Update on glucocorticoid action and resistance

Journal of Allergy and Clinical Immunology

Volumn 117, Issue 3, 2006, Pages 522-543

  Ito, Kazuhiro ^a   Chung, K Fian ^a   Adcock, Ian M ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

Future therapies; Glucocorticoid receptor; Molecular mechanisms; Severe asthma; Steroid resistance

Indexed keywords

DEXAMETHASONE; FLUORINATED HYDROCARBON; GLUCOCORTICOID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; PHOSPHODIESTERASE IV INHIBITOR; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA ANTIBODY;

ALLERGIC DISEASE; ASTHMA; CIGARETTE SMOKING; DRUG EFFICACY; DRUG MECHANISM; GENE ACTIVATION; GENE INDUCTION; GENE MUTATION; GENE REPRESSION; GENE STRUCTURE; GENETIC PREDISPOSITION; GENETIC TRANSCRIPTION; HUMAN; IMMUNOMODULATION; INFLAMMATION; LIGAND BINDING; NEUTROPHILIA; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVIEW; TRANSACTIVATION;

ANTI-ASTHMATIC AGENTS; ASTHMA; DRUG RESISTANCE; GLUCOCORTICOIDS; HUMANS; RECEPTORS, GLUCOCORTICOID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33644776504     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2006.01.032     Document Type: Review

References (234)

1. W.W. Busse, and R.F. Lemanske Jr. Asthma N Engl J Med 344 2001 350 362
2. P.J. Barnes, K.F. Chung, and C.P. Page Inflammatory mediators of asthma: an update Pharmacol Rev 50 1998 515 596
3. S.T. Holgate, P. Lackie, S. Wilson, W. Roche, and D. Davies Bronchial epithelium as a key regulator of airway allergen sensitization and remodeling in asthma Am J Respir Crit Care Med 162 suppl 2000 S113 S117
4. P.J. Barnes, and I.M. Adcock How do corticosteroids work in asthma? Ann Intern Med 139 2003 359 370
5. K.F. Chung, P. Godard, E. Adelroth, J. Ayres, N. Barnes, and P. Barnes Difficult/therapy-resistant asthma: the need for an integrated approach to define clinical phenotypes, evaluate risk factors, understand pathophysiology and find novel therapies. ERS Task Force on Difficult/Therapy-Resistant Asthma. European Respiratory Society Eur Respir J 13 1999 1198 1208
6. P.J. Barnes, and A.J. Woolcock Difficult asthma Eur Respir J 12 1998 1209 1218
7. K.F. Rabe, P.A. Vermeire, J.B. Soriano, and W.C. Maier Clinical management of asthma in 1999: the Asthma Insights and Reality in Europe (AIRE) study Eur Respir J 16 2000 802 807
8. R.J. Hache, R. Tse, T. Reich, J.G. Savory, and Y.A. Lefebvre Nucleocytoplasmic trafficking of steroid-free glucocorticoid receptor J Biol Chem 274 1999 1432 1439
9. * independent pathway Biochim Biophys Acta 1691 2004 73 77
10. M.R. Yudt, and J.A. Cidlowski The glucocorticoid receptor: coding a diversity of proteins and responses through a single gene Mol Endocrinol 16 2002 1719 1726
11. T. Rhen, and J.A. Cidlowski Antiinflammatory action of glucocorticoids - new mechanisms for old drugs N Engl J Med 353 2005 1711 1723
12. N.Z. Lu, and J.A. Cidlowski Translational regulatory mechanisms generate N-terminal glucocorticoid receptor isoforms with unique transcriptional target genes Mol Cell 18 2005 331 342
13. K. Feingold, M.S. Kim, J. Shigenaga, A. Moser, and C. Grunfeld Altered expression of nuclear hormone receptors and coactivators in mouse heart during the acute-phase response Am J Physiol Endocrinol Metab 286 2004 E201 E207
14. D.W. Ray, J.R. Davis, A. White, and A.J. Clark Glucocorticoid receptor structure and function in glucocorticoid-resistant small cell lung carcinoma cells Cancer Res 56 1996 3276 3280
15. C. Beger, K. Gerdes, M. Lauten, W.J. Tissing, I. Fernandez-Munoz, and M. Schrappe Expression and structural analysis of glucocorticoid receptor isoform gamma in human leukaemia cells using an isoform-specific real-time polymerase chain reaction approach Br J Haematol 122 2003 245 252
16. E.G. Haarman, G.J. Kaspers, R. Pieters, M.M. Rottier, and A.J. Veerman Glucocorticoid receptor alpha, beta and gamma expression vs in vitro glucocorticoid resistance in childhood leukemia Leukemia 18 2004 530 537
17. L.P. de, C.M. Segeren, J.W. Koper, E. Wiemer, P. Sonneveld, and A.O. Brinkmann Expression in hematological malignancies of a glucocorticoid receptor splice variant that augments glucocorticoid receptor-mediated effects in transfected cells Cancer Res 61 2001 3937 3941
18. T. Kino, and G.P. Chrousos Glucocorticoid and mineralocorticoid receptors and associated diseases Essays Biochem 40 2004 137 155
19. D.M. Hurley, D. Accili, C.A. Stratakis, M. Karl, N. Vamvakopoulos, and E. Rorer Point mutation causing a single amino acid substitution in the hormone binding domain of the glucocorticoid receptor in familial glucocorticoid resistance J Clin Invest 87 1991 680 686
20. A. Stevens, H. Garside, A. Berry, C. Waters, A. White, and D. Ray Dissociation of steroid receptor coactivator 1 and nuclear receptor corepressor recruitment to the human glucocorticoid receptor by modification of the ligand-receptor interface: the role of tyrosine 735 Mol Endocrinol 17 2003 845 859
21. R.K. Bledsoe, V.G. Montana, T.B. Stanley, C.J. Delves, C.J. Apolito, and D.D. McKee Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition Cell 110 2002 93 105
22. B. Kauppi, C. Jakob, M. Farnegardh, J. Yang, H. Ahola, and M. Alarcon The three-dimensional structures of antagonistic and agonistic forms of the glucocorticoid receptor ligand-binding domain: RU-486 induces a transconformation that leads to active antagonism J Biol Chem 278 2003 22748 22754
23. H. Garside, A. Stevens, S. Farrow, C. Normand, B. Houle, and A. Berry Glucocorticoid ligands specify different interactions with NF-kappaB by allosteric effects on the glucocorticoid receptor DNA binding domain J Biol Chem 279 2004 50050 50059
