메뉴 건너뛰기




Volumn 8, Issue 9, 2006, Pages 647-663

Somatic stem cells and the origin of cancer

Author keywords

Cancer; Cancer stem cells; Leukemia; Micro RNAS; Telomerase

Indexed keywords

ALPHA INTERFERON; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; DAUNORUBICIN; IDARUBICIN; IMATINIB; MICRORNA; TELOMERASE;

EID: 33750625937     PISSN: 1699048X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12094-006-0035-7     Document Type: Article
Times cited : (51)

References (233)
  • 1
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000;100:57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 4043181214 scopus 로고    scopus 로고
    • Cancer genes and the pathways they control
    • Vogelstein B, Kinzler KW. Cancer genes and the pathways they control. Nat Med. 2004;10:789-99.
    • (2004) Nat Med , vol.10 , pp. 789-799
    • Vogelstein, B.1    Kinzler, K.W.2
  • 4
    • 0345059767 scopus 로고    scopus 로고
    • Applying the principles of stem-cell biology to cancer
    • Pardal R, Clarke MF, Morrison SJ. Applying the principles of stem-cell biology to cancer. Nat Rev Cancer. 2003;3:895-902.
    • (2003) Nat Rev Cancer , vol.3 , pp. 895-902
    • Pardal, R.1    Clarke, M.F.2    Morrison, S.J.3
  • 5
    • 3242781055 scopus 로고    scopus 로고
    • Cancer stem cells refined
    • Scadden DT. Cancer stem cells refined. Nat Immunol. 2004;5:701-3.
    • (2004) Nat Immunol , vol.5 , pp. 701-703
    • Scadden, D.T.1
  • 6
    • 85047690508 scopus 로고    scopus 로고
    • Opinion: The origin of the cancer stem cell: Current controversies and new insights
    • Bjerkvig R, Tysnes BB, Aboody KS, Najbauer J, Terzis AJ. Opinion: The origin of the cancer stem cell: Current controversies and new insights. Nat Rev Cancer. 2005;5:899-904.
    • (2005) Nat Rev Cancer , vol.5 , pp. 899-904
    • Bjerkvig, R.1    Tysnes, B.B.2    Aboody, K.S.3    Najbauer, J.4    Terzis, A.J.5
  • 7
    • 33644826473 scopus 로고    scopus 로고
    • Roots and stems: Stem cells in cancer
    • Polyak K, Hahn WC. Roots and stems: Stem cells in cancer. Nat Med. 2006;12: 296-300.
    • (2006) Nat Med , vol.12 , pp. 296-300
    • Polyak, K.1    Hahn, W.C.2
  • 8
    • 30644471961 scopus 로고    scopus 로고
    • Stem cells in the etiology and treatment of cancer
    • Zhang M, Rosen JM. Stem cells in the etiology and treatment of cancer. Curr Opin Genet Dev. 2006;16:60-4.
    • (2006) Curr Opin Genet Dev , vol.16 , pp. 60-64
    • Zhang, M.1    Rosen, J.M.2
  • 9
    • 33646045010 scopus 로고    scopus 로고
    • Stem cells and cancer: Two faces of eve
    • Clarke MF, Fuller M. Stem cells and cancer: Two faces of eve. Cell. 2006;124:1111-5.
    • (2006) Cell , vol.124 , pp. 1111-1115
    • Clarke, M.F.1    Fuller, M.2
  • 10
    • 0017785769 scopus 로고
    • Primary bioassay of human tumor stem cells
    • Hamburger AW, Salmon SE. Primary bioassay of human tumor stem cells. Science. 1977;197:461-3.
    • (1977) Science , vol.197 , pp. 461-463
    • Hamburger, A.W.1    Salmon, S.E.2
  • 11
    • 0028091194 scopus 로고
    • A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
    • Lapidot T, Sirard C, Vormoor J, et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature. 1994;567:645-8.
    • (1994) Nature , vol.567 , pp. 645-648
    • Lapidot, T.1    Sirard, C.2    Vormoor, J.3
  • 13
    • 9244241576 scopus 로고    scopus 로고
    • Identification of human brain tumour initiating cells
    • Singh SK, Hawkins C, Clarke ID, et al. Identification of human brain tumour initiating cells. Nature. 2004;432:396-401.
    • (2004) Nature , vol.432 , pp. 396-401
    • Singh, S.K.1    Hawkins, C.2    Clarke, I.D.3
  • 14
    • 19044397160 scopus 로고    scopus 로고
    • Epidermal growth factor receptor and Ink4a/Arf: Convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis
    • Bachoo RM, Maher EA, Ligon KL, et al. Epidermal growth factor receptor and Ink4a/Arf: Convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell. 2002;1:269-77.
    • (2002) Cancer Cell , vol.1 , pp. 269-277
    • Bachoo, R.M.1    Maher, E.A.2    Ligon, K.L.3
  • 15
    • 49849103966 scopus 로고    scopus 로고
    • Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors
    • Cozzio A, Passague E, Ayton PM, Karsunky H, Cleary ML, Weissman IL. Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors. Genes Dev. 2005;17: 5029-55.
    • (2005) Genes Dev , vol.17 , pp. 5029-5055
    • Cozzio, A.1    Passague, E.2    Ayton, P.M.3    Karsunky, H.4    Cleary, M.L.5    Weissman, I.L.6
  • 16
    • 0018149630 scopus 로고
    • Histopathology and prognosis of Wilms tumors: Results from the First National Wilms' Tumor Study
    • Beckwith JB, Palmer NF. Histopathology and prognosis of Wilms tumors: results from the First National Wilms' Tumor Study. Cancer. 1978;41:1937-48.
    • (1978) Cancer , vol.41 , pp. 1937-1948
    • Beckwith, J.B.1    Palmer, N.F.2
  • 17
    • 0021226066 scopus 로고
    • Histopathologic prognostic factors in neuroblastic tumors: Definition of subtypes of ganglioneuroblastoma and an age-linked classification of neuroblastomas
    • Shimada H, Chatten J, Newton WA, Jr., et al. Histopathologic prognostic factors in neuroblastic tumors: Definition of subtypes of ganglioneuroblastoma and an age-linked classification of neuroblastomas. J Natl Cancer Inst. 1984;73:405-16.
    • (1984) J Natl Cancer Inst , vol.73 , pp. 405-416
    • Shimada, H.1    Chatten, J.2    Newton Jr., W.A.3
  • 18
    • 0346644386 scopus 로고    scopus 로고
    • Focus on embryonal malignancies
    • Maris JM, Denny CT. Focus on embryonal malignancies. Cancer Cell. 2002;2:447-50.
    • (2002) Cancer Cell , vol.2 , pp. 447-450
    • Maris, J.M.1    Denny, C.T.2
  • 19
    • 0018161298 scopus 로고
    • Teratomas, neoplasia and differentiation: A biological overview. I. The natural history of teratomas
    • O'Hare MJ. Teratomas, neoplasia and differentiation: A biological overview. I. The natural history of teratomas. Invest Cell Pathol. 1978;1:39-65.
    • (1978) Invest Cell Pathol , vol.1 , pp. 39-65
    • O'Hare, M.J.1
  • 20
    • 33645868964 scopus 로고    scopus 로고
    • Pediatric solid malignancies: Neuroblastoma and Wilms' tumor
    • xi
    • Kim S, Chung DH. Pediatric solid malignancies: Neuroblastoma and Wilms' tumor. Surg Clin North Am. 2006;86:469-87, xi.
    • (2006) Surg Clin North Am , vol.86 , pp. 469-487
    • Kim, S.1    Chung, D.H.2
  • 21
    • 84959796172 scopus 로고
    • Successful skin homografts after the administration of high dosage X radiation and homologous bone marrow
    • Main JM, Prelm RT. Successful skin homografts after the administration of high dosage X radiation and homologous bone marrow. J Natl Cancer Inst. 1955;15:1023-9.
    • (1955) J Natl Cancer Inst , vol.15 , pp. 1023-1029
    • Main, J.M.1    Prelm, R.T.2
  • 22
    • 84956427297 scopus 로고
    • A direct measurement of the radiation sensitivity of normal mouse bone marrow cells
    • Till JE, Mc CE. A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiat Res. 1961;14: 213-22.
    • (1961) Radiat Res , vol.14 , pp. 213-222
    • Till, J.E.1    Mc, C.E.2
  • 23
    • 0026535505 scopus 로고
    • Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system
    • Reynolds BA, Weiss S. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science. 1992;255:1707-10.
    • (1992) Science , vol.255 , pp. 1707-1710
    • Reynolds, B.A.1    Weiss, S.2
  • 24
    • 4444290010 scopus 로고    scopus 로고
    • Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche
    • Blanpain C, Lowry WE, Geoghegan A, Polak L, Fuchs E. Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche. Cell. 2004;118:635-48.
    • (2004) Cell , vol.118 , pp. 635-648
    • Blanpain, C.1    Lowry, W.E.2    Geoghegan, A.3    Polak, L.4    Fuchs, E.5
  • 25
    • 0031748344 scopus 로고    scopus 로고
    • An entire functional mammary gland may comprise the progeny from a single cell
    • Kordon EC, Smith GH. An entire functional mammary gland may comprise the progeny from a single cell. Development. 1998;125:1921-30.
    • (1998) Development , vol.125 , pp. 1921-1930
    • Kordon, E.C.1    Smith, G.H.2
  • 26
    • 0037019337 scopus 로고    scopus 로고
    • Pluripotency of mesenchymal stem cells derived from adult marrow
    • Jiang Y, Jahagirdar BN, Reinhardt RL, et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature. 2002;418:41-9.
    • (2002) Nature , vol.418 , pp. 41-49
    • Jiang, Y.1    Jahagirdar, B.N.2    Reinhardt, R.L.3
  • 28
    • 0034629129 scopus 로고    scopus 로고
    • Hematopoietic stem cell quiescence maintained by p21cip1/wafl
    • Cheng T, Rodrigues N, Shen H, et al. Hematopoietic stem cell quiescence maintained by p21cip1/wafl. Science. 2000; 287:1804-8.
    • (2000) Science , vol.287 , pp. 1804-1808
    • Cheng, T.1    Rodrigues, N.2    Shen, H.3
  • 29
    • 0015008867 scopus 로고
    • Mouse myeloma tumor stem cells: A primary cell culture assay
    • Park CH, Bergsagel DE, McCulloch EA. Mouse myeloma tumor stem cells: A primary cell culture assay. J Natl Cancer Inst. 1971;46:411-22.
    • (1971) J Natl Cancer Inst , vol.46 , pp. 411-422
    • Park, C.H.1    Bergsagel, D.E.2    McCulloch, E.A.3
  • 30
    • 0002740313 scopus 로고
    • A Quantitative Assay For The Number Of Murine Lymphoma Cells Capable Of Proliferation In Vivo
    • Bruce WR, Van Der Gaag H. A Quantitative Assay For The Number Of Murine Lymphoma Cells Capable Of Proliferation In Vivo. Nature. 1965;199:79-80.
    • (1965) Nature , vol.199 , pp. 79-80
    • Bruce, W.R.1    Van Der Gaag, H.2
  • 32
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med. 1997;3:730-7.
