Genetic networks that regulate B lymphopoiesis

Current Opinion in Hematology

Volumn 12, Issue 3, 2005, Pages 203-209

  Medina, Kay L ^a,b   Singh, Harinder ^a,c  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b Irvington Institute   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

Author keywords

B cell development; Cell fate specification; Cytokine signaling; Gene regulatory networks; Transcriptional control

Indexed keywords

CYTOKINE RECEPTOR; FLK2 RECEPTOR; IKAROS TRANSCRIPTION FACTOR; INTERLEUKIN 7 RECEPTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR BCL11A; TRANSCRIPTION FACTOR E2A; TRANSCRIPTION FACTOR EBF; TRANSCRIPTION FACTOR PAX5; TRANSCRIPTION FACTOR PU 1; UNCLASSIFIED DRUG;

ANIMAL CELL; B LYMPHOCYTE; CELL FATE; CELL LINEAGE; EMBRYONIC STEM CELL; GENE EXPRESSION; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC SYSTEM; LYMPHOID CELL; LYMPHOPOIESIS; MOUSE; MULTIPOTENT STEM CELL; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; B-LYMPHOCYTES; CELL LINEAGE; FMS-LIKE TYROSINE KINASE 3; GENE EXPRESSION REGULATION; HEMATOPOIETIC STEM CELLS; HUMANS; LYMPHOPOIESIS; PROTO-ONCOGENE PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, INTERLEUKIN-7; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 18744404228     PISSN: 10656251     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.moh.0000160735.67596.a0     Document Type: Review

References (55)

