MALT1 is deregulated by both chromosomal translocation and amplification in B-cell non-Hodgkin lymphoma

Blood

Volumn 101, Issue 11, 2003, Pages 4539-4546

  Sanchez Izquierdo, Dolors ^c   Buchonnet, Gerard ^c   Siebert, Reiner ^c   Gascoyne, Randy D ^c   Climent, Joan ^c   Karran, Loraine ^c   Marin, Miguel ^c   Blesa, David ^c   Horsman, Douglas ^c   Rosenwald, Andreas ^c   Staudt, Louis M ^c   Albertson, Donna G ^c   Du, Ming Qing ^c   Ye, Hongtao ^c   Marynen, Peter ^c   Garcia Conde, Javier ^c   Pinkel, Daniel ^c   Dyer, Martin J S ^a   Martinez Climent, Jose Angel ^b  

^a MRC TOXICOLOGY UNIT   (United Kingdom)

^b UNIVERSITY OF VALENCIA   (Spain)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; PROTEIN BCL 2; CASPASE; MALT1 PROTEIN, HUMAN; RNA; TUMOR PROTEIN;

ADULT; ARTICLE; B CELL LYMPHOMA; CASE REPORT; CHROMOSOME TRANSLOCATION; COMPARATIVE GENOMIC HYBRIDIZATION; EXON; FEMALE; FLUORESCENCE; GENE; GENE AMPLIFICATION; GENE CONTROL; GENE EXPRESSION; GENE LOCUS; GENE OVEREXPRESSION; GENOMICS; HUMAN; MALE; MALT1 GENE; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; ONCOGENE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; AGED; BIOSYNTHESIS; CHROMOSOME 14; CHROMOSOME 18; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE TRANSLOCATION; GENETICS; MIDDLE AGED; MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA; PATHOLOGY; PROTO ONCOGENE;

AGED; CASPASES; CHROMOSOMES, HUMAN, PAIR 14; CHROMOSOMES, HUMAN, PAIR 18; FEMALE; GENE AMPLIFICATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, BCL-2; HUMANS; LYMPHOMA, B-CELL; LYMPHOMA, MUCOSA-ASSOCIATED LYMPHOID TISSUE; MALE; MIDDLE AGED; NEOPLASM PROTEINS; RNA, NEOPLASM; TRANSLOCATION, GENETIC;

EID: 0012605299     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2002-10-3236     Document Type: Article

References (53)

