메뉴 건너뛰기




Volumn 4, Issue 7, 2004, Pages 529-540

CD4/CD8-lineage differentiation in the thymus: From nuclear effectors to membrane signals

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR;

EID: 3142769748     PISSN: 14741733     EISSN: None     Source Type: Journal    
DOI: 10.1038/nri1392     Document Type: Review
Times cited : (89)

References (155)
  • 1
    • 0028014460 scopus 로고
    • Signal transduction by lymphocyte antigen receptors
    • Weiss, A. & Littman, D. R. Signal transduction by lymphocyte antigen receptors. Cell 76, 263-274 (1994).
    • (1994) Cell , vol.76 , pp. 263-274
    • Weiss, A.1    Littman, D.R.2
  • 3
    • 0037184955 scopus 로고    scopus 로고
    • The organizing principle in the formation of the T cell receptor-CD3 complex
    • Call, M. E., Pyrdol, J., Wiedmann, M. & Wucherpfennig, K. W. The organizing principle in the formation of the T cell receptor-CD3 complex. Cell 111, 967-979 (2002).
    • (2002) Cell , vol.111 , pp. 967-979
    • Call, M.E.1    Pyrdol, J.2    Wiedmann, M.3    Wucherpfennig, K.W.4
  • 4
    • 0028178873 scopus 로고
    • Signals and signs for lymphocyte responses
    • Janeway, C. A. J. & Bottomly, K. Signals and signs for lymphocyte responses. Cell 76, 275-285 (1994).
    • (1994) Cell , vol.76 , pp. 275-285
    • Janeway, C.A.J.1    Bottomly, K.2
  • 5
    • 0024807506 scopus 로고
    • Engagement of CD4 and CD8 expressed on immature thymocytes induces activation of intracellular tyrosine phosphorylation pathways
    • Veillette, A., Zúñiga-Pflücker, J. C., Bolen, J. B. & Kruisbeek, A. M. Engagement of CD4 and CD8 expressed on immature thymocytes induces activation of intracellular tyrosine phosphorylation pathways. J. Exp. Med. 170, 1671-1680 (1989).
    • (1989) J. Exp. Med. , vol.170 , pp. 1671-1680
    • Veillette, A.1    Zúñiga-Pflücker, J.C.2    Bolen, J.B.3    Kruisbeek, A.M.4
  • 6
    • 0024425159 scopus 로고
    • The Ick tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain
    • Shaw, A. S. et al. The Ick tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain. Cell 59, 627-636 (1989).
    • (1989) Cell , vol.59 , pp. 627-636
    • Shaw, A.S.1
  • 7
    • 0033571795 scopus 로고    scopus 로고
    • Association of the adaptor molecule LAT with CD4 and CD8 coreceptors identifies a new coreceptor function in T cell receptor signal transduction
    • Bosselut, R. et al. Association of the adaptor molecule LAT with CD4 and CD8 coreceptors identifies a new coreceptor function in T cell receptor signal transduction. J. Exp. Med. 190, 1517-1526 (1999).
    • (1999) J. Exp. Med. , vol.190 , pp. 1517-1526
    • Bosselut, R.1
  • 8
    • 10744225431 scopus 로고    scopus 로고
    • LIME: A new membrane raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling
    • Brdièková, N. et al. LIME: a new membrane raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling. J. Exp. Med. 198, 1453-1462 (2003).
    • (2003) J. Exp. Med. , vol.198 , pp. 1453-1462
    • Brdièková, N.1
  • 9
    • 0345138999 scopus 로고    scopus 로고
    • LIME, a novel transmembrane adaptor protein, associates with P56Ick and mediates T cell activation
    • Hur, E. M. et al. LIME, a novel transmembrane adaptor protein, associates with P56Ick and mediates T cell activation. J. Exp. Med. 198, 1463-1473 (2003).
    • (2003) J. Exp. Med. , vol.198 , pp. 1463-1473
    • Hur, E.M.1
  • 11
    • 0025933951 scopus 로고
    • Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice
    • Huesmann, M., Scott, B., Kisielow, P. & von Boehmer, H. Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice. Cell 66, 533-540 (1991).
    • (1991) Cell , vol.66 , pp. 533-540
    • Huesmann, M.1    Scott, B.2    Kisielow, P.3    Von Boehmer, H.4
  • 12
    • 0023683669 scopus 로고
    • Positive selection of antigen-specific T cells in thymus by restricting MHC molecules
    • Kisielow, P., Teh, H. S., Bluthmann, H. & von, B. H. Positive selection of antigen-specific T cells in thymus by restricting MHC molecules. Nature 335, 730-733 (1988).
    • (1988) Nature , vol.335 , pp. 730-733
    • Kisielow, P.1    Teh, H.S.2    Bluthmann, H.3    Von, B.H.4
  • 13
    • 0023813094 scopus 로고
    • Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells
    • Teh, H. S. et al. Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells. Nature 335, 229-233 (1988).
