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Volumn 3, Issue 10, 2004, Pages 831-844

New drugs for asthma

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; AMINOPHYLLINE; ANTIASTHMATIC AGENT; ATRIAL NATRIURETIC FACTOR; BECLOMETASONE DIPROPIONATE; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BRONCHODILATING AGENT; BUDESONIDE; CICLESONIDE; CORTICOSTEROID DERIVATIVE; FLUTICASONE PROPIONATE; FORMOTEROL; FUROSEMIDE; INTERLEUKIN 5; IPRATROPIUM BROMIDE; MEPOLIZUMAB; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IV INHIBITOR; PROSTAGLANDIN RECEPTOR STIMULATING AGENT; SALBUTAMOL; SALMETEROL; TERBUTALINE; THEOPHYLLINE; TIOTROPIUM BROMIDE; TIPREDANE; UNINDEXED DRUG; URODILATIN; VASOACTIVE INTESTINAL POLYPEPTIDE;

EID: 6444222929     PISSN: 14741776     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrd1524     Document Type: Review
Times cited : (192)

References (172)
  • 1
    • 0035141851 scopus 로고    scopus 로고
    • The health economics of asthma and rhinitis. I. Assessing the economic impact
    • Weiss, K. B. & Sullivan, S. D. The health economics of asthma and rhinitis. I. Assessing the economic impact. J. Allergy Clin. Immunol. 107, 3-8 (2001).
    • (2001) J. Allergy Clin. Immunol. , vol.107 , pp. 3-8
    • Weiss, K.B.1    Sullivan, S.D.2
  • 3
    • 6344228082 scopus 로고    scopus 로고
    • Pathophysiology of asthma
    • Barnes, P. J. Pathophysiology of asthma. Eur. Respir. Mon. 8, 84-113 (2003).
    • (2003) Eur. Respir. Mon. , vol.8 , pp. 84-113
    • Barnes, P.J.1
  • 4
    • 0037214337 scopus 로고    scopus 로고
    • Early thickening of the reticular basement membrane in children with difficult asthma
    • Payne, D. N. et al. Early thickening of the reticular basement membrane in children with difficult asthma. Am. J. Respir. Crit. Care Med. 167, 78-82 (2003).
    • (2003) Am. J. Respir. Crit. Care Med. , vol.167 , pp. 78-82
    • Payne, D.N.1
  • 6
    • 0033542041 scopus 로고    scopus 로고
    • Systemic adverse effects of inhaled corticosteroid therapy: A systematic review and meta-analysis
    • Lipworth, B. J. Systemic adverse effects of inhaled corticosteroid therapy: A systematic review and meta-analysis. Arch. Intern. Med. 159, 941-955 (1999).
    • (1999) Arch. Intern. Med. , vol.159 , pp. 941-955
    • Lipworth, B.J.1
  • 7
    • 0013671084 scopus 로고
    • (ed. Barnes, P. J.) (IBC Technical Services Ltd, London,)
    • Brattsand, R. & Axelsson, B. New Drugs for Asthma Vol. 2 (ed. Barnes, P. J.) 192-207 (IBC Technical Services Ltd, London, 1992).
    • (1992) New Drugs for Asthma , vol.2 , pp. 192-207
    • Brattsand, R.1    Axelsson, B.2
  • 8
  • 9
    • 0032794908 scopus 로고    scopus 로고
    • A dose-dependent effect of the novel inhaled corticosteroid ciclesonide on airway responsiveness to adenosine-5′-monophosphate in asthmatic patients
    • Taylor, D. A. et al. A dose-dependent effect of the novel inhaled corticosteroid ciclesonide on airway responsiveness to adenosine-5′-monophosphate in asthmatic patients. Am. J. Respir. Crit. Care Med. 160, 237-243 (1999).
    • (1999) Am. J. Respir. Crit. Care Med. , vol.160 , pp. 237-243
    • Taylor, D.A.1
  • 10
    • 0141497509 scopus 로고    scopus 로고
    • How do corticosteroids work in asthma?
    • Barnes, P. J. & Adcock, I. M. How do corticosteroids work in asthma? Ann. Intern. Med. 139, 359-370 (2003).
    • (2003) Ann. Intern. Med. , vol.139 , pp. 359-370
    • Barnes, P.J.1    Adcock, I.M.2
  • 11
    • 0347719371 scopus 로고    scopus 로고
    • Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects
    • Schacke, H. et al. Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects. Proc. Natl Acad. Sci. USA 101, 227-232 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 227-232
    • Schacke, H.1
  • 12
    • 0027934108 scopus 로고
    • A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1
    • Heck, S. et al. A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1. EMBO J. 13, 4087-4095 (1994).
    • (1994) EMBO J. , vol.13 , pp. 4087-4095
    • Heck, S.1
  • 13
    • 0032982717 scopus 로고    scopus 로고
    • Ligand-induced differentiation of glucocorticoid receptor trans-repression and transactivation: Preferential targetting of NF-κB and lack of I-κB involvement
    • Adcock, I. M., Nasuhara, Y., Stevens, D. A. & Barnes, P. J. Ligand-induced differentiation of glucocorticoid receptor trans-repression and transactivation: preferential targetting of NF-κB and lack of I-κB involvement. Br. J. Pharmacol. 127, 1003-1011 (1999).
    • (1999) Br. J. Pharmacol. , vol.127 , pp. 1003-1011
    • Adcock, I.M.1    Nasuhara, Y.2    Stevens, D.A.3    Barnes, P.J.4
  • 14
    • 0031474156 scopus 로고    scopus 로고
    • Synthetic glucocorticoids that dissociate transactivation and AP-1 transrepression exhibit antiinflammatory activity in vivo
    • Vayssiere, B. M. et al. Synthetic glucocorticoids that dissociate transactivation and AP-1 transrepression exhibit antiinflammatory activity in vivo. Mol. Endocrinol. 11, 1245-1255 (1997).
    • (1997) Mol. Endocrinol. , vol.11 , pp. 1245-1255
    • Vayssiere, B.M.1
  • 15
    • 0035253604 scopus 로고    scopus 로고
    • Therapeutic benefit of a dissociated glucocorticoid and the relevance of in vitro separation of transrepression from transactivation activity
    • Belvisi, M. G. et al. Therapeutic benefit of a dissociated glucocorticoid and the relevance of in vitro separation of transrepression from transactivation activity. J. Immunol. 166, 1975-1982 (2001).
    • (2001) J. Immunol. , vol.166 , pp. 1975-1982
    • Belvisi, M.G.1
  • 16
    • 18444405534 scopus 로고    scopus 로고
    • Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition
    • Bledsoe, R. K. et al. Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition. Cell 110, 93-105 (2002).
    • (2002) Cell , vol.110 , pp. 93-105
    • Bledsoe, R.K.1
  • 17
    • 0021182753 scopus 로고
    • The effect of inhaled vasoactive intestinal peptide on bronchial hyperreactivity in man
    • Barnes, P. J. & Dixon, C. M. S. The effect of inhaled vasoactive intestinal peptide on bronchial hyperreactivity in man. Am. Rev. Respir. Dis. 130, 162-166 (1984).
    • (1984) Am. Rev. Respir. Dis. , vol.130 , pp. 162-166
    • Barnes, P.J.1    Dixon, C.M.S.2
  • 18
    • 0037340061 scopus 로고    scopus 로고
    • 2 receptor agonist in patients with stable asthma
    • 2 receptor agonist in patients with stable asthma. Thorax 58, 217-221 (2003).
    • (2003) Thorax , vol.58 , pp. 217-221
    • Linden, A.1
  • 19
    • 0029051402 scopus 로고
    • Effect of inhaled atrial natriuretic peptide and a neutral endopeptidase inhibitor on histamine-induced bronchoconstriction
    • Angus, R. M., Millar, E. A., Chalmers, G. W. & Thomson, N. C. Effect of inhaled atrial natriuretic peptide and a neutral endopeptidase inhibitor on histamine-induced bronchoconstriction. Am. J. Respir. Crit. Care Med. 151, 2003-2005 (1995).
    • (1995) Am. J. Respir. Crit. Care Med. , vol.151 , pp. 2003-2005
    • Angus, R.M.1    Millar, E.A.2    Chalmers, G.W.3    Thomson, N.C.4
  • 20
    • 0033569131 scopus 로고    scopus 로고
    • Bronchodilation using combined urodilatin-albuterol administration in asthma: A randomized, double-blind, placebo-controlled trial
    • Fluge, T. et al. Bronchodilation using combined urodilatin-albuterol administration in asthma: a randomized, double-blind, placebo-controlled trial. Eur J. Med. Res. 4, 411-415 (1999).
    • (1999) Eur. J. Med. Res. , vol.4 , pp. 411-415
    • Fluge, T.1
  • 21
    • 0027473832 scopus 로고
    • Effect of an oral potassium channel activator BRL 38227 on airway function and responsiveness in asthmatic patients: Comparison with oral salbutamol
    • Kidney, J. C. et al. Effect of an oral potassium channel activator BRL 38227 on airway function and responsiveness in asthmatic patients: comparison with oral salbutamol. Thorax 48 130-134 (1993).
