-
1
-
-
0035929353
-
Switching and signaling at the telomere
-
Blackburn, E. H. Switching and signaling at the telomere. Cell 106, 661-673 (2001).
-
(2001)
Cell
, vol.106
, pp. 661-673
-
-
Blackburn, E.H.1
-
2
-
-
0037148270
-
New ways not to make ends meet: Telomerase, DNA damage proteins and heterochromatin
-
Chan, S. W-L. & Blackburn, E. H. New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatin. Oncogene 21, 553-563 (2002).
-
(2002)
Oncogene
, vol.21
, pp. 553-563
-
-
Chan, S.W.-L.1
Blackburn, E.H.2
-
3
-
-
0037148277
-
Protection of mammalian telomeres
-
De Lange, T. Protection of mammalian telomeres. Oncogene 21, 532-540 (2002).
-
(2002)
Oncogene
, vol.21
, pp. 532-540
-
-
De Lange, T.1
-
4
-
-
0033553536
-
Mammalian telomeres and in a large duplex loop
-
Griffith, J. D. et al. Mammalian telomeres and in a large duplex loop. Cell 97, 503-514 (1999).
-
(1999)
Cell
, vol.97
, pp. 503-514
-
-
Griffith, J.D.1
-
5
-
-
0036241994
-
Targeting assay to study the cis functions of human telomeric proteins: Evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2
-
Ancelin, K. et al. Targeting assay to study the cis functions of human telomeric proteins: evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2. Mol. Cell. Biol. 22, 3474-3487 (2002).
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 3474-3487
-
-
Ancelin, K.1
-
6
-
-
0037192462
-
Senescence induced by altered telomere state, not telomere loss
-
Karlseder, J., Smogorzewska, A. and de Lange, T. Senescence induced by altered telomere state, not telomere loss. Science 295, 2446-2449 (2002).
-
(2002)
Science
, vol.295
, pp. 2446-2449
-
-
Karlseder, J.1
Smogorzewska, A.2
De Lange, T.3
-
7
-
-
0037148330
-
Many ways to telomere dysfunction: In vivo studies using mouse models
-
Goytisolo, F. A. & Blasco, M. A. Many ways to telomere dysfunction: in vivo studies using mouse models. Oncogene 21, 584-591 (2002).
-
(2002)
Oncogene
, vol.21
, pp. 584-591
-
-
Goytisolo, F.A.1
Blasco, M.A.2
-
8
-
-
0030931491
-
Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
-
Blasco, M. A. et al. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91, 25-34 (1997).
-
(1997)
Cell
, vol.91
, pp. 25-34
-
-
Blasco, M.A.1
-
9
-
-
0036566036
-
Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres
-
Espejel, S. et al. Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres. EMBO J. 21, 2207-2219 (2002).
-
(2002)
EMBO J.
, vol.21
, pp. 2207-2219
-
-
Espejel, S.1
-
10
-
-
0025279931
-
Telomeres shorten during ageing of human fibroblasts
-
Harley, C. B., Futcher, A. B. & Greider, C. W. Telomeres shorten during ageing of human fibroblasts. Nature 31, 458-460 (1990).
-
(1990)
Nature
, vol.31
, pp. 458-460
-
-
Harley, C.B.1
Futcher, A.B.2
Greider, C.W.3
-
11
-
-
0037148271
-
Telomerase in the human organism
-
Collins, K. & Mitchell, J. R. Telomerase in the human organism. Oncogene 21, 564-579 (2002).
-
(2002)
Oncogene
, vol.21
, pp. 564-579
-
-
Collins, K.1
Mitchell, J.R.2
-
12
-
-
0032499210
-
Essential role of mouse telomerase in highly proliferative organs
-
Lee, H-W. et al. Essential role of mouse telomerase in highly proliferative organs. Nature 392, 569-574 (1998).
-
(1998)
Nature
, vol.392
, pp. 569-574
-
-
Lee, H.-W.1
-
14
-
-
0035812845
-
The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability
-
Hemann, M. T., Strong, M. A., Hao, L. Y. and Greider, C. W. The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell 107, 67-77 (2001).