    • (1988) Nature , vol.335 , pp. 229-233
    • Teh, H.S.1
  • 14
    • 0023724209 scopus 로고
    • Positive and negative selection of an antigen receptor on T cells in transgenic mice
    • Sha, W. C. et al. Positive and negative selection of an antigen receptor on T cells in transgenic mice. Nature 336, 73-76 (1988).
    • (1988) Nature , vol.336 , pp. 73-76
    • Sha, W.C.1
  • 15
    • 0024444304 scopus 로고
    • + T cells in transgenic mice expressing a class II MHC-restricted antigen receptor
    • + T cells in transgenic mice expressing a class II MHC-restricted antigen receptor. Nature 341, 746-749 (1989).
    • (1989) Nature , vol.341 , pp. 746-749
    • Kaye, J.1
  • 16
    • 0030014002 scopus 로고    scopus 로고
    • T-cell-receptor affinity and thymocyte positive selection
    • Alam, S. M. et al. T-cell-receptor affinity and thymocyte positive selection. Nature 381, 616-620 (1996).
    • (1996) Nature , vol.381 , pp. 616-620
    • Alam, S.M.1
  • 17
    • 0024288672 scopus 로고
    • T-cell development. Accessories or coreceptors?
    • Janeway, C. A. J. T-cell development. Accessories or coreceptors? Nature 335, 208-210 (1988).
    • (1988) Nature , vol.335 , pp. 208-210
    • Janeway, C.A.J.1
  • 18
    • 0028032155 scopus 로고
    • Positive selection of lymphocytes
    • von Boehmer, H. Positive selection of lymphocytes. Cell 76, 219-228 (1994).
    • (1994) Cell , vol.76 , pp. 219-228
    • Von Boehmer, H.1
  • 19
    • 0029913780 scopus 로고    scopus 로고
    • CD4/CD8 lineage commitment: Back to instruction?
    • von Boehmer, H. CD4/CD8 lineage commitment: back to instruction? J. Exp. Med. 183, 713-715 (1996).
    • (1996) J. Exp. Med. , vol.183 , pp. 713-715
    • Von Boehmer, H.1
  • 20
    • 0026078307 scopus 로고
    • Development of the CD4 and CD8 lineage of T cells: Instruction versus selection
    • Borgulya, P., Kishi, H., Muller, U., Kirberg, J. & von, B. H. Development of the CD4 and CD8 lineage of T cells: instruction versus selection. EMBO J. 10, 913-918 (1991).
    • (1991) EMBO J. , vol.10 , pp. 913-918
    • Borgulya, P.1    Kishi, H.2    Muller, U.3    Kirberg, J.4    Von, B.H.5
  • 21
    • 0026034155 scopus 로고
    • Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage
    • Robey, E. A. et al. Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage. Cell 64, 99-107 (1991).
    • (1991) Cell , vol.64 , pp. 99-107
    • Robey, E.A.1
  • 22
    • 0028053092 scopus 로고
    • Stochastic component to development of class I major histocompatibility complex-specific T cells
    • Itano, A., Kioussis, D. & Robey, E. Stochastic component to development of class I major histocompatibility complex-specific T cells. Proc. Natl Acad. Sci. USA 91, 220-224 (1994).
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 220-224
    • Itano, A.1    Kioussis, D.2    Robey, E.3
  • 23
    • 0027153897 scopus 로고
    • Another view of the selective model of thymocyte selection
    • Chan, S. H., Cosgrove, D., Waltzinger, C., Benoist, C. & Mathis, D. Another view of the selective model of thymocyte selection. Cell 73, 225-236 (1993).
    • (1993) Cell , vol.73 , pp. 225-236
    • Chan, S.H.1    Cosgrove, D.2    Waltzinger, C.3    Benoist, C.4    Mathis, D.5
  • 24
    • 0027266755 scopus 로고
    • Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes
    • Davis, C. B., Killeen, N., Crooks, M. E., Raulet, D. & Littman, D. R. Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes. Cell 73, 237-247 (1993).
    • (1993) Cell , vol.73 , pp. 237-247
    • Davis, C.B.1    Killeen, N.2    Crooks, M.E.3    Raulet, D.4    Littman, D.R.5
  • 25
    • 0027164960 scopus 로고
    • + thymocytes: Selection rather than instruction?
    • + thymocytes: selection rather than instruction? Science 261, 911-915 (1993).
    • (1993) Science , vol.261 , pp. 911-915
    • Van Meerwijk, J.P.1    Germain, R.N.2
  • 26
    • 0028075391 scopus 로고
    • Role of coreceptors in positive selection and lineage commitment
    • Chan, S. H., Waltzinger, C., Baron, A., Benoist, C. & Mathis, D. Role of coreceptors in positive selection and lineage commitment. EMBO J. 13, 4482-4489 (1994).