1. Miyamoto T, Iwasaki H, Reizis B, et al. Myeloid or lymphoid promiscuity as a critical step in hematopoietic lineage commitment. Dev Cell 2002; 3: 137-147.
2. Cantor AB, Orkin SH. Transcriptional regulation of erythropoiesis: an affair involving multiple partners. Oncogene 2002; 21:3368-3376.
3. Dahl R, Walsh JC, Lancki D, et al. Regulation of macrophage and neutrophil cell fates by the PU.1:C/EBPalpha ratio and granulocyte colony-stimulating factor. Nat Immunol 2003.
4. Georgopoulos K, Bigby M, Wang JH, et al. The Ikaros gene is required for the development of all lymphoid lineages. Cell 1994; 79:143-156.
5. Scott EW, Simon MC, Anastasi J, Singh H. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science 1994; 265:1573-1577.
6. Bain G, Maandag EC, Izon DJ, et al. E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements. Cell 1994; 79:885-892.
7. Zhuang Y, Soriano P, Weintraub H. The helix-loop-helix gene E2A is required for B cell formation. Cell 1994; 79:875-884.
8. Nutt SL, Urbanek P, Rolink A, Busslinger M. Essential functions of Pax5 (BSAP) in pro-B cell development: difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus. Genes Dev 1997; 11:476-491.
9. Peschon JJ, Morrissey PJ, Grabstein KH, et al. Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J Exp Med 1994; 180:1955-1960.
10. Mackarenhtschian K, Hardin JD, Moore KA, et al. Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors. Immunity 1995; 3:147-161.
11. Liu P, Keller JR, Ortiz M, et al. Bcl11a is essential for normal lymphoid development. Nat Immunol 2003; 4:525-532.
12. Lin H, Grosschedl R. Failure of B-cell differentiation in mice lacking the transcription factor EBF. Nature 1995; 376:263-267.
13. Spangrude GJ, Smith L, Uchida N, et al. Mouse hematopoietic stem cells. Blood 1991; 78:1395-1402.
14. Adolfsson J, Borge OJ, Bryder D, et al. Upregulation of flt3 expression within the bone marrow lin-sca1+c-kit+ stem cell compartment is accompanied by loss of self-renewal capacity. Immunity 2001; 15:659-669.
15. Igarashi H, Gregory SC, Yokota T, et al. Transcription from the RAG1 locus marks the earliest lymphocyte progenitors in bone marrow. Immunity 2002; 17:117-130.
16. Schwarz BA, Bhandoola A. Circulating hematopoietic progenitors with T lineage potential. Nat Immunol 2004; 5:953-960. Characterizes multipotent progenitors in the blood, which efficiently generate T-lineage progeny upon emigrating to the thymus.
17. Akashi K, Reya T, Dalma-Weiszhausz D, Weissman IL. Lymphoid precursors. Curr Opin Immunol 2000; 12:144-150.
18. Maillard I, Adler SH, Pear WS. Notch and the immune system. Immunity 2003; 19:781-791.
19. Busslinger M. Transcriptional control of early B cell development. Annu Rev Immunol 2004; 22:55-79.
20. Hardy RR, Carmack CE, Shinton SA, et al. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J Exp Med 1991; 173:1213-1225.
21. Li YS, Hayakawa K, Hardy RR. The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver. J Exp Med 1993; 178:951-960.
22. Murre C, McCaw PS, Baltimore D. A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins. Cell 1989; 56:777-783.
23. Sun XH, Baltimore D. An inhibitory domain of E12 transcription factor prevents DNA binding in E12 homodimers but not in E12 heterodimers. Cell 1991; 64:459-470.
24. Hagman J, Belanger C, Travis A, et al. Cloning and functional characterization of early B-cell factor, a regulator of lymphocyte-specific gene expression. Genes Dev 1993; 7:760-773.
25. Romanow WJ, Langerak AW, Goebel P, et al. E2A and EBF act in synergy with the V(D)J recombinase to generate a diverse immunoglobulin repertoire in nonlymphoid cells. Mol Cell 2000; 5:343-353.
26. Quong MW, Romanow WJ, Murre C. E protein function in lymphocyte development. Annu Rev Immunol 2002; 20:301-322.
27. O'Riordan M, Grosschedl R. Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A. Immunity 1999; 11:21-31.
28. Nutt SL, Heavey B, Rolink AG, Busslinger M. Commitment to the B-lymphoid lineage depends on the transcription factor Pax5. Nature 1999; 401: 556-562.
29. Nutt SL, Eberhard D, Horcher M, et al. Pax5 determines the identity of B cells from the beginning to the end of B-lymphopoiesis. Int Rev Immunol 2001; 20:65-82.
30. Sitnicka E, Bryder D, Theilgaard-Monch K, et al. Key role of flts ligand in regulation of the common lymphoid progenitor but not in maintenance of the hematopoietic stem cell pool. Immunity 2002; 17:463-472.
31. Borge OJ, Adolfsson J, Martensson A, et al. Lymphoid-restricted development from multipotent candidate murine stem cells: distinct and complimentary functions of the c-kit and fltS-ligands. Blood 1999; 94:3781-3790.