-
(2001)
Cell
, vol.107
, pp. 67-77
-
-
Hemann, M.T.1
Strong, M.A.2
Hao, L.Y.3
Greider, C.W.4
-
15
-
-
0010045614
-
Extension of life-span by introduction of telomerase into normal human cells
-
Bodnar, A. G. et al. Extension of life-span by introduction of telomerase into normal human cells. Science 279, 349-352 (1998).
-
(1998)
Science
, vol.279
, pp. 349-352
-
-
Bodnar, A.G.1
-
16
-
-
0037148326
-
Clinical utility of telomerase in cancer
-
Hiyama, E. & Hiyama, K. Clinical utility of telomerase in cancer. Oncogene 21, 643-649 (2002).
-
(2002)
Oncogene
, vol.21
, pp. 643-649
-
-
Hiyama, E.1
Hiyama, K.2
-
17
-
-
0035978922
-
Emerging roles for telomerase in regulating cell differentiation and survival: A neuroscientist's perspective
-
Mattson, M. P., Fu, W. & Zhang, P. Emerging roles for telomerase in regulating cell differentiation and survival: a neuroscientist's perspective. Mech. Aging Dev. 122, 659-671 (2001).
-
(2001)
Mech. Aging Dev.
, vol.122
, pp. 659-671
-
-
Mattson, M.P.1
Fu, W.2
Zhang, P.3
-
18
-
-
0035355340
-
Increased epidermal tumors and increased wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes
-
González-Suárez, E. et al. Increased epidermal tumors and increased wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes. EMBO J. 20, 2619-2630 (2001).
-
(2001)
EMBO J.
, vol.20
, pp. 2619-2630
-
-
González-Suárez, E.1
-
19
-
-
0035525779
-
Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells
-
Reyes, M. et al. Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells. Blood 98, 2615-2625 (2001).
-
(2001)
Blood
, vol.98
, pp. 2615-2625
-
-
Reyes, M.1
-
20
-
-
0029102354
-
Runaway telomere elongation caused by telomerase RNA gene mutations
-
McEachern, M. J. & Blackburn, E. H. Runaway telomere elongation caused by telomerase RNA gene mutations. Nature 376, 403-409 (1995).
-
(1995)
Nature
, vol.376
, pp. 403-409
-
-
McEachern, M.J.1
Blackburn, E.H.2
-
21
-
-
0033961281
-
Control of human telomere length by TRF1 and TRF2
-
Smogorzewska, A. et al. Control of human telomere length by TRF1 and TRF2. Mol. Cell. Biol. 20, 1659-1668 (2000).
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 1659-1668
-
-
Smogorzewska, A.1
-
22
-
-
0034068910
-
Telomerase RNA template mutations reveal sequence-specific requirements for activation and repression of telomerase action at telomeres
-
Prescott, J. C. & Blackburn, E. H. Telomerase RNA template mutations reveal sequence-specific requirements for activation and repression of telomerase action at telomeres. Mol. Cell. Biol. 20, 2941-2948 (2000).
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 2941-2948
-
-
Prescott, J.C.1
Blackburn, E.H.2
-
23
-
-
0033153424
-
Disease states associated to telomerase deficiency appear earlier in mice with short telomeres
-
Herrera, E. et al. Disease states associated to telomerase deficiency appear earlier in mice with short telomeres. EMBO J. 18, 2950-2960 (1999).
-
(1999)
EMBO J.
, vol.18
, pp. 2950-2960
-
-
Herrera, E.1
-
24
-
-
0025143252
-
Telomere reduction in human colorectal carcinoma and with ageing
-
Hastie, N. D. et al. Telomere reduction in human colorectal carcinoma and with ageing. Nature 346, 866-868 (1990).
-
(1990)
Nature
, vol.346
, pp. 866-868
-
-
Hastie, N.D.1
-
25
-
-
0025115349
-
Structure and variability of human chromosome ends
-
de Lange, T. et al. Structure and variability of human chromosome ends. Mol. Cell. Biol. 10, 518-527 (1990).
-
(1990)
Mol. Cell. Biol.