24. M. Barker, M. Clackers, D.A. Demaine, D. Humphreys, M.J. Johnston, and H.T. Jones Design and synthesis of new nonsteroidal glucocorticoid modulators through application of an "agreement docking" method J Med Chem 48 2005 4507 4510
25. M. Karin New twists in gene regulation by glucocorticoid receptor: is DNA binding dispensable? Cell 93 1998 487 490
26. M. Johnson Pharmacodynamics and pharmacokinetics of inhaled glucocorticoids J Allergy Clin Immunol 97 suppl 1996 S169 S176
27. Y.M. Chook, and G. Blobel Karyopherins and nuclear import Curr Opin Struct Biol 11 2001 703 715
28. D. Picard, and K.R. Yamamoto Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor EMBO J 6 1987 3333 3340
29. J.G. Savory, B. Hsu, I.R. Laquian, W. Giffin, T. Reich, and R.J. Hache Discrimination between NL1- and NL2-mediated nuclear localization of the glucocorticoid receptor Mol Cell Biol 19 1999 1025 1037
30. N.D. Freedman, and K.R. Yamamoto Importin 7 and importin alpha/importin beta are nuclear import receptors for the glucocorticoid receptor Mol Biol Cell 15 2004 2276 2286
31. M.J. Schaaf, L.J. Lewis-Tuffin, and J.A. Cidlowski Ligand-selective targeting of the glucocorticoid receptor to nuclear subdomains is associated with decreased receptor mobility Mol Endocrinol 19 2005 1501 1515
32. J.C. Wang, M.K. Derynck, D.F. Nonaka, D.B. Khodabakhsh, C. Haqq, and K.R. Yamamoto Chromatin immunoprecipitation (ChIP) scanning identifies primary glucocorticoid receptor target genes Proc Natl Acad Sci U S A 101 2004 15603 15608
33. S.E. Hall, S. Lim, I.R. Witherden, T.D. Tetley, P.J. Barnes, and A.M. Kamal Lung type II cell and macrophage annexin I release: differential effects of two glucocorticoids Am J Physiol 276 1999 L114 L121
34. S. Heck, K. Bender, M. Kullmann, M. Gottlicher, P. Herrlich, and A.C. Cato I kappaB alpha-independent downregulation of NF-kappaB activity by glucocorticoid receptor EMBO J 16 1997 4698 4707
35. H. Schacke, W.D. Docke, and K. Asadullah Mechanisms involved in the side effects of glucocorticoids Pharmacol Ther 96 2002 23 43
36. C.L. Smith, and B.W. O'Malley Coregulator function: a key to understanding tissue specificity of selective receptor modulators Endocr Rev 25 2004 45 71
37. F.D. Urnov, and A.P. Wolffe Chromatin remodeling and transcriptional activation: the cast (in order of appearance) Oncogene 20 2001 2991 3006
38. T. Jenuwein, and C.D. Allis Translating the histone code Science 293 2001 1074 1080
39. J.C. Rice, and C.D. Allis Code of silence Nature 414 2001 258 261
40. K. Ito, P.J. Barnes, and I.M. Adcock Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12 Mol Cell Biol 20 2000 6891 6903
41. R.C. Wu, C.L. Smith, and B.W. O'Malley Transcriptional regulation by steroid receptor coactivator phosphorylation Endocr Rev 26 2005 393 399
42. X. Li, J. Wong, S.Y. Tsai, M.J. Tsai, and B.W. O'Malley Progesterone and glucocorticoid receptors recruit distinct coactivator complexes and promote distinct patterns of local chromatin modification Mol Cell Biol 23 2003 3763 3773
43. Z.Q. Huang, J. Li, L.M. Sachs, P.A. Cole, and J. Wong A role for cofactor-cofactor and cofactor-histone interactions in targeting p300, SWI/SNF and Mediator for transcription EMBO J 22 2003 2146 2155
44. A. Biola, K. Andreau, M. David, M. Sturm, M. Haake, and J. Bertoglio The glucocorticoid receptor and STAT6 physically and functionally interact in T-lymphocytes FEBS Lett 487 2000 229 233
45. E. Stocklin, M. Wissler, F. Gouilleux, and B. Groner Functional interactions between Stat5 and the glucocorticoid receptor Nature 383 1996 726 728
46. J. Mullick, H.K. Anandatheerthavarada, G. Amuthan, S.V. Bhagwat, G. Biswas, and V. Camasamudram Physical interaction and functional synergy between glucocorticoid receptor and Ets2 proteins for transcription activation of the rat cytochrome P-450c27 promoter J Biol Chem 276 2001 18007 18017
47. P.J. Barnes, K. Ito, and I.M. Adcock Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase Lancet 363 2004 731 733
48. E. Stoecklin, M. Wissler, D. Schaetzle, E. Pfitzner, and B. Groner Interactions in the transcriptional regulation exerted by Stat5 and by members of the steroid hormone receptor family J Steroid Biochem Mol Biol 69 1999 195 204
49. C.M. Bamberger, T. Else, I. Ellebrecht, K. Milde-Langosch, D. Pankoke, and F.U. Beil Vitamin B6 modulates glucocorticoid-dependent gene transcription in a promoter- and cell type-specific manner Exp Clin Endocrinol Diabetes 112 2004 595 600
50. M.G. Rosenfeld, and C.K. Glass Coregulator codes of transcriptional regulation by nuclear receptors J Biol Chem 276 2001 36865 36868
51. G. Pascual, A.L. Fong, S. Ogawa, A. Gamliel, A.C. Li, and V. Perissi A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma Nature 437 2005 759 763
52. H.F. Luecke, and K.R. Yamamoto The glucocorticoid receptor blocks P-TEFb recruitment by NFkappaB to effect promoter-specific transcriptional repression Genes Dev 19 2005 1116 1127
53. R.M. Nissen, and K.R. Yamamoto The glucocorticoid receptor inhibits NFkappaB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain Genes Dev 14 2000 2314 2329
54. M.A. Hermoso, T. Matsuguchi, K. Smoak, and J.A. Cidlowski Glucocorticoids and tumor necrosis factor alpha cooperatively regulate toll-like receptor 2 gene expression Mol Cell Biol 24 2004 4743 4756
55. C.A. Da Silva, C. Heilbock, O. Kassel, and N. Frossard Transcription of stem cell factor (SCF) is potentiated by glucocorticoids and interleukin-1beta through concerted regulation of a GRE-like and an NF-kappaB response element FASEB J 17 2003 2334 2336
56. S. Ogawa, J. Lozach, C. Benner, G. Pascual, R.K. Tangirala, and S. Westin Molecular determinants of crosstalk between nuclear receptors and toll-like receptors Cell 122 2005 707 721