    • (1993) Thorax , vol.48 , pp. 130-134
    • Kidney, J.C.1
  • 22
    • 0030821651 scopus 로고    scopus 로고
    • Activation of large conductance potassium channels inhibits the afferent and efferent function of airway sensory nerves
    • Fox, A. J., Barnes, P. J., Venkatesan, P. & Belvisi, M. G. Activation of large conductance potassium channels inhibits the afferent and efferent function of airway sensory nerves. J. Clin. Invest. 99, 513-519 (1997).
    • (1997) J. Clin. Invest. , vol.99 , pp. 513-519
    • Fox, A.J.1    Barnes, P.J.2    Venkatesan, P.3    Belvisi, M.G.4
  • 25
    • 12144288036 scopus 로고    scopus 로고
    • 4 Receptor Antagonist with Anti-inflammatory Properties
    • 4 Receptor Antagonist with Anti-inflammatory Properties. J. Pharmacol. Exp. Ther. (2004).
    • (2004) J. Pharmacol. Exp. Ther.
    • Thurmond, R.L.1
  • 26
    • 0033590513 scopus 로고    scopus 로고
    • Treatment of asthma with drugs modifying the leukotriene pathway
    • Drazen, J. M., Israel, E. & O'Byrne, P. M. Treatment of asthma with drugs modifying the leukotriene pathway. N. Engl. J. Med. 340, 197-206 (1999).
    • (1999) N. Engl. J. Med. , vol.340 , pp. 197-206
    • Drazen, J.M.1    Israel, E.2    O'Byrne, P.M.3
  • 27
    • 0037840370 scopus 로고    scopus 로고
    • Anti-leukotrienes: Here to stay?
    • Barnes, P. J. Anti-leukotrienes: here to stay? Curr. Opin. Pharmacol. 3, 257-263 (2003).
    • (2003) Curr. Opin. Pharmacol. , vol.3 , pp. 257-263
    • Barnes, P.J.1
  • 28
    • 0037189171 scopus 로고    scopus 로고
    • Functional characteristics of cysteinyl-leukotriene receptor subtypes
    • Back, M. Functional characteristics of cysteinyl-leukotriene receptor subtypes. Life Sci. 71, 611-622 (2002).
    • (2002) Life Sci. , vol.71 , pp. 611-622
    • Back, M.1
  • 29
    • 0029658108 scopus 로고    scopus 로고
    • 4 antagonist LY293111 on allergen-induced responses in asthma
    • 4 antagonist LY293111 on allergen-induced responses in asthma. Thorax 51, 1178-1184 (1996).
    • (1996) Thorax , vol.51 , pp. 1178-1184
    • Evans, D.J.1
  • 30
    • 0027938710 scopus 로고
    • Effect of the 5-lipoxygenase inhibitor ZD2138 on allergen-induced early and late responses
    • Nasser, S. M. S. et al. Effect of the 5-lipoxygenase inhibitor ZD2138 on allergen-induced early and late responses. Thorax 49, 743-748 (1994).
    • (1994) Thorax , vol.49 , pp. 743-748
    • Nasser, S.M.S.1
  • 31
    • 0034677595 scopus 로고    scopus 로고
    • 2 as a mediator of allergic asthma
    • 2 as a mediator of allergic asthma. Science 287, 2013-2017 (2000).
    • (2000) Science , vol.287 , pp. 2013-2017
    • Matsuoka, T.1
  • 32
    • 0035862329 scopus 로고    scopus 로고
    • 2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2
    • 2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. J. Exp. Med. 193, 255-261 (2001).
    • (2001) J. Exp. Med. , vol.193 , pp. 255-261
    • Hirai, H.1
  • 33
    • 0033537345 scopus 로고    scopus 로고
    • Endothelin antagonists
    • Benigni, A. & Remuzzi, G. Endothelin antagonists. Lancet 353, 133-138 (1999).
    • (1999) Lancet , vol.353 , pp. 133-138
    • Benigni, A.1    Remuzzi, G.2
  • 35
    • 0031857283 scopus 로고    scopus 로고
    • Increased formation of the potent oxidant peroxynitrite in the airways of asthmatic patients is associated with induction of nitric oxide synthase: Effect of inhaled glucocorticoid
    • Saleh, D., Ernst, P., Lim, S., Barnes, P. J. & Giaid, A. Increased formation of the potent oxidant peroxynitrite in the airways of asthmatic patients is associated with induction of nitric oxide synthase: effect of inhaled glucocorticoid. FASEB J. 12, 929-937 (1998).
    • (1998) FASEB J. , vol.12 , pp. 929-937
    • Saleh, D.1    Ernst, P.2    Lim, S.3    Barnes, P.J.4    Giaid, A.5
  • 36
    • 0034120179 scopus 로고    scopus 로고
    • Molecular mechanisms of increased nitric oxide (NO) in asthma: Evidence for transcriptional and post-translational regulation of NO synthesis
    • Guo, F. H. et al. Molecular mechanisms of increased nitric oxide (NO) in asthma: evidence for transcriptional and post-translational regulation of NO synthesis. J. Immunol. 164 5970-5980 (2000).
    • (2000) J. Immunol. , vol.164 , pp. 5970-5980
    • Guo, F.H.1
  • 37
    • 0038604348 scopus 로고    scopus 로고
    • A selective inhibitor of inducible nitric oxide synthase inhibits exhaled breath nitric oxide in healthy volunteers and asthmatics
    • Hansel, T. T. et al. A selective inhibitor of inducible nitric oxide synthase inhibits exhaled breath nitric oxide in healthy volunteers and asthmatics. FASEB J. 17, 1298-1300 (2003).
    • (2003) FASEB J. , vol.17 , pp. 1298-1300
    • Hansel, T.T.1
  • 38
    • 0035985601 scopus 로고    scopus 로고
    • Adenosine receptor ligands as potential therapeutics in asthma
    • Fozard, J. R. & McCarthy, C. Adenosine receptor ligands as potential therapeutics in asthma. Curr. Opin. Investig. Drugs 3 69-77 (2002).
    • (2002) Curr. Opin. Investig. Drugs , vol.3 , pp. 69-77
    • Fozard, J.R.1    McCarthy, C.2
  • 39
    • 0024419386 scopus 로고
    • Effect of theophylline and adenosine an eosinophil function
    • Yukawa, T. et al. Effect of theophylline and adenosine an eosinophil function. Am. Rev. Respir. Dis. 140, 327-333 (1989).
    • (1989) Am. Rev. Respir. Dis. , vol.140 , pp. 327-333
    • Yukawa, T.1
  • 42
    • 0033090898 scopus 로고    scopus 로고
    • ATP modulates anti-IgE-induced release of histamine from human lung mast cells
    • Schulman, E. S. et al. ATP modulates anti-IgE-induced release of histamine from human lung mast cells. Am. J. Respir Cell. Mol. Biol. 20, 530-537 (1999).
    • (1999) Am. J. Respir Cell. Mol. Biol. , vol.20 , pp. 530-537
    • Schulman, E.S.1
  • 43
    • 0030940777 scopus 로고    scopus 로고
    • Human mast cell tryptase: A stimulus of microvascular leakage and mast cell activation
    • He, S. & Walls, A. F. Human mast cell tryptase: a stimulus of microvascular leakage and mast cell activation. Eur. J. Pharmacol. 328, 89-97 (1997).
    • (1997) Eur. J. Pharmacol. , vol.328 , pp. 89-97
    • He, S.1    Walls, A.F.2
  • 44
    • 0035184146 scopus 로고    scopus 로고
    • Protease-activated receptors in human airways: Upregulation of PAR-2 in respiratory epithelium from patients with asthma
    • Knight, D. A. et al. Protease-activated receptors in human airways: upregulation of PAR-2 in respiratory epithelium from patients with asthma. J. Allergy Clin. Immunol. 108, 797-803 (2001).
    • (2001) J. Allergy Clin. Immunol. , vol.108 , pp. 797-803
    • Knight, D.A.1
  • 45
    • 0028820753 scopus 로고
    • Tryptase inhibitors block allergen-induced airway and inflammatory responses in allergic sheep
    • Clark, J. M. et al. Tryptase inhibitors block allergen-induced airway and inflammatory responses in allergic sheep. Am. J. Respir. Crit. Care Med. 152, 2076-2083 (1995).
    • (1995) Am. J. Respir. Crit. Care Med. , vol.152 , pp. 2076-2083
    • Clark, J.M.1
  • 46
    • 0035013541 scopus 로고    scopus 로고
    • Inhibition of mast cell tryptase by inhaled APC 366 attenuates allergen-induced late-phase airway obstruction in asthma
    • Krishna, M. T. et al. Inhibition of mast cell tryptase by inhaled APC 366 attenuates allergen-induced late-phase airway obstruction in asthma. J. Allergy Clin. Immunol. 107, 1039-1045 (2001).