    • (1997) Nat Med , vol.3 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 33
    • 0030988803 scopus 로고    scopus 로고
    • Lack of expression of Thy-1 (CD90) on acute myeloid leukemia cells with long-term proliferative ability in vitro and in vivo
    • Blair A, Hogge DE, Ailles LE, Lansdorp PM, Sutherland HJ. Lack of expression of Thy-1 (CD90) on acute myeloid leukemia cells with long-term proliferative ability in vitro and in vivo. Blood. 1997;89:3104-12.
    • (1997) Blood , vol.89 , pp. 3104-3112
    • Blair, A.1    Hogge, D.E.2    Ailles, L.E.3    Lansdorp, P.M.4    Sutherland, H.J.5
  • 34
    • 0034097928 scopus 로고    scopus 로고
    • Primitive acute myeloid leukemia cells with long-term proliferative ability in vitro and in vivo lack surface expression of c-kit (CD117)
    • Blair A, Sutherland HJ. Primitive acute myeloid leukemia cells with long-term proliferative ability in vitro and in vivo lack surface expression of c-kit (CD117). Exp Hematol. 2000;28:660-671.
    • (2000) Exp Hematol , vol.28 , pp. 660-671
    • Blair, A.1    Sutherland, H.J.2
  • 35
    • 0033815950 scopus 로고    scopus 로고
    • The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells
    • Jordan CT, Upchurch D, Szilvassy SJ, et al. The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells. Leukemia. 2000;14:1777-84.
    • (2000) Leukemia , vol.14 , pp. 1777-1784
    • Jordan, C.T.1    Upchurch, D.2    Szilvassy, S.J.3
  • 36
    • 3242754448 scopus 로고    scopus 로고
    • Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity
    • Hope KJ, Jin L, Dick JE. Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity. Nat Immunol. 2004; 5:738-43.
    • (2004) Nat Immunol , vol.5 , pp. 738-743
    • Hope, K.J.1    Jin, L.2    Dick, J.E.3
  • 37
    • 0034691092 scopus 로고    scopus 로고
    • AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation
    • Miyamoto T, Weissman IL, Akashi K. AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation. Proc Natl Acad Sci USA. 2000;97:7521-6.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 7521-7526
    • Miyamoto, T.1    Weissman, I.L.2    Akashi, K.3
  • 38
    • 19944385935 scopus 로고    scopus 로고
    • MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors
    • Huntly BJ, Shigematsu H, Deguchi K, et al. MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors. Cancer Cell. 2004;6:587-96.
    • (2004) Cancer Cell , vol.6 , pp. 587-596
    • Huntly, B.J.1    Shigematsu, H.2    Deguchi, K.3
  • 39
    • 0042872887 scopus 로고    scopus 로고
    • MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice
    • So CW, Karsunky H, Passegue E, Cozzio A, Weissman IL, Cleary ML. MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice. Cancer Cell. 2003;3: 161-71.
    • (2003) Cancer Cell , vol.3 , pp. 161-171
    • So, C.W.1    Karsunky, H.2    Passegue, E.3    Cozzio, A.4    Weissman, I.L.5    Cleary, M.L.6
  • 41
    • 0033614446 scopus 로고    scopus 로고
    • Chronic myeloid leukemia
    • Sawyers CL. Chronic myeloid leukemia. N Engl J Med. 1999;340:1330-40.
    • (1999) N Engl J Med , vol.340 , pp. 1330-1340
    • Sawyers, C.L.1
  • 42
    • 0141528828 scopus 로고    scopus 로고
    • Chronic myeloid leukemia-advances in biology and new approaches to treatment
    • Goldman JM, Melo JV. Chronic myeloid leukemia-advances in biology and new approaches to treatment. N Engl J Med. 2003;349:1451-64.
    • (2003) N Engl J Med , vol.349 , pp. 1451-1464
    • Goldman, J.M.1    Melo, J.V.2
  • 43
    • 0017653321 scopus 로고
    • Chronic myelocytic leukemia: Clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/macrophage
    • Fialkow PJ, Jacobson RJ, Papayannopoulou T. Chronic myelocytic leukemia: clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/macrophage. Am J Med. 1977; 65:125-30.
    • (1977) Am J Med. , vol.65 , pp. 125-130
    • Fialkow, P.J.1    Jacobson, R.J.2    Papayannopoulou, T.3
  • 44
    • 0021802841 scopus 로고
    • Fused transcript of abl and bcr genes in chronic myelogenous leukaemia
    • Shtivelman E, Lifshitz B, Gale RP, Canaani E. Fused transcript of abl and bcr genes in chronic myelogenous leukaemia. Nature. 1985;315:550-4.
    • (1985) Nature , vol.315 , pp. 550-554
    • Shtivelman, E.1    Lifshitz, B.2    Gale, R.P.3    Canaani, E.4
  • 45
    • 3943088431 scopus 로고    scopus 로고
    • Granulocyte-macrophage progenitors as candidate leukemic stem cells in blastcrisis CML
    • Jamieson CH, Ailles LE, Dylla SJ, et al. Granulocyte-macrophage progenitors as candidate leukemic stem cells in blastcrisis CML. N Engl J Med. 2004;351:657-67.
    • (2004) N Engl J Med , vol.351 , pp. 657-667
    • Jamieson, C.H.1    Ailles, L.E.2    Dylla, S.J.3
  • 46
    • 0034141934 scopus 로고    scopus 로고
    • A primitive hematopoietic cell is the target for the leukemic transformation in human philadelphia-positive acute lymphoblastic leukemia
    • Cobaleda C, Gutiérrez-Cianca N, Pérez-Losada J, et al. A primitive hematopoietic cell is the target for the leukemic transformation in human philadelphia-positive acute lymphoblastic leukemia. Blood. 2000;95:1007-13.
    • (2000) Blood , vol.95 , pp. 1007-1013
    • Cobaleda, C.1    Gutiérrez-Cianca, N.2    Pérez-Losada, J.3
  • 48
    • 0347379806 scopus 로고    scopus 로고
    • Pamphilon DH: Leukaemic stem cells
    • Blair A, Pamphilon DH: Leukaemic stem cells. Transfus Med. 2003;13:363-75.
    • (2003) Transfus Med , vol.13 , pp. 363-375
    • Blair, A.1
  • 49
    • 5444256238 scopus 로고    scopus 로고
    • Self-renewal and solid tumor stem cells
    • Al-Hajj M, Clarke MF. Self-renewal and solid tumor stem cells. Oncogene. 2004;23:7274-82.
    • (2004) Oncogene , vol.23 , pp. 7274-7282
    • Al-Hajj, M.1    Clarke, M.F.2
  • 50
    • 0141842674 scopus 로고    scopus 로고
    • Identification of a cancer stem cell in human brain tumors
    • Singh SK, Clarke ID, Terasaki M, et al. Identification of a cancer stem cell in human brain tumors. Cancer Res. 2003;63: 5821-8.
    • (2003) Cancer Res , vol.63 , pp. 5821-5828
    • Singh, S.K.1    Clarke, I.D.2    Terasaki, M.3
  • 51
    • 0344735881 scopus 로고    scopus 로고
    • Cancerous stem cells can arise from pediatric brain tumors
    • Hemmati HD, Nakano I, Lazareff JA, et al. Cancerous stem cells can arise from pediatric brain tumors. Proc Natl Acad Sci USA. 2003;100:15178-83.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 15178-15183
    • Hemmati, H.D.1    Nakano, I.2    Lazareff, J.A.3
  • 52
    • 0036737914 scopus 로고    scopus 로고
    • Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro
    • Ignatova TN, Kukekov VG, Laywell ED, Suslov ON, Vrionis FD, Steindler DA. Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro. Glia. 2002; 39:193-206.
    • (2002) Glia , vol.39 , pp. 193-206
    • Ignatova, T.N.1    Kukekov, V.G.2    Laywell, E.D.3    Suslov, O.N.4    Vrionis, F.D.5    Steindler, D.A.6
  • 53
  • 54
    • 0035893252 scopus 로고    scopus 로고
    • Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras
    • Jackson EL, Willis N, Mercer K, et al. Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev. 2001;15: 3243-8.
    • (2001) Genes Dev , vol.15 , pp. 3243-3248
    • Jackson, E.L.1    Willis, N.2    Mercer, K.3
  • 55
    • 20444397431 scopus 로고    scopus 로고
    • Identification of bronchioalveolar stem cells in normal lung and lung cancer
    • Kim CF, Jackson EL, Woolfenden AE, et al. Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell. 2005;121:823-35.
    • (2005) Cell , vol.121 , pp. 823-835
    • Kim, C.F.1    Jackson, E.L.2    Woolfenden, A.E.3
  • 56
    • 9444265320 scopus 로고    scopus 로고
    • Gastric cancer originating from bone marrow-derived cells
    • Houghton J, Stoicov C, Nomura S, et al. Gastric cancer originating from bone marrow-derived cells. Science. 2004;306: 1568-71.
    • (2004) Science , vol.306 , pp. 1568-1571
    • Houghton, J.1    Stoicov, C.2    Nomura, S.3
  • 57
    • 3543066288 scopus 로고    scopus 로고
    • MALT lymphoma: From morphology to molecules
    • Isaacson PG, Du MQ. MALT lymphoma: From morphology to molecules. Nat Rev Cancer. 2004;4:644-53.
    • (2004) Nat Rev Cancer , vol.4 , pp. 644-653
    • Isaacson, P.G.1    Du, M.Q.2
  • 58
    • 0033151510 scopus 로고    scopus 로고
    • The apoptosis inhibitor gene AP12 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomas
    • Dierlamm J, Baens M, Wlodarska I, et al. The apoptosis inhibitor gene AP12 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomas. Blood. 1999;93:5601-9.
    • (1999) Blood , vol.93 , pp. 5601-5609
    • Dierlamm, J.1    Baens, M.2    Wlodarska, I.3
  • 59
    • 0033534627 scopus 로고    scopus 로고
    • Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types
    • Willis TG, Jadayel DM, Du MQ, et al. Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types. Cell. 1999;96:35-45.
    • (1999) Cell , vol.96 , pp. 35-45
    • Willis, T.G.1    Jadayel, D.M.2    Du, M.Q.3
  • 60
    • 0032958801 scopus 로고    scopus 로고
    • Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32)
    • Zhang Q, Siebert R, Yan M, et al. Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32). Nat Genet. 1999;22:63-8.
    • (1999) Nat Genet , vol.22 , pp. 63-68
    • Zhang, Q.1    Siebert, R.2    Yan, M.3
  • 61
    • 0012605299 scopus 로고    scopus 로고
    • MALT1 is deregulated by both chromosomal translocation and amplification in B-cell non-Hodgkin lymphoma
    • Sanchez-Izquierdo D, Buchonnet G, Siebert R, et al. MALT1 is deregulated by both chromosomal translocation and amplification in B-cell non-Hodgkin lymphoma. Blood. 2003;101:4539-46.
    • (2003) Blood , vol.101 , pp. 4539-4546
    • Sanchez-Izquierdo, D.1    Buchonnet, G.2    Siebert, R.3
  • 62
    • 0037041427 scopus 로고    scopus 로고
    • Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion
    • Terada N, Hamazaki T, Oka M, et al. Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion. Nature. 2002;416:542-5.