57. A.S. Baldwin Jr. Series introduction: the transcription factor NF-kappaB and human disease J Clin Invest 107 2001 3 6
58. P.J. Barnes, and M. Karin Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases N Engl J Med 336 1997 1066 1071
59. S. Ghosh, and M. Karin Missing pieces in the NF-kappaB puzzle Cell 109 suppl 2002 S81 S96
60. H. Zhong, M.J. May, E. Jimi, and S. Ghosh The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1 Mol Cell 9 2002 625 636
61. K.Y. Lee, K. Ito, R. Hayashi, E.P. Jazrawi, P.J. Barnes, and I.M. Adcock NF-κB and activator protein 1 response elements and the role of histone modifications in IL-1β-induced TGF-β1 gene transcription J Immunol 176 2006 603 615
62. M.W. Covert, T.H. Leung, J.E. Gaston, and D. Baltimore Achieving stability of lipopolysaccharide-induced NF-kappaB activation Science 309 2005 1854 1857
63. S.L. Werner, D. Barken, and A. Hoffmann Stimulus specificity of gene expression programs determined by temporal control of IKK activity Science 309 2005 1857 1861
64. D.E. Nelson, A.E. Ihekwaba, M. Elliott, J.R. Johnson, C.A. Gibney, and B.E. Foreman Oscillations in NF-kappaB signaling control the dynamics of gene expression Science 306 2004 704 708
65. H.M. Reichardt, J.P. Tuckermann, M. Gottlicher, M. Vujic, F. Weih, and P. Angel Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor EMBO J 20 2001 7168 7173
66. H.M. Reichardt, K.H. Kaestner, J. Tuckermann, O. Kretz, O. Wessely, and R. Bock DNA binding of the glucocorticoid receptor is not essential for survival Cell 93 1998 531 541
67. M. Nie, A.J. Knox, and L. Pang beta2-Adrenoceptor agonists, like glucocorticoids, repress eotaxin gene transcription by selective inhibition of histone H4 acetylation J Immunol 175 2005 478 486
68. S. Saccani, S. Pantano, and G. Natoli p38-Dependent marking of inflammatory genes for increased NF-kappa B recruitment Nat Immunol 3 2002 69 75
69. Y. Hasegawa, K. Tomita, M. Watanabe, A. Yamasaki, H. Sano, and Y. Hitsuda Dexamethasone inhibits phosphorylation of histone H3 at serine 10 Biochem Biophys Res Commun 336 2005 1049 1055
70. N. Auphan, J.A. Didonato, C. Rosette, A. Helmberg, and M. Karin Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis Science 270 1995 286 290
71. P.R. Mittelstadt, and J.D. Ashwell Inhibition of AP-1 by the glucocorticoid-inducible protein GILZ J Biol Chem 276 2001 29603 29610
72. C. Caelles, J.M. Gonzalez-Sancho, and A. Munoz Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway Genes Dev 11 1997 3351 3364
73. I. Rogatsky, S.K. Logan, and M.J. Garabedian Antagonism of glucocorticoid receptor transcriptional activation by the c-Jun N-terminal kinase Proc Natl Acad Sci U S A 95 1998 2050 2055
74. O. Kassel, A. Sancono, J. Kratzschmar, B. Kreft, M. Stassen, and A.C. Cato Glucocorticoids inhibit MAP kinase via increased expression and decreased degradation of MKP-1 EMBO J 20 2001 7108 7116
75. E. Irusen, J.G. Matthews, A. Takahashi, P.J. Barnes, K.F. Chung, and I.M. Adcock p38 Mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: role in steroid-insensitive asthma J Allergy Clin Immunol 109 2002 649 657
76. Z. Szatmary, M.J. Garabedian, and J. Vilcek Inhibition of glucocorticoid receptor-mediated transcriptional activation by p38 mitogen-activated protein (MAP) kinase J Biol Chem 279 2004 43708 43715
77. J. Fan, N.M. Heller, M. Gorospe, U. Atasoy, and C. Stellato The role of post-transcriptional regulation in chemokine gene expression in inflammation and allergy Eur Respir J 26 2005 933 947
78. S. Meyer, C. Temme, and E. Wahle Messenger RNA turnover in eukaryotes: pathways and enzymes Crit Rev Biochem Mol Biol 39 2004 197 216
79. J. Shim, and M. Karin The control of mRNA stability in response to extracellular stimuli Mol Cells 14 2002 323 331
80. M. Lasa, M. Brook, J. Saklatvala, and A.R. Clark Dexamethasone destabilizes cyclooxygenase 2 mRNA by inhibiting mitogen-activated protein kinase p38 Mol Cell Biol 21 2001 771 780
81. M.W. Bergmann, K.J. Staples, S.J. Smith, P.J. Barnes, and R. Newton Glucocorticoid inhibition of granulocyte macrophage-colony-stimulating factor from T cells is independent of control by nuclear factor-kappaB and conserved lymphokine element 0 Am J Respir Cell Mol Biol 30 2004 555 563
82. U. Jalonen, A. Lahti, R. Korhonen, H. Kankaanranta, and E. Moilanen Inhibition of tristetraprolin expression by dexamethasone in activated macrophages Biochem Pharmacol 69 2005 733 740
83. A.W. Norman, M.T. Mizwicki, and D.P. Norman Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model Nat Rev Drug Discov 3 2004 27 41
84. Y.Z. Chen, and J. Qiu Pleiotropic signaling pathways in rapid, nongenomic action of glucocorticoid Mol Cell Biol Res Commun 2 1999 145 149
85. C.E. Powell, C.S. Watson, and B. Gametchu Immunoaffinity isolation of native membrane glucocorticoid receptor from S-49++ lymphoma cells: biochemical characterization and interaction with Hsp 70 and Hsp 90 Endocrine 10 1999 271 280
86. S.J. Evans, T.F. Murray, and F.L. Moore Partial purification and biochemical characterization of a membrane glucocorticoid receptor from an amphibian brain J Steroid Biochem Mol Biol 72 2000 209 221
87. E.S. Mendes, A. Pereira, I. Danta, R.C. Duncan, and A. Wanner Comparative bronchial vasoconstrictive efficacy of inhaled glucocorticosteroids Eur Respir J 21 2003 989 993
88. I.M. Adcock, K. Maneechotesuwan, and O. Usmani Molecular interactions between glucocorticoids and long-acting beta2-agonists J Allergy Clin Immunol 110 suppl 2002 S261 S268
89. J.D. Croxtall, P.T. Van Hal, Q. Choudhury, D.W. Gilroy, and R.J. Flower Different glucocorticoids vary in their genomic and non-genomic mechanism of action in A549 cells Br J Pharmacol 135 2002 511 519
