Positional cloning of a novel gene influencing asthma from Chromosome 2q14

Nature Genetics

Volumn 35, Issue 3, 2003, Pages 258-263

  Allen, Maxine ^a   Heinzmann, Andrea ^b   Noguchi, Emiko ^b   Abecasis, Gonçalo ^b   Broxholme, John ^b   Ponting, Chris P ^c   Bhattacharyya, Sumit ^b   Tinsley, Jon ^a   Zhang, Youming ^b   Holt, Richard ^b   Yvonne Jones, E ^b   Lench, Nick ^a   Carey, Alisoun ^a   Jones, Helene ^a   Dickens, Nicholas J ^c   Dimon, Claire ^a   Nicholls, Rosie ^a   Baker, Crystal ^a   Xue, Luzheng ^a   Townsend, Elizabeth ^a   Kabesch, Michael ^d   Weiland, Stephan K ^e   Carr, David ^d   Von Mutius, Erika ^d   Adcock, Ian M ^f   Barnes, Peter J ^f   Mark Lathrop, G ^g   Edwards, Mark ^a   Moffatt, Miriam F ^b   Cookson, William O C M ^b   more..

^a Oxagen   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^e UNIVERSITY OF ULM   (Germany)

^f NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^g CENTRE NATIONAL DE GÉNOTYPAGE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CYTOKINE; DIPEPTIDYL PEPTIDASE; IMMUNOGLOBULIN E;

ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; CHROMOSOME 2Q; CLUSTER ANALYSIS; DPP10 GENE; GENE; GENE ACTIVATION; GENE CLUSTER; GENE LINKAGE DISEQUILIBRIUM; GENE TARGETING; GENETIC ASSOCIATION; GENETIC SCREENING; GENETIC SUSCEPTIBILITY; HUMAN; MOLECULAR CLONING; MULTIGENE FAMILY; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

AMINO ACID SEQUENCE; ASTHMA; CHROMOSOMES, HUMAN, PAIR 2; CLONING, MOLECULAR; GENOTYPE; HUMANS; MICROSATELLITE REPEATS; SEQUENCE HOMOLOGY, AMINO ACID;

BRONCHUS;

EID: 0242329880     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng1256     Document Type: Article

References (30)