    • (2002) Nature , vol.416 , pp. 542-545
    • Terada, N.1    Hamazaki, T.2    Oka, M.3
  • 63
    • 0033711624 scopus 로고    scopus 로고
    • Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism
    • Reya T, O'Riordan M, Okamura R, et al. Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism. Immunity. 2000;13:15-24.
    • (2000) Immunity , vol.13 , pp. 15-24
    • Reya, T.1    O'Riordan, M.2    Okamura, R.3
  • 64
    • 0035902140 scopus 로고    scopus 로고
    • The Hedgehog and Wnt signalling pathways in cancer
    • Taipale J, Beachy PA. The Hedgehog and Wnt signalling pathways in cancer. Nature. 2001;411:549-54.
    • (2001) Nature , vol.411 , pp. 549-554
    • Taipale, J.1    Beachy, P.A.2
  • 65
    • 0037737728 scopus 로고    scopus 로고
    • A role for Wnt signalling in self-renewal of haematopoietic stem cells
    • Reya T, Duncan AW, Ailles L, et al. A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature. 2003; 423:409-14.
    • (2003) Nature , vol.423 , pp. 409-414
    • Reya, T.1    Duncan, A.W.2    Ailles, L.3
  • 66
    • 0033694305 scopus 로고    scopus 로고
    • Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling
    • Varnum-Finney B, Xu L, Brashem-Stein C, et al. Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling. Nat Med. 2000;6:1278-81.
    • (2000) Nat Med , vol.6 , pp. 1278-1281
    • Varnum-Finney, B.1    Xu, L.2    Brashem-Stein, C.3
  • 67
    • 0035257660 scopus 로고    scopus 로고
    • Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation
    • Bhardwaj G, Murdoch B, Wu D, et al. Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation. Nat Immunol. 2001; 2:172-80.
    • (2001) Nat Immunol , vol.2 , pp. 172-180
    • Bhardwaj, G.1    Murdoch, B.2    Wu, D.3
  • 69
  • 70
    • 33744457653 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia
    • Martelli AM, Nyakern M, Tabellini G, et al. Phosphoinositide 3-kinase/ Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia. Leukemia. 2006;20:911-28.
    • (2006) Leukemia , vol.20 , pp. 911-928
    • Martelli, A.M.1    Nyakern, M.2    Tabellini, G.3
  • 72
    • 17444379015 scopus 로고    scopus 로고
    • Deregulated expression of Polycomb-group oncogenes in human malignant lymphomas and epithelial tumors
    • Spec 1
    • Raaphorst FM. Deregulated expression of Polycomb-group oncogenes in human malignant lymphomas and epithelial tumors. Hum Mol Genet. 2005;14 Spec 1:R95-R100.
    • (2005) Hum Mol Genet , vol.14
    • Raaphorst, F.M.1
  • 73
    • 0030611381 scopus 로고    scopus 로고
    • Pertubation of B and T cell development and predisposition to lymphomagenesis in Emu Bmi1 transgenic mice require the Bmi1 RING finger
    • Alkema MJ, Jacobs H, van Lohuizen M, Berns A. Pertubation of B and T cell development and predisposition to lymphomagenesis in Emu Bmi1 transgenic mice require the Bmi1 RING finger. Oncogene. 1997;15:899-910.
    • (1997) Oncogene , vol.15 , pp. 899-910
    • Alkema, M.J.1    Jacobs, H.2    van Lohuizen, M.3    Berns, A.4
  • 74
    • 0035866814 scopus 로고    scopus 로고
    • BMI-1 gene amplification and overexpression in hematological malignancies occur mainly in mantle cell lymphomas
    • Bea S, Tort F, Pinyol M, et al. BMI-1 gene amplification and overexpression in hematological malignancies occur mainly in mantle cell lymphomas. Cancer Res. 2001;61:2409-12.
    • (2001) Cancer Res , vol.61 , pp. 2409-2412
    • Bea, S.1    Tort, F.2    Pinyol, M.3
  • 75
    • 21144446267 scopus 로고    scopus 로고
    • Mantle-cell lymphoma genotypes identified with CGH to BAC microarrays define a leukemic subgroup of disease and predict patient outcome
    • Rubio-Moscardo F, Climent J, Siebert R, et al. Mantle-cell lymphoma genotypes identified with CGH to BAC microarrays define a leukemic subgroup of disease and predict patient outcome. Blood. 2005; 105:4445-54.
    • (2005) Blood , vol.105 , pp. 4445-4454
    • Rubio-Moscardo, F.1    Climent, J.2    Siebert, R.3
  • 76
    • 0028201742 scopus 로고
    • Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene
    • van der Lugt NM, Domen J, Linders K, et al. Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene. Genes Dev. 1994;8:757-69.
    • (1994) Genes Dev , vol.8 , pp. 757-769
    • van der Lugt, N.M.1    Domen, J.2    Linders, K.3
  • 77
    • 0033552813 scopus 로고    scopus 로고
    • The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
    • Jacobs JJ, Kieboom K, Marino S, DePinho RA, van Lohuizen M. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature. 1999;397:164-8.
    • (1999) Nature , vol.397 , pp. 164-168
    • Jacobs, J.J.1    Kieboom, K.2    Marino, S.3    DePinho, R.A.4    van Lohuizen, M.5
  • 78
    • 0037673984 scopus 로고    scopus 로고
    • Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells
    • Lessard J, Sauvageau G. Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature. 2003; 423:255-60.
    • (2003) Nature , vol.423 , pp. 255-260
    • Lessard, J.1    Sauvageau, G.2
  • 79
    • 0038349957 scopus 로고    scopus 로고
    • Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
    • Park IK, Qian D, Kiel M, et al. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature. 2003;423:302-5.
    • (2003) Nature , vol.423 , pp. 302-305
    • Park, I.K.1    Qian, D.2    Kiel, M.3
  • 80
    • 0242667922 scopus 로고    scopus 로고
    • Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation
    • Molofsky AV, Pardal R, Iwashita T, Park IK, Clarke MF, Morrison SJ. Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature. 2003;425:962-7.
    • (2003) Nature , vol.425 , pp. 962-967
    • Molofsky, A.V.1    Pardal, R.2    Iwashita, T.3    Park, I.K.4    Clarke, M.F.5    Morrison, S.J.6
  • 81
    • 0034681264 scopus 로고    scopus 로고
    • The multiple roles of PTEN in tumor suppression
    • Di Cristofano A, Pandolfi PP. The multiple roles of PTEN in tumor suppression. Cell. 2000;100:387-90.
    • (2000) Cell , vol.100 , pp. 387-390
    • Di Cristofano, A.1    Pandolfi, P.P.2
  • 82
    • 0032898096 scopus 로고    scopus 로고
    • PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies
    • Dahia PL, Aguiar RC, Alberta J, et al. PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies. Hum Mol Genet. 1999; 8:185-93.
    • (1999) Hum Mol Genet , vol.8 , pp. 185-193
    • Dahia, P.L.1    Aguiar, R.C.2    Alberta, J.3
  • 83
    • 4944236206 scopus 로고    scopus 로고
    • Promoter hypermethylation of cancer-related genes: A strong independent prognostic factor in acute lymphoblastic leukemia
    • Román-Gómez J, Jiménez-Velasco A, Castillejo JA, et al. Promoter hypermethylation of cancer-related genes: A strong independent prognostic factor in acute lymphoblastic leukemia. Blood. 2004; 104:2492-8.
    • (2004) Blood , vol.104 , pp. 2492-2498
    • Román-Gómez, J.1    Jiménez-Velasco, A.2    Castillejo, J.A.3
  • 85
    • 33646376411 scopus 로고    scopus 로고
    • Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
    • Yilmaz OH, Valdez R, Theisen BK, et al. Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature. 2006;441:475-82.
    • (2006) Nature , vol.441 , pp. 475-482
    • Yilmaz, O.H.1    Valdez, R.2    Theisen, B.K.3
  • 86
    • 33646351002 scopus 로고    scopus 로고
    • PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention
    • Zhang J, Grindley JC, Yin T, et al. PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention. Nature. 2006;441:518-22.
    • (2006) Nature , vol.441 , pp. 518-522
    • Zhang, J.1    Grindley, J.C.2    Yin, T.3
  • 87
    • 2942724235 scopus 로고    scopus 로고
    • mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
    • Majumder PK, Febbo PG, Bikoff R, et al. mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. Nat Med. 2004;10:594-601.
    • (2004) Nat Med , vol.10 , pp. 594-601
    • Majumder, P.K.1    Febbo, P.G.2    Bikoff, R.3
  • 88
    • 11244297916 scopus 로고    scopus 로고
    • Dysregulation of the TSC-mTOR pathway in human disease
    • Inoki K, Corradetti MN, Guan KL. Dysregulation of the TSC-mTOR pathway in human disease. Nat Genet. 2005;37:19-24.
    • (2005) Nat Genet , vol.37 , pp. 19-24
    • Inoki, K.1    Corradetti, M.N.2    Guan, K.L.3
  • 89
    • 20144363954 scopus 로고    scopus 로고
    • Antileukemic activity of rapamycin in acute myeloid leukemia
    • Recher C, Beyne-Rauzy O, Demur C, et al. Antileukemic activity of rapamycin in acute myeloid leukemia. Blood. 2005;105: 2527-34.
    • (2005) Blood , vol.105 , pp. 2527-2534
    • Recher, C.1    Beyne-Rauzy, O.2    Demur, C.3
  • 90
    • 0033553516 scopus 로고    scopus 로고
    • p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis
    • Chin L, Artandi SE, Shen Q, et al. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell. 1999;97:527-38.
    • (1999) Cell , vol.97 , pp. 527-538
    • Chin, L.1    Artandi, S.E.2    Shen, Q.3
  • 91
    • 3042699460 scopus 로고    scopus 로고
    • Adult human mesenchymal stem cell as a target for neoplastic transformation
    • Serakinci N, Guldberg P, Burns JS, et al. Adult human mesenchymal stem cell as a target for neoplastic transformation. Oncogene. 2004;23:5095-8.
    • (2004) Oncogene , vol.23 , pp. 5095-5098
    • Serakinci, N.1    Guldberg, P.2    Burns, J.S.3
  • 92
    • 17144384449 scopus 로고    scopus 로고
    • Tumorigenic heterogeneity in cancer stem cells evolved from long-term cultures of telomerase-immortalized human mesenchymal stem cells
    • Burns JS, Abdallah BM, Guldberg P, Rygaard J, Schroder HD, Kassem M. Tumorigenic heterogeneity in cancer stem cells evolved from long-term cultures of telomerase-immortalized human mesenchymal stem cells. Cancer Res. 2005;65:3126-35.
    • (2005) Cancer Res , vol.65 , pp. 3126-3135
    • Burns, J.S.1    Abdallah, B.M.2    Guldberg, P.3    Rygaard, J.4    Schroder, H.D.5    Kassem, M.6
  • 93
    • 17144363265 scopus 로고    scopus 로고
    • Spontaneous human adult stem cell transformation
    • Rubio D, García-Castro J, Martín MC, et al. Spontaneous human adult stem cell transformation. Cancer Res. 2005;65: 3035-9.