    • (2001) J. Allergy Clin. Immunol. , vol.107 , pp. 1039-1045
    • Krishna, M.T.1
  • 47
    • 0141508030 scopus 로고    scopus 로고
    • Tryptase inhibitors - Review of the recent patent literature
    • Newhouse, B. J. Tryptase inhibitors - review of the recent patent literature. IDrugs. 5, 682-688 (2002).
    • (2002) IDrugs. , vol.5 , pp. 682-688
    • Newhouse, B.J.1
  • 48
    • 18644381739 scopus 로고    scopus 로고
    • Synthesis of potent and highly selective inhibitors of human tryptase
    • Slusarchyk, W. A. et al. Synthesis of potent and highly selective inhibitors of human tryptase. Bioorg. Med. Chem. Lett. 12, 3235-3238 (2002).
    • (2002) Bioorg. Med. Chem. Lett. , vol.12 , pp. 3235-3238
    • Slusarchyk, W.A.1
  • 49
    • 0031718925 scopus 로고    scopus 로고
    • Inhibitory cytokines in asthma
    • Barnes, P. J. & Lim, S. Inhibitory cytokines in asthma. Mol. Med. Today 4, 452-458 (1998).
    • (1998) Mol. Med. Today , vol.4 , pp. 452-458
    • Barnes, P.J.1    Lim, S.2
  • 50
    • 0034108146 scopus 로고    scopus 로고
    • Endogenous inhibitory mechanisms in asthma
    • Barnes, P. J. Endogenous inhibitory mechanisms in asthma. Am. J. Respir. Crit. Care Med. 161, S176-S181 (2000).
    • (2000) Am. J. Respir. Crit. Care Med. , vol.161
    • Barnes, P.J.1
  • 52
    • 6644229440 scopus 로고    scopus 로고
    • Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyperresponsiveness and the late asthmatic response
    • Leckie, M. J. et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyperresponsiveness and the late asthmatic response. Lancet 356, 2144-2148 (2000).
    • (2000) Lancet , vol.356 , pp. 2144-2148
    • Leckie, M.J.1
  • 53
    • 0038643527 scopus 로고    scopus 로고
    • Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: A pilot study
    • Kips, J. C. et al. Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: a pilot study. Am. J. Respir. Crit. Care Med. 167, 1655-1659 (2003 ).
    • (2003) Am. J. Respir. Crit. Care Med. , vol.167 , pp. 1655-1659
    • Kips, J.C.1
  • 54
    • 0037438409 scopus 로고    scopus 로고
    • Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airways
    • Flood-Page, P. T., Menzies-Gow, A. N., Kay, A. B. & Robinson, D. S. Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airways. Am. J. Respir. Crit. Care Med. (2003).
    • (2003) Am. J. Respir. Crit. Care Med.
    • Flood-Page, P.T.1    Menzies-Gow, A.N.2    Kay, A.B.3    Robinson, D.S.4
  • 55
    • 0036843836 scopus 로고    scopus 로고
    • Characterization of YM-90709 as a novel antagonist which inhibits the binding of interleukin-5 to interleukin-5 receptor
    • Morokata, T., Ida, K. & Yamada, T. Characterization of YM-90709 as a novel antagonist which inhibits the binding of interleukin-5 to interleukin-5 receptor. Int. Immunopharmacol. 2 1693-1702 (2002).
    • (2002) Int. Immunopharmacol. , vol.2 , pp. 1693-1702
    • Morokata, T.1    Ida, K.2    Yamada, T.3
  • 56
    • 0035719975 scopus 로고    scopus 로고
    • Interleukins-4: Its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists
    • Steinke, J. W. & Borish, L. Interleukins-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists. Respir. Res. 2, 66-70 (2001).
    • (2001) Respir. Res. , vol.2 , pp. 66-70
    • Steinke, J.W.1    Borish, L.2
  • 57
    • 0031004365 scopus 로고    scopus 로고
    • Interleukin-4 receptor blockade prevents airway responses induced by antigen challenge in mice
    • Gavett, S. H. et al. Interleukin-4 receptor blockade prevents airway responses induced by antigen challenge in mice. Am. J. Physiol. 272, L253-61 (1997).
    • (1997) Am. J. Physiol. , vol.272
    • Gavett, S.H.1
  • 58
    • 0033454115 scopus 로고    scopus 로고
    • Interleukin-4 receptor in moderate atopic asthma. A phase I/II randomized, placebo-controlled trial
    • Borish, L. C. et al. Interleukin-4 receptor in moderate atopic asthma. A phase I/II randomized, placebo-controlled trial. Am. J. Respir. Crit. Care Med. 160, 1816-1823 (1999).
    • (1999) Am. J. Respir. Crit. Care Med. , vol.160 , pp. 1816-1823
    • Borish, L.C.1
  • 59
    • 0034995872 scopus 로고    scopus 로고
    • Efficacy of soluble IL-4 receptor for the treatment of adults with asthma
    • Borish, L. C. et al. Efficacy of soluble IL-4 receptor for the treatment of adults with asthma. J. Allergy Clin. Immunol. 107, 963-970 (2001).
    • (2001) J. Allergy Clin. Immunol. , vol.107 , pp. 963-970
    • Borish, L.C.1
  • 60
    • 0037231664 scopus 로고    scopus 로고
    • Cytokine traps: Multi-component, high-affinity blockers of cytokine action
    • Economides, A. N. et al. Cytokine traps: multi-component, high-affinity blockers of cytokine action. Nature Med. 9, 47-52 (2003).
    • (2003) Nature Med. , vol.9 , pp. 47-52
    • Economides, A.N.1
  • 61
    • 0032482979 scopus 로고    scopus 로고
    • An immune cell-selective interleukin 4 agonist
    • Shanafelt, A. B. et al. An immune cell-selective interleukin 4 agonist. Proc. Natl Acad. Sci. USA 95, 9454-9458 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 9454-9458
    • Shanafelt, A.B.1
  • 63
    • 0032955328 scopus 로고    scopus 로고
    • STAT6: An intracellular target for the inhibition of allergic disease
    • Foster, P. S. STAT6: an intracellular target for the inhibition of allergic disease. Clin. Exp. Allergy 29, 12-16 (1999).
    • (1999) Clin. Exp. Allergy , vol.29 , pp. 12-16
    • Foster, P.S.1
  • 65
    • 0035888013 scopus 로고    scopus 로고
    • Critical role for IL-13 in the development of allergen-induced airway hyperreactivity
    • Walter, D. M. et al. Critical role for IL-13 in the development of allergen-induced airway hyperreactivity. J. Immunol. 167, 4668-4675 (2001).
    • (2001) J. Immunol. , vol.167 , pp. 4668-4675
    • Walter, D.M.1
  • 66
    • 0036344597 scopus 로고    scopus 로고
    • Direct effects of interleukin- 13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma
    • Kuperman, D. A. et al. Direct effects of interleukin- 13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nature Med. 8, 885-889 (2002).
    • (2002) Nature Med. , vol.8 , pp. 885-889
    • Kuperman, D.A.1
  • 67
    • 0032545213 scopus 로고    scopus 로고
    • Interleukin-13: Central mediator of allergic asthma
    • Wills-Karp, M. et al. Interleukin-13: central mediator of allergic asthma. Science 282, 2258-2261 (1998).
    • (1998) Science , vol.282 , pp. 2258-2261
    • Wills-Karp, M.1
  • 68
    • 0033024432 scopus 로고    scopus 로고
    • IL-9 pathway in asthma: New therapeutic targets for allergic inflammatory disorders
    • Levitt, R. C. et al. IL-9 pathway in asthma: new therapeutic targets for allergic inflammatory disorders. J. Allergy Clin. Immunol. 103, S485-S491 (1999).
    • (1999) J. Allergy Clin. Immunol. , vol.103
    • Levitt, R.C.1
  • 69
    • 0032700856 scopus 로고    scopus 로고
    • Allergen-induced IL-9 directly stimulates mucin transcription in respiratory epithelial cells
    • Longphre, M. et al. Allergen-induced IL-9 directly stimulates mucin transcription in respiratory epithelial cells. J. Clin. Invest. 104, 1375-1382 (1999).
    • (1999) J. Clin. Invest. , vol.104 , pp. 1375-1382
    • Longphre, M.1
  • 70
    • 4444262198 scopus 로고    scopus 로고
    • IL-9 and its receptor in allergic and nonallergic lung disease: Increased expression in asthma
    • Shimbara, A. et al. IL-9 and its receptor in allergic and nonallergic lung disease: increased expression in asthma. J. Allergy Clin. Immunol. 105, 108-115 (2000).