1. Daniels, S.E. et al. A genome-wide search for quantitative trait loci underlying asthma. Nature 383, 247-250 (1996).
2. Hizawa, N. et al. Genetic regulation of Dermatophagoides pteronyssinus-specific IgE responsiveness: a genome-wide multipoint linkage analysis in families recruited through 2 asthmatic sibs. Collaborative Study on the Genetics of Asthma (CSGA). J. Allergy Clin. Immunol. 102, 436-442 (1998).
3. Koppelman, G.H. et al. Genome-wide search for atopy susceptibility genes in Dutch families with asthma. J. Allergy Clin. Immunol. 109, 498-506 (2002).
4. Wjst, M. et al. A genome-wide search for linkage to asthma. German Asthma Genetics Group. Genomics 58, 1-8 (1999).
5. Ewart, S.L. et al. Quantitative trait loci controlling allergen-induced airway hyperresponsiveness in inbred mice. Am. J. Respir. Cell. Mol. Biol. 23, 537-545 (2000).
6. De Sanctis, G.T. et al. Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice. Nat. Genet. 11, 150-154 (1995).
7. Pociot, F., Molvig, J., Wogensen, L., Worsaae, H. & Nerup, J. A Taql polymorphism in the human interleukin-1 beta (IL-1 beta) gene correlates with IL-1 beta secretion in vitro. Eur. J. Clin. Invest. 22, 396-402 (1992).
8. di Giovine, F.S., Takhsh, E., Blakemore, A.I. & Duff, G.W. Single base polymorphism at -511 in the human interleukin-1 beta gene (IL1 beta). Hum. Mol. Genet. 1, 450 (1992).
9. Bailly, S., di Giovine, F.S., Blakemore, A.I. & Duff, G.W. Genetic polymorphism of human interleukin-1 alpha. Eur. J. Immunol. 23, 1240-1245 (1993).
10. Epplen, C. et al. Dinucleotide repeat polymorphism in the human ILIA gene. Hum. Mol. Genet. 3, 1710 (1994).
11. O'Connor, G.T. & Weiss, S.T. Clinical and symptom measures. Am. J. Respir. Crit. Care Med. 149, S21-S28 (1994).
12. Duffy, D.L., Martin, N.G., Battistutta, D., Hopper, J.L. & Mathews, J.D. Genetics of asthma and hay fever in Australian twins. Am. Rev. Respir. Dis. 142, 1351-1358 (1990).
13. Zhang, Y. et al. Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma. Nat. Genet. 34, 181-186 (2003).
14. Sham, P.C. & Curtis, D. An extended transmission/disequilibrium test (TDT) for multiallele marker loci. Ann. Hum. Genet. 59 (Pt 3), 323-336 (1995).
15. Abecasis, G.R. et al. Extent and distribution of linkage disequilibrium in three genomic regions. Am. J. Hum. Genet. 68, 191-197 (2001).
16. Rao, N.V., Rao, G.V. & Hoidal, J.R. Human dipeptidyl-peptidase I. Gene characterization, localization, and expression. J. Biol. Chem. 272, 10260-10265 (1997).
17. Kabesch, M. et al. Association between polymorphisms in caspase recruitment domain containing protein 15 and allergy in two German populations. J. Allergy Clin. Immunol. 111, 813-817 (2003).
18. Qi, S.Y., Riviere, P.J., Trojnar, J., Junien, J.L. & Akinsanya, K.O. Cloning and characterization of dipeptidyl peptidase 10, a new member of an emerging subgroup of serine proteases. Biochem. J. 373, 179-189 (2003).
19. Lambeir, A.M. et al. Kinetic investigation of chemokine truncation by CD26/dipeptidyl peptidase IV reveals a striking selectivity within the chemokine family. J. Biol. Chem. 276, 29839-29845 (2001).
20. Pulleyn, L.J., Newton, R., Adcock, I.M. & Barnes, P.J. TGFbeta1 allele association with asthma severity. Hum. Genet. 109, 623-627 (2001).
21. Cox, H.E. et al. Association of atopic dermatitis to the beta subunit of the high affinity immunoglobulin E receptor. Br. J. Dermatol. 138, 182-187 (1998).
22. Hill, M.R. et al. Fc epsilon RI-beta polymorphism and risk of atopy in a general population sample. Brit. Med. J. 311, 776-779 (1995).
23. ISAAC. Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee. Lancet 351, 1225-1232 (1998).
24. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, November 1986. Am. Rev. Respir. Dis. 136, 225-244 (1987).
25. Kruglyak, L. & Nickerson, D.A. Variation is the spice of life. Nat. Genet. 27, 234-236 (2001).
26. Abecasis, G.R., Cherny, S.S., Cookson, W.O. & Cardon, L.R. Merlin-rapid analysis of dense genetic maps using sparse gene flow trees. Nat. Genet. 30, 97-101 (2002).
27. Abecasis, G.R., Cardon, L.R. & Cookson, W.O. A general test of association for quantitative traits in nuclear families. Am. J. Hum. Genet. 66, 279-292 (2000).
28. Abecasis, G.R. & Cookson, W.O. GOLD-graphical overview of linkage disequilibrium. Bioinformatics 16, 182-183 (2000).
29. Jones, T.A., Zou, J.Y., Cowan, S.W. & Kjeldgaard. Improved methods for binding protein models in electron density maps and the location of errors in these models. Acta Crystallogr. A 47 (Pt 2), 110-119 (1991).
30. Duke-Cohan, J.S., Morimoto, C., Rocker, J.A. & Schlossman, S.F. A novel form of dipeptidylpeptidase IV found in human serum. Isolation, characterization, and comparison with T lymphocyte membrane dipeptidylpeptidase IV (CD26). J. Biol. Chem. 270, 14107-14114 (1995).