    • (2005) Cancer Res , vol.65 , pp. 3035-3039
    • Rubio, D.1    García-Castro, J.2    Martín, M.C.3
  • 94
    • 33745433769 scopus 로고    scopus 로고
    • Accumulated chromosomal instability in murine bone marrow mesenchymal stem cells leads to malignant transformation
    • Miura M, Miura Y, Padilla-Nash HM, et al. Accumulated chromosomal instability in murine bone marrow mesenchymal stem cells leads to malignant transformation. Stem Cells. 2006;24:1095-103.
    • (2006) Stem Cells , vol.24 , pp. 1095-1103
    • Miura, M.1    Miura, Y.2    Padilla-Nash, H.M.3
  • 95
    • 0036674425 scopus 로고    scopus 로고
    • Telomerase beyond telomeres
    • Blasco MA. Telomerase beyond telomeres. Nat Rev Cancer. 2002;2:627-33.
    • (2002) Nat Rev Cancer , vol.2 , pp. 627-633
    • Blasco, M.A.1
  • 97
    • 0035355340 scopus 로고    scopus 로고
    • Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes
    • González-Suarez E, Samper E, Ramírez A, et al. Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes. Embo J. 2001;20:2619-30.
    • (2001) Embo J , vol.20 , pp. 2619-2630
    • González-Suarez, E.1    Samper, E.2    Ramírez, A.3
  • 98
    • 33744535197 scopus 로고    scopus 로고
    • Telomeres and telomerease in cancer stem cells
    • Ju Z, Rudolph KL. Telomeres and telomerease in cancer stem cells. Eur J Cancer. 2006;42:1197-203.
    • (2006) Eur J Cancer , vol.42 , pp. 1197-1203
    • Ju, Z.1    Rudolph, K.L.2
  • 99
    • 0035896731 scopus 로고    scopus 로고
    • Telomere shortening accompanies increased cell cycle activity during serial transplantation of hematopoietic stem cells
    • Allsopp RC, Cheshier S, Weissman IL. Telomere shortening accompanies increased cell cycle activity during serial transplantation of hematopoietic stem cells. J Exp. Med. 2001;193:917-24.
    • (2001) J Exp. Med. , vol.193 , pp. 917-924
    • Allsopp, R.C.1    Cheshier, S.2    Weissman, I.L.3
  • 100
    • 0037480961 scopus 로고    scopus 로고
    • Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation
    • Allsopp RC, Morin GB, DePinho R, Harley CB, Weissman IL. Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation. Blood. 2005;102:517-20.
    • (2005) Blood , vol.102 , pp. 517-520
    • Allsopp, R.C.1    Morin, G.B.2    DePinho, R.3    Harley, C.B.4    Weissman, I.L.5
  • 101
    • 0345636016 scopus 로고    scopus 로고
    • Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells
    • Allsopp RC, Morin GB, Horner JW, DePinho R, Harley CB, Weissman IL. Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells. Nat Med. 2003;9:569-71.
    • (2003) Nat Med , vol.9 , pp. 569-571
    • Allsopp, R.C.1    Morin, G.B.2    Horner, J.W.3    DePinho, R.4    Harley, C.B.5    Weissman, I.L.6
  • 103
    • 23844540299 scopus 로고    scopus 로고
    • Effects of telomerase and telomere length on epidermal stem cell behavior
    • Flores I, Cayuela ML, Blasco MA. Effects of telomerase and telomere length on epidermal stem cell behavior. Science. 2005;309:1253-6.
    • (2005) Science , vol.309 , pp. 1253-1256
    • Flores, I.1    Cayuela, M.L.2    Blasco, M.A.3
  • 104
    • 23944516520 scopus 로고    scopus 로고
    • Conditional telomerase induction causes proliferation of hair follicle stem cells
    • Sarin KY, Cheung P, Gilison, D, et al. Conditional telomerase induction causes proliferation of hair follicle stem cells. Nature. 2005;436:1048-52.
    • (2005) Nature , vol.436 , pp. 1048-1052
    • Sarin, K.Y.1    Cheung, P.2    Gilison, D.3
  • 105
    • 0036457006 scopus 로고    scopus 로고
    • Asymmetric cell kinetics genes: The key to expansion of adult stem cells in culture
    • Sherley JL. Asymmetric cell kinetics genes: The key to expansion of adult stem cells in culture. Stem Cells. 2002;20:561-72.
    • (2002) Stem Cells , vol.20 , pp. 561-572
    • Sherley, J.L.1
  • 106
    • 4043170088 scopus 로고    scopus 로고
    • Epithelial polarity and proliferation control: Links from the Drosophila neoplastic tumor suppressors
    • Bilder D. Epithelial polarity and proliferation control: Links from the Drosophila neoplastic tumor suppressors. Genes Dev. 2004;18:1909-25.
    • (2004) Genes Dev , vol.18 , pp. 1909-1925
    • Bilder, D.1
  • 107
    • 31844432828 scopus 로고    scopus 로고
    • Lgl, Pins and aPKC regulate neuroblast self-renewal versus differentiation
    • Lee CY, Robinson KJ, Doe CQ. Lgl, Pins and aPKC regulate neuroblast self-renewal versus differentiation. Nature. 2006; 459:594-8.
    • (2006) Nature , vol.459 , pp. 594-598
    • Lee, C.Y.1    Robinson, K.J.2    Doe, C.Q.3
  • 108
    • 27144555447 scopus 로고    scopus 로고
    • Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster
    • Caussinus E, González C. Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster. Nat Genet. 2005;57:1125-9.
    • (2005) Nat Genet , vol.57 , pp. 1125-1129
    • Caussinus, E.1    González, C.2
  • 109
    • 33645525794 scopus 로고    scopus 로고
    • Doe CQ Brat is a Miranda cargo protein that promotes neuronal differentiation and inhibits neuroblast self-renewal
    • Lee CY, Wilkinson BD, Siegrist SE, Wharton RP, Doe CQ Brat is a Miranda cargo protein that promotes neuronal differentiation and inhibits neuroblast self-renewal. Dev Cell. 2006;10:441-9.
    • (2006) Dev Cell , vol.10 , pp. 441-449
    • Lee, C.Y.1    Wilkinson, B.D.2    Siegrist, S.E.3    Wharton, R.P.4
  • 110
    • 33646027006 scopus 로고    scopus 로고
    • Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells
    • Betschinger J, Mechtler K, Knoblich JA. Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells. Cell. 2006;124:1241-53.
    • (2006) Cell , vol.124 , pp. 1241-1253
    • Betschinger, J.1    Mechtler, K.2    Knoblich, J.A.3
  • 111
    • 33745600820 scopus 로고    scopus 로고
    • Asymmetric and symmetric stem-cell divisions in development and cancer
    • Morrison SJ, Kimble J. Asymmetric and symmetric stem-cell divisions in development and cancer. Nature. 2006;441:1068-74.
    • (2006) Nature , vol.441 , pp. 1068-1074
    • Morrison, S.J.1    Kimble, J.2
  • 112
    • 0141483737 scopus 로고    scopus 로고
    • Orientation of asymmetric stem cell division by the APC tumor suppressor and centrosome
    • Yamashita, YM, Jones DL, Fuller MT. Orientation of asymmetric stem cell division by the APC tumor suppressor and centrosome. Science 2003;301:1547-50.
    • (2003) Science , vol.301 , pp. 1547-1550
    • Yamashita, Y.M.1    Jones, D.L.2    Fuller, M.T.3
  • 113
    • 0025938038 scopus 로고
    • Identification and characterization of the familial adenomatous polyposis coli gene
    • Groden J, Thliveris A, Samowitz W, et al. Identification and characterization of the familial adenomatous polyposis coli gene. Cell. 1991;66:589-600.
    • (1991) Cell , vol.66 , pp. 589-600
    • Groden, J.1    Thliveris, A.2    Samowitz, W.3
  • 114
    • 0025817880 scopus 로고
    • Identification of FAP locus genes from chromosome 5q21
    • Kinzler KW, Nilbert MC, Su LK, et al. Identification of FAP locus genes from chromosome 5q21. Science. 1991;253:661-5.
    • (1991) Science , vol.253 , pp. 661-665
    • Kinzler, K.W.1    Nilbert, M.C.2    Su, L.K.3
  • 115
    • 21044453012 scopus 로고    scopus 로고
    • Reduced expression of Hugl-1, the human homologue of Drosophila tumour suppressor gene lgl, contributes to progression of colorectal cancer
    • Schimanski CC, Schmitz G, Kashyap A, et al. Reduced expression of Hugl-1, the human homologue of Drosophila tumour suppressor gene lgl, contributes to progression of colorectal cancer. Oncogene. 2005;24:3100-9.
    • (2005) Oncogene , vol.24 , pp. 3100-3109
    • Schimanski, C.C.1    Schmitz, G.2    Kashyap, A.3
  • 116
    • 30044446588 scopus 로고    scopus 로고
    • Expression of Hugl-1 is strongly reduced in malignant melanoma
    • Kuphal S, Wallner S, Schimanski CC et al. Expression of Hugl-1 is strongly reduced in malignant melanoma. Oncogene. 2006;25:103-10.
    • (2006) Oncogene , vol.25 , pp. 103-110
    • Kuphal, S.1    Wallner, S.2    Schimanski, C.C.3
  • 117
    • 1642276419 scopus 로고    scopus 로고
    • Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice
    • Klezovitch O, Fernández TE, Tapscott SJ, Vasioukhin V. Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice. Genes Dev. 2004;18:559-71.
    • (2004) Genes Dev , vol.18 , pp. 559-571
    • Klezovitch, O.1    Fernández, T.E.2    Tapscott, S.J.3    Vasioukhin, V.4
  • 118
    • 7244250027 scopus 로고    scopus 로고
    • Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis
    • Pece S, Serresi M, Santolini E, et al. Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis. J Cell Biol. 2004;167:215-21.
    • (2004) J Cell Biol , vol.167 , pp. 215-221
    • Pece, S.1    Serresi, M.2    Santolini, E.3
  • 119
    • 5044225888 scopus 로고    scopus 로고
    • Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
    • Weng AP, Ferrando AA, Lee W, et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science. 2004;306:269-71.
    • (2004) Science , vol.306 , pp. 269-271
    • Weng, A.P.1    Ferrando, A.A.2    Lee, W.3
  • 122
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • Bartel DP. MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 2004; 116:281-97.
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 123
  • 124
    • 18744396337 scopus 로고    scopus 로고
    • Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
    • Calin GA, Dumitru CD, Shimizu M, et al. Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci USA, 2002;99:15524-9.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 15524-15529
    • Calin, G.A.1    Dumitru, C.D.2    Shimizu, M.3
  • 125
    • 12144290519 scopus 로고    scopus 로고
    • Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers
    • Calin GA, Sevignani C, Dumitru CD, et al. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci USA. 2004;101:2999-5004.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 2999-5004
    • Calin, G.A.1    Sevignani, C.2    Dumitru, C.D.3
  • 126
    • 25444520537 scopus 로고    scopus 로고
    • miR-15 and miR-16 induce apoptosis by targeting BCL2
    • Cimmino A, Calin GA, Fabbri M, et al. miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci USA. 2005;102:15944-9.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 15944-15949
    • Cimmino, A.1    Calin, G.A.2    Fabbri, M.3
  • 127
    • 20444467290 scopus 로고    scopus 로고
    • A microRNA polycistron as a potential human oncogene
    • He L, Thomson JM, Hemann MT, et al. A microRNA polycistron as a potential human oncogene. Nature. 2005;455:828-55.