    • (1994) EMBO J. , vol.13 , pp. 4482-4489
    • Chan, S.H.1    Waltzinger, C.2    Baron, A.3    Benoist, C.4    Mathis, D.5
  • 29
    • 0028904213 scopus 로고
    • + T cell lineages: A new perspective on thymic commitment and selection
    • + T cell lineages: a new perspective on thymic commitment and selection. Immunity 2, 413-425 (1995).
    • (1995) Immunity , vol.2 , pp. 413-425
    • Suzuki, H.1    Punt, J.A.2    Granger, L.G.3    Singer, A.4
  • 30
    • 0030293636 scopus 로고    scopus 로고
    • + thymocyte differentiation
    • + thymocyte differentiation. Immunity 5, 461-477 (1996).
    • (1996) Immunity , vol.5 , pp. 461-477
    • Lucas, B.1    Germain, R.N.2
  • 31
    • 0033696599 scopus 로고    scopus 로고
    • + T cells
    • + T cells. Immunity 13, 59-71 (2000). An in vitro study exploring the role of TCR-signal duration in lineage differentiation. The authors propose the initial formulation of the kinetic signalling model.
    • (2000) Immunity , vol.13 , pp. 59-71
    • Brugnera, E.1
  • 33
    • 0036582215 scopus 로고    scopus 로고
    • T-cell development and the CD4-CD8 lineage decision
    • Germain, R. N. T-cell development and the CD4-CD8 lineage decision. Nature Rev. Immunol. 2, 309-322 (2002).
    • (2002) Nature Rev. Immunol. , vol.2 , pp. 309-322
    • Germain, R.N.1
  • 34
    • 2442708080 scopus 로고    scopus 로고
    • CD4/CD8 coreceptors in thymocyte development, selection, and lineage commitment: Analysis of the CD4/CD8 lineage decision
    • Bosselut, R. & Singer, A. CD4/CD8 coreceptors in thymocyte development, selection, and lineage commitment: Analysis of the CD4/CD8 lineage decision. Adv. Immunol. 83, 91-131 (2004).
    • (2004) Adv. Immunol. , vol.83 , pp. 91-131
    • Bosselut, R.1    Singer, A.2
  • 35
    • 0036281949 scopus 로고    scopus 로고
    • T cell development: Bottoms-up
    • Hedrick, S. M. T cell development: bottoms-up. Immunity 16, 619-622 (2002).
    • (2002) Immunity , vol.16 , pp. 619-622
    • Hedrick, S.M.1
  • 36
    • 0024542793 scopus 로고
    • Molecular biology and function of CD4 and CD8
    • Parnes, J. R. Molecular biology and function of CD4 and CD8. Adv. Immunol. 44, 265-311 (1989).
    • (1989) Adv. Immunol. , vol.44 , pp. 265-311
    • Parnes, J.R.1
  • 37
    • 0036885036 scopus 로고    scopus 로고
    • Chromatin and CD4, CD8A and CD8B gene expression during thymic differentiation
    • Kioussis, D. & Ellmeier, W. Chromatin and CD4, CD8A and CD8B gene expression during thymic differentiation. Nature Rev. Immunol. 2, 909-919 (2002).
    • (2002) Nature Rev. Immunol. , vol.2 , pp. 909-919
    • Kioussis, D.1    Ellmeier, W.2
  • 38
    • 0030725991 scopus 로고    scopus 로고
    • A region in the CD8 gene locus that directs expression to the mature CD8 T cell subset in transgenic mice
    • Hostert, A. et al. A region in the CD8 gene locus that directs expression to the mature CD8 T cell subset in transgenic mice. Immunity 7, 525-536 (1997).
    • (1997) Immunity , vol.7 , pp. 525-536
    • Hostert, A.1
  • 39
    • 0030670312 scopus 로고    scopus 로고
    • An enhancer that directs lineage-specific expression of CD8 in positively selected thymocytes and mature T cells
    • Ellmeier, W., Sunshine, M. J., Losos, K., Hatam, F. & Littman, D. R. An enhancer that directs lineage-specific expression of CD8 in positively selected thymocytes and mature T cells. Immunity 7, 537-547 (1997).
    • (1997) Immunity , vol.7 , pp. 537-547
    • Ellmeier, W.1    Sunshine, M.J.2    Losos, K.3    Hatam, F.4    Littman, D.R.5
  • 40
    • 0032192483 scopus 로고    scopus 로고
    • Hierarchical interactions of control elements determine CD8A gene expression in subsets of thymocytes and peripheral T cells
    • Hostert, A. et al. Hierarchical interactions of control elements determine CD8A gene expression in subsets of thymocytes and peripheral T cells. Immunity 9, 497-508 (1998).