, vol.10
, pp. 518-527
-
-
De Lange, T.1
-
26
-
-
0033616762
-
Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening
-
Zhu, J., Wang, H., Bishop, M. and Blackburn, E. H. Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening. Proc. Natl Acad. Sci. USA 96, 3723-3728 (1999).
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 3723-3728
-
-
Zhu, J.1
Wang, H.2
Bishop, M.3
Blackburn, E.H.4
-
27
-
-
0033553516
-
p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis
-
Chin, L. et al. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell 97, 527-538 (1999).
-
(1999)
Cell
, vol.97
, pp. 527-538
-
-
Chin, L.1
-
28
-
-
0343228751
-
Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis
-
GonzáJez-Suárez, E., Samper, E., Rores, J. M. & Blasco, M. A. Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis. Nature Genet. 26, 114-117 (2000).
-
(2000)
Nature Genet.
, vol.26
, pp. 114-117
-
-
GonzáJez-Suárez, E.1
Samper, E.2
Rores, J.M.3
Blasco, M.A.4
-
29
-
-
0037148329
-
Telomerase inhibition, oligonucleotides, and clinical trials
-
Corey, D. R. Telomerase inhibition, oligonucleotides, and clinical trials. Oncogene 21, 631-727 (2002).
-
(2002)
Oncogene
, vol.21
, pp. 631-727
-
-
Corey, D.R.1
-
30
-
-
0034578478
-
G-quadruplexes as therapeutic targets
-
Neidle, S. & Read, M. A. G-quadruplexes as therapeutic targets. Biopolymers 56, 195-208 (2001).
-
(2001)
Biopolymers
, vol.56
, pp. 195-208
-
-
Neidle, S.1
Read, M.A.2
-
31
-
-
4243937106
-
A highly selective telomerase inhibitor limiting human cancer cell proliferation
-
Damm, K. et al. A highly selective telomerase inhibitor limiting human cancer cell proliferation. EMBO J. 20, 6958-6968 (2001).
-
(2001)
EMBO J.
, vol.20
, pp. 6958-6968
-
-
Damm, K.1
-
32
-
-
0030070054
-
Differential regulation of telomerase activity and its RNA component during multistage tumorigenesis
-
Blasco, M. A., Rizen, M., Greider, C. W. and Hanahan, D. Differential regulation of telomerase activity and its RNA component during multistage tumorigenesis. Nature Genet. 12, 200-204 (1996).
-
(1996)
Nature Genet.
, vol.12
, pp. 200-204
-
-
Blasco, M.A.1
Rizen, M.2
Greider, C.W.3
Hanahan, D.4
-
33
-
-
0029941676
-
Telomerase activation in mouse mammary tumors: Lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation
-
Broccoli, D., Godley, L. A., Donehower, L. A., Varmus, H. E. & de Lange, T. Telomerase activation in mouse mammary tumors: lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation. Mol. Cell. Biol. 16, 3765-3772 (1996).
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 3765-3772
-
-
Broccoli, D.1
Godley, L.A.2
Donehower, L.A.3
Varmus, H.E.4
De Lange, T.5
-
34
-
-
0036787840
-
Cooperation between p53 mutation and high telomerase transgenic expression in spontaneous cancer development
-
in the press
-
González-Suárez, E., Flores, J. M. & Blasco, M. A. Cooperation between p53 mutation and high telomerase transgenic expression in spontaneous cancer development. Mol. Cell. Biol. (in the press).
-
Mol. Cell. Biol.
-
-
González-Suárez, E.1
Flores, J.M.2
Blasco, M.A.3
-
35
-
-
0037062454
-
Constitutive telomerase expression promotes mammary carcinomas in aging mice
-
Artandi, S. E. et al. Constitutive telomerase expression promotes mammary carcinomas in aging mice. Proc. Natl Acad. Sci. USA 99, 8191-8196 (2002).
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 8191-8196
-
-
Artandi, S.E.1
-
36
-
-
0036858627
-
Cooperation between hTERT, SV40 T antigen and oncogenic Ras in tumorigenesis: A cell transplantation model using bovine adrenocortical cells
-
in the press
-
Thomas, M. et al. Cooperation between hTERT, SV40 T antigen and oncogenic Ras in tumorigenesis: a cell transplantation model using bovine adrenocortical cells. Neoplasia (in the press).
