A defect in corticosteroid-induced IL-10 production in T lymphocytes from corticosteroid-resistant asthmatic patients [1]

Journal of Allergy and Clinical Immunology

Volumn 109, Issue 2, 2002, Pages 369-370

  Hawrylowicz, Catherine ^a   Richards, David ^a   Loke, Tuck Kay ^a   Corrigan, Christopher ^a   Lee, Tak ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CD4 ANTIGEN; CD8 ANTIGEN; CORTICOSTEROID; DEXAMETHASONE; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; MESSENGER RNA; MONOCLONAL ANTIBODY CD3; PREDNISOLONE;

ADULT; ASTHMA; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORTICOSTEROID THERAPY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; FORCED EXPIRATORY VOLUME; GENE EXPRESSION; HUMAN; HUMAN CELL; LETTER; LUNG FUNCTION; MALE; MONONUCLEAR CELL; PRICK TEST; PRIORITY JOURNAL; T LYMPHOCYTE; TREATMENT FAILURE;

EID: 0036173939     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1067/mai.2002.121455     Document Type: Letter

References (5)

1. Dysregulation of interleukin 4, interleukin 5, and interferon γ gene expression in steroid-resistant asthma
2. Glucocorticolds drive human CD8+ T cell differentiation towards a phenotype with high IL-10 and reduced IL-4, IL-5 and IL-13 production
3. Interleukin-10 and the interleukin-10 receptor
4. Interleukin-10 regulation in normal subjects and patients with asthma
5. Inhaled corticosteroids increase interleukin-10 but reduce macrophage inflammatory protein-la, granulocyte-macrophage colony stimulating factor, and interferon-γ release from alveolar macrophages in asthma