Increased exhaled 8-isoprostane in childhood asthma

Chest

Volumn 124, Issue 1, 2003, Pages 25-31

  Baraldi, Eugenio ^a   Ghiro, Laura ^a   Piovan, Vania ^a   Carraro, Silvia ^a   Ciabattoni, Giovanni ^b   Barnes, Peter J ^c   Montuschi, Paolo ^d  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF CHIETI   (Italy)

^c NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^d CATHOLIC UNIVERSITY   (Italy)

Author keywords

8 isoprostane; Airway inflammation; Asthma; Exhaled breath condensate; Nitric oxide; Noninvasive markers; Oxidative stress; Prostaglandin E2

Indexed keywords

8 ISOPROSTANE; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BUDESONIDE; CORTICOSTEROID; FLUTICASONE PROPIONATE; ISOPROSTANE DERIVATIVE; NITRIC OXIDE; PROSTAGLANDIN E2; SALMETEROL; UNCLASSIFIED DRUG;

ADOLESCENT; ARTICLE; ASTHMA; BREATH ANALYSIS; CHEMOLUMINESCENCE; CHILD; CHILDHOOD DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; CORTICOSTEROID THERAPY; DISEASE MARKER; DISEASE SEVERITY; EXHALATION; FEMALE; HUMAN; MALE; ONLINE ANALYSIS; OUTPATIENT DEPARTMENT; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RESPIRATORY TRACT INFLAMMATION;

EID: 0038498568     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.124.1.25     Document Type: Article

References (33)

1. Henricks PA, Nijkamp FP. Reactive oxygen species as mediators in asthma. Pulm Pharmacol Ther 2001; 14: 409-420
2. Zayasu K, Sekizawa K, Okinaga S, et al. Increased carbon monoxide in exhaled air of asthmatic patients. Am J Respir Crit Care Med 1997; 156:1140-1143
3. Paredi P, Kharitonov SA, Barnes PJ. Elevation of exhaled ethane concentration in asthma. Am J Respir Crit Care Med 2000; 162:1450-1454
4. Mutlu GM, Garey KW, Bobbins RA, et al. Collection and analysis of exhaled breath condensate in humans. Am J Respir Crit Care Med 2001; 164:731-737
5. Montuschi P, Barnes PJ. Analysis of exhaled breath condensate for monitoring airway inflammation. Trends Pharmacol Sci 2002; 23:232-237
6. Emelyanov A, Fedoseev G, Abulimity A, et al. Elevated concentrations of exhaled hydrogen peroxide in asthmatic patients. Chest 2001; 120:1136-1139
7. Corradi M, Montuschi P, Donnelly LE, et al. Increased nitrosothiols in exhaled breath condensate in inflammatory airway diseases. Am J Respir Crit Care Med 2001; 163:854-858
8. Hanazawa T, Kharitonov SA, Barnes PJ. Increased nitrotyrosine in exhaled breath condensate of patients with asthma. Am J Respir Crit Care Med 2000; 162:1273-1276
9. Hunt JF, Fang K, Malik R, et al. Endogenous airway acidification: implications for asthma pathophysiology. Am J Respir Crit Care Med 2000; 161:694-699
10. Hunt JF, Erwin E, Palmer L, et al. Expression and activity of pH-regulatory glutaminase in the human airway epithelium. Am J Respir Crit Care Med 2002; 165:101-107
11. Kharitonov SA, Barnes PJ. Exhaled markers of pulmonary disease. Am J Respir Crit Care Med 2001; 163:1693-1722
12. Dwyer TM. Expired breath condensate (EBC) and the ultimate disposition of airway surface liquid (ASL). Am J Respir Crit Care Med 2001; 163:A406
13. Effros RM, Hoagland KW, Bosbous M, et al. Dilution of respiratory solutes in exhaled condensates. Am J Respir Crit Care Med 2002; 165:663-669
14. Praticò D, Lawson JA, Rokach J, et al. The isoprostanes in biology and medicine. Trends Endocrinol Metab 2001; 12:243-247
15. Montuschi P, Corradi M, Ciabattoni G, et al. Increased 8-isoprostane, a biomarker of oxidative stress, in exhaled condensate of asthma patients. Am J Respir Crit Care Med 1999; 160:216-220
16. 2α, a novel noncyclooxygenase-derived prostaglandin, constricts airways in vitro. Am J Respir Crit Care Med 1996; 153:590-596
17. Uasuf CG, Jatakanon A, James A, et al. Exhaled carbon monoxide in childhood asthma. J Pediatr 1999; 135:569-574
18. Jobsis Q, Raatgeep HC, Hermans PW, et al. Hydrogen peroxide in exhaled air is increased in stable asthmatic children. Eur Respir J 1997; 10:519-521
19. 2. Lancet 1995; 334:436-438
20. Montuschi P, Barnes PJ. Exhaled leukotrienes and prostaglandins in asthma. J Allergy Clin Immunol 2002; 109:615-620
21. Baraldi E, Ghiro L, Zanconato S. Nitric oxide in childhood asthma. Monaldi Arch Chest Dis 2001; 56:167-168
22. National Institutes of Health. Global strategy for asthma management and prevention: WHO/NHLBI workshop report. Bethesda, MD: National Institutes of Health, National Heart, Lung, and Blood Institute, 1995; Publication No. 95-3659
23. Montuschi P, Kharitonov SA, Ciabattoni G, et al. Exhaled 8-isoprostane as a new non-invasive biomarker of oxidative stress in cystic fibrosis. Thorax 2000; 55:205-209
24. 2α excretion in man. J Pharmacol Exp Ther 1995; 275:94-100
25. 2α release from guinea-pig lung in vitro. Eur J Pharmacol 1999; 365:59-64
26. 2α in human urine J Endocrinol Invest 1979; 2:173-182
27. American Thoracic Society. Recommendations for standardized procedures for the on-line and off-line measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide in adults and children: 1999; official statement of the American Thoracic Society. Am J Respir Crit Care Med 1999; 160:2104-2117
28. Baraldi E, Seollo M, Zaramella C, et al. A simple flow-driven method for online measurement of exhaled NO starting at the age of 4 to 5 years. Am J Respir Crit Care Med 2000; 162:1828-1832
29. Bland MJ, Altman D. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1986; 1:307-310
30. Montuschi P. Indirect monitoring of lung inflammation. Nat Rev Drug Discov 2002; 1:238-242
31. Janssen LJ. Isoprostanes: an overview and putative roles in pulmonary pathophysiology. Am J Physiol Lung Cell Mol Physiol 2001; 280:L1067-L1082
32. Montuschi P, Nightingale J, Kharitonov SA, et al. Ozone-induced increase in exhaled 8-isoprostane in healthy subjects is resistant to inhaled budesonide. Free Radio Biol Med 2002; 33:1403-1408
33. Barnes PJ, Chung KP, Page PC. Inflammatory mediators of asthma: an update. Pharmacol Rev 1998; 50:515-596