003)
DNA Repair (Amst.)
, vol.2
, pp. 135-149
-
-
Kunkel, T.A.1
Pavlov, Y.I.2
Bebenek, K.3
-
15
-
-
0033578040
-
The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta
-
Masutani, C., R. Kusumoto, A. Yamada, N. Dohmae, M. Yokoi, M. Yuasa, M. Araki, S. Iwai, K. Takio, and F. Hanaoka. 1999. The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta. Nature. 399:700-704.
-
(1999)
Nature
, vol.399
, pp. 700-704
-
-
Masutani, C.1
Kusumoto, R.2
Yamada, A.3
Dohmae, N.4
Yokoi, M.5
Yuasa, M.6
Araki, M.7
Iwai, S.8
Takio, K.9
Hanaoka, F.10
-
16
-
-
0035377269
-
DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes
-
Zeng, X., D.B. Winter, C. Kasmer, K.H. Kraemer, A.R. Lehmann, and P.J. Gearhart. 2001. DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes. Nat. Immunol. 2:537-541.
-
(2001)
Nat. Immunol.
, vol.2
, pp. 537-541
-
-
Zeng, X.1
Winter, D.B.2
Kasmer, C.3
Kraemer, K.H.4
Lehmann, A.R.5
Gearhart, P.J.6
-
17
-
-
1642499721
-
DNA polymerase ε is involved in hypermutation occurring during immunoglobulin class switch recombination
-
Faili, A., S. Aoufouchi, S. Weller, F. Vuillier, A. Stary, A. Sarasin, C.A. Reynaud, and J.C. Weill. 2004. DNA polymerase ε is involved in hypermutation occurring during immunoglobulin class switch recombination. J. Exp. Med. 199:265-270.
-
(2004)
J. Exp. Med.
, vol.199
, pp. 265-270
-
-
Faili, A.1
Aoufouchi, S.2
Weller, S.3
Vuillier, F.4
Stary, A.5
Sarasin, A.6
Reynaud, C.A.7
Weill, J.C.8
-
18
-
-
1842732235
-
Absence of DNA polymerase ε reveals targeting of C mutations on the nontranscribed strand in immunoglobulin switch regions
-
Zeng, X., G.A. Negrete, C. Kasmer, W.W. Yang, and P.J. Gearhart. 2004. Absence of DNA polymerase ε reveals targeting of C mutations on the nontranscribed strand in immunoglobulin switch regions. J. Exp. Med. 199:917-924.
-
(2004)
J. Exp. Med.
, vol.199
, pp. 917-924
-
-
Zeng, X.1
Negrete, G.A.2
Kasmer, C.3
Yang, W.W.4
Gearhart, P.J.5
-
19
-
-
18744413609
-
Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells
-
Kannouche, P., A.R. Fernandez de Henestrosa, B. Coull, A.E. Vidal, C. Gray, D. Zicha, R. Woodgate, and A.R. Lehmann. 2002. Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells. EMBO J. 21:6246-6256.
-
(2002)
EMBO J.
, vol.21
, pp. 6246-6256
-
-
Kannouche, P.1
Fernandez De Henestrosa, A.R.2
Coull, B.3
Vidal, A.E.4
Gray, C.5
Zicha, D.6
Woodgate, R.7
Lehmann, A.R.8
-
20
-
-
0037206851
-
Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota
-
Faili, A., S. Aoufouchi, E. Flatter, Q. Guéranger, C.-A. Reynaud, and J.-C. Weill. 2002. Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota. Nature. 419:944-947.
-
(2002)
Nature
, vol.419
, pp. 944-947
-
-
Faili, A.1
Aoufouchi, S.2
Flatter, E.3
Guéranger, Q.4
Reynaud, C.-A.5
Weill, J.-C.6
-
21
-
-
0042422042
-
129-Derived strains of mice are deficient in DNA polymerase iota and have normal immunoglobulin hypermutation
-
McDonald, J.P., E.G. Frank, B.S. Plosky, I.B. Rogozin, C. Masutani, F. Hanaoka, R. Woodgate, and P.J. Gearhart. 2003. 129-derived strains of mice are deficient in DNA polymerase iota and have normal immunoglobulin hypermutation. J. Exp. Med. 198:635-643.