    • (2000) J. Allergy Clin. Immunol. , vol.105 , pp. 108-115
    • Shimbara, A.1
  • 71
    • 0036683621 scopus 로고    scopus 로고
    • Anti-interleukin-9 antibody treatment inhibits airway inflammation and hyperreactivity in mouse asthma model
    • Cheng, G. et al. Anti-interleukin-9 antibody treatment inhibits airway inflammation and hyperreactivity in mouse asthma model. Am. J. Respir. Crit. Care Med. 166, 409-416 (2002).
    • (2002) Am. J. Respir. Crit. Care Med. , vol.166 , pp. 409-416
    • Cheng, G.1
  • 72
    • 0035719955 scopus 로고    scopus 로고
    • Interleukin-9 as a therapeutic target for asthma
    • Zhou, Y., McLane, M. & Levitt, R. C. Interleukin-9 as a therapeutic target for asthma. Respir. Res. 2, 80-84 (2001 ).
    • (2001) Respir. Res. , vol.2 , pp. 80-84
    • Zhou, Y.1    McLane, M.2    Levitt, R.C.3
  • 73
    • 0029966181 scopus 로고    scopus 로고
    • Expression of interleukin-1β (IL-1β) and interleukin-1 receptor antagonist (IL-1ra) on asthmatic bronchial epithelium
    • Sousa, A. R., Lane, S. J., Nakhosteen, J. A., Lee, T. H. & Poston, R. N. Expression of interleukin-1β (IL-1β) and interleukin-1 receptor antagonist (IL-1ra) on asthmatic bronchial epithelium. Am. J. Respir. Crit. Care Med. 154, 1061-1066 (1996).
    • (1996) Am. J. Respir. Crit. Care Med. , vol.154 , pp. 1061-1066
    • Sousa, A.R.1    Lane, S.J.2    Nakhosteen, J.A.3    Lee, T.H.4    Poston, R.N.5
  • 75
    • 0031691352 scopus 로고    scopus 로고
    • Biologic activities of IL-1 and its role in human disease
    • Rosenwasser, L. J. Biologic activities of IL-1 and its role in human disease. J. Allergy Clin. Immunol. 102, 344-350 (1998).
    • (1998) J. Allergy Clin. Immunol. , vol.102 , pp. 344-350
    • Rosenwasser, L.J.1
  • 78
    • 0035935706 scopus 로고    scopus 로고
    • Design of selective and soluble inhibitors of tumor necrosis factor-α converting enzyme (TACE)
    • Rabinowitz, M. H. et al. Design of selective and soluble inhibitors of tumor necrosis factor-α converting enzyme (TACE). J. Med. Chem. 44, 4252-4267 (2001).
    • (2001) J. Med. Chem. , vol.44 , pp. 4252-4267
    • Rabinowitz, M.H.1
  • 79
    • 0034839865 scopus 로고    scopus 로고
    • IL-10: A key regulator of allergic disease
    • Barnes, P. J. IL-10: a key regulator of allergic disease. Clin. Exp. Allergy 31, 667-669 (2001).
    • (2001) Clin. Exp. Allergy , vol.31 , pp. 667-669
    • Barnes, P.J.1
  • 80
    • 0029984767 scopus 로고    scopus 로고
    • Interleukin-10 regulation in normal subjects and patients with asthma
    • Borish, L. et al. Interleukin-10 regulation in normal subjects and patients with asthma. J. Allergy Clin. Immunol. 97 1288-1296 (1996).
    • (1996) J. Allergy Clin. Immunol. , vol.97 , pp. 1288-1296
    • Borish, L.1
  • 81
    • 0031943945 scopus 로고    scopus 로고
    • Inhaled corticosteroids increase IL-10 but reduce MIP-1α, GM-CSF and IFN-γ release from alveolar macrophages in asthma
    • John, M. et al. Inhaled corticosteroids increase IL-10 but reduce MIP-1α, GM-CSF and IFN-γ release from alveolar macrophages in asthma. Am. J. Respir. Crit. Care Med. 157, 256-262 (1998).
    • (1998) Am. J. Respir. Crit. Care Med. , vol.157 , pp. 256-262
    • John, M.1
  • 82
    • 0029075489 scopus 로고
    • Interleukin-10 inhibits antigen-induced cellular recruitment into the airways of sensitized mice
    • Zuany-Amorim, C. et al. Interleukin-10 inhibits antigen-induced cellular recruitment into the airways of sensitized mice. J. Clin. Invest. 95, 2644-2651 (1995).
    • (1995) J. Clin. Invest. , vol.95 , pp. 2644-2651
    • Zuany-Amorim, C.1
  • 83
    • 0036736840 scopus 로고    scopus 로고
    • CD4 T-helper cells engineered to produce IL-10 prevent allergen-induced airway hyperreactivity and inflammation
    • Oh, J. W. et al. CD4 T-helper cells engineered to produce IL-10 prevent allergen-induced airway hyperreactivity and inflammation. J. Allergy Clin. Immunol. 110, 460-468 (2002 ).
    • (2002) J. Allergy Clin. Immunol. , vol.110 , pp. 460-468
    • Oh, J.W.1
  • 84
    • 0038363534 scopus 로고    scopus 로고
    • IL-10 and TGF-β cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy
    • Jutel, M. et al. IL-10 and TGF-β cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy. Eur. J. Immunol. 33, 1205-1214 (2003).
    • (2003) Eur. J. Immunol. , vol.33 , pp. 1205-1214
    • Jutel, M.1
  • 85
    • 0034463305 scopus 로고    scopus 로고
    • Recombinant human interleukin 10 in the treatment of patients with mild to moderately active Crohn's disease
    • Fedorak, R. N. et al. Recombinant human interleukin 10 in the treatment of patients with mild to moderately active Crohn's disease. Gastroenterology 119, 1473-1482 (2000).
    • (2000) Gastroenterology , vol.119 , pp. 1473-1482
    • Fedorak, R.N.1
  • 86
    • 0034846480 scopus 로고    scopus 로고
    • Suppression of granulocyte/macrophage colony-stimulating factor release from human monocytes by cyclic AMP-elevating drugs: Role of interleukin-10
    • Seldon, P. M. & Giembycz, M. A. Suppression of granulocyte/macrophage colony-stimulating factor release from human monocytes by cyclic AMP-elevating drugs: role of interleukin-10. Br. J. Pharmacol. 134, 58-67 (2001).
    • (2001) Br. J. Pharmacol. , vol.134 , pp. 58-67
    • Seldon, P.M.1    Giembycz, M.A.2
  • 87
    • 0030586669 scopus 로고    scopus 로고
    • Nebulized IFN-γ inhibits the development of secondary allergic responses in mice
    • Lack, G. et al. Nebulized IFN-γ inhibits the development of secondary allergic responses in mice. J. Immunol. 157, 1432-1439 (1996).
    • (1996) J. Immunol. , vol.157 , pp. 1432-1439
    • Lack, G.1
  • 89
    • 0033016327 scopus 로고    scopus 로고
    • The kinetics of change in cytokine production by CD4 T cells during conventional allergen immunotherapy
    • Benjaponpitak, S. et al. The kinetics of change in cytokine production by CD4 T cells during conventional allergen immunotherapy. J. Allergy Clin. Immunol. 103, 468-475 (1999).
    • (1999) J. Allergy Clin. Immunol. , vol.103 , pp. 468-475
    • Benjaponpitak, S.1
  • 90
    • 0030003889 scopus 로고    scopus 로고
    • Grass pollen immunotherapy inhibits allergen-induced infiltration of CD4+ T lymphocytes and eosinophils in the nasal mucosa and increases the number of cells expressing messenger RNA for interferon-γ
    • Durham, S. R. et al. Grass pollen immunotherapy inhibits allergen-induced infiltration of CD4+ T lymphocytes and eosinophils in the nasal mucosa and increases the number of cells expressing messenger RNA for interferon-γ. J. Allergy Clin. Immunol. 97, 1356-1365 (1996).
    • (1996) J. Allergy Clin. Immunol. , vol.97 , pp. 1356-1365
    • Durham, S.R.1
  • 91
    • 0344393717 scopus 로고    scopus 로고
    • Clinical and immunological effects of low-dose IFN-γ treatment in patients with corticosteroid-resistant asthma
    • Simon, H. U., Seelbach, H., Ehmann, R. & Schmitz, M. Clinical and immunological effects of low-dose IFN-γ treatment in patients with corticosteroid-resistant asthma. Allergy 58, 1250-1255 (2003).
    • (2003) Allergy , vol.58 , pp. 1250-1255
    • Simon, H.U.1    Seelbach, H.2    Ehmann, R.3    Schmitz, M.4
  • 92
    • 0034268386 scopus 로고    scopus 로고
    • Interleukin-18, a proinflammatory cytokine
    • Dinarello, C. A. Interleukin-18, a proinflammatory cytokine. Eur. Cytokine Netw. 11, 483-486 (2000).
    • (2000) Eur. Cytokine Netw. , vol.11 , pp. 483-486
    • Dinarello, C.A.1
  • 93
    • 0345358584 scopus 로고    scopus 로고
    • The IL-12 family of heterodimeric cytokines: New players in the regulation of T cell responses
    • Trinchieri, G., Pflanz, S. & Kastelein, R. A. The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses. Immunity 19, 641-644 (2003).