    • (2005) Nature , vol.455 , pp. 828-855
    • He, L.1    Thomson, J.M.2    Hemann, M.T.3
  • 129
    • 20044395613 scopus 로고    scopus 로고
    • RAS is regulated by the let-7 microRNA family
    • Johnson SM, Grosshans H, Shingara J, et al. RAS is regulated by the let-7 microRNA family. Cell. 2005;120:655-47.
    • (2005) Cell , vol.120 , pp. 655-747
    • Johnson, S.M.1    Grosshans, H.2    Shingara, J.3
  • 130
    • 2342449399 scopus 로고    scopus 로고
    • Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma
    • Ota A, Tagawa H, Karnan S, et al. Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma. Cancer Res. 2004;64:5087-95.
    • (2004) Cancer Res , vol.64 , pp. 5087-5095
    • Ota, A.1    Tagawa, H.2    Karnan, S.3
  • 131
    • 85044550651 scopus 로고    scopus 로고
    • A microRNA cluster as a target of genomic amplification in malignant lymphoma
    • Tagawa H, Seto M. A microRNA cluster as a target of genomic amplification in malignant lymphoma. Leukemia. 2005;19:2015-6.
    • (2005) Leukemia , vol.19 , pp. 2015-2016
    • Tagawa, H.1    Seto, M.2
  • 132
    • 20444460289 scopus 로고    scopus 로고
    • MicroRNA expression profiles classify human cancers
    • Lu J, Getz G, Miska EA, et al. MicroRNA expression profiles classify human cancers. Nature. 2005;435:834-8.
    • (2005) Nature , vol.435 , pp. 834-838
    • Lu, J.1    Getz, G.2    Miska, E.A.3
  • 134
    • 0346727524 scopus 로고    scopus 로고
    • MicroRNAs modulate hematopoietic line-age differentiation
    • Chen CZ, Li L, Lodish HF, Bartel DP. MicroRNAs modulate hematopoietic line-age differentiation. Science. 2004;303:83-6.
    • (2004) Science , vol.303 , pp. 83-86
    • Chen, C.Z.1    Li, L.2    Lodish, H.F.3    Bartel, D.P.4
  • 135
    • 29144440077 scopus 로고    scopus 로고
    • MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation
    • Felli N, Fontana L, Pelosi E, et al. MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation. Proc Natl Acad Sci USA. 2005;102:18081-6.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 18081-18086
    • Felli, N.1    Fontana, L.2    Pelosi, E.3
  • 136
    • 28444469246 scopus 로고    scopus 로고
    • Silencing of microRNAs in vivo with
    • Krutzfeldt J, Rajewsky N, Braich R, et al. Silencing of microRNAs in vivo with . Nature. 2005;458:685-9.
    • (2005) Nature , vol.458 , pp. 685-689
    • Krutzfeldt, J.1    Rajewsky, N.2    Braich, R.3
  • 137
    • 29244469466 scopus 로고    scopus 로고
    • The epigenetic progenitor origin of human cancer
    • Feinberg AP, Ohlsson R, Henikoff S. The epigenetic progenitor origin of human cancer. Nat Rev Genet. 2006;7:21-33.
    • (2006) Nat Rev Genet , vol.7 , pp. 21-33
    • Feinberg, A.P.1    Ohlsson, R.2    Henikoff, S.3
  • 138
    • 0020699979 scopus 로고
    • Hypomethylation distinguishes genes of some human cancers from their normal counterparts
    • Feinberg AP, Vogelstein B. Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature. 1985;301:89-92.
    • (1985) Nature , vol.301 , pp. 89-92
    • Feinberg, A.P.1    Vogelstein, B.2
  • 140
    • 1642503735 scopus 로고    scopus 로고
    • Histologically normal human mammary epithelia with silenced p16(INK4a) overexpress COX-2, promoting a premalignant program
    • Crawford YG, Gauthier ML, Joubel A, et al. Histologically normal human mammary epithelia with silenced p16(INK4a) overexpress COX-2, promoting a premalignant program. Cancer Cell. 2004;5:263-73.
    • (2004) Cancer Cell , vol.5 , pp. 263-273
    • Crawford, Y.G.1    Gauthier, M.L.2    Joubel, A.3
  • 141
    • 0037436509 scopus 로고    scopus 로고
    • Loss of IGF2 imprinting: A potential marker of colorectal cancer risk
    • Cui H, Cruz-Correa M, Giardiello FM, et al. Loss of IGF2 imprinting: A potential marker of colorectal cancer risk. Science. 2005;299:1753-5.
    • (2005) Science , vol.299 , pp. 1753-1755
    • Cui, H.1    Cruz-Correa, M.2    Giardiello, F.M.3
  • 142
    • 20144374299 scopus 로고    scopus 로고
    • Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice
    • Sakatani T, Kaneda A, Iacobuzio-Donahue CA, et al. Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice. Science. 2005;307:1976-8.
    • (2005) Science , vol.307 , pp. 1976-1978
    • Sakatani, T.1    Kaneda, A.2    Iacobuzio-Donahue, C.A.3
  • 143
    • 0035930134 scopus 로고    scopus 로고
    • Loss of imprinting of insulin-like growth factor-II (IGF2) gene in distinguishing specific biologic subtypes of Wilms tumor
    • Ravenel JD, Broman KW, Perlman EJ, et al. Loss of imprinting of insulin-like growth factor-II (IGF2) gene in distinguishing specific biologic subtypes of Wilms tumor. J Natl Cancer Inst. 2001; 93:1698-703.
    • (2001) J Natl Cancer Inst , vol.93 , pp. 1698-1703
    • Ravenel, J.D.1    Broman, K.W.2    Perlman, E.J.3
  • 144
    • 1542318319 scopus 로고    scopus 로고
    • Loss of insulin-like growth factor-II imprinting and the presence of screen-detected colorectal adenomas in women
    • Woodson K, Flood A, Green L, et al. Loss of insulin-like growth factor-II imprinting and the presence of screen-detected colorectal adenomas in women. J Natl Cancer Inst. 2004;96:407-10.
    • (2004) J Natl Cancer Inst , vol.96 , pp. 407-410
    • Woodson, K.1    Flood, A.2    Green, L.3
  • 145
    • 0032582513 scopus 로고    scopus 로고
    • Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4
    • Nichols J, Zevnik B, Anastassiadis K, et al. Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell. 1998;95:379-91.
    • (1998) Cell , vol.95 , pp. 379-391
    • Nichols, J.1    Zevnik, B.2    Anastassiadis, K.3
  • 146
    • 0037108047 scopus 로고    scopus 로고
    • Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo
    • Hanna LA, Foreman RK, Tarasenko IA, Kessler DS, Labosky PA. Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo. Genes Dev. 2002;16:2650-61.
    • (2002) Genes Dev , vol.16 , pp. 2650-2661
    • Hanna, L.A.1    Foreman, R.K.2    Tarasenko, I.A.3    Kessler, D.S.4    Labosky, P.A.5
  • 147
    • 27244434794 scopus 로고    scopus 로고
    • Pathogenesis of mantle-cell lymphoma: All oncogenic roads lead to dysregulation of cell cycle and DNA damage response pathways
    • Fernandez V, Hartmann E, Ott G, Campo E, Rosenwald A. Pathogenesis of mantle-cell lymphoma: All oncogenic roads lead to dysregulation of cell cycle and DNA damage response pathways. J Clin Oncol. 2005;23:6364-9.
    • (2005) J Clin Oncol , vol.23 , pp. 6364-6369
    • Fernandez, V.1    Hartmann, E.2    Ott, G.3    Campo, E.4    Rosenwald, A.5
  • 148
    • 0036090306 scopus 로고    scopus 로고
    • ATM gene inactivation in mantle cell lymphoma mainly occurs by truncating mutations and missense mutations involving the phosphatidylinositol-3 kinase domain and is associated with increasing numbers of chromosomal imbalances
    • Camacho E, Hernández L, Hernández S, et al. ATM gene inactivation in mantle cell lymphoma mainly occurs by truncating mutations and missense mutations involving the phosphatidylinositol-3 kinase domain and is associated with increasing numbers of chromosomal imbalances. Blood. 2002;99:238-44.
    • (2002) Blood , vol.99 , pp. 238-244
    • Camacho, E.1    Hernández, L.2    Hernández, S.3
  • 149
    • 0037114634 scopus 로고    scopus 로고
    • CHK2-decreased protein expression and infrequent genetic alterations mainly occur in aggressive types of non-Hodgkin lymphomas
    • Tort F, Hernández S, Bea S, et al. CHK2-decreased protein expression and infrequent genetic alterations mainly occur in aggressive types of non-Hodgkin lymphomas. Blood. 2002;100:4602-8.
    • (2002) Blood , vol.100 , pp. 4602-4608
    • Tort, F.1    Hernández, S.2    Bea, S.3
  • 150
    • 33745635043 scopus 로고    scopus 로고
    • The stem-cell niche as an entity of action
    • Scadden DT. The stem-cell niche as an entity of action. Nature. 2006;441:1075-9.
    • (2006) Nature , vol.441 , pp. 1075-1079
    • Scadden, D.T.1
  • 151
    • 33646428091 scopus 로고    scopus 로고
    • Normal stem cells and cancer stem cells: The niche matters
    • Li L, Neaves WB. Normal stem cells and cancer stem cells: The niche matters. Cancer Res. 2006;66:4553-7.
    • (2006) Cancer Res , vol.66 , pp. 4553-4557
    • Li, L.1    Neaves, W.B.2
  • 152
    • 28644432204 scopus 로고    scopus 로고
    • VEGFR1-positive haematopoietic bone marrow progenitors initiate the premetastatic niche
    • Kaplan RN, Riba RD, Zacharoulis S, et al. VEGFR1-positive haematopoietic bone marrow progenitors initiate the premetastatic niche. Nature. 2005;458:820-7.
    • (2005) Nature , vol.458 , pp. 820-827
    • Kaplan, R.N.1    Riba, R.D.2    Zacharoulis, S.3
  • 153
  • 154
    • 2542442633 scopus 로고    scopus 로고
    • Transcriptional control of early B cell development
    • Busslinger M. Transcriptional control of early B cell development. Annu Rev Immunol. 2004;22:55-79.
    • (2004) Annu Rev Immunol , vol.22 , pp. 55-79
    • Busslinger, M.1
  • 155
    • 20644461729 scopus 로고    scopus 로고
    • Transcriptional networks in developing and mature B cells
    • Matthias P, Rolink AG. Transcriptional networks in developing and mature B cells. Nat Rev Immunol 2005;5:497-508.
    • (2005) Nat Rev Immunol , vol.5 , pp. 497-508
    • Matthias, P.1    Rolink, A.G.2
  • 156
    • 18744404228 scopus 로고    scopus 로고
    • Genetic networks that regulate B lymphopoiesis
    • Medina KL, Singh H. Genetic networks that regulate B lymphopoiesis. Curr Opin Hematol. 2005;12:205-9.