    • (1998) Immunity , vol.9 , pp. 497-508
    • Hostert, A.1
  • 41
    • 0032191963 scopus 로고    scopus 로고
    • Multiple developmental stage-specific enhancers regulate CD8 expression in developing thymocytes and in thymus-independent T cells
    • Ellmeier, W., Sunshine, M. J., Losos, K. & Littman, D. R. Multiple developmental stage-specific enhancers regulate CD8 expression in developing thymocytes and in thymus-independent T cells. Immunity 9, 485-496 (1998). References 40 and 41 present a detailed dissection of the CD8 locus cis-regulatory elements that are active in DP thymocytes and mature T cells.
    • (1998) Immunity , vol.9 , pp. 485-496
    • Ellmeier, W.1    Sunshine, M.J.2    Losos, K.3    Littman, D.R.4
  • 42
    • 0036285006 scopus 로고    scopus 로고
    • Combined deletion of CD8 locus cis-regulatory elements affects initiation but not maintenance of CD8 expression
    • Ellmeier, W., Sunshine, M. J., Maschek, R. & Littman, D. R. Combined deletion of CD8 locus cis-regulatory elements affects initiation but not maintenance of CD8 expression. Immunity 16, 623-634 (2002).
    • (2002) Immunity , vol.16 , pp. 623-634
    • Ellmeier, W.1    Sunshine, M.J.2    Maschek, R.3    Littman, D.R.4
  • 43
    • 0036286001 scopus 로고    scopus 로고
    • Variegated expression of CD8α resulting from in situ deletion of regulatory sequences
    • Garefalaki, A. et al. Variegated expression of CD8α resulting from in situ deletion of regulatory sequences. Immunity 16, 635-647 (2002). Using homologous recombination techniques, references 42 and 43 demonstrate the role of two CD8 enhancers for CD8 gene expression, and indicate that these enhancers act, at least in part, to prevent chromatin modifications that would silence the CD8 locus.
    • (2002) Immunity , vol.16 , pp. 635-647
    • Garefalaki, A.1
  • 44
    • 0036886895 scopus 로고    scopus 로고
    • The CD8α gene locus is regulated by the Ikaros family of proteins
    • Harker, N. et al. The CD8α gene locus is regulated by the Ikaros family of proteins. Mol. Cell 10, 1403-1415 (2002).
    • (2002) Mol. Cell , vol.10 , pp. 1403-1415
    • Harker, N.1
  • 45
    • 0033006012 scopus 로고    scopus 로고
    • The regulation of CD4 and CD8 coreceptor gene expression during T cell development
    • Ellmeier, W., Sawada, S. & Littman, D. R. The regulation of CD4 and CD8 coreceptor gene expression during T cell development. Annu. Rev. Immunol. 17, 523-554 (1999).
    • (1999) Annu. Rev. Immunol. , vol.17 , pp. 523-554
    • Ellmeier, W.1    Sawada, S.2    Littman, D.R.3
  • 46
    • 0025989268 scopus 로고
    • Identification and characterization of a T-cell-specific enhancer adjacent to the murine CD4 gene
    • Sawada, S. & Littman, D. R. Identification and characterization of a T-cell-specific enhancer adjacent to the murine CD4 gene. Mol. Cell. Biol. 11, 5506-5515 (1991).
    • (1991) Mol. Cell. Biol. , vol.11 , pp. 5506-5515
    • Sawada, S.1    Littman, D.R.2
  • 47
    • 0028066834 scopus 로고
    • A transcriptional silencer controls the developmental expression of the CD4 gene
    • Siu, G., Wurster, A. L., Duncan, D. D., Soliman, T. M. & Hedrick, S. M. A transcriptional silencer controls the developmental expression of the CD4 gene. EMBO J. 13, 3570-3579 (1994). References 46 and 47 report the initial identification and characterization of the CD4 silencer.
    • (1994) EMBO J. , vol.13 , pp. 3570-3579
    • Siu, G.1    Wurster, A.L.2    Duncan, D.D.3    Soliman, T.M.4    Hedrick, S.M.5
  • 48
    • 0028242609 scopus 로고
    • A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development
    • Sawada, S., Scarborough, J. D., Killeen, N. & Littman, D. R. A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development. Cell 77, 917-929 (1994).
    • (1994) Cell , vol.77 , pp. 917-929
    • Sawada, S.1    Scarborough, J.D.2    Killeen, N.3    Littman, D.R.4
  • 49
    • 0036864610 scopus 로고    scopus 로고
    • Evidence for distinct CD4 silencer functions at different stages of thymocyte differentiation
    • Taniuchi, I., Sunshine, M. J., Festenstein, R. & Littman, D. R. Evidence for distinct CD4 silencer functions at different stages of thymocyte differentiation. Mol. Cell 10, 1083-1096 (2002). This study uses knocked-in point mutations to characterize functional regions within the CD4 silencer. It also dissects the 'repressor' from the 'silencing' function of the minimal silencer element.