90. J.D. Croxtall, Q. Choudhury, and R.J. Flower Glucocorticoids act within minutes to inhibit recruitment of signalling factors to activated EGF receptors through a receptor-dependent, transcription-independent mechanism Br J Pharmacol 130 2000 289 298
91. J.M. Hu, J.E. Bodwell, and A. Munck Cell cycle-dependent glucocorticoid receptor phosphorylation and activity Mol Endocrinol 8 1994 1709 1713
92. Z. Zuo, G. Urban, J.G. Scammell, N.M. Dean, T.K. McLean, and I. Aragon Ser/Thr protein phosphatase type 5 (PP5) is a negative regulator of glucocorticoid receptor-mediated growth arrest Biochemistry 38 1999 8849 8857
93. J.P. Somers, and D.B. DeFranco Effects of okadaic acid, a protein phosphatase inhibitor, on glucocorticoid receptor-mediated enhancement Mol Endocrinol 6 1992 26 34
94. S.C. Hsu, M. Qi, and D.B. DeFranco Cell cycle regulation of glucocorticoid receptor function EMBO J 11 1992 3457 3468
95. M.D. Galigniana, P.R. Housley, D.B. DeFranco, and W.B. Pratt Inhibition of glucocorticoid receptor nucleocytoplasmic shuttling by okadaic acid requires intact cytoskeleton [in process citation] J Biol Chem 274 1999 16222 16227
96. J.E. Bodwell, J.M. Hu, E. Orti, and A. Munck Hormone-induced hyperphosphorylation of specific phosphorylated sites in the mouse glucocorticoid receptor J Steroid Biochem Mol Biol 52 1995 135 140
97. J.E. Bodwell, J.M. Hu, L.M. Hu, and A. Munck Glucocorticoid receptors: ATP and cell cycle dependence, phosphorylation, and hormone resistance Am J Respir Crit Care Med 154 suppl 1996 S2 S6
98. M. Itoh, M. Adachi, H. Yasui, M. Takekawa, H. Tanaka, and K. Imai Nuclear export of glucocorticoid receptor is enhanced by c-Jun N-terminal kinase-mediated phosphorylation Mol Endocrinol 16 2002 2382 2392
99. A.D. Wallace, and J.A. Cidlowski Proteasome-mediated glucocorticoid receptor degradation restricts transcriptional signaling by glucocorticoids J Biol Chem 276 2001 42714 42721
100. D.Y. Le, N. Mincheneau, G.P. Le, and D. Michel Potentiation of glucocorticoid receptor transcriptional activity by sumoylation Endocrinology 143 2002 3482 3489
101. D.Y. Lin, M.Z. Lai, D.K. Ann, and H.M. Shih Promyelocytic leukemia protein (PML) functions as a glucocorticoid receptor co-activator by sequestering Daxx to the PML oncogenic domains (PODs) to enhance its transactivation potential J Biol Chem 278 2003 15958 15965
102. M.D. Galigniana, G. Piwien-Pilipuk, and J. Assreuy Inhibition of glucocorticoid receptor binding by nitric oxide Mol Pharmacol 55 1999 317 323
103. L. Chen, W. Fischle, E. Verdin, and W.C. Greene Duration of nuclear NF-kappaB action regulated by reversible acetylation Science 293 2001 1653 1657
104. K. Ito, S. Yamamura, S. Essilfie-Quaye, B. Cosio, M. Ito, and P.J. Barnes Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-κB suppression J Exp Med 203 2006 7 13
105. D.Y. Leung, J.D. Spahn, and S.J. Szefler Immunologic basis and management of steroid-resistant asthma Allergy Asthma Proc 20 1999 9 14
106. M. Norman, and S.D. Hearing Glucocorticoid resistance - what is known? Curr Opin Pharmacol 2 2002 723 729
107. S.J. Lane, and T.H. Lee Corticosteroid resistance in other disease states and tissues Am J Respir Crit Care Med 154 suppl 1996 S62 S65
108. I.M. Adcock, and S.J. Lane Corticosteroid-insensitive asthma: molecular mechanisms J Endocrinol 178 2003 347 355
109. C. Charman, and H. Williams The use of corticosteroids and corticosteroid phobia in atopic dermatitis Clin Dermatol 21 2003 193 200
110. M.A. Magiakou, and G.P. Chrousos Cushing's syndrome in children and adolescents: current diagnostic and therapeutic strategies J Endocrinol Invest 25 2002 181 194
111. H. Schacke, H. Rehwinkel, and K. Asadullah Dissociated glucocorticoid receptor ligands: compounds with an improved therapeutic index Curr Opin Investig Drugs 6 2005 503 507
112. H. Schacke, A. Schottelius, W.D. Docke, P. Strehlke, S. Jaroch, and N. Schmees Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects Proc Natl Acad Sci U S A 101 2004 227 232
113. R. Lofberg, A. Danielsson, O. Suhr, A. Nilsson, R. Schioler, and A. Nyberg Oral budesonide versus prednisolone in patients with active extensive and left-sided ulcerative colitis Gastroenterology 110 1996 1713 1718
114. D.R. Friend Review article: issues in oral administration of locally acting glucocorticosteroids for treatment of inflammatory bowel disease Aliment Pharmacol Ther 12 1998 591 603
115. M.C. de Kaski, A.M. Peters, J.P. Lavender, and H.J. Hodgson Fluticasone propionate in Crohn's disease Gut 32 1991 657 661
116. F. Kanniess, K. Richter, S. Bohme, R.A. Jorres, and H. Magnussen Effect of inhaled ciclesonide on airway responsiveness to inhaled AMP, the composition of induced sputum and exhaled nitric oxide in patients with mild asthma Pulm Pharmacol Ther 14 2001 141 147
117. Global Initiative for Asthma, Global Strategy for asthma management and prevention 2002 National Institutes of Health Bethesda (MD) NIH publication no. 02-3659
118. D.Y. Leung, and J.W. Bloom Update on glucocorticoid action and resistance J Allergy Clin Immunol 111 2003 3 22
119. B.A. ten, P.J. Sterk, A.A. Masclee, P. Spinhoven, J.T. Schmidt, and A.H. Zwinderman Risk factors of frequent exacerbations in difficult-to-treat asthma Eur Respir J 26 2005 812 818
120. K.F. Rabe, M. Adachi, C.K. Lai, J.B. Soriano, P.A. Vermeire, and K.B. Weiss Worldwide severity and control of asthma in children and adults: the global asthma insights and reality surveys J Allergy Clin Immunol 114 2004 40 47
121. Proceedings of the ATS workshop on refractory asthma: current understanding, recommendations, and unanswered questions. American Thoracic Society. Am J Respir Crit Care Med 2000;162:2341-51.