32. Sitnicka E, Brakebusch C, Martensson IL, et al. Complementary signaling through fits and interleukin-7 receptor alpha is indispensable for fetal and adult B cell genesis. J Exp Med 2003; 198:1495-1506.
33. Vosshenrich CA, Cumano A, Muller W, et al. Thymic stromal-derived lymphopoietin distinguishes fetal from adult B cell development. Nat Immunol 2003; 4:773-779.
34. Miller JP, Izon D, DeMuth W, et al. The earliest step in B lineage differentiation from common lymphoid progenitors is critically dependent upon interleukin 7. J Exp Med 2002; 196:705-711.
35. Dias S, Silva Jr. H, Cumano A, Vieira P. Interleukin-7 is necessary to maintain the B cell potential in common lymphoid progenitors. J Exp Med 2005; 201: 971-979. Epub 2005 Mar 14.
36. Carvalho TL, Mota-Santos T, Cumano A, et al. Arrested B lymphopoiesis and persistence of activated b cells in adult interleukin-7-/- mice. J Exp Med 2001; 194:1141-1150.
37. Rothenberg EV. T-lineage specification and commitment: a gene regulation perspective. Semin Immunol 2002; 14:431-440.
38. Nichogiannopoulou A, Trevisan M, Neben S, et al. Defects in hemopoietic stem cell activity in Karats mutant mice. J Exp Med 1999; 190:1201-1214.
39. DeKoter RP, Lee HJ, Singh H. PU.1 regulates expression of the interleukin-7 receptor in lymphoid progenitors. Immunity 2002; 16:297-309.
40. Medina KL, Pongubala JM, Reddy KL, et al. Assembling a gene regulatory network for specification of the B cell fate. Dev Cell 2004; 7:607-617. Analysis of the PU.1 and EBF mutations using complementation and functional bypass experiments. Assembly of inter-dependent regulatory modules that orchestrate B cell fate specification and commitment.
41. Kee BL, Murre C. Induction of early B cell factor (EBF) and multiple B lineage genes by the basic helix-loop-helix transcription factor E12. J Exp Med 1998; 188:699-713.
42. Zhang Z, Cotta CV, Stephan RP, et al. Enforced expression of EBF in hematopoietic stem cells restricts lymphopoiesis to the B cell lineage. EMBO J 2003; 22:4759-4769.
43. Seet CS, Brumbaugh RL, Kee BL. Early B cell factor promotes B lymphopoiesis with reduced interleukin 7 responsiveness in the absence of E2A. J Exp Med 2004; 199:1689-1700. EBF is shown to bypass the requirement for E2A in specification of the B cell fate.
44. Maier H, Ostraat R, Gao H, et al. Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription. Nat Immunol 2004; 5:1069-1077. Analysis of mb-1 gene activation that provides a molecular explanation for the contingency of Pax-5 function on EBF. Includes evidence for EBF-dependent DNA demethylation of the mb-1 promoter during early B cell development.
45. Ikawa T, Kawamoto H, Wright LY, Murre C. Long-term cultured E2A-deficient hematopoietic progenitor cells are pluripotent. Immunity 2004; 20:349-360. Demonstrates that E2A mutant hematopoietic progenitors can be established as cell lines and display multilineage potential.
46. Mikkola I, Heavey B, Horcher M, Busslinger M. Reversion of B cell commitment upon loss of Pax5 expression. Science 2002; 297:110-113.
47. Zhuang Y, Jackson A, Pan L, et al. Regulation of E2A gene expression in B-lymphocyte development. Mol Immunol 2004; 40:1165-1177. Utilizes an E2A-GFP knock-in allele to examine the regulation of E2A expression during B cell development.
48. Smith EM, Gisler R, Sigvardsson M. Cloning and characterization of a promoter flanking the early B cell factor (EBF) gene indicates roles for E-proteins and autoregulation in the control of EBF expression. J Immunol 2002; 169: 261-270.
49. Saiki Y, Yamazaki Y, Yoshida M, et al. Human EVI9, a homologue of the mouse myeloid leukemia gene, is expressed in the hematopoietic progenitors and down-regulated during myeloid differentiation of HL60 cells. Genomics 2000; 70:387-391.
50. Satterwhite E, Sonoki T, Willis TG, et al. The BCL11 gene family: involvement of BCL11A in lymphoid malignancies. Blood 2001; 98:3413-3420.
51. Greenbaum S, Lazorchak AS, Zhuang Y. Differential functions for the transcription factor E2A in positive and negative gene regulation in pre-B lymphocytes. J Biol Chem 2004; 279:45028-45035. Analyzes phenotypic consequences of loss of E2A activity in Abelson transformed pro-B cells.
52. Xie H, Ye M, Feng R, Graf T. Stepwise reprogramming of B cells into macrophages. Cell 2004; 117:663-676. Provides evidence for C/EBP instigated re-programming of B-lineage cells into macrophages.
53. Saisanit S, Sun XH. Regulation of the pro-B-cell-specific enhancer of the Id1 gene involves the C/EBP family of proteins. Mol Cell Biol 1997; 17:844-850.
54. Sun XH, Copeland NG, Jenkins NA, Baltimore D. Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins. Mol Cell Biol 1991; 11:5603-5611.
55. Sun XH. Constitutive expression of the Id1 gene impairs mouse B cell development. Cell 1994; 79:893-900.