    • (2002) Mol. Cell , vol.10 , pp. 1083-1096
    • Taniuchi, I.1    Sunshine, M.J.2    Festenstein, R.3    Littman, D.R.4
  • 50
    • 0035190986 scopus 로고    scopus 로고
    • Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage
    • + T cells.
    • (2001) Nature Genet. , vol.29 , pp. 332-336
    • Zou, Y.R.1
  • 51
    • 0029944714 scopus 로고    scopus 로고
    • Asymmetric redundancy in CD4 silencer function
    • Duncan, D. D., Adlam, M. & Siu, G. Asymmetric redundancy in CD4 silencer function. Immunity 4, 301-311 (1996).
    • (1996) Immunity , vol.4 , pp. 301-311
    • Duncan, D.D.1    Adlam, M.2    Siu, G.3
  • 52
    • 18744398397 scopus 로고    scopus 로고
    • Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development
    • Taniuchi, I. et al. Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. Cell 111, 621-633 (2002). This study identifies the crucial role of RUNX1 and RUNX3 proteins in preventing inappropriate expression of CD4 by non-CD4-lineage T cells.
    • (2002) Cell , vol.111 , pp. 621-633
    • Taniuchi, I.1
  • 53
    • 0033584241 scopus 로고    scopus 로고
    • Subclass-specific nuclear localization of a novel CD4 silencer binding factor
    • Kim, W. W. & Siu, G. Subclass-specific nuclear localization of a novel CD4 silencer binding factor. J. Exp. Med. 190, 281-291 (1999).
    • (1999) J. Exp. Med. , vol.190 , pp. 281-291
    • Kim, W.W.1    Siu, G.2
  • 54
    • 0038610795 scopus 로고    scopus 로고
    • Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis
    • Woolf, E. et al. Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis. Proc. Natl Acad. Sci. USA 100, 7731-7736 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 7731-7736
    • Woolf, E.1
  • 55
    • 0141920621 scopus 로고    scopus 로고
    • + thymocytes
    • + thymocytes. J. Immunol. 171, 3594-3604 (2003).
    • (2003) J. Immunol. , vol.171 , pp. 3594-3604
    • Ehlers, M.1
  • 56
    • 0030061554 scopus 로고    scopus 로고
    • AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis
    • Okuda, T., van, D. J., Hiebert, S. W., Grosveld, G. & Downing, J. R. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell 84, 321-330 (1996).
    • (1996) Cell , vol.84 , pp. 321-330
    • Okuda, T.1    Van, D.J.2    Hiebert, S.W.3    Grosveld, G.4    Downing, J.R.5
  • 57
    • 0030678549 scopus 로고    scopus 로고
    • Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation
    • Ducy, P., Zhang, R., Geoffroy, V., Ridall, A. L. & Karsenty, G. Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 89, 747-754 (1997).
    • (1997) Cell , vol.89 , pp. 747-754
    • Ducy, P.1    Zhang, R.2    Geoffroy, V.3    Ridall, A.L.4    Karsenty, G.5
  • 58
    • 0029417351 scopus 로고
    • A PEBP2 α/AML-1-related factor increases osteocalcin promoter activity through its binding to an osteoblast-specific cis-acting element
    • Geoffroy, V., Ducy, P. & Karsenty, G. A PEBP2 α/AML-1-related factor increases osteocalcin promoter activity through its binding to an osteoblast-specific cis-acting element. J. Biol. Chem. 270, 30973-30979 (1995).
    • (1995) J. Biol. Chem. , vol.270 , pp. 30973-30979
    • Geoffroy, V.1    Ducy, P.2    Karsenty, G.3
  • 59
    • 0031723955 scopus 로고    scopus 로고
    • The notch pathway intermediate HES-1 silences CD4 gene expression
    • Kim, H. K. & Siu, G. The notch pathway intermediate HES-1 silences CD4 gene expression. Mol. Cell. Biol. 18, 7166-7175 (1998).
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 7166-7175
    • Kim, H.K.1    Siu, G.2
  • 61
    • 0036236895 scopus 로고    scopus 로고
    • An invitation to T and more: Notch signaling in lymphopoiesis
    • Allman, D., Punt, J. A., Izon, D. J., Aster, J. C. & Pear, W. S. An invitation to T and more: notch signaling in lymphopoiesis. Cell 109, Suppl. S1-S11 (2002).
    • (2002) Cell , vol.109 , Issue.SUPPL.
    • Allman, D.1    Punt, J.A.2    Izon, D.J.3    Aster, J.C.4    Pear, W.S.5
  • 62
    • 0030297895 scopus 로고    scopus 로고
    • An activated form of Notch influences the choice between CD4 and CD8 T cell lineages
    • Robey, E. et al. An activated form of Notch influences the choice between CD4 and CD8 T cell lineages. Cell 87, 483-492 (1996).