122. D. Bumbacea, D. Campbell, L. Nguyen, D. Carr, P.J. Barnes, and D. Robinson Parameters associated with persistent airflow obstruction in chronic severe asthma Eur Respir J 24 2004 122 128
123. D.S. Robinson, D.A. Campbell, S.R. Durham, J. Pfeffer, P.J. Barnes, and K.F. Chung Systematic assessment of difficult-to-treat asthma Eur Respir J 22 2003 478 483
124. P.E. Silkoff, A.M. Lent, A.A. Busacker, R.K. Katial, S. Balzar, and M. Strand Exhaled nitric oxide identifies the persistent eosinophilic phenotype in severe refractory asthma J Allergy Clin Immunol 116 2005 1249 1255
125. B.A. ten, A.H. Zwinderman, P.J. Sterk, K.F. Rabe, and E.H. Bel "Refractory" eosinophilic airway inflammation in severe asthma: effect of parenteral corticosteroids Am J Respir Crit Care Med 170 2004 601 605
126. M.T. Chan, D.Y. Leung, S.J. Szefler, and J.D. Spahn Difficult-to-control asthma: clinical characteristics of steroid-insensitive asthma J Allergy Clin Immunol 101 1998 594 601
127. L.G. Heaney, E. Conway, C. Kelly, B.T. Johnston, C. English, and M. Stevenson Predictors of therapy resistant asthma: outcome of a systematic evaluation protocol Thorax 58 2003 561 566
128. P.J. Barnes, A.P. Greening, and G.K. Crompton Glucocorticoid resistance in asthma Am J Respir Crit Care Med 152 suppl 1995 S125 S140
129. C.M. Dolan, K.E. Fraher, E.R. Bleecker, L. Borish, B. Chipps, and M.L. Hayden Design and baseline characteristics of the epidemiology and natural history of asthma: Outcomes and Treatment Regimens (TENOR) study: a large cohort of patients with severe or difficult-to-treat asthma Ann Allergy Asthma Immunol 92 2004 32 39
130. M.K. Miller, C. Johnson, D.P. Miller, Y. Deniz, E.R. Bleecker, and S.E. Wenzel Severity assessment in asthma: an evolving concept J Allergy Clin Immunol 116 2005 990 995
131. C.J. Corrigan Asthma refractory to glucocorticoids: the role of newer immunosuppressants Am J Respir Med 1 2002 47 54
132. J.W. Eckstein, and J. Fung A new class of cyclosporin analogues for the treatment of asthma Expert Opin Investig Drugs 12 2003 647 653
133. The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma. European Network for Understanding Mechanisms of Severe Asthma Eur Respir J 22 2003 470 477
134. S.E. Wenzel, L.B. Schwartz, E.L. Langmack, J.L. Halliday, J.B. Trudeau, and R.L. Gibbs Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics Am J Respir Crit Care Med 160 1999 1001 1008
135. P. Flood-Page, A. Menzies-Gow, S. Phipps, S. Ying, A. Wangoo, and M.S. Ludwig Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics J Clin Invest 112 2003 1029 1036
136. D.Y. Leung, R.J. Martin, S.J. Szefler, E.R. Sher, S. Ying, and A.B. Kay Dysregulation of interleukin 4, interleukin 5, and interferon gamma gene expression in steroid-resistant asthma J Exp Med 181 1995 33 40
137. M.L. Huynh, K.C. Malcolm, C. Kotaru, J.A. Tilstra, J.Y. Westcott, and V.A. Fadok Defective apoptotic cell phagocytosis attenuates prostaglandin E2 and 15-hydroxyeicosatetraenoic acid in severe asthma alveolar macrophages Am J Respir Crit Care Med 172 2005 972 979
138. J. Chakir, Q. Hamid, M. Bosse, L.P. Boulet, and M. Laviolette Bronchial inflammation in corticosteroid-sensitive and corticosteroid-resistant asthma at baseline and on oral corticosteroid treatment Clin Exp Allergy 32 2002 578 582
139. A.L. Lazaar, and R.A. Panettieri Jr. Is airway remodeling clinically relevant in asthma? Am J Med 115 2003 652 659
140. J.M. Vonk, H. Jongepier, C.I. Panhuysen, J.P. Schouten, E.R. Bleecker, and D.S. Postma Risk factors associated with the presence of irreversible airflow limitation and reduced transfer coefficient in patients with asthma after 26 years of follow up Thorax 58 2003 322 327
141. D.M. Malchoff, A. Brufsky, G. Reardon, P. McDermott, E.C. Javier, and C.H. Bergh A mutation of the glucocorticoid receptor in primary cortisol resistance J Clin Invest 91 1993 1918 1925
142. S.J. Lane, B.A. Atkinson, R. Swaminathan, and T.H. Lee Hypothalamic-pituitary-adrenal axis in corticosteroid-resistant bronchial asthma Am J Respir Crit Care Med 153 1996 557 560
143. S.J. Lane, J.P. Arm, D.Z. Staynov, and T.H. Lee Chemical mutational analysis of the human glucocorticoid receptor cDNA in glucocorticoid-resistant bronchial asthma Am J Respir Cell Mol Biol 11 1994 42 48
144. I.M. Adcock, S.J. Lane, C.R. Brown, T.H. Lee, and P.J. Barnes Abnormal glucocorticoid receptor-activator protein 1 interaction in steroid-resistant asthma J Exp Med 182 1995 1951 1958
145. S.J. Szefler, and D.Y. Leung Glucocorticoid-resistant asthma: pathogenesis and clinical implications for management Eur Respir J 10 1997 1640 1647
146. S.J. Lane, and T.H. Lee Glucocorticoid receptor characteristics in monocytes of patients with corticosteroid-resistant bronchial asthma Am Rev Respir Dis 143 1991 1020 1024
147. C.J. Corrigan, P.H. Brown, N.C. Barnes, J.J. Tsai, A.J. Frew, and A.B. Kay Glucocorticoid resistance in chronic asthma. Peripheral blood T lymphocyte activation and comparison of the T lymphocyte inhibitory effects of glucocorticoids and cyclosporin A Am Rev Respir Dis 144 1991 1026 1032
148. C.J. Corrigan, P.H. Brown, N.C. Barnes, S.J. Szefler, J.J. Tsai, and A.J. Frew Glucocorticoid resistance in chronic asthma. Glucocorticoid pharmacokinetics, glucocorticoid receptor characteristics, and inhibition of peripheral blood T cell proliferation by glucocorticoids in vitro Am Rev Respir Dis 144 1991 1016 1025
149. E.R. Sher, D.Y. Leung, W. Surs, J.C. Kam, G. Zieg, and A.K. Kamada Steroid-resistant asthma. Cellular mechanisms contributing to inadequate response to glucocorticoid therapy J Clin Invest 93 1994 33 39