    • (2003) Immunity , vol.19 , pp. 641-644
    • Trinchieri, G.1    Pflanz, S.2    Kastelein, R.A.3
  • 94
    • 6644223789 scopus 로고    scopus 로고
    • Effects of recombinant human interleukin-12 on eosinophils, airway hyperreactivity and the late asthmatic response
    • Bryan, S. et al. Effects of recombinant human interleukin-12 on eosinophils, airway hyperreactivity and the late asthmatic response. Lancet 356, 2149-2153 (2000).
    • (2000) Lancet , vol.356 , pp. 2149-2153
    • Bryan, S.1
  • 95
    • 0031134912 scopus 로고    scopus 로고
    • An ovalbumin-IL- 12 fusion protein is more effective than ovalbumin plus free recombinant IL-12 in inducing a T helper cell type 1-dominated immune response and inhibiting antigen-specific IgE production
    • Kim, T S. et al. An ovalbumin-IL- 12 fusion protein is more effective than ovalbumin plus free recombinant IL-12 in inducing a T helper cell type 1-dominated immune response and inhibiting antigen-specific IgE production. J. Immunol. 158, 4137-4144 (1997).
    • (1997) J. Immunol. , vol.158 , pp. 4137-4144
    • Kim, T.S.1
  • 96
    • 0034080318 scopus 로고    scopus 로고
    • The biology of chemokines and their receptors
    • Rossi, D. & Zlotnik, A. The biology of chemokines and their receptors. Annu. Rev. Immunol. 18, 217-242 (2000).
    • (2000) Annu. Rev. Immunol. , vol.18 , pp. 217-242
    • Rossi, D.1    Zlotnik, A.2
  • 97
    • 0036485214 scopus 로고    scopus 로고
    • Chemokine receptors: Multifaceted therapeutic targets
    • Proudfoot, A. E. Chemokine receptors: multifaceted therapeutic targets. Nature Rev. Immunol. 2, 106-115 (2002 ).
    • (2002) Nature Rev. Immunol. , vol.2 , pp. 106-115
    • Proudfoot, A.E.1
  • 98
    • 0032704977 scopus 로고    scopus 로고
    • Eotaxin: From an eosinophilic chemokine to a major regulator of allergic reactions
    • Gutierrez-Ramos, J. C., Lloyd, C. & Gonzalo, J. A. Eotaxin: from an eosinophilic chemokine to a major regulator of allergic reactions. Immunol. Today 20, 500-504 (1999).
    • (1999) Immunol. Today , vol.20 , pp. 500-504
    • Gutierrez-Ramos, J.C.1    Lloyd, C.2    Gonzalo, J.A.3
  • 99
    • 0033485409 scopus 로고    scopus 로고
    • Eosinophil chemotactic chemokines (eotaxin, eotaxin-2, RANTES, monocyte chemoattractant protein-3 (MCP-3), and MCP-4), and C-C chemokine receptor 3 expression in bronchial biopsies from atopic and nonatopic (Intrinsic) asthmatics
    • Ying, S. et al. Eosinophil chemotactic chemokines (eotaxin, eotaxin-2, RANTES, monocyte chemoattractant protein-3 (MCP-3), and MCP-4), and C-C chemokine receptor 3 expression in bronchial biopsies from atopic and nonatopic (Intrinsic) asthmatics. J. Immunol. 163, 6321-6329 (1999).
    • (1999) J. Immunol. , vol.163 , pp. 6321-6329
    • Ying, S.1
  • 100
    • 0029826642 scopus 로고    scopus 로고
    • Eosinophil recruitment to the lung in a murine model of allergic inflammation. The role of T cells, chemokines, and adhesion receptors
    • Gonzalo, J. A. et al. Eosinophil recruitment to the lung in a murine model of allergic inflammation. The role of T cells, chemokines, and adhesion receptors. J. Clin. Invest. 98, 2332-2345(1996).
    • (1996) J. Clin. Invest. , vol.98 , pp. 2332-2345
    • Gonzalo, J.A.1
  • 102
    • 0033566926 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein-1 mediates cockroach allergen-induced bronchial hyperreactivity in normal but not CCR2-/- mice: The role of mast cells
    • Campbell, E. M. et al. Monocyte chemoattractant protein-1 mediates cockroach allergen-induced bronchial hyperreactivity in normal but not CCR2-/- mice: the role of mast cells. J. Immunol. 163, 2160-2167 (1999).
    • (1999) J. Immunol. , vol.163 , pp. 2160-2167
    • Campbell, E.M.1
  • 103
    • 0034677038 scopus 로고    scopus 로고
    • CC chemokine receptor (CCR)3/eotaxin is followed by CCR4/monocyte-derived chemokine in mediating pulmonary T helper lymphocyte type 2 recruitment after serial antigen challenge in vivo
    • Lloyd, C. M. et al. CC chemokine receptor (CCR)3/eotaxin is followed by CCR4/monocyte-derived chemokine in mediating pulmonary T helper lymphocyte type 2 recruitment after serial antigen challenge in vivo. J. Exp. Med. 191, 265-274 (2000 ).
    • (2000) J. Exp. Med. , vol.191 , pp. 265-274
    • Lloyd, C.M.1
  • 104
    • 0037222228 scopus 로고    scopus 로고
    • CCR8 is not essential for the development of inflammation in a mouse model of allergic airway disease
    • Chung, C. D. et al. CCR8 is not essential for the development of inflammation in a mouse model of allergic airway disease. J. Immunol. 170, 581-587 (2003).
    • (2003) J. Immunol. , vol.170 , pp. 581-587
    • Chung, C.D.1
  • 105
    • 0036116174 scopus 로고    scopus 로고
    • AMD3100, a CxCR4 antagonist, attenuates allergic lung inflammation and airway hyperreactivity
    • Lukacs, N. W., Berlin, A., Schols, D., Skerlj, R. T. & Bridger, G. J. AMD3100, a CxCR4 antagonist, attenuates allergic lung inflammation and airway hyperreactivity. Am. J. Pathol. 160, 1353-1360 (2002).
    • (2002) Am. J. Pathol. , vol.160 , pp. 1353-1360
    • Lukacs, N.W.1    Berlin, A.2    Schols, D.3    Skerlj, R.T.4    Bridger, G.J.5
  • 106
    • 0035188826 scopus 로고    scopus 로고
    • Cyclic nucleotide phosphodiesterases
    • Essayan, D. M. Cyclic nucleotide phosphodiesterases, J. Allergy Clin. Immunol. 108, 671-680 (2001).
    • (2001) J. Allergy Clin. Immunol. , vol.108 , pp. 671-680
    • Essayan, D.M.1
  • 108
    • 0037443097 scopus 로고    scopus 로고
    • PDE4 cAMP phosphodiesterases: Modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization
    • Houslay, M. D. & Adams, D. R. PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization. Biochem. J. 370, 1-18 (2003).
    • (2003) Biochem. J. , vol.370 , pp. 1-18
    • Houslay, M.D.1    Adams, D.R.2
  • 109
    • 0034792886 scopus 로고    scopus 로고
    • Cilomilast: A breath of relief?
    • Giembycz, M. A. Cilomilast: a breath of relief? Trends Mol. Med. 7, 433-434 (2001).
    • (2001) Trends Mol. Med. , vol.7 , pp. 433-434
    • Giembycz, M.A.1
  • 110
    • 0030984905 scopus 로고    scopus 로고
    • The effect of a novel orally active selective PDE4 isoenzyme inhibitor (CD840) on allergen-induced responses in asthmatic subjects
    • Harbison, P. L. et al. The effect of a novel orally active selective PDE4 isoenzyme inhibitor (CD840) on allergen-induced responses in asthmatic subjects. Eur. Respir. J. 10, 1008-1014 (1997).
    • (1997) Eur. Respir. J. , vol.10 , pp. 1008-1014
    • Harbison, P.L.1
  • 112
    • 0035963952 scopus 로고    scopus 로고
    • Cilomilast, a selective phosphodiesterase-4 inhibitor for treatment of patients with chronic obstructive pulmonary disease: A randomised, dose-ranging study
    • Compton, C. H. et al. Cilomilast, a selective phosphodiesterase-4 inhibitor for treatment of patients with chronic obstructive pulmonary disease: a randomised, dose-ranging study. Lancet 358, 265-270 (2001).
    • (2001) Lancet , vol.358 , pp. 265-270
    • Compton, C.H.1
  • 113
    • 0035976546 scopus 로고    scopus 로고
    • Localization of phosphodiesterase-4 isoforms in the medulla and nodose ganglion of the squirrel monkey
    • Lamontagne, S. et al. Localization of phosphodiesterase-4 isoforms in the medulla and nodose ganglion of the squirrel monkey. Brain Res. 920, 84-96 (2001).
