Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism

Immunity

Volumn 13, Issue 1, 2000, Pages 15-24

  Reya, Tannishtha ^a   O'Riordan, Mary ^a   Okamura, Ross ^a   Devaney, Erik ^a   Willert, Karl ^b   Nusse, Roel ^b   Grosschedl, Rudolf ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FAS ANTIGEN; LYMPHOID ENHANCER FACTOR 1; MITOGENIC AGENT; MYC PROTEIN; PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; WNT PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL MATURATION; CELL SURVIVAL; CONTROLLED STUDY; FETUS; LYMPHOCYTE PROLIFERATION; MITOGENESIS; MOUSE; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE C MYC; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

EID: 0033711624     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)00004-2     Document Type: Article

References (60)

1. A role for the Wnt gene family in hematopoiesis: Expansion of multilineage progenitor cells
2. Characterization of Wnt-1 and Wnt-2 induced growth alterations and signaling pathways in NIH3T3 fibroblasts
3. Functional interaction of β-catenin with the transcription factor LEF-1
4. A soluble form of Wnt-1 protein with mitogenic activity on mammary epithelial cells
5. ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function
6. Pangolin encodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosopila
7. Wnt signaling: A common theme in animal development
8. Fetal liver organ cultures allow the proliferative expansion of pre-B receptor-expressing pre-B-cells and the differentiation of immature and mature B cells in vitro
9. Regulatory cells and cytokines involved in primary B lymphocyte production
10. Regulation of LEF-1/TCF transcription factors by Wnt and other signals
11. Induction of apoptosis in fibroblasts by c-myc protein
12. Lymphoproliferative disorders in IL-7 transgenic mice: Expansion of immature B cells which retain macrophage potential
13. Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1
14. Fas ligation induces apoptosis of CD40-activated human B lymphocytes
15. Assembly and function of a TCRa enhancer complex is dependent on LEF-1 induced DNA bending and multiple protein-protein interactions
16. Inhibition of murine B and T lymphopoiesis in vivo by an anti-interleukin 7 monoclonal antibody
17. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow
18. Identification of c-MYC as a target of the APC pathway
19. Modulation of transcriptional regulation by LEF-1 in response to Wnt-1 signaling and association with β-catenin
20. Nuclear localization of beta-catenin by interaction with transcription factor LEF-1
21. The mouse Wnt-1 gene can act via a paracrine mechanism in transformation of mammary epithelial cells
22. Neoplastic transformation of RK3E by mutant beta-catenin requires deregulation of Tcf/Lef transcription but not activation of c-myc expression
23. Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes
24. Constitutive transcriptional activation by a β-catenin-Tcf complex in APC(-/-) colon carcinoma
25. Two members of the Tcf family implicated in the Wnt/β-catenin signaling during embryogenesis in the mouse
26. B-cell lymphopoiesis in mouse and man
27. Insertional mutagenesis identifies a member of the Wnt gene family as a candidate oncogene in the mammary epithelium of int-2/Fgf-3 transgenic mice
28. T and B cell development in BP-1/6C3/aminopeptidase A-deficient mice
29. Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia
30. XTcf-3 transcription factor mediates β-catenin-induced axis formation in Xenopus embryos
31. Targeted disruption of the Wnt2 gene results in placentation defects
32. WNTs modulate cell fate and behavior during vertebrate development
33. Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC
34. Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome
35. Redundant regulation of T cell differentiation and TCRa gene expression by the transcription factors LEF-1 and TCF-1
36. Expression and function of the murine CD95/FasR/APO-1 receptor in relation to B cell ontogeny
37. Cloning of murine TCF-1, a T cell-specific transcription factor interacting with functional motifs in the CD3-ε and TCR-α enhancers
38. Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice
39. Transcriptional regulation of B-cell diferentiation
40. Control of lymphocyte development by the LEF-1/TCF family of transcription factors
41. LEF-1, a nuclear factor coordinating signaling inputs from wingless and decapentaplegic
42. Antisense cyclin D1 induces apoptosis and tumor shrinkage in human squamous carcinomas
43. Critical involvement of Tcf-1 in expansion of thymocytes
44. Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas
45. Cytoskeletal reorganization by soluble Wnt-3a protein signalling
46. The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway
47. Drosophila wingless: A paradigm for the function and mechanism of Wnt signaling
48. Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells
49. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells
50. LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain regulates T-cell receptor a enhancer function
51. Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice
52. Identification and cloning of TCF-1, a T lymphocite-specific transcription containing a sequence-specific HMG-box
53. Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1 deficient mice
54. An HMG-box-containing T-cell factor required for thymocyte differentiation
55. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine
56. Expression and function of Fas antigen on activated murine B cells
57. Casein kinase 2 associates with and phosphorylates dishevelled
58. Differential transformation of mammary epithelial cells by Wnt genes
59. Evidence that absence of Wnt-3a signaling promotes neuralization instead of paraxial mesoderm development in the mouse
60. Wnt-1 induces growth, cytosolic beta-catenin, and Tcf/Lef transcriptional activation in Rat-1 fibroblasts