150. Y.J. Cho, and K.E. Lee Decreased glucocorticoid binding affinity to glucocorticoid receptor is important in the poor response to steroid therapy of older-aged patients with severe bronchial asthma Allergy Asthma Proc 24 2003 353 358
151. A. Torrego, L. Pujols, J. Roca-Ferrer, J. Mullol, A. Xaubet, and C. Picado Glucocorticoid receptor isoforms alpha and beta in in vitro cytokine-induced glucocorticoid insensitivity Am J Respir Crit Care Med 170 2004 420 425
152. R. Gagliardo, P. Chanez, A.M. Vignola, J. Bousquet, I. Vachier, and P. Godard Glucocorticoid receptor alpha and beta in glucocorticoid dependent asthma Am J Respir Crit Care Med 162 2000 7 13
153. I. Strickland, K. Kisich, P.J. Hauk, A. Vottero, G.P. Chrousos, and D.J. Klemm High constitutive glucocorticoid receptor beta in human neutrophils enables them to reduce their spontaneous rate of cell death in response to corticosteroids J Exp Med 193 2001 585 593
154. A.R. Sousa, S.J. Lane, J.A. Cidlowski, D.Z. Staynov, and T.H. Lee Glucocorticoid resistance in asthma is associated with elevated in vivo expression of the glucocorticoid receptor beta-isoform J Allergy Clin Immunol 105 2000 943 950
155. E. Goleva, L.B. Li, P.T. Eves, M.J. Strand, R.J. Martin, and D.Y. Leung Increased glucocorticoid receptor beta alters steroid response in glucocorticoid insensitive asthma Am J Respir Crit Care Med 2005 Epub ahead of print
156. H. Bantel, M.L. Schmitz, A. Raible, M. Gregor, and K. Schulze-Osthoff Critical role of NF-kappaB and stress-activated protein kinases in steroid unresponsiveness FASEB J 16 2002 1832 1834
157. J.G. Matthews, K. Ito, P.J. Barnes, and I.M. Adcock Defective glucocorticoid receptor nuclear translocation and altered histone acetylation patterns in glucocorticoid-resistant patients J Allergy Clin Immunol 113 2004 1100 1108
158. I.M. Adcock, S.J. Lane, C.R. Brown, M.J. Peters, T.H. Lee, and P.J. Barnes Differences in binding of glucocorticoid receptor to DNA in steroid-resistant asthma J Immunol 154 1995 3500 3505
159. M. Lasa, S.M. Abraham, C. Boucheron, J. Saklatvala, and A.R. Clark Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38 Mol Cell Biol 22 2002 7802 7811
160. A.R. Clark, and M. Lasa Crosstalk between glucocorticoids and mitogen-activated protein kinase signalling pathways Curr Opin Pharmacol 3 2003 404 411
161. E. Goleva, K.O. Kisich, and D.Y. Leung A role for STAT5 in the pathogenesis of IL-2-induced glucocorticoid resistance J Immunol 169 2002 5934 5940
162. M. Cetkovic-Cvrlje, A.L. Dragt, A. Vassilev, X.P. Liu, and F.M. Uckun Targeting JAK3 with JANEX-1 for prevention of autoimmune type 1 diabetes in NOD mice Clin Immunol 106 2003 213 225
163. J. Elliott, and J.A. Johnston SOCS: role in inflammation, allergy and homeostasis Trends Immunol 25 2004 434 440
164. S. Canfield, Y. Lee, A. Schroder, and P. Rothman Cutting edge: IL-4 induces suppressor of cytokine signaling-3 expression in B cells by a mechanism dependent on activation of p38 MAPK J Immunol 174 2005 2494 2498
165. K. Tanigawa, H. Nagase, K. Ohmori, K. Tanaka, H. Miyake, and M. Kiniwa Species-specific differences in the glucocorticoid receptor transactivation function upon binding with betamethasone-esters Int Immunopharmacol 2 2002 941 950
166. S.J. Lane, I.M. Adcock, D. Richards, C. Hawrylowicz, P.J. Barnes, and T.H. Lee Corticosteroid-resistant bronchial asthma is associated with increased c-fos expression in monocytes and T lymphocytes J Clin Invest 102 1998 2156 2164
167. A.R. Sousa, S.J. Lane, C. Soh, and T.H. Lee In vivo resistance to corticosteroids in bronchial asthma is associated with enhanced phosyphorylation of JUN N-terminal kinase and failure of prednisolone to inhibit JUN N-terminal kinase phosphorylation J Allergy Clin Immunol 104 1999 565 574
168. E. Takahashi, K. Onda, T. Hirano, K. Oka, N. Maruoka, and M. Tsuyuguchi Expression of c-fos, rather than c-jun or glucocorticoid-receptor mRNA, correlates with decreased glucocorticoid response of peripheral blood mononuclear cells in asthma Int Immunopharmacol 2 2002 1419 1427
169. E. Shaulian, and M. Karin AP-1 as a regulator of cell life and death Nat Cell Biol 4 2002 E131 E136
170. C.Y. Wang, A.G. Bassuk, L.H. Boise, C.B. Thompson, R. Bravo, and J.M. Leiden Activation of the granulocyte-macrophage colony-stimulating factor promoter in T cells requires cooperative binding of Elf-1 and AP-1 transcription factors Mol Cell Biol 14 1994 1153 1159
171. R.P. de Groot, T.B. van Dijk, E. Caldenhoven, P.J. Coffer, J.A. Raaijmakers, and J.W. Lammers Activation of 12-O-tetradecanoylphorbol-13-acetate response element- and dyad symmetry element-dependent transcription by interleukin-5 is mediated by Jun N-terminal kinase/stress-activated protein kinase kinases J Biol Chem 272 1997 2319 2325
172. C. Hawrylowicz, D. Richards, T.K. Loke, C. Corrigan, and T. Lee A defect in corticosteroid-induced IL-10 production in T lymphocytes from corticosteroid-resistant asthmatic patients J Allergy Clin Immunol 109 2002 369 370
173. E. Xystrakis, S. Kusumakar, S. Boswell, E. Peek, Z. Urry, and D.F. Richards Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients J Clin Invest 116 2006 146 155
174. A. Kibe, H. Inoue, S. Fukuyama, K. Machida, K. Matsumoto, and H. Koto Differential regulation by glucocorticoid of interleukin-13-induced eosinophilia, hyperresponsiveness, and goblet cell hyperplasia in mouse airways Am J Respir Crit Care Med 167 2003 50 56
175. D.C. Tsitoura, and P.B. Rothman Enhancement of MEK/ERK signaling promotes glucocorticoid resistance in CD4+ T cells J Clin Invest 113 2004 619 627