    • (2001) Brain Res. , vol.920 , pp. 84-96
    • Lamontagne, S.1
  • 114
    • 0037188511 scopus 로고    scopus 로고
    • Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-α responses
    • Jin, S. L. & Conti, M. Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-α responses. Proc. Natl Acad. Sci. USA 99, 7628-7633 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 7628-7633
    • Jin, S.L.1    Conti, M.2
  • 115
    • 0141630489 scopus 로고    scopus 로고
    • In vivo efficacy in airway disease models of N-(3, 5-dichloropyrid-4-yl)-[1-(4-fluorobenzyl)-5-hydroxy-indole-3-yl]-glyo xylic acid amide (AWD 12-281), a selective phosphodiesterase 4 inhibitor for inhaled administration
    • Kuss, H., Hoefgen, N., Johanssen, S., Kronbach, T. & Rundfeldt, C. In vivo efficacy in airway disease models of N-(3, 5-dichloropyrid-4-yl)-[1-(4-fluorobenzyl)-5-hydroxy-indole-3-yl]-glyo xylic acid amide (AWD 12-281), a selective phosphodiesterase 4 inhibitor for inhaled administration. J. Pharmacol. Exp. Ther. 307, 373-385 (2003).
    • (2003) J. Pharmacol. Exp. Ther. , vol.307 , pp. 373-385
    • Kuss, H.1    Hoefgen, N.2    Johanssen, S.3    Kronbach, T.4    Rundfeldt, C.5
  • 116
    • 0034720896 scopus 로고    scopus 로고
    • Kinase regulation in inflammatory response
    • Delhase, M., Li, N. & Karin, M. Kinase regulation in inflammatory response. Nature 406, 367-368 (2000).
    • (2000) Nature , vol.406 , pp. 367-368
    • Delhase, M.1    Li, N.2    Karin, M.3
  • 117
    • 0036605858 scopus 로고    scopus 로고
    • Small-molecule inhibitors of NF-κB for the treatment of inflammatory joint disease
    • Roshak, A. K., Callahan, J. F. & Blake, S. M. Small-molecule inhibitors of NF-κB for the treatment of inflammatory joint disease. Curr. Opin. Pharmacol. 2, 316-321 (2002).
    • (2002) Curr. Opin. Pharmacol. , vol.2 , pp. 316-321
    • Roshak, A.K.1    Callahan, J.F.2    Blake, S.M.3
  • 118
    • 0033538340 scopus 로고    scopus 로고
    • Differential IKK activation and IκBα degradation by interleukin-1β and tumor necrosis factor-α in human U937 monocytic cells: Evidence for additional regulatory steps in κ B-dependent transcription
    • Nasuhara, Y., Adcock, I. M., Catley, M., Barnes, P. J. & Newton, R. Differential IKK activation and IκBα degradation by interleukin-1β and tumor necrosis factor-α in human U937 monocytic cells: evidence for additional regulatory steps in κ B-dependent transcription. J. Biol. Chem. 274, 19965-19972 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 19965-19972
    • Nasuhara, Y.1    Adcock, I.M.2    Catley, M.3    Barnes, P.J.4    Newton, R.5
  • 119
    • 0037501014 scopus 로고    scopus 로고
    • Cyclosporin as an oral corticosteroid sparing agent in stable asthma
    • (Cochrane Review)
    • Evans, D. J., Cullinan, P. & Geddes, D. M. Cyclosporin as an oral corticosteroid sparing agent in stable asthma (Cochrane Review). Cochrane. Database. Syst. Rev. 2, CD002993 (2001).
    • (2001) Cochrane Database Syst. Rev. , vol.2
    • Evans, D.J.1    Cullinan, P.2    Geddes, D.M.3
  • 120
    • 0038299000 scopus 로고    scopus 로고
    • Sirolimus: Its discovery, biological properties, and mechanism of action
    • Sehgal, S. N. Sirolimus: its discovery, biological properties, and mechanism of action. Transplant. Proc. 35, 7S-14S (2003).
    • (2003) Transplant. Proc. , vol.35
    • Sehgal, S.N.1
  • 121
    • 0041374389 scopus 로고    scopus 로고
    • The function role of GATA-3 in Th1 and Th2 differentiation
    • Zhou, M. & Ouyang, W. The function role of GATA-3 in Th1 and Th2 differentiation. Immunol. Res. 28, 25-37 (2003).
    • (2003) Immunol. Res. , vol.28 , pp. 25-37
    • Zhou, M.1    Ouyang, W.2
  • 122
    • 0037059509 scopus 로고    scopus 로고
    • Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet
    • Finotto, S. et al. Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science 295, 336-338 (2002).
    • (2002) Science , vol.295 , pp. 336-338
    • Finotto, S.1
  • 123
    • 0142026209 scopus 로고    scopus 로고
    • p38 MAP kinases: Key signalling molecules as therapeutic targets for inflammatory diseases
    • Kumar, S., Boehm, J. & Lee, J. C. p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases. Nature Rev. Drug Discov. 2, 717-726 (2003).
    • (2003) Nature Rev. Drug Discov. , vol.2 , pp. 717-726
    • Kumar, S.1    Boehm, J.2    Lee, J.C.3
  • 125
    • 0032763790 scopus 로고    scopus 로고
    • SB203580, an inhibitor of p38 mitogen-activated protein kinase, enhances constitutive apoptosis of cytokine-deprived human eosinophils
    • Kankaanranta, H., Giembycz, M. A., Barnes, P. J. & Lindsay, D. A. SB203580, an inhibitor of p38 mitogen-activated protein kinase, enhances constitutive apoptosis of cytokine-deprived human eosinophils. J. Pharmacol. Exp. Ther. 290, 621-628 (1999).
    • (1999) J. Pharmacol. Exp. Ther. , vol.290 , pp. 621-628
    • Kankaanranta, H.1    Giembycz, M.A.2    Barnes, P.J.3    Lindsay, D.A.4
  • 126
    • 0036231010 scopus 로고    scopus 로고
    • p38 Mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: Role in steroid-insensitive asthma
    • Irusen, E. et al. p38 Mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: Role in steroid-insensitive asthma. J. Allergy Clin. Immunol. 109, 649-657 (2002).
    • (2002) J. Allergy Clin. Immunol. , vol.109 , pp. 649-657
    • Irusen, E.1
  • 127
    • 0035163864 scopus 로고    scopus 로고
    • A novel transcription factor inhibitor, SP100030, inhibits cytokine gene expression, but not airway eosinophilia or hyperresponsiveness in sensitized and allergen-exposed rat
    • Huang, T. J., Adcock, I. M. & Chung, K. F. A novel transcription factor inhibitor, SP100030, inhibits cytokine gene expression, but not airway eosinophilia or hyperresponsiveness in sensitized and allergen-exposed rat. Br. J. Pharmacol. 134, 1029-1036 (2001).
    • (2001) Br. J. Pharmacol. , vol.134 , pp. 1029-1036
    • Huang, T.J.1    Adcock, I.M.2    Chung, K.F.3
  • 128
    • 0032843944 scopus 로고    scopus 로고
    • In vivo resistance to corticosteroids in bronchial asthma is associated with enhanced phosylphorylation of JUN N-terminal kinase and failure of prednisolone to inhibit JUN N-terminal kinase phosphorylation
    • Sousa, A. R., Lane, S. J., Soh, C. & Lee, T H. In vivo resistance to corticosteroids in bronchial asthma is associated with enhanced phosylphorylation of JUN N-terminal kinase and failure of prednisolone to inhibit JUN N-terminal kinase phosphorylation. J. Allergy Clin. Immunol. 104, 565-574 (1999).
    • (1999) J. Allergy Clin. Immunol. , vol.104 , pp. 565-574
    • Sousa, A.R.1    Lane, S.J.2    Soh, C.3    Lee, T.H.4
  • 129
    • 0030472724 scopus 로고    scopus 로고
    • Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells
    • Costello, P. S. et al. Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells. Oncogene 13, 2595-2605 (1996).
    • (1996) Oncogene , vol.13 , pp. 2595-2605
    • Costello, P.S.1
  • 130
    • 0029913802 scopus 로고    scopus 로고
    • Requirement of Lyn and Syk tyrosine kinases for the prevention of apoptosis by cytokines in human eosinophils
    • Yousefi, S., Hoessli, D. C., Blaser, K., Mills, G. B. & Simon, H. U. Requirement of Lyn and Syk tyrosine kinases for the prevention of apoptosis by cytokines in human eosinophils. J. Exp. Med. 183, 1407-1414 (1996).
    • (1996) J. Exp. Med. , vol.183 , pp. 1407-1414
    • Yousefi, S.1    Hoessli, D.C.2    Blaser, K.3    Mills, G.B.4    Simon, H.U.5
  • 131
    • 0037100457 scopus 로고    scopus 로고
    • Inhibition of allergic inflammation in the airways using aerosolized antisense to Syk kinase
    • Stenton, G. R. et al. Inhibition of allergic inflammation in the airways using aerosolized antisense to Syk kinase. J. Immunol. 169, 1028-1036 (2002).