    • (2005) Curr Opin Hematol , vol.12 , pp. 205-209
    • Medina, K.L.1    Singh, H.2
  • 157
    • 0028136726 scopus 로고
    • Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages
    • Scott EW, Simon MC, Anastasi J, Singh H. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science. 1994;265:1575-7.
    • (1994) Science , vol.265 , pp. 1575-1577
    • Scott, E.W.1    Simon, M.C.2    Anastasi, J.3    Singh, H.4
  • 158
    • 0034717335 scopus 로고    scopus 로고
    • Regulation of B lymphocyte and macrophage development by graded expression of PU.1
    • DeKoter RP, Singh H. Regulation of B lymphocyte and macrophage development by graded expression of PU.1. Science. 2000;288:1459-41.
    • (2000) Science , vol.288 , pp. 1459-1461
    • DeKoter, R.P.1    Singh, H.2
  • 159
    • 0028001362 scopus 로고
    • The ikaros gene is required for the development of all lymphoid lineages
    • Georgopoulos K, Bigby M, Wang JH, et al. The ikaros gene is required for the development of all lymphoid lineages. Cell. 1994;79:145-56.
    • (1994) Cell , vol.79 , pp. 145-156
    • Georgopoulos, K.1    Bigby, M.2    Wang, J.H.3
  • 160
    • 0027992622 scopus 로고
    • E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements
    • Bain G, Maandag EC, Izon DJ, et al. E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements. Cell. 1994;79:885-92.
    • (1994) Cell , vol.79 , pp. 885-982
    • Bain, G.1    Maandag, E.C.2    Izon, D.J.3
  • 161
    • 0029045161 scopus 로고
    • Failure of B-cell differentiation in mice lacking the transcription factor EBF
    • Lin H, Grosschedl R. Failure of B-cell differentiation in mice lacking the transcription factor EBF. Nature. 1995;376:265-7.
    • (1995) Nature , vol.376 , pp. 265-267
    • Lin, H.1    Grosschedl, R.2
  • 162
    • 0033533891 scopus 로고    scopus 로고
    • Commitment to the B-lymphoid lineage depends on the transciption factor Pax5
    • Nutt SL, Heavey B, Rolink AG, Busslinger M. Commitment to the B-lymphoid lineage depends on the transciption factor Pax5. Nature. 1999;401:556-62.
    • (1999) Nature , vol.401 , pp. 556-562
    • Nutt, S.L.1    Heavey, B.2    Rolink, A.G.3    Busslinger, M.4
  • 163
    • 0033533822 scopus 로고    scopus 로고
    • Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors
    • Rolink AG, Nutt SL, Melchers F, Busslinger M. Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors. Nature. 1999;401:605-6.
    • (1999) Nature , vol.401 , pp. 605-606
    • Rolink, A.G.1    Nutt, S.L.2    Melchers, F.3    Busslinger, M.4
  • 164
    • 0035760903 scopus 로고    scopus 로고
    • The BCL11 gene family: Involvement of BCL11A in lymphoid malignancies
    • Satterwhite E, Sonoki T, Willis TG, et al. The BCL11 gene family: involvement of BCL11A in lymphoid malignancies. Blood. 2001;98:3413-20.
    • (2001) Blood , vol.98 , pp. 3413-3420
    • Satterwhite, E.1    Sonoki, T.2    Willis, T.G.3
  • 165
    • 0038516237 scopus 로고    scopus 로고
    • Bc111a is essential for normal lymphoid development
    • Liu P, Keller JR, Ortiz M, et al. Bc111a is essential for normal lymphoid development. Nat Immunol. 2003;4:523-32.
    • (2003) Nat Immunol , vol.4 , pp. 523-532
    • Liu, P.1    Keller, J.R.2    Ortiz, M.3
  • 167
    • 5444222634 scopus 로고    scopus 로고
    • Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription
    • Maier H, Ostraat R, Gao H, et al. Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription. Nat Immunol. 2004;5:1069-77.
    • (2004) Nat Immunol , vol.5 , pp. 1069-1077
    • Maier, H.1    Ostraat, R.2    Gao, H.3
  • 168
    • 0036529989 scopus 로고    scopus 로고
    • Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome
    • Stier S, Cheng T, Dombkowski D, Carlesso N, Scadden DT. Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome. Blood. 2002;99:2569-78.
    • (2002) Blood , vol.99 , pp. 2569-2578
    • Stier, S.1    Cheng, T.2    Dombkowski, D.3    Carlesso, N.4    Scadden, D.T.5
  • 169
    • 33746150775 scopus 로고    scopus 로고
    • Foxp1 is an essential transcriptional regulator of B cell development
    • Hu H, Wang B, Borde M, et al. Foxp1 is an essential transcriptional regulator of B cell development. Nat Immunol. 2006;7:819-26.
    • (2006) Nat Immunol , vol.7 , pp. 819-826
    • Hu, H.1    Wang, B.2    Borde, M.3
  • 170
    • 0038506030 scopus 로고    scopus 로고
    • IRF-4,8 orchestrate the pre-B-to-B transition in lymphocyte development
    • Lu R, Medina KL, Lancki DW, Singh H. IRF-4,8 orchestrate the pre-B-to-B transition in lymphocyte development. Genes Dev. 2003;17:1703-8.
    • (2003) Genes Dev , vol.17 , pp. 1703-1708
    • Lu, R.1    Medina, K.L.2    Lancki, D.W.3    Singh, H.4
  • 171
    • 0029917392 scopus 로고    scopus 로고
    • The B-cell-specific transcription coactivator OCA-B/OBF-1/Bob-1 is essential for normal production of immunoglobulin isotypes
    • Kim U, Qin XF, Gong S, et al. The B-cell-specific transcription coactivator OCA-B/OBF-1/Bob-1 is essential for normal production of immunoglobulin isotypes. Nature. 1996;383:542-7.
    • (1996) Nature , vol.383 , pp. 542-547
    • Kim, U.1    Qin, X.F.2    Gong, S.3
  • 172
    • 0029967024 scopus 로고    scopus 로고
    • B-cell-specific coactivator OBF-1/OCA-B/Bob1 required for immune response and germinal centre formation
    • Schubart DB, Rolink A, Kosco-Vilbois MH, Botteri F, Matthias P. B-cell-specific coactivator OBF-1/OCA-B/Bob1 required for immune response and germinal centre formation. Nature. 1996;385:538-42.
    • (1996) Nature , vol.385 , pp. 538-542
    • Schubart, D.B.1    Rolink, A.2    Kosco-Vilbois, M.H.3    Botteri, F.4    Matthias, P.5
  • 173
    • 0028804551 scopus 로고
    • Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses
    • Sha WC, Liou HC, Tuomanen EI, Baltimore D. Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses. Cell. 1995: 80:321-30.
    • (1995) Cell , vol.80 , pp. 321-330
    • Sha, W.C.1    Liou, H.C.2    Tuomanen, E.I.3    Baltimore, D.4
  • 174
    • 17144439800 scopus 로고    scopus 로고
    • The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation
    • Ye BH, Cattoretti G, Shen Q, et al. The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation. Nat Genet. 1997;16:161-70.
    • (1997) Nat Genet , vol.16 , pp. 161-170
    • Ye, B.H.1    Cattoretti, G.2    Shen, Q.3
  • 175
    • 0035913294 scopus 로고    scopus 로고
    • Plasma cell differentiation requires the transcription factor XBP-1
    • Reimold AM, Iwakoshi NN, Manis J, et al. Plasma cell differentiation requires the transcription factor XBP-1. Nature. 2001; 412:500-7.
    • (2001) Nature , vol.412 , pp. 500-507
    • Reimold, A.M.1    Iwakoshi, N.N.2    Manis, J.3
  • 176
    • 18444395232 scopus 로고    scopus 로고
    • Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program
    • Shaffer AL, Lin KI, Kuo TC, et al. Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program. Immunity. 2002;17:51-62.
    • (2002) Immunity , vol.17 , pp. 51-62
    • Shaffer, A.L.1    Lin, K.I.2    Kuo, T.C.3
  • 177
    • 3142658576 scopus 로고    scopus 로고
    • XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation
    • Shaffer AL, Shapiro-Shelef M, Iwakoshi NN, et al. XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation. Immunity. 2004;21:81-93.
    • (2004) Immunity , vol.21 , pp. 81-93
    • Shaffer, A.L.1    Shapiro-Shelef, M.2    Iwakoshi, N.N.3
  • 179
    • 17144418984 scopus 로고    scopus 로고
    • Complement receptors regulate differentiation of bone marrow plasma cell precursors expressing transcription factors Blimp-1 and XBP-1
    • Gatto D, Pfister T, Jegerlehner A, Martin SW, Kopf M, Bachmann MF. Complement receptors regulate differentiation of bone marrow plasma cell precursors expressing transcription factors Blimp-1 and XBP-1. J Exp Med. 2005;201:995-1005.
    • (2005) J Exp Med , vol.201 , pp. 995-1005
    • Gatto, D.1    Pfister, T.2    Jegerlehner, A.3    Martin, S.W.4    Kopf, M.5    Bachmann, M.F.6
  • 180
    • 33745182931 scopus 로고    scopus 로고
    • Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination
    • Klein U, Casola S, Cattoretti G, et al. Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination. Nat Immunol. 2006;7:773-82.
    • (2006) Nat Immunol , vol.7 , pp. 773-782
    • Klein, U.1    Casola, S.2    Cattoretti, G.3
  • 181
    • 10344247666 scopus 로고    scopus 로고
    • The BCL6 proto-oncogene suppresses p55 expression in germinal-centre B cells
    • Phan RT, Dalla-Favera R. The BCL6 proto-oncogene suppresses p55 expression in germinal-centre B cells. Nature. 2004;432:635-9.
    • (2004) Nature , vol.432 , pp. 635-639
    • Phan, R.T.1    Dalla-Favera, R.2
  • 182
    • 27144462049 scopus 로고    scopus 로고
    • BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cells
    • Phan RT, Saito M, Basso K, Niu H, Dalla-Favera R. BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cells. Nat Immunol. 2005;6:1054-60.
    • (2005) Nat Immunol , vol.6 , pp. 1054-1060
    • Phan, R.T.1    Saito, M.2    Basso, K.3    Niu, H.4    Dalla-Favera, R.5
  • 183
    • 0034254687 scopus 로고    scopus 로고
    • The role of immunoglobulin translocations in the pathogenesis of B-cell malignancies
    • Willis TG, Dyer MJ. The role of immunoglobulin translocations in the pathogenesis of B-cell malignancies. Blood. 2000; 96:808-22.
    • (2000) Blood , vol.96 , pp. 808-822
    • Willis, T.G.1    Dyer, M.J.2
  • 184
    • 0035839959 scopus 로고    scopus 로고
    • Mechanisms of chromosomal translocations in B cell lymphomas
    • Kuppers R, Dalla-Favera R. Mechanisms of chromosomal translocations in B cell lymphomas. Oncogene. 2001;20:5580-94.