176. O. Tliba, J. Cidlowski, and Y. Amrani CD38 expression is insensitive to steroid action in cells treated with TNFα and IFNγ by a mechanism involving the upregulation of glucocorticoid receptor β isoform Mol Pharmacol 69 2006 588 596
177. R. Pawliczak, C. Logun, P. Madara, J. Barb, A.F. Suffredini, and P.J. Munson Influence of IFN-gamma on gene expression in normal human bronchial epithelial cells: modulation of IFN-gamma effects by dexamethasone Physiol Genomics 23 2005 28 45
178. X. Hu, W.P. Li, C. Meng, and L.B. Ivashkiv Inhibition of IFN-gamma signaling by glucocorticoids J Immunol 170 2003 4833 4839
179. C.S. Hinrichs, D.C. Palmer, S.A. Rosenberg, and N.P. Restifo Glucocorticoids do not inhibit antitumor activity of activated CD8+ T cells J Immunother 28 2005 517 524
180. S.J. Heasman, K.M. Giles, A.G. Rossi, J.E. Allen, C. Haslett, and I. Dransfield Interferon gamma suppresses glucocorticoid augmentation of macrophage clearance of apoptotic cells Eur J Immunol 34 2004 1752 1761
181. A. De, H.M. Blotta, R.L. Mamoni, P. Louzada, M.B. Bertolo, and N.T. Foss Effects of dexamethasone on lymphocyte proliferation and cytokine production in rheumatoid arthritis J Rheumatol 29 2002 46 51
182. G.W. Chalmers, K.J. Macleod, S.A. Little, L.J. Thomson, C.P. McSharry, and N.C. Thomson Influence of cigarette smoking on inhaled corticosteroid treatment in mild asthma Thorax 57 2002 226 230
183. R. Chaudhuri, E. Livingston, A.D. McMahon, L. Thomson, W. Borland, and N.C. Thomson Cigarette smoking impairs the therapeutic response to oral corticosteroids in chronic asthma Am J Respir Crit Care Med 168 2003 1308 1311
184. K. Okamoto, H. Tanaka, H. Ogawa, Y. Makino, H. Eguchi, and S. Hayashi Redox-dependent regulation of nuclear import of the glucocorticoid receptor J Biol Chem 274 1999 10363 10371
185. K. Ito, T. Hanazawa, K. Tomita, P.J. Barnes, and I.M. Adcock Oxidative stress reduces histone deacetylase 2 activity and enhances IL-8 gene expression: role of tyrosine nitration Biochem Biophys Res Commun 315 2004 240 245
186. S.A. Kharitonov, and P.J. Barnes Nitric oxide, nitrotyrosine, and nitric oxide modulators in asthma and chronic obstructive pulmonary disease Curr Allergy Asthma Rep 3 2003 121 129
187. K. Katsoulis, T. Kontakiotis, I. Leonardopoulos, A. Kotsovili, I.N. Legakis, and D. Patakas Serum total antioxidant status in severe exacerbation of asthma: correlation with the severity of the disease J Asthma 40 2003 847 854
188. E. Baraldi, L. Ghiro, V. Piovan, S. Carraro, G. Ciabattoni, and P.J. Barnes Increased exhaled 8-isoprostane in childhood asthma Chest 124 2003 25 31
189. K. Ito, M. Ito, W.M. Elliott, B. Cosio, G. Caramori, and O.M. Kon Decreased histone deacetylase activity in chronic obstructive pulmonary disease N Engl J Med 352 2005 1967 1976
190. T. Rangasamy, J. Guo, W.A. Mitzner, J. Roman, A. Singh, and A.D. Fryer Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice J Exp Med 202 2005 47 59
191. S.T. Weiss, and B.A. Raby Asthma genetics 2003 Hum Mol Genet 13 2004 R83 R89
192. W. Cookson, and M. Moffatt Making sense of asthma genes N Engl J Med 351 2004 1794 1796
193. Y. Zhang, N.I. Leaves, G.G. Anderson, C.P. Ponting, J. Broxholme, and R. Holt Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma Nat Genet 34 2003 181 186
194. M. Allen, A. Heinzmann, E. Noguchi, G. Abecasis, J. Broxholme, and C.P. Ponting Positional cloning of a novel gene influencing asthma from chromosome 2q14 Nat Genet 35 2003 258 263
195. E.G. Burchard, E.K. Silverman, L.J. Rosenwasser, L. Borish, C. Yandava, and A. Pillari Association between a sequence variant in the IL-4 gene promoter and FEV(1) in asthma Am J Respir Crit Care Med 160 1999 919 922
196. M.J. Federico, R.A. Covar, E.E. Brown, D.Y. Leung, and J.D. Spahn Racial differences in T-lymphocyte response to glucocorticoids Chest 127 2005 571 578
197. L. Rosa-Rosa, N. Zimmermann, J.A. Bernstein, M.E. Rothenberg, and G.K. Khurana Hershey The R576 IL-4 receptor alpha allele correlates with asthma severity J Allergy Clin Immunol 104 1999 1008 1014
198. M. Isidoro-Garcia, I. Davila, E. Laffond, E. Moreno, F. Lorente, and R. Gonzalez-Sarmiento Interleukin-4 (IL4) and Interleukin-4 receptor (IL4RA) polymorphisms in asthma: a case control study Clin Mol Allergy 3 2005 15
199. H. Hakonarson, U.S. Bjornsdottir, E. Halapi, J. Bradfield, F. Zink, and M. Mouy Profiling of genes expressed in peripheral blood mononuclear cells predicts glucocorticoid sensitivity in asthma patients Proc Natl Acad Sci U S A 102 2005 14789 14794
200. K. Salari, S. Choudhry, H. Tang, M. Naqvi, D. Lind, and P.C. Avila Genetic admixture and asthma-related phenotypes in Mexican American and Puerto Rican asthmatics Genet Epidemiol 29 2005 76 86
201. S.L. Johnston Overview of virus-induced airway disease Proc Am Thorac Soc 2 2005 150 156
202. C. Bellattato, I.M. Adcock, K. Ito, G. Caramori, P. Casolari, and A. Ciaccia Rhinovirus infection reduces glucocorticoid receptor nuclear translocation in airway epithelial cells Eur Respir J 22 suppl 2003 565S
203. P.J. Busse, J.J. Wang, and E.A. Halm Allergen sensitization evaluation and allergen avoidance education in an inner-city adult cohort with persistent asthma J Allergy Clin Immunol 116 2005 146 152
204. S.R. Nimmagadda, S.J. Szefler, J.D. Spahn, W. Surs, and D.Y. Leung Allergen exposure decreases glucocorticoid receptor binding affinity and steroid responsiveness in atopic asthmatics Am J Respir Crit Care Med 155 1997 87 93
205. P.J. Hauk, S.E. Wenzel, A.E. Trumble, S.J. Szefler, and D.Y. Leung Increased T-cell receptor vbeta8+ T cells in bronchoalveolar lavage fluid of subjects with poorly controlled asthma: a potential role for microbial superantigens J Allergy Clin Immunol 104 1999 37 45