    • (2002) J. Immunol. , vol.169 , pp. 1028-1036
    • Stenton, G.R.1
  • 132
    • 1842414894 scopus 로고    scopus 로고
    • Src family-selective tyrosine kinase inhibitor, PP1, inhibits both Fc epsilonRI- and Thy-1-mediated activation of rat basophilic leukemia cells
    • Amoui, M., Draber, P. & Draberova, L. Src family-selective tyrosine kinase inhibitor, PP1, inhibits both Fc epsilonRI- and Thy-1-mediated activation of rat basophilic leukemia cells. Eur. J. Immunol. 27, 1881-1886 (1997).
    • (1997) Eur. J. Immunol. , vol.27 , pp. 1881-1886
    • Amoui, M.1    Draber, P.2    Draberova, L.3
  • 134
    • 0033565287 scopus 로고    scopus 로고
    • A novel Lyn-binding peptide inhibitor blocks eosinophil differentiation, survival, and airway eosinophilic inflammation
    • Adachi, T., Stafford, S., Sur, S. & Alam, R. A novel Lyn-binding peptide inhibitor blocks eosinophil differentiation, survival, and airway eosinophilic inflammation. J. Immunol. 163 939-946 (1999).
    • (1999) J. Immunol. , vol.163 , pp. 939-946
    • Adachi, T.1    Stafford, S.2    Sur, S.3    Alam, R.4
  • 135
    • 0031928167 scopus 로고    scopus 로고
    • The role of adhesion molecules in allergic inflammation and their suitability as targets of antiallergic therapy
    • Schleimer, R. P. & Bochner, B. S. The role of adhesion molecules in allergic inflammation and their suitability as targets of antiallergic therapy. Clin. Exp. Allergy 28 Suppl. 3), 15-23 (1998).
    • (1998) Clin. Exp. Allergy , vol.28 , Issue.SUPPL. 3 , pp. 15-23
    • Schleimer, R.P.1    Bochner, B.S.2
  • 136
    • 0025020024 scopus 로고
    • Intracellular adhesion molecule-1 (ICAM-1) in the pathogenesis of asthma
    • Wegner, C. D. et al. Intracellular adhesion molecule-1 (ICAM-1) in the pathogenesis of asthma. Science 247, 456-459 (1990).
    • (1990) Science , vol.247 , pp. 456-459
    • Wegner, C.D.1
  • 137
    • 0028231944 scopus 로고
    • Contribution of intracellular adhesion molecule-1 in allergen-induced airway hyperresponsiveness and inflammation in sensitised Brown-Norway rats
    • Sun, J. et al. Contribution of intracellular adhesion molecule-1 in allergen-induced airway hyperresponsiveness and inflammation in sensitised Brown-Norway rats. Int Arch Allergy Immunol 104, 291-295 (1994).
    • (1994) Int. Arch. Allergy Immunol. , vol.104 , pp. 291-295
    • Sun, J.1
  • 138
    • 0032836272 scopus 로고    scopus 로고
    • Regulatory mechanisms of eosinophil adhesion to and transmigration across endothelial cells by α4 and β2 integrins
    • Yamamoto, H. & Nagata, M. Regulatory mechanisms of eosinophil adhesion to and transmigration across endothelial cells by α4 and β2 integrins. Int. Arch. Allergy Immunol. 120 (Suppl. 1), 24-26 (1999).
    • (1999) Int. Arch. Allergy Immunol. , vol.120 , Issue.SUPPL. 1 , pp. 24-26
    • Yamamoto, H.1    Nagata, M.2
  • 139
    • 0033545639 scopus 로고    scopus 로고
    • Selective, tight-binding inhibitors of integrin α4β1 that inhibit allergic airway responses
    • Lin Kc et al. Selective, tight-binding inhibitors of integrin α4β1 that inhibit allergic airway responses. J. Med. Chem. 42, 920-934 (1999).
    • (1999) J. Med. Chem. , vol.42 , pp. 920-934
    • Lin, Kc.1
  • 140
    • 0037413468 scopus 로고    scopus 로고
    • Natalizumab for active Crohn's disease
    • Ghosh, S, et al. Natalizumab for active Crohn's disease. N. Engl. J. Med. 348, 24-32 (2003).
    • (2003) N. Engl. J. Med. , vol.348 , pp. 24-32
    • Ghosh, S.1
  • 141
    • 0032905458 scopus 로고    scopus 로고
    • Selectin blockade prevents antigen-induced late bronchial responses and airway hyperresponsiveness in allergic sheep
    • Abraham, W. M. et al. Selectin blockade prevents antigen-induced late bronchial responses and airway hyperresponsiveness in allergic sheep. Am. J. Respir. Crit. Care Med. 159, 1205-1214 (1999).
    • (1999) Am. J. Respir. Crit. Care Med. , vol.159 , pp. 1205-1214
    • Abraham, W.M.1
  • 142
    • 0032209703 scopus 로고    scopus 로고
    • Antagonism of selectin-dependent adhesion of human eosinophils and neutrophils by glycomimetics and oligosaccharide compounds
    • Kim, M. K., Brandley, B. K., Anderson, M. B. & Bochner, B. S. Antagonism of selectin-dependent adhesion of human eosinophils and neutrophils by glycomimetics and oligosaccharide compounds. Am. J. Respir. Cell Mol. Biol. 19, 836-841 (1998).
    • (1998) Am. J. Respir. Cell Mol. Biol. , vol.19 , pp. 836-841
    • Kim, M.K.1    Brandley, B.K.2    Anderson, M.B.3    Bochner, B.S.4
  • 143
    • 0029124794 scopus 로고
    • Inhibition of volume-activated chloride currents in endothelial cells by chromones
    • Heinke, S., Szucs, G., Norris, A., Droogmans, G. & Nilius, B. Inhibition of volume-activated chloride currents in endothelial cells by chromones. Br. J. Pharmacol. 115, 1393-1398 (1995).
    • (1995) Br. J. Pharmacol. , vol.115 , pp. 1393-1398
    • Heinke, S.1    Szucs, G.2    Norris, A.3    Droogmans, G.4    Nilius, B.5
  • 144
    • 0029936806 scopus 로고    scopus 로고
    • Chloride transport and the action of sodium cromoglycate and nedocromil sodium in asthma
    • Norris, A. A. & Alton, E. W. Chloride transport and the action of sodium cromoglycate and nedocromil sodium in asthma. Clin. Exp. Allergy 26, 250-253 (1996).
    • (1996) Clin. Exp. Allergy , vol.26 , pp. 250-253
    • Norris, A.A.1    Alton, E.W.2
  • 145
    • 0027533291 scopus 로고
    • Inhaled loop diuretics as potential new anti-asthmatic drugs
    • Bianco, S. et al. Inhaled loop diuretics as potential new anti-asthmatic drugs. Eur. Resp. J. 6, 130-134 (1993).
    • (1993) Eur. Resp. J. , vol.6 , pp. 130-134
    • Bianco, S.1
  • 146
    • 0029080403 scopus 로고
    • Effect of acute and chronic inhaled furosemide on bronchial hyperresponsiveness in mild asthma
    • Yates, D. H. et al. Effect of acute and chronic inhaled furosemide on bronchial hyperresponsiveness in mild asthma. Am. J, Respir, Crit. Care Med. 152, 892-896 (1995).
    • (1995) Am. J. Respir. Crit. Care Med. , vol.152 , pp. 892-896
    • Yates, D.H.1
  • 147
    • 0034120110 scopus 로고    scopus 로고
    • The role of co-stimulation in airway inflammation
    • Djukanovic, R. The role of co-stimulation in airway inflammation. Clin. Exp. Allergy 30 (Suppl. 1), 46-50 (2000).
    • (2000) Clin. Exp. Allergy , vol.30 , Issue.SUPPL. 1 , pp. 46-50
    • Djukanovic, R.1
  • 148
    • 0032914146 scopus 로고    scopus 로고
    • Anti-CD86 (B7.2) treatment abolishes allergic airway hyperresponsiveness in mice
    • Haczku, A. et al. Anti-CD86 (B7.2) treatment abolishes allergic airway hyperresponsiveness in mice. Am. J. Respir. Crit. Care Med. 159, 1638-1643 (1999).
    • (1999) Am. J. Respir. Crit. Care Med. , vol.159 , pp. 1638-1643
    • Haczku, A.1
  • 150
    • 0031228810 scopus 로고    scopus 로고
    • Murine CTLA4-IgG treatment inhibits airway eosinophilia and hyperresponsiveness and attenuates IgE upregulation in a murine model of allergic asthma
    • Van Oosterhout, A. J. et al. Murine CTLA4-IgG treatment inhibits airway eosinophilia and hyperresponsiveness and attenuates IgE upregulation in a murine model of allergic asthma. Am. J. Respir. Cell Mol. Biol. 17, 386-392 (1997).
