Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome

Blood

Volumn 99, Issue 7, 2002, Pages 2369-2378

  Stier, Sebastian ^a,b   Cheng, Tao ^a,b   Dombkowski, David ^a,b   Carlesso, Nadia ^a,b   Scadden, David T ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CELL RECEPTOR; NOTCH RECEPTOR;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADOLESCENT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CELL LINEAGE; CELL RENEWAL; FEMALE; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; IMMUNE DEFICIENCY; LYMPHOPOIESIS; MOUSE; MYELOPOIESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0036529989     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V99.7.2369     Document Type: Article

References (53)

1. Notch signaling
2. Notch signaling: Cell fate control and signal integration in development
3. Notch as a mediator of cell fate determination in hematopoiesis: Evidence and speculation
4. A homolog of Drosophila Notch expressed during mammalian development
5. Notch2: A second mammalian Notch gene
6. Expression analysis of a Notch homologue in the mouse embryo
7. Motch A motch B - Two mouse Notch homologues coexpressed in a wide variety of tissues
8. Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene
9. Specific EGF repeats of Notch mediate interactions with Delta and Serrate: Implications for Notch as a multi-functional receptor
10. Expression of a Delta homologue in prospective neurons in the chick
11. Jagged: A mammalian ligand that activates Notch1
12. A chick homologue of Serrate and its relationship with Notch and Delta homologues during central neurogenesis
13. Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor
14. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
15. Nuclear access and action of notch in vivo
16. Signalling downstream of activated mammalian Notch
17. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms
18. Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription
19. A human homologue of the Drosophila developmental gene, Notch, is expressed in CD34+ hematopoietic precursors
20. The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1
21. The Notch ligand, Jagged-1, influences the development of primitive hematopoietic precursor cells
22. Stromal expression of Jagged 1 promotes colony formation by fetal hematopoietic progenitor cells
23. Modulated expression of notch1 during thymocyte development
24. Notch1 expression in early lymphopoiesis influences B versus T lineage determination
25. Notch activity influences the alphabeta versus gammadelta T cell lineage decision
26. An activated form of Notch influences the choice between CD4 and CD8 T cell lineages
27. Notch inhibition of E47 supports the existence of a novel signaling pathway
28. Inhibition of granulocytic differentiation by mNotch1
29. Hematopoietic activity of a stromal cell transmembrane protein containing epidermal growth factor-like repeat motifs
30. Notch1-induced delay of human hematopoietic progenitor cell differentiation is associated with altered cell cycle kinetics
31. The Notch/Jagged pathway inhibits proliferation of human hematopoietic progenitors in vitro
32. A soluble form of human Delta-like-1 inhibits differentiation of hematopoietic progenitor cells
33. Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive notch1 signaling
34. Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles
35. RAG-1-deficient mice have no mature B and T lymphocytes
36. Transplantable myeloproliferative disease induced in mice by an interleukin 6 retrovirus
37. Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system
38. Hematopoietic stem cell quiescence maintained by p21cip1/wafl
39. Use of limiting-dilution type long-term marrow cultures in frequency analysis of marrow-repopulating and spleen colony-forming hematopoietic stem cells in the mouse
40. A critical role for PU.1 in homing and long-term engraftment by hematopoietic stem cells in the bone marrow
41. Competitive repopulation: A new assay for long-term stem cell functional capacity
42. Purification and characterization of mouse hematopoietic stem cells
43. The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype
44. High doses of purified stem cells cause early hematopoietic recovery in syngeneic and allogeneic hosts
45. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow
46. + cells in murine bone marrow does not express CD19 and contains natural killer cell progenitors
47. Control points in early T-cell development
48. Identification of clonogenic common lymphoid progenitors in mouse bone marrow
49. Maintenance of neuroepithelial progenitor cells by Delta-Notch signaling in the embryonic chick retina
50. An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells
51. The role of apoptosis in the regulation of hematopoietic stem cells: Overexpression of Bcl-2 increases both their number and repopulation potential
52. Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cells
53. Deficient T cell fate specification in mice with an induced inactivation of Notch1