206. B.L. Kotzin, D.Y. Leung, J. Kappler, and P. Marrack Superantigens and their potential role in human disease Adv Immunol 54 1993 99 166
207. P.J. Hauk, Q.A. Hamid, G.P. Chrousos, and D.Y. Leung Induction of corticosteroid insensitivity in human PBMCs by microbial superantigens J Allergy Clin Immunol 105 2000 782 787
208. L.B. Li, E. Goleva, C.F. Hall, L.S. Ou, and D.Y. Leung Superantigen-induced corticosteroid resistance of human T cells occurs through activation of the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (MEK-ERK) pathway J Allergy Clin Immunol 114 2004 1059 1069
209. S.E. Wenzel, S.J. Szefler, D.Y. Leung, S.I. Sloan, M.D. Rex, and R.J. Martin Bronchoscopic evaluation of severe asthma. Persistent inflammation associated with high dose glucocorticoids Am J Respir Crit Care Med 156 1997 737 743
210. S.R. Walmsley, K.A. Cadwallader, and E.R. Chilvers The role of HIF-1alpha in myeloid cell inflammation Trends Immunol 26 2005 434 439
211. M. Camps, T. Ruckle, H. Ji, V. Ardissone, F. Rintelen, and J. Shaw Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis Nat Med 11 2005 936 943
212. X. Zhang, E. Moilanen, I.M. Adcock, M.A. Lindsay, and H. Kankaanranta Divergent effect of mometasone on human eosinophil and neutrophil apoptosis Life Sci 71 2002 1523 1534
213. Q. Xu, D.Y. Leung, and K.O. Kisich Serine-arginine-rich protein p30 directs alternative splicing of glucocorticoid receptor pre-mRNA to glucocorticoid receptor beta in neutrophils J Biol Chem 278 2003 27112 27118
214. B. Bender, H. Milgrom, and A. Apter Adherence intervention research: what have we learned and what do we do next? J Allergy Clin Immunol 112 2003 489 494
215. K.F. Chung, and I.M. Adcock Combination therapy of long-acting beta2-adrenoceptor agonists and corticosteroids for asthma Treat Respir Med 3 2004 279 289
216. H.S. Nelson Combination therapy of long-acting beta agonists and inhaled corticosteroids in the management of chronic asthma Curr Allergy Asthma Rep 5 2005 123 129
217. S.A. Kharitonov, and P.J. Barnes Effects of corticosteroids on noninvasive biomarkers of inflammation in asthma and chronic obstructive pulmonary disease Proc Am Thorac Soc 1 2004 191 199
218. C.E. Brightling, R.H. Green, and I.D. Pavord Biomarkers predicting response to corticosteroid therapy in asthma Treat Respir Med 4 2005 309 316
219. S.T. Holgate, A.G. Chuchalin, J. Hebert, J. Lotvall, G.B. Persson, and K.F. Chung Efficacy and safety of a recombinant anti-immunoglobulin E antibody (omalizumab) in severe allergic asthma Clin Exp Allergy 34 2004 632 638
220. E.M. Varga, K. Nouri-Aria, S.J. Till, and S.R. Durham Immunomodulatory treatment strategies for allergic diseases Curr Drug Targets Inflamm Allergy 2 2003 31 46
221. F.S. Wamboldt, J.D. Spahn, M.D. Klinnert, M.Z. Wamboldt, L.A. Gavin, and S.J. Szefler Clinical outcomes of steroid-insensitive asthma Ann Allergy Asthma Immunol 83 1999 55 60
222. D. Ledford, A. Apter, A.M. Brenner, K. Rubin, K. Prestwood, and M. Frieri Osteoporosis in the corticosteroid-treated patient with asthma J Allergy Clin Immunol 102 1998 353 362
223. R.A. Covar, D.Y. Leung, D. McCormick, J. Steelman, P. Zeitler, and J.D. Spahn Risk factors associated with glucocorticoid-induced adverse effects in children with severe asthma J Allergy Clin Immunol 106 2000 651 659
224. R.J. Martin, S.J. Szefler, V.M. Chinchilli, M. Kraft, M. Dolovich, and H.A. Boushey Systemic effect comparisons of six inhaled corticosteroid preparations Am J Respir Crit Care Med 165 2002 1377 1383
225. S. Szefler, S. Rohatagi, J. Williams, M. Lloyd, S. Kundu, and D. Banerji Ciclesonide, a novel inhaled steroid, does not affect hypothalamic-pituitary- adrenal axis function in patients with moderate-to-severe persistent asthma Chest 128 2005 1104 1114
226. P.J. Barnes New drugs for asthma Nat Rev Drug Discov 3 2004 831 844
227. O.M. Kon, B.S. Sihra, L.C. Loh, J. Barkans, C.H. Compton, and N.C. Barnes The effects of an anti-CD4 monoclonal antibody, keliximab, on peripheral blood CD4+ T-cells in asthma Eur Respir J 18 2001 45 52
228. T.J. Creed, M.R. Norman, C.S. Probert, R.F. Harvey, I.S. Shaw, and J. Smithson Basiliximab (anti-CD25) in combination with steroids may be an effective new treatment for steroid-resistant ulcerative colitis Aliment Pharmacol Ther 18 2003 65 75
229. A.M. Manning, and R.J. Davis Targeting JNK for therapeutic benefit: from junk to gold? Nat Rev Drug Discov 2 2003 554 565
230. I.M. Adcock, and G. Caramori Kinase targets and inhibitors for the treatment of airway inflammatory diseases: the next generation of drugs for severe asthma and COPD? BioDrugs 18 2004 167 180
231. N. Sizemore, A. Agarwal, K. Das, N. Lerner, M. Sulak, and S. Rani Inhibitor of kappaB kinase is required to activate a subset of interferon gamma-stimulated genes Proc Natl Acad Sci U S A 101 2004 7994 7998
232. F. Turlais, A. Hardcastle, M. Rowlands, Y. Newbatt, A. Bannister, and T. Kouzarides High-throughput screening for identification of small molecule inhibitors of histone acetyltransferases using scintillating microplates (FlashPlate) Anal Biochem 298 2001 62 68
233. K. Ito, S. Lim, G. Caramori, B. Cosio, K.F. Chung, and I.M. Adcock A molecular mechanism of action of theophylline: induction of histone deacetylase activity to decrease inflammatory gene expression Proc Natl Acad Sci U S A 99 2002 8921 8926
234. L. Jayaram, M. Duong, M.M. Pizzichini, E. Pizzichini, D. Kamada, and A. Efthimiadis Failure of montelukast to reduce sputum eosinophilia in high-dose corticosteroid-dependent asthma Eur Respir J 25 2005 41 46