1. Offit K, Chaganti RSK. Chromosomal aberrations in non-Hodgkin's lymphoma: biological and clinical correlations. Hematol Oncol Clin North Am. 1991;5:853-869.
2. Buchonnet G, Lenain P, Ruminy P, et al. Characterisation of BCL2-JH rearrangements in follicular lymphoma: PCR detection of 3′ BCL2 break-points and evidence of a new cluster. Leukemia. 2000;14:1563-1569.
3. Amakawa R, Fukuhara S, Ohno H, et al. Amplified and rearranged bcl-2 gene in two lymphoma cell lines, FL-218 and FL-318, carrying a 14;18 translocation. Cancer Res. 1990;50:2423-2428.
4. Monni O, Joensuu H, Franssila K, Klefstrom J, Alitalo K, Knuutila S. BCL2 overexpression associated with chromosomal amplification in diffuse large B-cell lymphoma. Blood. 1997;90:1168-1174.
5. Hanada M, Delia D, Aiello A, Stadtmauer E, Reed JC. Bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia. Blood. 1993;82:1820-1828.
6. Rimokh R, Gadoux M, Bertheas MF, et al. FV7-1, a novel human transcription unit affected by variant translocation t(2;18)(p11;q21) of follicular lymphoma. Blood. 1993;81:136-142.
7. Weber T, Weber RG, Kaulich K, et al. Characteristic chromosomal imbalances in primary central nervous system lymphomas of the diffuse large B-cell type. Brain Pathol. 2000;10:73-84.
8. Montesinos-Rongen M, Zühlke-Jenisch R, Gesk S, et al. Interphase cytogenetic analysis of lymphoma-associated chromosomal breakpoints in primary diffuse large B-cell lymphomas of the central nervous system. J Neuropathol Exp Neurol. 2002;61:926-933.
9. Bentz M, Plesch A, Bullinger L, et al. t(11;14)-positive mantle cell lymphomas exhibit complex karyotypes and share similarities with B-cell chronic lymphocytic leukemia. Genes Chromosomes Cancer. 2000;27:285-294.
10. Bea S, Ribas M, Hernandez JM, et al. Increased number of chromosomal imbalances and high-level DNA amplifications in mantle cell lymphoma are associated with blastoid variants. Blood. 1999;93:4365-4374.
11. Ott G, Katzenberger T, Greiner A, et al. The t(11; 18)(q21;q21) chromosome translocation is a frequent and specific aberration in low-grade but not high-grade malignant non-Hodgkin's lymphomas of the mucosa-associated lymphoid tissue (MALT) type. Cancer Res. 1997;57:3944-3948.
12. Auer IA, Gascoyne RD, Connors JM, et al. t(11; 18)(q21;q21) is the most common translocation in MALT lymphomas. Ann Oncol. 1997;8:979-985.
13. Rosenwald A, Ott G, Stilgenbauer S, et al. Exclusive detection of the t(11;18)(q21;q21) in extranodal marginal zone B cell lymphomas (MZBL) of MALT type in contrast to other MZBL and extranodal large B cell lymphomas. Am J Pathol. 1999;155:1817-1821.
14. Dierlamm J, Baens M, Wlodarska I, et al. The apoptosis inhibitor gene API2 and a novel 18q gene, MALT1, are recurrently rearranged in the t(11; 18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomas. Blood. 1999;93: 3601-3609.
15. Morgan JA, Yin Y, Borowsky AD, et al. Break-points of the t(11;18)(q21;q21) in mucosa-associated lymphoid tissue (MALT) lymphoma lie within or near the previously undescribed gene MALT1 in chromosome 18. Cancer Res. 1999;59:6205-6213.
16. Akagi T, Motegi M, Tamura A, et al. A novel gene, MALT1 at 18q21, is involved in t(11;18)(q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue. Oncogene. 1999;18: 5785-5794.
17. Uren GA, O'Rourke K, Aravind L, et al: Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma, Mol Cell. 2000;6:961-967
18. Lucas PC,Yonezumi M, Inohara N, et al. Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-κB signaling pathway. J Biol Chem. 2001;276:19012-19019.
19. Ruland J, Duncan GS, Elia A, et al. Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure. Cell. 2001;104:33-42.
20. Hernandez JM, Garcia JL, Gutierrez NC, et al. Novel genomic imbalances in B-cell splenic marginal zone lymphomas revealed by comparative genomic hybridization and cytogenetics. Am J Pathol. 2001;158:1843-1850.
21. Jaffe ES, Harris NL, Stein H, Vardiman JW. Pathology and genetics of tumors of haematopoietic and lymphoid tissues. World Health Organization Classification of Tumors. Lyon, France: IARC Press; 2001.
22. Martinez-Climent JA, Vizcarra E, Sanchez D, et al. Loss of a novel tumor suppressor gene locus at chromosome 8p is associated with leukemic mantle cell lymphoma. Blood. 2001;98;3479-3482.
23. Dierlamm J, Baens M, Stefanova-Ouzounova M, et al. Detection of t(11;18)(q21;q21) by interphase fluorescence in situ hybridization using API2 and MALT1 specific probes. Blood. 2000;96:2215-2218.
24. Willis TG, Jadayel DM, Coignet LJ, et al. Rapid molecular cloning of rearrangements of the IGHJ locus using long-distance inverse polymerase chain reaction. Blood. 1997;90:2456-2464.
25. Snijders AM, Nowak N, Segraves R, et al. Assembly of microarrays for genome-wide measurement of DNA copy number. Nat Genet. 2001;29: 263-264.
26. Jain AN, Tokuyasu TA, Snijders AM, Segraves R, Albertson DG, Pinkel D. Fully automatic quantification of microarray image data. Genome Res. 2002;12:325-332.
