Gastric cancer originating from bone marrow-derived cells

Science

Volumn 306, Issue 5701, 2004, Pages 1568-1571

  Houghton, JeanMarie ^a   Stoicov, Calin ^a   Nomura, Sachiyo ^b,c   Rogers, Arlin B ^d   Carlson, Jane ^a   Li, Hanchen ^a   Cai, Xun ^a   Fox, James G ^d   Goldenring, James R ^b,e   Wang, Timothy C ^a,f  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b VANDERBILT INGRAM CANCER CENTER   (United States)

^c UNIVERSITY OF TOKYO   (Japan)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^e VETERANS AFFAIRS MEDICAL CENTER   (United States)

^f Columbia Coll of Phys and Surgeons ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE; CARCINOGENS; CELLS; TISSUE; TUMORS;

BONE MARROW-DERIVED CELLS (BMDC); TISSUE INJURY;

DISEASES;

BETA ACTIN; BETA GALACTOSIDASE; CARCINOGEN; CD45 ANTIGEN; CYTOKERATIN; DNA; GREEN FLUORESCENT PROTEIN; TREFOIL PEPTIDE;

CANCER;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW; CANCER GROWTH; ENZYME ACTIVITY; EPITHELIUM; FLUORESCENCE IN SITU HYBRIDIZATION; HELICOBACTER INFECTION; HELICOBACTER PYLORI; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; STOMACH CANCER;

ANIMALS; APOPTOSIS; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; CARCINOMA IN SITU; CELL DIFFERENTIATION; CELL FUSION; DISEASE PROGRESSION; FEMALE; GASTRIC MUCOSA; GASTRITIS; HELICOBACTER FELIS; HELICOBACTER INFECTIONS; KERATINS; MALE; MESENCHYMAL STEM CELLS; METAPLASIA; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUCINS; MUSCLE PROTEINS; PARIETAL CELLS, GASTRIC; PEPTIDES; PHENOTYPE; STEM CELLS; STOMACH NEOPLASMS;

CANCERS; CARCINOGENS; CELLS; DISEASES; TISSUE;

ANIMALIA; HELICOBACTER; HELICOBACTER PYLORI; LOTUS;

EID: 9444265320     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1099513     Document Type: Article

References (20)

1. F. Balkwill, A. Mantovani, Lancet 357, 539 (2001).
2. T. C. Wang et al., Gastroenterology 114, 675 (1998).
3. D. S. Krause et al., Cell 105, 369 (2002).
4. Y. Jiang et al., Nature 418, 41 (2002).
5. D. J. Anderson, F. H. Gage, I. L. Weissman, Nature Med. 7, 393 (2001).
6. A. J. Wagers, I. L. Weissman, Cell 116, 639 (2004).
7. M. LaBarge, H. M. Blau, Cell 111, 589 (2002).
8. J. C. Fox et al., Cancer Res. 62, 696 (2002).
9. Materials and methods are available as supporting material on Science Online.
10. P. H. Schmidt et al., Lab. Invest. 79, 639 (1999).
11. J. R. Goldenring et al., Gastroenterology 118, 1080 (2002).
12. C. P. Boivin et al., Gastroenterology 124, 762 (2003).
13. A. D. Clouston, Pathology 33, 271 (2001).
14. J. C. Fox et al., Cancer Res. 63, 942 (2003).
15. R. Okamoto et al., Nature Med. 8, 1011 (2002).
16. Q. Li, S. M. Karam, J. I. Cordon, J. Biol. Chem. 271, 3671 (1996).
17. D. Normille, Science 298, 1869 (2002).
18. J. Couzin, Science 299, 1002 (2003).
19. N. Serakinci et al., Oncogene 23, 5095 (2004).
20. We thank K. Cormier and the Division of Comparative Medicine histology lab for technical support and expertise in IHC, and D. Altieri and E. Kurt-Jones for their helpful comments and suggestions. Supported by NIH grants K22 CA90518 U-H.), RO1 CA87958 (T.C.W. and J.C.F.), RO1 DK58889 (T.C.W.), and a VA Merit Review and Vanderbilt GI SPORE 1P50 CA95103 (J.R.G.)