Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma

Nature Genetics

Volumn 17, Issue 2, 1997, Pages 230-

  Iida, Shinsuke ^a   Rao, Pulivarthi H ^b   Butler, Marion ^a   Corradini, Paolo ^c   Boccadoro, Mario ^c   Klein, Bernard ^d   Chaganti, R S K ^b   Dalla Favera, Riccardo ^a  

^a The New York Presbyterian Hospital   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c UNIVERSITY OF TURIN   (Italy)

^d UNIV MONTPELLIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; PRIMER DNA;

ANIMAL; ARTICLE; CELL CULTURE; CELL LINE; CHROMOSOME 14; CHROMOSOME 6; GENE EXPRESSION REGULATION; GENE TRANSLOCATION; GENETIC TRANSFECTION; GENETICS; HUMAN; IMMUNOGLOBULIN GENE; MOLECULAR GENETICS; MULTIPLE MYELOMA; NUCLEOTIDE SEQUENCE; ONCOGENE; POLYMERASE CHAIN REACTION; RAT; YEAST ARTIFICIAL CHROMOSOME;

ANIMALS; BASE SEQUENCE; CELL LINE; CHROMOSOMES, ARTIFICIAL, YEAST; CHROMOSOMES, HUMAN, PAIR 14; CHROMOSOMES, HUMAN, PAIR 6; DNA PRIMERS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, IMMUNOGLOBULIN; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; MOLECULAR SEQUENCE DATA; MULTIPLE MYELOMA; ONCOGENES; POLYMERASE CHAIN REACTION; RATS; TRANSFECTION; TRANSLOCATION, GENETIC; TUMOR CELLS, CULTURED;

EID: 84984756503     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng1097-226     Document Type: Letter

References (30)

1. Barlogie, B. et al. Biology and therapy of multiple myeloma in 1996. Sem. Hematol 34, 67-72(1997).
2. Dewald, G.W. et al. The clinical significance of cytogenetic studies in 100 patients with multiple myeloma, plasma cell leukemia, or amyloidosis. Blood 66, 380-390 (1985).
3. Calasanz, M.J. et al. Cytogenetic analysis of 280 patients with multiple myeloma and related disorders: Primary breakpoints and clinical correlations. Genes Chromosomes Cancert B, 84-93 (1997).
4. Taniwaki, M. et al. Nonrandom chromosomal rearrangements of 14q32.3 and 19p13.3 and preferential deletion of 1p in 21 patients with multiple myeloma and plasma cell leukemia. Blood 84, 2283-2290 (1994).
5. Bergsagel, P.L. et al. Promiscuous translocations into immunoglobulin heavy chain switch regions in multiple myeloma, Proc. Natl. Acad. Sci. USA 93, 13931-13936 (1996).
6. Chesi, M. et al. Dysregulation of Cydin D1 by translocation into an IgH gamma switch region in two multiple myeloma cell lines. Blood SB, 674-681 (1996).
7. Dalla-Favera, R., Martinotti, S., Gallo, R.C., Erikson, J. & Croce, CM. Translocation and rearrangements of the c-myc oncogene locus in human undifferentiated B-cell lymphomas. Science 219, 963-967 (1983).
8. Matsuyama, T. et al. Molecular cloning of LSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element ISRE. Nucleic Acids Res. 23, 2127-2136 (1995).
9. Eisenbeis, C.F., Singh, H. & Storb, U. Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependenttranscriptional activator. GenesDev. 9, 1377-1387 (1995).
10. Yamagata, T. et al. A novel interferon regulatory factor family transcription factor, ICSAT/Pip/LSIRF, that negatively regulates the activity of interferon-regulated genes. Mol. Cell. Biol. 16, 1283-1294(1996).
11. Grossman, A. et al. Cloning of human lymphocyte-specific interferon regulatory factor (hLSIRF/hlRF4) and mapping of the gene to 6p23-p25. Genomics 37, 229-233(1996).
12. Harada, H. et al. Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of I FN and IFN-inducible genes. Cell 58, 729-739(1989).
13. Bovolenta, C. et al. Molecular interactions between interferon consensus sequence binding protein and members of the interferon regulatory factor family. Proc. Natl. Acad. Sci. USA 91, 5046-5050 (1994).
14. Veals, S.A. et al. Subunit of an alfa-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins. Mol. Cell. Biol. 12, 3315-3324 (1992).
15. Au, W.-C, Moore, P.A., Lowther, W., Juang, Y.-T. & Pitha, P.M. Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes. Proc. Natl. Acad. Sci. USA 92, 11657-11661 (1995).
16. Madisen, L. & Groudine, M. Identification of a locus control region in the immunoglobulin heavy-chain locus that deregulates c-myc expression in plasmacytoma and Burkitt’s lymphoma cells. Genes Dev. 8, 2212-2226(1994).
17. lida, S. et al. The t(9;14)(p13;q32) translocation associated with lymphoplasmacytoid lymphoma involves the PAX-5 gene. Blood 88, 4110-4117 (1996).
18. Neri, A. et al. p53 gene mutations in multiple myeloma are associated with advanced form of malignancy. Blood SI, 128-135 (1993).
19. Neri, A. et al. Ras oncogene mutation in multiple myeloma. J. Exp. Med. 170, 1715-1725(1989).
20. Gaidano, G. & Dalla-Favera, R. Molecular biology of lymphomas, in Principles and Practice of Oncology, 5th Ed. (eds DeVita, V.T., Hellman, S. & Rosenberg, S.A.) 2131-2144. (J.B. Lippincott, Philadelphia, 1997).
21. Harada, H. et al. Anti-oncogenic and oncogenic potentials of interferon regulatory factors-1 and -2. Science 259, 971-974 (1993).
22. Tanaka, N. et at. Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1. Cell 77, 829-839 (1994).
23. Tamura, T. et al. An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes. Nature 376, 596-599 (1995).
24. Holtschke, T. et al. Immunodeficiency and chronic myelogeneous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene. Cell 87, 307-317 (1996).
25. Mittrucker, H.-W. et al. Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function. Science 275, 540-543(1997).
26. Klein, B. et al. Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6. Blood 73, 517-526 (1989).
27. Eton, O., Scheinberg, D.A. & Houghton, A.N. Establishment and characterization of two human myeloma cell lines secreting kappa light chains. Leukemia 3, 729-735 (1989).
28. Jernberg, H., Zech, L & Nilsson, K. Cytogenetic studies on human myeloma cell lines. Int. J. Cancer 40, 811-817 (1987).
29. Zhang, X.-G. et al. Reproducible obtaining of human myeloma cell lines as a model for tumor stem cell study in human multiple myeloma. Blood 83, 3654-3663 (1994).
30. Gu, W., Cechova, K., Tassi, V. & Dalla-Favera, R. Opposite regulation of gene transcription and cell proliferation by c-Myc and Max. Proc. Natl. Acad. Sci. USA 90, 2935-2939(1993).