-
(2003)
J. Exp. Med.
, vol.198
, pp. 635-643
-
-
McDonald, J.P.1
Frank, E.G.2
Plosky, B.S.3
Rogozin, I.B.4
Masutani, C.5
Hanaoka, F.6
Woodgate, R.7
Gearhart, P.J.8
-
22
-
-
0035399804
-
Decreased frequency of somatic hypermutation and impaired affinity maturation but intact germinal center formation in mice expressing anti-sense RNA to DNA polymerase zeta
-
Diaz, M., L.K. Verkoczy, M.F. Flajnik, and N.R. Klinman. 2001. Decreased frequency of somatic hypermutation and impaired affinity maturation but intact germinal center formation in mice expressing anti-sense RNA to DNA polymerase zeta. J. Immunol. 167:327-335.
-
(2001)
J. Immunol.
, vol.167
, pp. 327-335
-
-
Diaz, M.1
Verkoczy, L.K.2
Flajnik, M.F.3
Klinman, N.R.4
-
23
-
-
0035005241
-
The translesion DNA polymerase zeta plays a major role in Ig and bcl-6 somatic hypermutation
-
Zan, H., A. Komori, Z. Li, A. Cerutti, A. Schaffer, M.F. Flajnik, M. Diaz, and P. Casali. 2001. The translesion DNA polymerase zeta plays a major role in Ig and bcl-6 somatic hypermutation. Immunity. 14:643-653.
-
(2001)
Immunity
, vol.14
, pp. 643-653
-
-
Zan, H.1
Komori, A.2
Li, Z.3
Cerutti, A.4
Schaffer, A.5
Flajnik, M.F.6
Diaz, M.7
Casali, P.8
-
24
-
-
0035012235
-
Acidic residues critical for the activity and biological function of yeast DNA polymerase eta
-
Kondratick, C.M., M.T. Washington, S. Prakash, and L. Prakash. 2001. Acidic residues critical for the activity and biological function of yeast DNA polymerase eta. Mol. Cell. Biol. 21:2018-2025.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 2018-2025
-
-
Kondratick, C.M.1
Washington, M.T.2
Prakash, S.3
Prakash, L.4
-
25
-
-
0942268173
-
Xeroderma pigmentosum variant and error-prone DNA polymerases
-
Kannouche, P., and A. Stary. 2003. Xeroderma pigmentosum variant and error-prone DNA polymerases. Biochimie. 85:1123-1132.
-
(2003)
Biochimie
, vol.85
, pp. 1123-1132
-
-
Kannouche, P.1
Stary, A.2
-
26
-
-
0034671730
-
Fidelity and processivity of DNA synthesis by DNA polymerase kappa, the product of the human DINB1 gene
-
Ohmori, and T.A. Kunkel. 2000. Fidelity and processivity of DNA synthesis by DNA polymerase kappa, the product of the human DINB1 gene. J. Biol. Chem. 275:39678-3984.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 39678-43984
-
-
Ohmori1
Kunkel, T.A.2
-
27
-
-
0034327552
-
Human DNA polymerase kappa synthesizes DNA with extraordinarily low fidelity
-
Zhang, Y., F. Yuan, H. Xin, X. Wu, D.K. Rajpal, D. Yang, and Z. Wang. 2000. Human DNA polymerase kappa synthesizes DNA with extraordinarily low fidelity. Nucleic Acids Res. 28:4147-4156.
-
(2000)
Nucleic Acids Res.
, vol.28
, pp. 4147-4156
-
-
Zhang, Y.1
Yuan, F.2
Xin, H.3
Wu, X.4
Rajpal, D.K.5
Yang, D.6
Wang, Z.7
-
28
-
-
0036859318
-
DNA polymerase kappa deficiency does not affect somatic hypermutation in mice
-
Schenten, D., V.L. Gerlach, C. Guo, S. Velasco-Miguel, C.L. Hladik, C.L. White, E.C. Friedberg, K. Rajewsky, and G. Esposito. 2002. DNA polymerase kappa deficiency does not affect somatic hypermutation in mice. Eur. J. Immunol. 32:3152-3160.
-
(2002)
Eur. J. Immunol.
