Superantigen-induced corticosteroid resistance of human T cells occurs through activation of the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (MEK-ERK) pathway

Journal of Allergy and Clinical Immunology

Volumn 114, Issue 5, 2004, Pages 1059-1069

  Li, Ling Bo ^a   Goleva, Elena ^a   Hall, Clifton F ^a   Ou, Liang Shiou ^c   Leung, Donald Y M ^a,b  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c Department of Pediatrics   (Taiwan)

Author keywords

corticosteroids; glucocorticoid receptor; MEK ERK pathway; steroid resistance; Superantigens; T cells

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CD28 ANTIGEN; CD3 ANTIGEN; CD40 ANTIGEN; CORTICOSTEROID; DEXAMETHASONE; ENZYME INHIBITOR; GLUCOCORTICOID RECEPTOR; GLUCOCORTICOID RECEPTOR ALPHA; LIGAND; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN KINASE C DELTA INHIBITOR; STAPHYLOCOCCUS ENTEROTOXIN B; STEROID; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; SUPERANTIGEN; T LYMPHOCYTE RECEPTOR; TER 14687; UNCLASSIFIED DRUG; WORTMANNIN;

ANTIGEN PRESENTING CELL; ARTICLE; CELL ACTIVATION; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG INHIBITION; DRUG RESISTANCE; DRUG RESPONSE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; INFLAMMATION; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; STAINING; T LYMPHOCYTE; WESTERN BLOTTING;

ACTIVE TRANSPORT, CELL NUCLEUS; ADRENAL CORTEX HORMONES; ANTIGENS, CD28; ANTIGENS, CD40; DRUG RESISTANCE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; MAP KINASE SIGNALING SYSTEM; PHOSPHORYLATION; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, GLUCOCORTICOID; SUPERANTIGENS; T-LYMPHOCYTES;

EID: 7944220552     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2004.08.005     Document Type: Article

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