    • (1997) Am. J. Respir. Cell Mol. Biol. , vol.17 , pp. 386-392
    • Van Oosterhout, A.J.1
  • 152
    • 0031867521 scopus 로고    scopus 로고
    • Requirement of CD28-CD86 costimulation for allergen-specific T cell proliferation and cytokine expression
    • van Neerven, R. J. et al. Requirement of CD28-CD86 costimulation for allergen-specific T cell proliferation and cytokine expression. Clin. Exp. Allergy 28, 808-816 (1998).
    • (1998) Clin. Exp. Allergy , vol.28 , pp. 808-816
    • van Neerven, R.J.1
  • 153
    • 0034912364 scopus 로고    scopus 로고
    • ICOS is critical for T helper cell-mediated lung mucosal inflammatory responses
    • Gonzalo, J. A. et al. ICOS is critical for T helper cell-mediated lung mucosal inflammatory responses. Nature Immunol. 2, 597-604 (2001).
    • (2001) Nature Immunol. , vol.2 , pp. 597-604
    • Gonzalo, J.A.1
  • 155
    • 0042736310 scopus 로고    scopus 로고
    • Alergic asthma and an anti-CD23 mAb (IDEC-152): Results of a phase I, single-dose, dose-escalating clinical trial
    • Rosenwasser, L. J., Busse, W. W., Lizambri, R. G., Olejnik, T. A. & Totoritis, M. C. Alergic asthma and an anti-CD23 mAb (IDEC-152): results of a phase I, single-dose, dose-escalating clinical trial. J. Allergy Clin. Immunol. 112, 563-570 (2003).
    • (2003) J. Allergy Clin. Immunol. , vol.112 , pp. 563-570
    • Rosenwasser, L.J.1    Busse, W.W.2    Lizambri, R.G.3    Olejnik, T.A.4    Totoritis, M.C.5
  • 156
    • 0029925502 scopus 로고    scopus 로고
    • Immunoprophylaxis of allergen-induced immunoglobulin E synthesis and airway hyperresponsiveness in vivo by genetic immunization
    • Hsu, C. H. et al. Immunoprophylaxis of allergen-induced immunoglobulin E synthesis and airway hyperresponsiveness in vivo by genetic immunization. Nature Med. 2, 540-544 (1996).
    • (1996) Nature Med. , vol.2 , pp. 540-544
    • Hsu, C.H.1
  • 157
    • 0037031090 scopus 로고    scopus 로고
    • Effect of T-cell peptides derived from Fel d 1 on allergic reactions and cytokine production in patients sensitive to cats: A randomised controlled trial
    • Oldfield, W. L., Larche, M. & Kay, A. B. Effect of T-cell peptides derived from Fel d 1 on allergic reactions and cytokine production in patients sensitive to cats: a randomised controlled trial. Lancet 360, 47-53 (2002).
    • (2002) Lancet , vol.360 , pp. 47-53
    • Oldfield, W.L.1    Larche, M.2    Kay, A.B.3
  • 158
    • 0031782864 scopus 로고    scopus 로고
    • BCG infection suppresses allergic sensitization and development of increased airway reactivity in an animal model
    • Herz, U. et al. BCG infection suppresses allergic sensitization and development of increased airway reactivity in an animal model. J. Allergy Clin. Immunol. 102, 867-874 (1998).
    • (1998) J. Allergy Clin. Immunol. , vol.102 , pp. 867-874
    • Herz, U.1
  • 159
    • 0036627624 scopus 로고    scopus 로고
    • Therapeutic effects of BCG vaccination in adult asthmatic patients: A randomized, controlled trial
    • Choi, I. S. & Koh, Y. I. Therapeutic effects of BCG vaccination in adult asthmatic patients: a randomized, controlled trial. Ann. Allergy Asthma Immunol. 88, 584-591 (2002).
    • (2002) Ann. Allergy Asthma Immunol. , vol.88 , pp. 584-591
    • Choi, I.S.1    Koh, Y.I.2
  • 160
    • 0035101984 scopus 로고    scopus 로고
    • DNA-based immunotherapeutics for the treatment of allergic disease
    • Horner, A. A., Van Uden, J. H., Zubeldia, J. M., Broide, D. & Raz, E. DNA-based immunotherapeutics for the treatment of allergic disease. Immunol. Rev. 179, 102-118 (2001).
    • (2001) Immunol. Rev. , vol.179 , pp. 102-118
    • Horner, A.A.1    Van Uden, J.H.2    Zubeldia, J.M.3    Broide, D.4    Raz, E.5
  • 161
    • 0033563211 scopus 로고    scopus 로고
    • Long term prevention of allergic lung inflammation in a mouse model of asthma by CpG oligodeoxynucleotides
    • Sur, S. et al. Long term prevention of allergic lung inflammation in a mouse model of asthma by CpG oligodeoxynucleotides. J. Immunol. 162, 6284-6293 (1999).
    • (1999) J. Immunol. , vol.162 , pp. 6284-6293
    • Sur, S.1
  • 163
    • 0036126748 scopus 로고    scopus 로고
    • Amb a 1-linked CpG oligodeoxynucleotides reverse established airway hyperresponsiveness in a murine model of asthma
    • Santeliz, J. V., Van Nest, G,, Traquina, P., Larsen, E. & Wills-Karp, M. Amb a 1-linked CpG oligodeoxynucleotides reverse established airway hyperresponsiveness in a murine model of asthma. J. Allergy Clin. Immunol. 109, 455-462 (2002).
    • (2002) J. Allergy Clin. Immunol. , vol.109 , pp. 455-462
    • Santeliz, J.V.1    Van Nest, G.2    Traquina, P.3    Larsen, E.4    Wills-Karp, M.5
  • 164
    • 0036090792 scopus 로고    scopus 로고
    • Medicinal chemistry and therapeutic potential of CpG DNA
    • Agrawal, S. & Kandimalla, E. R. Medicinal chemistry and therapeutic potential of CpG DNA. Trends Mol. Med. 8, 114-121 (2002).
    • (2002) Trends Mol. Med. , vol.8 , pp. 114-121
    • Agrawal, S.1    Kandimalla, E.R.2
  • 165
    • 0036128210 scopus 로고    scopus 로고
    • Asthma genetics
    • Cookson, W. O. Asthma genetics. Chest 121, 7S-13S (2002).
    • (2002) Chest , vol.121
    • Cookson, W.O.1
  • 166
    • 0034017468 scopus 로고    scopus 로고
    • Pharmacogenetics of asthma
    • Hall, I. P. Pharmacogenetics of asthma. Eur. Respir. J. 15, 449-451 (2000).
    • (2000) Eur. Respir. J. , vol.15 , pp. 449-451
    • Hall, I.P.1
  • 168
    • 0031025249 scopus 로고    scopus 로고
    • DNA antisense therapy for asthma in an animal model
    • Nyce, J. W. & Metzger, W. J. DNA antisense therapy for asthma in an animal model. Nature 385, 721-725 (1997).
    • (1997) Nature , vol.385 , pp. 721-725
    • Nyce, J.W.1    Metzger, W.J.2
  • 169
    • 0035992686 scopus 로고    scopus 로고
    • Discovery and development of respirable antisense therapeutics for asthma
    • Sandrasagra, A. et al. Discovery and development of respirable antisense therapeutics for asthma. Antisense Nucleic Acid Drug Dev. 12, 177-181 (2002).
    • (2002) Antisense Nucleic Acid Drug Dev. , vol.12 , pp. 177-181
    • Sandrasagra, A.1
  • 170
    • 1842558596 scopus 로고    scopus 로고
    • Molecular therapy to inhibit NF-κB activation by transcription factor decoy oligonucleotides
    • Morishita, R., Tomita, N., Kaneda, Y., & Ogihara, T. Molecular therapy to inhibit NF-κB activation by transcription factor decoy oligonucleotides. Curr. Opin. Pharmacol. 4, 139-146 (2004).
    • (2004) Curr. Opin. Pharmacol. , vol.4 , pp. 139-146
    • Morishita, R.1    Tomita, N.2    Kaneda, Y.3    Ogihara, T.4
  • 171
    • 0242317385 scopus 로고    scopus 로고
    • Small RNA: Can RNA interference be exploited for therapy?
    • Wall, N. R. & Shi, Y. Small RNA: can RNA interference be exploited for therapy? Lancet 362, 1401-1403 (2003).
    • (2003) Lancet , vol.362 , pp. 1401-1403
    • Wall, N.R.1    Shi, Y.2
  • 172
    • 1642291631 scopus 로고    scopus 로고
    • Small interfering RNA targeting heme oxygenase-1 enhances ischemia-reperfusion-induced lung apoptosis
    • Zhang, X. et al. Small interfering RNA targeting heme oxygenase-1 enhances ischemia-reperfusion-induced lung apoptosis. J. Biol. Chem. 279, 10677-10684 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 10677-10684
    • Zhang, X.1


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