Nuclear factor κB is required for the development of marginal zone B lymphocytes

Journal of Experimental Medicine

Volumn 192, Issue 8, 2000, Pages 1175-1182

  Cariappa, Annaiah ^a   Liou, Hsiou Chi ^b   Horwitz, Bruce H ^c   Pillai, Shiv ^a,d  

^a HARVARD MEDICAL SCHOOL   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

Author keywords

Bruton's tyrosine kinase; Lymphocyte development; Peripheral B cells; Recombination activating gene 2( ) mice; Transcription factors

Indexed keywords

COMPLEMENT COMPONENT C3D RECEPTOR; IMMUNOGLOBULIN D; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN M; PROTEIN TYROSINE KINASE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; BONE MARROW CELL; CELL MATURATION; CELL SUBPOPULATION; FETUS; GENE CONTROL; LIVER CELL; LYMPHOID CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPLEEN CELL;

ANIMALS; ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; B-LYMPHOCYTES; BONE MARROW CELLS; DNA-BINDING PROTEINS; IMMUNOGLOBULIN M; IMMUNOPHENOTYPING; LIVER; MICE; MICE, KNOCKOUT; NF-KAPPA B; NF-KAPPA B P50 SUBUNIT; PROTO-ONCOGENE PROTEINS C-REL; TRANSCRIPTION FACTOR RELA;

EID: 0034676014     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.192.8.1175     Document Type: Article

References (30)

1. Antigen driven selection of virgin and memory B cells
2. Cells in the marginal zone of the spleen
3. Marginal zone B cells exhibit unique activation, proliferative and immunoglobulin secretory responses
4. IgM(high)CD21(high) lymphocytes enriched in the splenic marginal zone generate effector cells more rapidly than the bulk of follicular B cells
5. CD1(high) B cells: A population of mixed origin
6. Positive selection from newly formed to marginal zone B cells depends on the rate of clonal production, CD19, and btk
7. Absence of marginal zone B cells in Pyk-2 deficient mice defines their role in the humoral response
8. Aiolos regulates B cell activation and maturation to effector state
9. Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses
10. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB
11. Mice lacking the c-Rel protooncogene exhibit defects in lymphocyte proliferation, tumoral immunity and interleukin-2 expression
12. c-Rel is essential for B lymphocyte survival and cell cycle progression
13. Failure of lymphopoiesis after adoptive transfer of NFκB deficient fetal liver cells
14. Accelerated emigration of B lymphocytes in the Xid mouse
15. B cells from p50/NF-κB knockout mice have selective defects in proliferation, differentiation, germline CH transcription, and Ig class switching
16. Mice deficient in NFκB/p52 present with defects in humoral responses, germinal center reactions, and splenic microarchitecture
17. The p65 subunit of NFκB is redundant with p50 during B cell proliferative responses, and is required for germline CH transcription and class switching to IgG3
18. Regulation of immune responses by NF-κB/Rel transcription factors
19. NF-κB RelA deficient lymphocytes: Normal development of T cells and B cells, impaired production of IgA and IgG1 and reduced proliferative responses
20. B lymphocytes differentially use the Rel and NF-κB1 transcription factors to regulate cell cycle progression and apoptosis in quiescent and mitogen-activated cells
21. Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation induced apoptosis
22. The chosen few? Positive selection and the generation of naive B lymphocytes
23. B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals
24. Bruton's tyrosine kinase links the B cell receptor to nuclear factor κB activation
25. Bruton's tyrosine kinase is required for activation of IκB kinase and nuclear factor κB in response to B cell receptor engagement
26. Receptor-specific induction of NFκB components in primary B cells
27. TACI and BCMA are receptors for a TNF homologue implicated in B cell autoimmune disease
28. BLyS: Member of the tumor necrosis family and B lymphocyte stimulator
29. BAFF, a new ligand of the tumor necrosis factor family stimulates B cell growth
30. Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations