Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in mice

Cancer Cell

Volumn 7, Issue 5, 2005, Pages 445-455

  Cattoretti, Giorgio ^a   Pasqualucci, Laura ^a   Ballon, Gianna ^a,b   Tam, Wayne ^a,b   Nandula, Subhadra V ^a   Shen, Qiong ^a   Mo, Tongwei ^a   Murty, Vundavalli V ^a   Dalla Favera, Riccardo ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BCL 6;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B CELL LYMPHOMA; B LYMPHOCYTE; BIOENGINEERING; CELL COUNT; CELL DIFFERENTIATION; CHROMOSOME TRANSLOCATION; GENE CONTROL; GENE EXPRESSION; GENE FUNCTION; GERMINAL CENTER; LARGE CELL LYMPHOMA; LYMPHOMA; LYMPHOPROLIFERATIVE DISEASE; MOUSE; NONHUMAN; ONCOGENE; PATHOGENESIS; PLASMA CELL; PRIORITY JOURNAL;

EID: 19344368745     PISSN: 15356108     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ccr.2005.03.037     Document Type: Article

References (45)

1. B.W. Baron, J. Anastasi, A. Montag, D. Huo, R.M. Baron, T. Karrison, M.J. Thirman, S.K. Subudhi, R.K. Chin, and D.W. Felsher The human BCL6 transgene promotes the development of lymphomas in the mouse Proc. Natl. Acad. Sci. USA 101 2004 14198 14203
2. O.R. Bereshchenko, W. Gu, and R. Dalla-Favera Acetylation inactivates the transcriptional repressor BCL6 Nat. Genet. 32 2002 606 613
3. D. Capello, U. Vitolo, L. Pasqualucci, S. Quattrone, G. Migliaretti, L. Fassone, C. Ariatti, D. Vivenza, A. Gloghini, and C. Pastore Distribution and pattern of BCL-6 mutations throughout the spectrum of B-cell neoplasia Blood 95 2000 651 659
4. G. Cattoretti, C.C. Chang, K. Cechova, J. Zhang, B.H. Ye, B. Falini, D.C. Louie, K. Offit, R.S. Chaganti, and R. Dalla-Favera BCL-6 protein is expressed in germinal-center B cells Blood 86 1995 45 53
5. C.C. Chang, B.H. Ye, R.S. Chaganti, and R. Dalla-Favera BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor Proc. Natl. Acad. Sci. USA 93 1996 6947 6952
6. W. Chen, S. Iida, D.C. Louie, R. Dalla-Favera, and R.S. Chaganti Heterologous promoters fused to BCL6 by chromosomal translocations affecting band 3q27 cause its deregulated expression during B-cell differentiation Blood 91 1998 603 607
7. R. Dalla-Favera, and G. Gaidano Molecular Biology of Lymphomas V.T. De Vita S. Hellman S.A. Rosenberg Cancer, Principles and Practice of Oncology. 2001 Lippincott Williams & Wilkins Philadelphia 2215 2235
8. A.L. Dent, A.L. Shaffer, X. Yu, D. Allman, and L.M. Staudt Control of inflammation, cytokine expression, and germinal center formation by BCL-6 Science 276 1997 589 592
9. B. Falini, M. Fizzotti, A. Pucciarini, B. Bigerna, T. Marafioti, M. Gambacorta, R. Pacini, C. Alunni, L. Natali-Tanci, and B. Ugolini A monoclonal antibody (MUM1p) detects expression of the MUM1/IRF4 protein in a subset of germinal center B cells, plasma cells, and activated T cells Blood 95 2000 2084 2092
10. N. Fujita, D.L. Jaye, C. Geigerman, A. Akyildiz, M.R. Mooney, J.M. Boss, and P.A. Wade MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation Cell 119 2004 75 86
11. M.B. Harris, C.C. Chang, M.T. Berton, N.N. Danial, J. Zhang, D. Kuehner, B.H. Ye, M. Kvatyuk, P.P. Pandolfi, and G. Cattoretti Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: Specific regulation of i epsilon transcription and immunoglobulin E switching Mol. Cell. Biol. 19 1999 7264 7275
12. C.P. Harris, X.Y. Lu, G. Narayan, B. Singh, V.V. Murty, and P.H. Rao Comprehensive molecular cytogenetic characterization of cervical cancer cell lines Genes Chromosomes Cancer 36 2003 233 241
13. K.K. Hoyer, S.W. French, D.E. Turner, M.T. Nguyen, M. Renard, C.S. Malone, S. Knoetig, C.F. Qi, T.T. Su, and H. Cheroutre Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma Proc. Natl. Acad. Sci. USA 99 2002 14392 14397
14. C.J. Jolly, N. Klix, and M.S. Neuberger Rapid methods for the analysis of immunoglobulin gene hypermutation: Application to transgenic and gene targeted mice Nucleic Acids Res. 25 1997 1913 1919
15. J.P. Kerckaert, C. Deweindt, H. Tilly, S. Quief, G. Lecocq, and C. Bastard LAZ3, a novel zinc-finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas Nat. Genet. 5 1993 66 70
16. R. Küppers, and R. Dalla-Favera Mechanisms of chromosomal translocation in B-cell lymphoma Oncogene 20 2001 5580 5594
17. R. Küppers, U. Klein, M.L. Hansmann, and K. Rajewsky Cellular origin of human B-cell lymphomas N. Engl. J. Med. 341 1999 1520 1529
18. G.G. Lennon, and R.P. Perry C mu-containing transcripts initiate heterogeneously within the IgH enhancer region and contain a novel 5′-nontranslatable exon Nature 318 1985 475 478
19. S.C. Li, P.B. Rothman, J. Zhang, C. Chan, D. Hirsh, and F.W. Alt Expression of I mu-C gamma hybrid germline transcripts subsequent to immunoglobulin heavy chain class switching Int. Immunol. 6 1994 491 497
20. K.I. Lin, C. Tunyaplin, and K. Calame Transcriptional regulatory cascades controlling plasma cell differentiation Immunol. Rev. 194 2003 19 28
21. F. Lo Coco, B.H. Ye, F. Lista, P. Corradini, K. Offit, D.M. Knowles, R.S. Chaganti, and R. Dalla-Favera Rearrangements of the BCL6 gene in diffuse large cell non-Hodgkin's lymphoma Blood 83 1994 1757 1759
22. A. Migliazza, S. Martinotti, W. Chen, C. Fusco, B.H. Ye, D.M. Knowles, K. Offit, R.S. Chaganti, and R. Dalla-Favera Frequent somatic hypermutation of the 5′ noncoding region of the BCL6 gene in B-cell lymphoma Proc. Natl. Acad. Sci. USA 92 1995 12520 12524
23. M. Muramatsu, K. Kinoshita, S. Fagarasan, S. Yamada, Y. Shinkai, and T. Honjo Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme Cell 102 2000 553 563
24. H. Niu, B.H. Ye, and R. Dalla-Favera Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor Genes Dev. 12 1998 1953 1961
25. H. Niu, G. Cattoretti, and R. Dalla-Favera BCL6 controls the expression of the B7-1/CD80 costimulatory receptor in germinal center B cells J. Exp. Med. 198 2003 211 221
26. L. Pasqualucci, A. Migliazza, N. Fracchiolla, C. William, A. Neri, L. Baldini, R.S. Chaganti, U. Klein, R. Küppers, K. Rajewsky, and R. Dalla-Favera BCL-6 mutations in normal germinal center B cells: Evidence of somatic hypermutation acting outside Ig loci Proc. Natl. Acad. Sci. USA 95 1998 11816 11821
27. L. Pasqualucci, O. Bereschenko, H. Niu, U. Klein, K. Basso, R. Guglielmino, G. Cattoretti, and R. Dalla-Favera Molecular pathogenesis of non-Hodgkin's lymphoma: The role of Bcl-6 Leuk. Lymphoma 44 Suppl 3 2003 S5 12
28. L. Pasqualucci, A. Migliazza, K. Basso, J. Houldsworth, R.S. Chaganti, and R. Dalla-Favera Mutations of the BCL6 proto-oncogene disrupt its negative autoregulation in diffuse large B-cell lymphoma Blood 101 2003 2914 2923
29. H.Z. Peng, M.Q. Du, A. Koulis, A. Aiello, A. Dogan, L.X. Pan, and P.G. Isaacson Nonimmunoglobulin gene hypermutation in germinal center B cells Blood 93 1999 2167 2172
30. R.T. Phan, and R. Dalla-Favera The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells Nature 432 2004 635 639
31. J.M. Polo, T. Dell'Oso, S.M. Ranuncolo, L. Cerchietti, D. Beck, G.F. Da Silva, G.G. Prive, J.D. Licht, and A. Melnick Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells Nat. Med. 10 2004 1329 1335
32. K. Rajewsky Clonal selection and learning in the antibody system Nature 381 1996 751 758
33. A.M. Ranger, J. Zha, H. Harada, S.R. Datta, N.N. Danial, A.P. Gilmore, J.L. Kutok, M.M. Le Beau, M.E. Greenberg, and S.J. Korsmeyer Bad-deficient mice develop diffuse large B cell lymphoma Proc. Natl. Acad. Sci. USA 100 2003 9324 9329
34. R. Reljic, S.D. Wagner, L.J. Peakman, and D.T. Fearon Suppression of signal transducer and activator of transcription 3-dependent B lymphocyte terminal differentiation by BCL-6 J. Exp. Med. 192 2000 1841 1848
35. V.L. Seyfert, D. Allman, Y. He, and L.M. Staudt Transcriptional repression by the proto-oncogene BCL-6 Oncogene 12 1996 2331 2342
36. A.L. Shaffer, X. Yu, Y. He, J. Boldrick, E.P. Chan, and L.M. Staudt BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control Immunity 13 2000 199 212
37. A.L. Shaffer, K.I. Lin, T.C. Kuo, X. Yu, E.M. Hurt, A. Rosenwald, J.M. Giltnane, L. Yang, H. Zhao, K. Calame, and L.M. Staudt Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program Immunity 17 2002 51 62
38. H.M. Shen, A. Peters, B. Baron, X. Zhu, and U. Storb Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes Science 280 1998 1750 1752
39. J. Stavnezer, S. Sirlin, and J. Abbott Induction of immunoglobulin isotype switching in cultured I.29 B lymphoma cells. Characterization of the accompanying rearrangements of heavy chain genes J. Exp. Med. 161 1985 577 601
40. C. Tunyaplin, A.L. Shaffer, C.D. Angelin-Duclos, X. Yu, L.M. Staudt, and K.L. Calame Direct repression of prdm1 by Bcl-6 inhibits plasmacytic differentiation J. Immunol. 173 2004 1158 1165
41. X. Wang, Z. Li, A. Naganuma, and B.H. Ye Negative autoregulation of BCL-6 is bypassed by genetic alterations in diffuse large B cell lymphomas Proc. Natl. Acad. Sci. USA 99 2002 15018 15023
42. B.H. Ye, F. Lista, F. Lo Coco, D.M. Knowles, K. Offit, R.S. Chaganti, and R. Dalla-Favera Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma Science 262 1993 747 750
43. B.H. Ye, P.H. Rao, R.S. Chaganti, and R. Dalla-Favera Cloning of bcl-6, the locus involved in chromosome translocations affecting band 3q27 in B-cell lymphoma Cancer Res. 53 1993 2732 2735
44. B.H. Ye, S. Chaganti, C.C. Chang, H. Niu, P. Corradini, R.S. Chaganti, and R. Dalla-Favera Chromosomal translocations cause deregulated BCL6 expression by promoter substitution in B cell lymphoma EMBO J. 14 1995 6209 6217
45. B.H. Ye, G. Cattoretti, Q. Shen, J. Zhang, N. Hawe, R. de Waard, C. Leung, M. Nouri-Shirazi, A. Orazi, and R.S. Chaganti The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation Nat. Genet. 16 1997 161 170