-
Neoplasia
-
-
Thomas, M.1
-
37
-
-
0035964313
-
Telomerase reverse transcriptase promotes cardiac muscle cell proliferation, hypertrophy, and survival
-
Oh, H. et al. Telomerase reverse transcriptase promotes cardiac muscle cell proliferation, hypertrophy, and survival. Proc. Natl Acad. Sci. USA 98, 10308-11033 (2001).
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 10308-11033
-
-
Oh, H.1
-
38
-
-
0035836727
-
Expression of the telomerase catalytic subunit, hTERT, induces resistance to transforming growth factor-β growth inhibition in p16INK4A(-) human mammary epithelial cells
-
Stampfer, M. R. et al. Expression of the telomerase catalytic subunit, hTERT, induces resistance to transforming growth factor-β growth inhibition in p16INK4A(-) human mammary epithelial cells. Proc. Natl Acad. Sci. USA 98, 4498-4503 (2001).
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 4498-4503
-
-
Stampfer, M.R.1
-
39
-
-
0035955938
-
Telomerase protects developing neurons against DNA damage-induced cell death
-
Lu, C. L., Fu, W. & Mattson, M. P. Telomerase protects developing neurons against DNA damage-induced cell death. Dev. Brain Res. 131, 167-171 (2001).
-
(2001)
Dev. Brain Res.
, vol.131
, pp. 167-171
-
-
Lu, C.L.1
Fu, W.2
Mattson, M.P.3
-
40
-
-
0034086553
-
The catalytic subunit of telomerase protects neurones against amyloid β-peptide induced apoptosis
-
Zhu, H., Fu, W. & Mattson, M. P. The catalytic subunit of telomerase protects neurones against amyloid β-peptide induced apoptosis. J. Neurochem. 75, 117-124 (2000).
-
(2000)
J. Neurochem.
, vol.75
, pp. 117-124
-
-
Zhu, H.1
Fu, W.2
Mattson, M.P.3
-
41
-
-
0037161961
-
Human telomerase accelerates growth of lens epithelial cells through regulation of the genes mediating Rb/E2F pathway
-
Xiang, H. et al. Human telomerase accelerates growth of lens epithelial cells through regulation of the genes mediating Rb/E2F pathway. Oncogene 21, 3784-3791 (2002).
-
(2002)
Oncogene
, vol.21
, pp. 3784-3791
-
-
Xiang, H.1
-
42
-
-
17844373798
-
The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo
-
Liu, Y. et al. The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo. Curr. Biol. 10, 1459-1462 (2000).
-
(2000)
Curr. Biol.
, vol.10
, pp. 1459-1462
-
-
Liu, Y.1
-
43
-
-
6544263270
-
Presence of telomeric G-strand tails in the telomerase catalytic subunit Tert knockout mice
-
Nikaido, R. et al. Presence of telomeric G-strand tails in the telomerase catalytic subunit Tert knockout mice. Genes Cells 4, 563-572 (1999).
-
(1999)
Genes Cells
, vol.4
, pp. 563-572
-
-
Nikaido, R.1
-
44
-
-
0035964864
-
Strand-specific postreplicative processing of mammalian telomeres
-
Bailey, S. M., Conforth, M. N., Kurimasa, A., Chen, D. J. and Goodwin, E. H. Strand-specific postreplicative processing of mammalian telomeres. Science 293, 2462-2465 (2001).
-
(2001)
Science
, vol.293
, pp. 2462-2465
-
-
Bailey, S.M.1
Conforth, M.N.2
Kurimasa, A.3
Chen, D.J.4
Goodwin, E.H.5
-
45
-
-
0034606226
-
Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals
-
Goytisolo, F. A. et al. Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals. J. Exp. Med. 192, 1625-1636 (2000).
-
(2000)
J. Exp. Med.
, vol.192
, pp. 1625-1636
-
-
Goytisolo, F.A.1
|