Accumulated chromosomal instability in murine bone marrow mesenchymal stem cells leads to malignant transformation

Stem Cells

Volumn 24, Issue 4, 2006, Pages 1095-1103

  Miura, Masako ^a   Miura, Yasuo ^a   Padilla Nash, Hesed M ^b   Molinolo, Alfredo A ^a   Fu, Baojin ^b   Patel, Vyomesh ^a   Seo, Byoung Moo ^a   Sonoyama, Wataru ^a   Zheng, Jenny J ^c   Baker, Carl C ^b   Chen, Wanjun ^a   Ried, Thomas ^b   Shi, Songtao ^a  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Bone marrow derived mesenchymal stem cell; Chromosomal instability; Fibrosarcoma; Malignant transformation

Indexed keywords

DOXORUBICIN; ETOPOSIDE; MYC PROTEIN; TELOMERASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW; CANCER STEM CELL; CARCINOGENESIS; CELL MUTANT; CELL POPULATION; CELL TRANSFORMATION; CELL VIABILITY; CHROMOSOMAL INSTABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG EFFECT; ENZYME ACTIVITY; FIBROSARCOMA; HISTOPATHOLOGY; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; ANIMAL; CHROMOSOME ABERRATION; DRUG SCREENING; FLUORESCENCE IN SITU HYBRIDIZATION; GENETICS; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; IN VITRO STUDY; MESENCHYMAL STEM CELL TRANSPLANTATION; MUTATION; NUDE MOUSE; PATHOLOGY;

MURINAE;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOMAL INSTABILITY; CHROMOSOME ABERRATIONS; DRUG SCREENING ASSAYS, ANTITUMOR; FIBROSARCOMA; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; IN SITU HYBRIDIZATION, FLUORESCENCE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; MICE; MICE, NUDE; MUTATION; TUMOR STEM CELL ASSAY;

EID: 33745433769     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.2005-0403     Document Type: Article

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