    • (1996) Cell , vol.87 , pp. 483-492
    • Robey, E.1
  • 63
    • 0033681301 scopus 로고    scopus 로고
    • Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes
    • Deftos, M. L., Huang, E., Ojala, E. W., Forbush, K. A. & Bevan, M. J. Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes. Immunity 13, 73-84 (2000).
    • (2000) Immunity , vol.13 , pp. 73-84
    • Deftos, M.L.1    Huang, E.2    Ojala, E.W.3    Forbush, K.A.4    Bevan, M.J.5
  • 64
    • 0037103148 scopus 로고    scopus 로고
    • A reassessment of the effect of activated notch 1 on CD4 and CD8 T cell development
    • Fowlkes, B. J. & Robey, E. A. A reassessment of the effect of activated notch1 on CD4 and CD8 T cell development. J. Immunol 169, 1817-1821 (2002).
    • (2002) J. Immunol. , vol.169 , pp. 1817-1821
    • Fowlkes, B.J.1    Robey, E.A.2
  • 65
    • 17744363445 scopus 로고    scopus 로고
    • + thymocytes by modulating TCR signal strength
    • + thymocytes by modulating TCR signal strength. Immunity 14, 253-264 (2001).
    • (2001) Immunity , vol.14 , pp. 253-264
    • Izon, D.J.1
  • 66
    • 5844299536 scopus 로고    scopus 로고
    • Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8 T cell development
    • Wolfer, A. et al. Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8 T cell development. Nature Immunol 2, 235-241 (2001).
    • (2001) Nature Immunol. , vol.2 , pp. 235-241
    • Wolfer, A.1
  • 67
    • 0038742790 scopus 로고    scopus 로고
    • Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development
    • Saito, T. et al. Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development. Immunity 18, 675-685 (2003).
    • (2003) Immunity , vol.18 , pp. 675-685
    • Saito, T.1
  • 68
    • 0033966375 scopus 로고    scopus 로고
    • A role for pref-1 and HES-1 in thymocyte development
    • Kaneta, M. et al. A role for pref-1 and HES-1 in thymocyte development. J. Immunol. 164, 256-264 (2000).
    • (2000) J. Immunol. , vol.164 , pp. 256-264
    • Kaneta, M.1
  • 69
    • 0029085935 scopus 로고
    • Signalling downstream of activated mammalian Notch
    • Jarriault, S. et al. Signalling downstream of activated mammalian Notch. Nature 377, 355-358 (1995).
    • (1995) Nature , vol.377 , pp. 355-358
    • Jarriault, S.1
  • 70
    • 0035988246 scopus 로고    scopus 로고
    • Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision
    • Han, H. et al. Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision. Int. Immunol. 14, 637-645 (2002).
    • (2002) Int. Immunol. , vol.14 , pp. 637-645
    • Han, H.1
  • 71
    • 0033136717 scopus 로고    scopus 로고
    • Deficient T cell fate specification in mice with an induced inactivation of Notch1
    • Radtke, F. et al. Deficient T cell fate specification in mice with an induced inactivation of Notch1. Immunity 10, 547-558 (1999).
    • (1999) Immunity , vol.10 , pp. 547-558
    • Radtke, F.1
  • 72
    • 0037963483 scopus 로고    scopus 로고
    • The establishment and maintenance of lymphocyte identity through gene silencing
    • Smale, S. T. The establishment and maintenance of lymphocyte identity through gene silencing. Nature Immunol. 4, 607-615 (2003).
    • (2003) Nature Immunol. , vol.4 , pp. 607-615
    • Smale, S.T.1
  • 74
    • 0029787059 scopus 로고    scopus 로고
    • Diversity and specialization of mammalian SWI/SNF complexes
    • Wang, W. et al. Diversity and specialization of mammalian SWI/SNF complexes. Genes Dev. 10, 2117-2130 (1996).
    • (1996) Genes Dev. , vol.10 , pp. 2117-2130
    • Wang, W.1
  • 75
    • 0031906816 scopus 로고    scopus 로고
    • Architectural DNA binding by a high-mobility-group/kinesin-like subunit in mammalian SWI/SNF-related complexes
    • Wang, W. et al. Architectural DNA binding by a high-mobility-group/ kinesin-like subunit in mammalian SWI/SNF-related complexes. Proc. Natl Acad. Sci. USA 95, 492-498 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 492-498
    • Wang, W.1
  • 76
    • 0026485046 scopus 로고
    • Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages
    • Mombaerts, P. et al. Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages. Nature 360, 225-231 (1992).