    • (2001) Oncogene , vol.20 , pp. 5580-5594
    • Kuppers, R.1    Dalla-Favera, R.2
  • 185
    • 0029998350 scopus 로고    scopus 로고
    • Deregulation of PAX-5 by translocation of the Emu enhancer of the IgH locus adjacent to two alternative PAX-5 promoters in a diffuse large-cell lymphoma
    • Busslinger M, Klix N, Pfeffer P, Graninger PG, Kozmik Z. Deregulation of PAX-5 by translocation of the Emu enhancer of the IgH locus adjacent to two alternative PAX-5 promoters in a diffuse large-cell lymphoma. Proc Natl Acad Sci USA. 1996; 95:6129-34.
    • (1996) Proc Natl Acad Sci USA , vol.95 , pp. 6129-6134
    • Busslinger, M.1    Klix, N.2    Pfeffer, P.3    Graninger, P.G.4    Kozmik, Z.5
  • 186
    • 0028230387 scopus 로고
    • Rearrangements of the BCL6 gen in diffuse large cell non-Hodgkin's lymphoma
    • Lo Coco F, Ye BH, Lista F, et al. Rearrangements of the BCL6 gen in diffuse large cell non-Hodgkin's lymphoma. Blood. 1994;85:1757-9.
    • (1994) Blood , vol.85 , pp. 1757-1759
    • Lo Coco, F.1    Ye, B.H.2    Lista, F.3
  • 187
    • 16844369469 scopus 로고    scopus 로고
    • T(3;14)(p14.1;q32) involving IGH and FOXP1 is a novel recurrent chromosomal aberration in MALT lymphoma
    • Streubel B, Vinatzer U, Lamprecht A, Raderer M, Chott A. T(3;14)(p14.1;q32) involving IGH and FOXP1 is a novel recurrent chromosomal aberration in MALT lymphoma. Leukemia. 2005;19:652-8.
    • (2005) Leukemia , vol.19 , pp. 652-658
    • Streubel, B.1    Vinatzer, U.2    Lamprecht, A.3    Raderer, M.4    Chott, A.5
  • 188
    • 84984756503 scopus 로고    scopus 로고
    • Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma
    • Iida S, Rao PH, Butler M, et al. Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma. Nat Genet. 1997;17:226-50.
    • (1997) Nat Genet , vol.17 , pp. 226-250
    • Iida, S.1    Rao, P.H.2    Butler, M.3
  • 189
    • 0025856717 scopus 로고
    • TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms
    • Ellisen LW, Bird J, West DC, et al. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell. 1991;66:649-61.
    • (1991) Cell , vol.66 , pp. 649-661
    • Ellisen, L.W.1    Bird, J.2    West, D.C.3
  • 190
    • 0034655581 scopus 로고    scopus 로고
    • The Ikaros gene, a central regulator of lymphoid differentiation, fuses to the BCL6 gene as a result of t(3;7)(q27;p12) translocation in a patient with diffuse large B-cell lymphoma
    • Hosokawa Y, Maeda Y, Ichinohasama R, Miura I, Taniwaki M, Seto M. The Ikaros gene, a central regulator of lymphoid differentiation, fuses to the BCL6 gene as a result of t(3;7)(q27;p12) translocation in a patient with diffuse large B-cell lymphoma. Blood. 2000;95:2719-21.
    • (2000) Blood , vol.95 , pp. 2719-2721
    • Hosokawa, Y.1    Maeda, Y.2    Ichinohasama, R.3    Miura, I.4    Taniwaki, M.5    Seto, M.6
  • 191
    • 0040596930 scopus 로고    scopus 로고
    • The B cell transcriptional coactivator BOB1/OBF1 gene fuses to the LAZ3/ BCL6 gene by t(3;11)(q27;q23.1) chromosomal translocation in a B cell leukemia line (Karpas 231)
    • Galique Zouitina S, Quief S, Hildebrand MP, et al. The B cell transcriptional coactivator BOB1/OBF1 gene fuses to the LAZ3/BCL6 gene by t(3;11)(q27;q23.1) chromosomal translocation in a B cell leukemia line (Karpas 231). Leukemia. 1996;10:579-87.
    • (1996) Leukemia , vol.10 , pp. 579-587
    • Galique Zouitina, S.1    Quief, S.2    Hildebrand, M.P.3
  • 192
    • 0030041048 scopus 로고    scopus 로고
    • Primary mediastinal (thymic) B-cell lymphoma is characterized by gains of chromosomal material including 9p and amplification of the REL gene
    • Joos S, Otano-Joos MI, Ziegler S, et al. Primary mediastinal (thymic) B-cell lymphoma is characterized by gains of chromosomal material including 9p and amplification of the REL gene. Blood. 1996; 87:1571-1578.
    • (1996) Blood , vol.87 , pp. 1571-1578
    • Joos, S.1    Otano-Joos, M.I.2    Ziegler, S.3
  • 193
    • 33344454909 scopus 로고    scopus 로고
    • Inactivation of the PRDM1/BLIMP1 gene in diffuse large B cell lymphoma
    • Pasqualucci L, Compagno M, Houldsworth J, et al. Inactivation of the PRDM1/BLIMP1 gene in diffuse large B cell lymphoma. J Exp Med. 2006;203:511-7.
    • (2006) J Exp Med , vol.203 , pp. 511-517
    • Pasqualucci, L.1    Compagno, M.2    Houldsworth, J.3
  • 194
    • 33646569453 scopus 로고    scopus 로고
    • Mutational analysis of PRDM1 indicates a tumor-suppressor role in diffuse large B-cell lymphomas
    • Tam W, Gomez M, Chadburn A, Lee JW, Chan WC, Knowles DM. Mutational analysis of PRDM1 indicates a tumor-suppressor role in diffuse large B-cell lymphomas. Blood. 2006;107:4090-100.
    • (2006) Blood , vol.107 , pp. 4090-4100
    • Tam, W.1    Gomez, M.2    Chadburn, A.3    Lee, J.W.4    Chan, W.C.5    Knowles, D.M.6
  • 195
    • 4644302712 scopus 로고    scopus 로고
    • The human BCL6 transgene promotes the development of lymphomas in the mouse
    • Baron BW, Anastasi J, Montag A, et al. The human BCL6 transgene promotes the development of lymphomas in the mouse. Proc Natl Acad Sci USA. 2004;101:14198-205.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 14198-14205
    • Baron, B.W.1    Anastasi, J.2    Montag, A.3
  • 196
    • 0022380768 scopus 로고
    • The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
    • Adams JM, Harris AW, Pinkert CA, et al. The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature. 1985;318:535-8.
    • (1985) Nature , vol.318 , pp. 535-538
    • Adams, J.M.1    Harris, A.W.2    Pinkert, C.A.3
  • 197
    • 0026053958 scopus 로고
    • Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14; 18)
    • McDonnell TJ, Korsmeyer SJ. Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14; 18). Nature. 1991;349:254-6.
    • (1991) Nature , vol.349 , pp. 254-256
    • McDonnell, T.J.1    Korsmeyer, S.J.2
  • 198
    • 0028049592 scopus 로고
    • Cyclin D1/bcl-1 cooperates with myc genes in the generation of B-cell lymphoma in transgenic mice
    • Lovec H, Grezeschiczek A, Kowalski MB, Moroy T. Cyclin D1/bcl-1 cooperates with myc genes in the generation of B-cell lymphoma in transgenic mice. Embo J. 1994;13:3487-95.
    • (1994) Embo J. , vol.13 , pp. 3487-3495
    • Lovec, H.1    Grezeschiczek, A.2    Kowalski, M.B.3    Moroy, T.4
  • 199
    • 33244481730 scopus 로고    scopus 로고
    • Expression of constitutively nuclear cyclin D1 in murine lymphocytes induces B-cell lymphoma
    • Gladden AB, Woolery R, Aggarwal P, Wasik MA, Diehl JA. Expression of constitutively nuclear cyclin D1 in murine lymphocytes induces B-cell lymphoma. Oncogene. 2006;25:998-1007.
    • (2006) Oncogene , vol.25 , pp. 998-1007
    • Gladden, A.B.1    Woolery, R.2    Aggarwal, P.3    Wasik, M.A.4    Diehl, J.A.5
  • 200
    • 0036906546 scopus 로고    scopus 로고
    • Pax5 promotes B lymphopoiesis and blocks T cell development by repressing Notch1
    • Souabni A, Cobaleda C, Schebesta M, Busslinger M. Pax5 promotes B lymphopoiesis and blocks T cell development by repressing Notch1. Immunity. 2002; 17:781-93.
    • (2002) Immunity , vol.17 , pp. 781-793
    • Souabni, A.1    Cobaleda, C.2    Schebesta, M.3    Busslinger, M.4
  • 201
    • 19344368745 scopus 로고    scopus 로고
    • Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in mice
    • Cattoretti G, Pasqualucci L, Ballon G, et al. Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in mice. Cancer Cell. 2005;7:445-55.
    • (2005) Cancer Cell , vol.7 , pp. 445-455
    • Cattoretti, G.1    Pasqualucci, L.2    Ballon, G.3
  • 202
    • 8544262178 scopus 로고    scopus 로고
    • T cell acute lymphoblastic leukemia/lymphoma: A human cancer commonly associated with aberrant NOTCH1 signaling
    • Pear WS, Aster JC. T cell acute lymphoblastic leukemia/lymphoma: A human cancer commonly associated with aberrant NOTCH1 signaling. Curr Opin Hematol. 2004;11:426-33.
    • (2004) Curr Opin Hematol , vol.11 , pp. 426-433
    • Pear, W.S.1    Aster, J.C.2
  • 203
    • 16844378799 scopus 로고    scopus 로고
    • Leukaemia stem cells and the evolution of cancer-stem-cell research
    • Huntly BJ, Gilliland DG. Leukaemia stem cells and the evolution of cancer-stem-cell research. Nat Rev Cancer. 2005;5:511-21.
    • (2005) Nat Rev Cancer , vol.5 , pp. 511-521
    • Huntly, B.J.1    Gilliland, D.G.2
  • 204
    • 2542455620 scopus 로고    scopus 로고
    • Stepwise reprogramming of B cells into macrophages
    • Xie H, Ye M, Feng R, Graf T. Stepwise reprogramming of B cells into macrophages. Cell. 2004;117:663-76.
    • (2004) Cell , vol.117 , pp. 663-676
    • Xie, H.1    Ye, M.2    Feng, R.3    Graf, T.4
  • 205
    • 31344451370 scopus 로고    scopus 로고
    • Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma
    • Mathas S, Janz M, Hummel F, et al. Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma. Nat Immunol. 2006;7:207-15.
    • (2006) Nat Immunol , vol.7 , pp. 207-215
    • Mathas, S.1    Janz, M.2    Hummel, F.3
  • 207
    • 1542283717 scopus 로고    scopus 로고
    • Characterization of clonogenic multiple myeloma cells
    • Matsui W, Huff CA, Wang Q, et al. Characterization of clonogenic multiple myeloma cells. Blood. 2004;103:2332-6.
    • (2004) Blood , vol.103 , pp. 2332-2336
    • Matsui, W.1    Huff, C.A.2    Wang, Q.3
  • 209
    • 0025799513 scopus 로고
    • Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells
    • Chaudhary PM, Roninson IB. Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells. Cell. 1991;66:85-94.