27. Alizadeh AA, Eisen MB, Davis RE, et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature. 2000;403: 503-511.
28. Bieche I, Onody P, Laurendeau I, et al. Real-time reverse transcription-PCR assay for future management of ERBB2-based clinical applications. Clin Chem. 1999;45:1148-1156.
29. Ye H, Dogan A, Karran L, et al. BCL10 expression in normal and neoplastic lymphoid tissue. Nuclear localization in MALT lymphoma. Am J Pathol. 2000;157:1147-1154.
30. Horsman DE, Connors JM, Pantzar T, Gascoyne RD. Analysis of secondary chromosomal alterations in 165 cases of follicular lymphoma with t(14;18). Genes Chromosomes Cancer. 2001;30: 375-382.
31. Gabrea A, Bergsagel PL, Chesi M, Shou Y, Kuehl WM. Insertion of excised IgH switch sequences causes overexpression of cyclin D1 in a myeloma tumor cell. Mol Cell. 1999;3:119-123.
32. Willis TG, Dyer MJS. The role of immunoglobulin translocations in the pathogenesis of B-cell malignancies. Blood. 2000;96:808-822.
33. Maes B, Demunter A, Peeters B, de Wolf-Peeters C. BCL10 mutation does not represent an important pathogenetic mechanism in gastric MALT-type lymphoma, and the presence of the ApI2-MALT1 fusion is associated with aberrant nuclear expression. Blood. 2002;99:1398-1404.
34. Nacheva E, Dyer MJS, Metivier C, et al. B-cell non-Hodgkin's lymphoma cell line (Karpas1106) with complex translocation involving 18q21.3 but lacking BCL2 rearrangement and expression. Blood. 1994;84:3422-3428.
35. Sideras P, Mizuta TR, Kanamori H, et al. Production of sterile transcripts of Cγ genes in an IgM-producing human neoplastic B cell line that switches to IgG-producing cells. Int Immunol. 1989;1:631-639.
36. Sonoki T, Matsuzaki H, Miyamoto K, et al. Establishment of the novel B acute lymphoblastic leukemia (FAB L3) cell line KHM-10B with a 13q34 abnormality and constitutive expression of c-myc and max during cell cycle. Leukemia. 1995;2093-2099.
37. Baens M, Steyls A, Dierlamm J, De wolf-Peeters C, Marynen P. Structure of the MALT1 gene and molecular characterization of the genomic break-point junctions in the t(11;18)(q21;q21) of marginal zone B-cell lymphomas of MALT type. Genes Chromosomes Cancer. 2000;29:281-291
38. Willis TG, Jadayel DM, Du MQ, et al. BCL10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types. Cell. 1999;96:35-45.
39. Zhang Q, Siebert R, Yan M, et al. Inactivating mutations and over-expression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32). Nat Genet. 1999;22:63-68.
40. Isaacson PG. MALT lymphoma: from concept to cure. Ann Oncol. 1999;10:637-645.
41. Mollejo M, Menarguez J, Lloret E, et al. Splenic marginal zone lymphoma: a distinctive type of low-grade B-cell lymphoma. A clinicopathological study of 13 cases. Am J Surg Pathol. 1995;19: 1146-1157.
42. Mateo M, Mollejo M, Villuendas R, et al. 7q31-q32 allelic loss is a frequent finding in splenic marginal zone lymphoma. Am J Pathol. 1999; 154:1583-1589.
43. Corcoran MM, Mould SJ, Orchard JA, et al. Dysregulation of cyclin dependent kinase 6 expression in splenic marginal zone lymphoma through chromosome 7q translocations. Oncogene. 1999; 18:6271-6277.
44. Sonoki T, Harder L, Horsman DE, et al. Cyclin D3 is a target gene of t(6;14)(p21.1;q32.3) of mature B-cell malignancies. Blood. 2001;98:2837-2844.
45. Dierlamm J, Michaux L, Wlodarska I, et al. Trisomy 3 in low-grade B-cell lymphomas of mucosa-associated lymphoid tissue. Blood. 1995;85: 2000-2004.
46. Batanian JR, Dunphy CH, Richart JM, Petruska PJ, Perkins SL. Simultaneous presence of t(2; 8)(p12;q24) and t(14;18)(q32;q21) in a B-cell lymphoproliferative disorder with features suggestive of an aggressive variant of splenic marginal-zone lymphoma. Cancer Genet Cytogenet. 2000;120: 136-140.
47. Streubel B, Lamprecht A, Dierlamm J, et al. T(14; 18)(q32;q21) involving IGH and MALT1 is a frequent chromosomal aberration in MALT lymphoma. Blood. 2003;101:2335-2339.
48. Remstein ED, Kurtin PJ, Einerson RR, Dewald GW. Primary pulmonary MALT lymphomas show frequent and heterogeneous cytogenetic abnormalities, including a previously unreported MALT1-IGH translocation [abstract]. Blood. 2002; 100:1515a.
49. Erdel M, Dirnhofer S, Tzankov A, et al. Molecular-cytogenetic analysis of gastrointestinal MALT lymphoma [abstract]. Med Genet. 2002;14:279.
50. Werner CA, Dohner H, Joos S, et al. High-level DNA amplifications are common genetic aberrations in B-cell neoplasms. Am J Pathol. 1997;151: 335-342.
51. Rao PH, Houldsworth J, Dyomina K, et al. Chromosomal and gene amplification in diffuse large B-cell lymphoma. Blood. 1998;92;234-240.
52. Mao X, Lillington D, Child F, Russell-Jones R, Young B, Whittaker S. Comparative genomic hybridization analysis of primary cutaneous B-cell lymphomas: identification of common genomic alterations in disease pathogenesis. Genes Chromosomes Cancer 2002;35:144-155.
53. Satterwhite E, Sonoki T, Willis TG, et al. The BCL11 gene family: Involvement of BCL11A in lymphoid malignancies. Blood. 2001;98:3413-3420.