    • (1992) Nature , vol.360 , pp. 225-231
    • Mombaerts, P.1
  • 77
    • 0029065488 scopus 로고
    • Crucial role of the pre-T-cell receptor α gene in development of αβ but not γδ T cells
    • Fehling, H.J., Krotkova, A., Saint-Ruf, C. & von Boehmer, H. Crucial role of the pre-T-cell receptor α gene in development of αβ but not γδ T cells. Nature 375, 795-798 (1995).
    • (1995) Nature , vol.375 , pp. 795-798
    • Fehling, H.J.1    Krotkova, A.2    Saint-Ruf, C.3    Von Boehmer, H.4
  • 78
    • 0037062922 scopus 로고    scopus 로고
    • Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes
    • Chi, T. H. et al. Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes. Nature 418, 195-199 (2002). This paper identifies the role of BAF chromatin-remodelling complexes in the control of CD4 and CD8 gene expression.
    • (2002) Nature , vol.418 , pp. 195-199
    • Chi, T.H.1
  • 79
    • 0041429637 scopus 로고    scopus 로고
    • Sequential roles of Brg, the ATPase subunit of BAF chromatin remodeling complexes, in thymocyte development
    • Chi, T. H. et al. Sequential roles of Brg, the ATPase subunit of BAF chromatin remodeling complexes, in thymocyte development. Immunity 19, 169-182 (2003).
    • (2003) Immunity , vol.19 , pp. 169-182
    • Chi, T.H.1
  • 80
    • 1542377327 scopus 로고    scopus 로고
    • Duration of TCR signaling controls CD4-CD8 lineage differentiation in vivo
    • Liu, X. & Bosselut, R. Duration of TCR signaling controls CD4-CD8 lineage differentiation in vivo. Nature Immunol. 5, 280-288 (2004). Using a transgenic approach to dissect positive selection, this paper shows that the duration of intrathymic TCR signalling controls CD4/CD8-lineage choice.
    • (2004) Nature Immunol. , vol.5 , pp. 280-288
    • Liu, X.1    Bosselut, R.2
  • 81
    • 0036211013 scopus 로고    scopus 로고
    • Histone acetylation: A switch between repressive and permissive chromatin. Second in review series on chromatin dynamics
    • Eberharter, A. & Becker, P. B. Histone acetylation: a switch between repressive and permissive chromatin. Second in review series on chromatin dynamics. EMBO Rep. 3, 224-229 (2002).
    • (2002) EMBO Rep. , vol.3 , pp. 224-229
    • Eberharter, A.1    Becker, P.B.2
  • 82
    • 0036727514 scopus 로고    scopus 로고
    • Distinct in vivo requirements for establishment versus maintenance of transcriptional repression
    • Wheeler, J. C. et al. Distinct in vivo requirements for establishment versus maintenance of transcriptional repression. Nature Genet. 32, 206-210 (2002).
    • (2002) Nature Genet. , vol.32 , pp. 206-210
    • Wheeler, J.C.1
  • 83
    • 0032567080 scopus 로고    scopus 로고
    • Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling
    • Zhao, K. et al. Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling. Call 95, 625-636 (1998).
    • (1998) Call , vol.95 , pp. 625-636
    • Zhao, K.1
  • 84
    • 0037414839 scopus 로고    scopus 로고
    • Modulation of ATP-dependent chromatin-remodeling complexes by inositol polyphosphates
    • Shen, X., Xiao, H., Ranallo, R., Wu, W. H. & Wu, C. Modulation of ATP-dependent chromatin-remodeling complexes by inositol polyphosphates. Science 299, 112-114 (2003).
    • (2003) Science , vol.299 , pp. 112-114
    • Shen, X.1    Xiao, H.2    Ranallo, R.3    Wu, W.H.4    Wu, C.5
  • 85
    • 0037414868 scopus 로고    scopus 로고
    • Regulation of chromatin remodeling by inositol polyphosphates
    • Steger, D. J., Haswell, E. S., Miller, A. L., Wente, S. R. & O'Shea, E. K. Regulation of chromatin remodeling by inositol polyphosphates. Science 299, 114-116 (2003).
    • (2003) Science , vol.299 , pp. 114-116
    • Steger, D.J.1    Haswell, E.S.2    Miller, A.L.3    Wente, S.R.4    O'Shea, E.K.5
  • 86
    • 0037315777 scopus 로고    scopus 로고
    • Second messenger control of chromatin remodeling
    • Rando, O. J., Chi, T. H. & Crabtree, G. R. Second messenger control of chromatin remodeling. Nature Struct. Biol. 10,81-83 (2003).
    • (2003) Nature Struct. Biol. , vol.10 , pp. 81-83
    • Rando, O.J.1    Chi, T.H.2    Crabtree, G.R.3
  • 87
    • 0025094356 scopus 로고
    • Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction
    • June, C. H. et al. Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction. Proc. Natl Acad. Sci. USA 87, 7722-7726 (1990).