    • (1991) Cell , vol.66 , pp. 85-94
    • Chaudhary, P.M.1    Roninson, I.B.2
  • 210
    • 0034795256 scopus 로고    scopus 로고
    • The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype
    • Zhou S, Schuetz JD, Bunting KD, et al. The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype. Nat Med. 2001;7:1028-54.
    • (2001) Nat Med , vol.7 , pp. 1028-1054
    • Zhou, S.1    Schuetz, J.D.2    Bunting, K.D.3
  • 211
    • 0032055166 scopus 로고    scopus 로고
    • Systemic overexpression of BCL-2 in the hematopoietic system protects transgenic mice from the consequences of lethal irradiation
    • Domen J, Gandy KL, Weissman IL. Systemic overexpression of BCL-2 in the hematopoietic system protects transgenic mice from the consequences of lethal irradiation. Blood. 1998;91:2272-82.
    • (1998) Blood , vol.91 , pp. 2272-2282
    • Domen, J.1    Gandy, K.L.2    Weissman, I.L.3
  • 212
    • 0034662606 scopus 로고    scopus 로고
    • Human acute myeloid leukemia CD34+/CD38-progenitor cells have decreased sensitivity to chemotherapy and Fas-induced apoptosis, reduced immunogenicity, and impaired dendritic cell transformation capacities
    • Costello RT, Mallet F, Gaugler B, et al. Human acute myeloid leukemia CD34+/CD38-progenitor cells have decreased sensitivity to chemotherapy and Fas-induced apoptosis, reduced immunogenicity, and impaired dendritic cell transformation capacities. Cancer Res. 2000;60: 4405-11.
    • (2000) Cancer Res , vol.60 , pp. 4405-4411
    • Costello, R.T.1    Mallet, F.2    Gaugler, B.3
  • 213
    • 0037059012 scopus 로고    scopus 로고
    • Preferential induction of apoptosis for primary human leukemic stem cells
    • Guzman ML, Swiderski CF, Howard DS, et al. Preferential induction of apoptosis for primary human leukemic stem cells. Proc Natl Acad Sci U S A. 2002;99:16220-5.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 16220-16225
    • Guzman, M.L.1    Swiderski, C.F.2    Howard, D.S.3
  • 214
    • 0029947186 scopus 로고    scopus 로고
    • Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Ber-Abl tyrosine kinase on the growth of Ber-Abl positive cells
    • Druker BJ, Tamura S, Buchdunger E, et al. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Ber-Abl tyrosine kinase on the growth of Ber-Abl positive cells. Nat Med. 1996;2:561-6.
    • (1996) Nat Med , vol.2 , pp. 561-566
    • Druker, B.J.1    Tamura, S.2    Buchdunger, E.3
  • 215
    • 10744233716 scopus 로고    scopus 로고
    • Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
    • O'Brien SG, Guilhot F, Larson RA, et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med. 2003;548:994-1004.
    • (2003) N Engl J Med , vol.548 , pp. 994-1004
    • O'Brien, S.G.1    Guilhot, F.2    Larson, R.A.3
  • 216
    • 30444446406 scopus 로고    scopus 로고
    • The paradox of response and survival in cancer therapeutics
    • Huff CA, Matsui W, Smith BD, Jones RJ. The paradox of response and survival in cancer therapeutics. Blood. 2006;107:431-4.
    • (2006) Blood , vol.107 , pp. 431-434
    • Huff, C.A.1    Matsui, W.2    Smith, B.D.3    Jones, R.J.4
  • 217
    • 21744462100 scopus 로고    scopus 로고
    • Dynamics of chronic myeloid leukaemia
    • Michor F, Hughes TP, Iwasa Y, et al. Dynamics of chronic myeloid leukaemia. Nature. 2005;435:1267-70.
    • (2005) Nature , vol.435 , pp. 1267-1270
    • Michor, F.1    Hughes, T.P.2    Iwasa, Y.3
  • 218
    • 4644341516 scopus 로고    scopus 로고
    • Discontinuation of imatinib therapy after achieving a molecular response
    • Cortés J, O'Brien S, Kantarjian H. Discontinuation of imatinib therapy after achieving a molecular response. Blood. 2004; 104:2204-5.
    • (2004) Blood , vol.104 , pp. 2204-2205
    • Cortés, J.1    O'Brien, S.2    Kantarjian, H.3
  • 219
    • 0036090222 scopus 로고    scopus 로고
    • Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to ST1571 in vitro
    • Graham SM, Jorgensen HG, Allan E, et al. Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to ST1571 in vitro. Blood. 2002;99:319-25.
    • (2002) Blood , vol.99 , pp. 319-325
    • Graham, S.M.1    Jorgensen, H.G.2    Allan, E.3
  • 220
    • 0037093082 scopus 로고    scopus 로고
    • Imatinib mesylate (ST1571) inhibits growth of primitive malignant progenitors in chronic myelogenous leukemia through reversal of abnormally increased proliferation
    • Holtz MS, Slovak ML, Zhang F, Sawyers CL, Forman SJ, Bhatia R. Imatinib mesylate (ST1571) inhibits growth of primitive malignant progenitors in chronic myelogenous leukemia through reversal of abnormally increased proliferation. Blood. 2002;99:5792-800.
    • (2002) Blood , vol.99 , pp. 5792-5800
    • Holtz, M.S.1    Slovak, M.L.2    Zhang, F.3    Sawyers, C.L.4    Forman, S.J.5    Bhatia, R.6
  • 221
    • 24944450475 scopus 로고    scopus 로고
    • Effects of imatinib and interferon on primitive chronic myeloid leukaemia progenitors
    • Angstreich GR, Matsui W, Huff CA, et al. Effects of imatinib and interferon on primitive chronic myeloid leukaemia progenitors. Br J Haematol. 2005;150:373-81.
    • (2005) Br J Haematol , vol.150 , pp. 373-381
    • Angstreich, G.R.1    Matsui, W.2    Huff, C.A.3
  • 222
    • 33745020412 scopus 로고    scopus 로고
    • Killing time for cancer stem cells (CSC): Discovery and development of selective CSC inhibitors
    • Pérez-Caro M, Sánchez-García I. Killing time for cancer stem cells (CSC): Discovery and development of selective CSC inhibitors. Curr Med Chem. 2006;13:1719-25.
    • (2006) Curr Med Chem , vol.13 , pp. 1719-1725
    • Pérez-Caro, M.1    Sánchez-García, I.2
  • 223
    • 33745086350 scopus 로고    scopus 로고
    • Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL
    • Kantarjian H, Giles F, Wunderle L, et al. Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL. N Engl J Med. 2006;554:2542-51.
    • (2006) N Engl J Med , vol.554 , pp. 2542-2551
    • Kantarjian, H.1    Giles, F.2    Wunderle, L.3
  • 224
    • 33745102555 scopus 로고    scopus 로고
    • Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias
    • Talpaz M, Shah NP, Kantarjian H, et al. Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N Engl J Med. 2006;554:2531-41.
    • (2006) N Engl J Med , vol.554 , pp. 2531-2541
    • Talpaz, M.1    Shah, N.P.2    Kantarjian, H.3
  • 225
    • 0035913362 scopus 로고    scopus 로고
    • Hypermutation of multiple protooncogenes in B-cell diffuse large-cell lymphomas
    • Pasqualucci L, Neumeister P, Goossens T, et al. Hypermutation of multiple protooncogenes in B-cell diffuse large-cell lymphomas. Nature. 2001;412:341-6.
    • (2001) Nature , vol.412 , pp. 341-346
    • Pasqualucci, L.1    Neumeister, P.2    Goossens, T.3
  • 226
    • 0026069091 scopus 로고
    • The t(1;19)(q23;p15) results in consistent fusion of E2A and PBX1 coding sequences in acute lymphoblastic leukemias
    • Hunger SP, Galili N, Carroll AJ, Crist WM, Link MP, Cleary ML. The t(1;19)(q23;p15) results in consistent fusion of E2A and PBX1 coding sequences in acute lymphoblastic leukemias. Blood. 1991;77:687-93.
    • (1991) Blood , vol.77 , pp. 687-693
    • Hunger, S.P.1    Galili, N.2    Carroll, A.J.3    Crist, W.M.4    Link, M.P.5    Cleary, M.L.6
  • 227
    • 0032520975 scopus 로고    scopus 로고
    • Molecular cloning of translocation t(1;14) (q21;q32) defines a novel gene (BCL9) at chromosome 1q21
    • Willis TG, Zalcberg IR, Coignet LJ, et al. Molecular cloning of translocation t(1;14) (q21;q32) defines a novel gene (BCL9) at chromosome 1q21. Blood. 1998; 91:1873-81.
    • (1998) Blood , vol.91 , pp. 1873-1881
    • Willis, T.G.1    Zalcberg, I.R.2    Coignet, L.J.3
  • 228
    • 0037023584 scopus 로고    scopus 로고
    • Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex
    • Kramps T, Peter O, Brunner E, et al. Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex. Cell. 2002;109:47-60.
    • (2002) Cell , vol.109 , pp. 47-60
    • Kramps, T.1    Peter, O.2    Brunner, E.3
  • 229
    • 0034676014 scopus 로고    scopus 로고
    • Nuclear factor kappa B is required for the development of marginal zone B lymphocytes
    • Cariappa A, Liou HC, Horwitz BH, Pilai S. Nuclear factor kappa B is required for the development of marginal zone B lymphocytes. J Exp Med. 2000;192:1175-82.
    • (2000) J Exp Med , vol.192 , pp. 1175-1182
    • Cariappa, A.1    Liou, H.C.2    Horwitz, B.H.3    Pilai, S.4
  • 230
    • 0023694835 scopus 로고
    • The proto-onco-gene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus
    • Chabot B, Stephenson DA, Chapman VM, Besmer P, Bernstein A. The proto-onco-gene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus. Nature. 1988;335:88-9.
    • (1988) Nature , vol.335 , pp. 88-89
    • Chabot, B.1    Stephenson, D.A.2    Chapman, V.M.3    Besmer, P.4    Bernstein, A.5
  • 231
    • 12144257058 scopus 로고    scopus 로고
    • Kit as a human oncogenic tyrosine kinase
    • Kitamura Y, Hirotab S. Kit as a human oncogenic tyrosine kinase. Cell Mol Life Sci. 2004;61:2924-31.
    • (2004) Cell Mol Life Sci , vol.61 , pp. 2924-2931
    • Kitamura, Y.1    Hirotab, S.2
  • 232
    • 0036595143 scopus 로고    scopus 로고
    • Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412
    • Weisberg E, Boulton C, Kelly LM, et al. Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412. Cancer Cell. 2002;1:433-43.
    • (2002) Cancer Cell , vol.1 , pp. 433-443
    • Weisberg, E.1    Boulton, C.2    Kelly, L.M.3
  • 233
    • 33645850703 scopus 로고    scopus 로고
    • Repression of Flt3 by Pax5 is crucial for B-cell lineage commitment
    • Holmes ML, Carotta S, Corcoran LM, Nutt SL. Repression of Flt3 by Pax5 is crucial for B-cell lineage commitment. Genes Dev. 2006;20:933-8.
    • (2006) Genes Dev , vol.20 , pp. 933-938
    • Holmes, M.L.1    Carotta, S.2    Corcoran, L.M.3    Nutt, S.L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.