, vol.32
, pp. 3152-3160
-
-
Schenten, D.1
Gerlach, V.L.2
Guo, C.3
Velasco-Miguel, S.4
Hladik, C.L.5
White, C.L.6
Friedberg, E.C.7
Rajewsky, K.8
Esposito, G.9
-
29
-
-
0035158355
-
Highly frequent frameshift synthesis by human DNA polymerase mu
-
Zhang, Y., X. Wu, F. Yuan, Z. Xie, and Z. Wang. 2001. Highly frequent frameshift synthesis by human DNA polymerase mu. Mol. Cell. Biol. 21:7995-8006.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 7995-8006
-
-
Zhang, Y.1
Wu, X.2
Yuan, F.3
Xie, Z.4
Wang, Z.5
-
30
-
-
0037388452
-
Rev1 is essential for DNA damage tolerance and non-templated immunoglobulin gene mutation in a vertebrate cell line
-
Simpson, L.J., and J.E. Sale. 2003. Rev1 is essential for DNA damage tolerance and non-templated immunoglobulin gene mutation in a vertebrate cell line. EMBO J. 22:1654-1664.
-
(2003)
EMBO J.
, vol.22
, pp. 1654-1664
-
-
Simpson, L.J.1
Sale, J.E.2
-
31
-
-
4344700569
-
Replication protein A interacts with AID to promote deamination of somatic hypermutation targets
-
Chaudhuri, J., C. Khuong, and F.W. Alt. 2004. Replication protein A interacts with AID to promote deamination of somatic hypermutation targets. Nature. 430:992-998.
-
(2004)
Nature
, vol.430
, pp. 992-998
-
-
Chaudhuri, J.1
Khuong, C.2
Alt, F.W.3
-
32
-
-
1642488349
-
Hepatitis C virus induces a mutator phenotype: Enhanced mutations of immunoglobulin and protooncogenes
-
Machida, K., K.T. Cheng, V.M. Sung, S. Shimodaira, K.L. Lindsay, A.M. Levine, M.Y. Lai, and M.M. Lai. 2004. Hepatitis C virus induces a mutator phenotype: enhanced mutations of immunoglobulin and protooncogenes. Proc. Natl. Acad. Sci. USA. 101:4262-4267.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 4262-4267
-
-
Machida, K.1
Cheng, K.T.2
Sung, V.M.3
Shimodaira, S.4
Lindsay, K.L.5
Levine, A.M.6
Lai, M.Y.7
Lai, M.M.8
-
33
-
-
3543122310
-
Hepatitis C virus infection activates the immunologic (type II) isoform of nitric oxide synthase and thereby enhances DNA damage and mutations of cellular genes
-
Machida, K., K.T. Cheng, V.M. Sung, K.J. Lee, A.M. Levine, and M.M. Lai. 2004. Hepatitis C virus infection activates the immunologic (type II) isoform of nitric oxide synthase and thereby enhances DNA damage and mutations of cellular genes. J. Virol. 78:8835-8843.
-
(2004)
J. Virol.
, vol.78
, pp. 8835-8843
-
-
Machida, K.1
Cheng, K.T.2
Sung, V.M.3
Lee, K.J.4
Levine, A.M.5
Lai, M.M.6
-
34
-
-
0028059099
-
Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting
-
Gu, H., J.D. Marth, P.C. Orban, H. Mossmann, and K. Rajewsky. 1994. Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting. Science. 265:103-106.
-
(1994)
Science
, vol.265
, pp. 103-106
-
-
Gu, H.1
Marth, J.D.2
Orban, P.C.3
Mossmann, H.4
Rajewsky, K.5
-
36
-
-
0037090311
-
DNA polymerases mu and lambda are dispeasable for Ig gene hypermutation
-
Bertocci, B., A. De Smet, E. Flatter, A. Dahan, J.C. Bories, C. Landreau, J.C. Weill, and C.A. Reynaud. 2002. DNA polymerases mu and lambda are dispeasable for Ig gene hypermutation. J. Immunol. 168:3702-3706.
-
(2002)
J. Immunol.
, vol.168
, pp. 3702-3706
-
-
Bertocci, B.1
De Smet, A.2
Flatter, E.3
Dahan, A.4
Bories, J.C.5
Landreau, C.6
Weill, J.C.7
Reynaud, C.A.8
|