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 7722-7726
    • June, C.H.1
  • 88
    • 0025835006 scopus 로고
    • T-cell antigen receptor ligation induces tyrosine phosphorylation of phospholipase C-γ1
    • Secrist, J. P., Karnitz, L. & Abraham, R. T. T-cell antigen receptor ligation induces tyrosine phosphorylation of phospholipase C-γ1. J. Biol. Chem. 266, 12135-12139 (1991).
    • (1991) J. Biol. Chem. , vol.266 , pp. 12135-12139
    • Secrist, J.P.1    Karnitz, L.2    Abraham, R.T.3
  • 89
    • 0030802186 scopus 로고    scopus 로고
    • A spontaneously arising mutation in the DLAARN motiff of murine ZAP-70 abrogates kinase activity and arrests thymocyte development
    • Wiest, D. L. et al. A spontaneously arising mutation in the DLAARN motiff of murine ZAP-70 abrogates kinase activity and arrests thymocyte development. Immunity 6, 663-671 (1997).
    • (1997) Immunity , vol.6 , pp. 663-671
    • Wiest, D.L.1
  • 90
    • 0036574913 scopus 로고    scopus 로고
    • Unravelling heterochromatin: Competition between positive and negative factors regulates accessibility
    • Dillon, N. & Festenstein, R. Unravelling heterochromatin: competition between positive and negative factors regulates accessibility. Trends Genet. 18, 252-258 (2002).
    • (2002) Trends Genet. , vol.18 , pp. 252-258
    • Dillon, N.1    Festenstein, R.2
  • 91
    • 0032590004 scopus 로고    scopus 로고
    • Heterochromatin protein 1 modifies mammalian PEV in a dose- and chromosomal-context-dependent manner
    • Festenstein, R. et al. Heterochromatin protein 1 modifies mammalian PEV in a dose- and chromosomal-context-dependent manner. Nature Genet. 23, 457-461 (1999).
    • (1999) Nature Genet. , vol.23 , pp. 457-461
    • Festenstein, R.1
  • 92
    • 0035501077 scopus 로고    scopus 로고
    • Overexpression of AML1 transcription factor drives thymocytes into the CD8 single-positive lineage
    • Hayashi, K. et al. Overexpression of AML1 transcription factor drives thymocytes into the CD8 single-positive lineage, J. Immunol. 167, 4957-4965 (2001).
    • (2001) J. Immunol. , vol.167 , pp. 4957-4965
    • Hayashi, K.1
  • 93
    • 0028883199 scopus 로고
    • GATA transcription factors: Key regulators of hematopoiesis
    • Weiss, M. J. & Orkin, S. H. GATA transcription factors: key regulators of hematopoiesis. Exp. Hematol. 23, 99-107 (1995).
    • (1995) Exp. Hematol. , vol.23 , pp. 99-107
    • Weiss, M.J.1    Orkin, S.H.2
  • 94
    • 0036885067 scopus 로고    scopus 로고
    • The lineage decisions of helper T cells
    • Murphy, K. M. & Reiner, S. L. The lineage decisions of helper T cells. Nature Rev. Immunol. 2, 933-944 (2002).
    • (2002) Nature Rev. Immunol. , vol.2 , pp. 933-944
    • Murphy, K.M.1    Reiner, S.L.2
  • 95
    • 1242274405 scopus 로고    scopus 로고
    • GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells
    • Pai, S. Y., Truitt, M. L. & Ho, I. C. GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells. Proc. Natl Acad. Sci. USA 101, 1993-1998 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 1993-1998
    • Pai, S.Y.1    Truitt, M.L.2    Ho, I.C.3
  • 96
    • 0032992351 scopus 로고    scopus 로고
    • Expression of the transcription factor GATA-3 is required for the development of the earliest T cell progenitors and correlates with stages of cellular proliferation in the thymus
    • Hendriks, R. W. et al. Expression of the transcription factor GATA-3 is required for the development of the earliest T cell progenitors and correlates with stages of cellular proliferation in the thymus. Eur. J. Immunol. 29, 1912-1918 (1999).
    • (1999) Eur. J. Immunol. , vol.29 , pp. 1912-1918
    • Hendriks, R.W.1
  • 97
    • 0038783583 scopus 로고    scopus 로고
    • GATA-3 expression is controlled by TCR signals and regulates CD4/CD8 differentiation
    • Hernandez-Hoyos, G., Anderson, M. K., Wang, C., Rothenberg, E. V. & Alberola-Ila, J. GATA-3 expression is controlled by TCR signals and regulates CD4/CD8 differentiation. Immunity 19, 83-94 (2003). This study identifies the role of GATA3 in CD4-lineage differentiation using thymic reaggregation cultures,
    • (2003) Immunity , vol.19 , pp. 83-94
    • Hernandez-Hoyos, G.1    Anderson, M.K.2    Wang, C.3    Rothenberg, E.V.4    Alberola-Ila, J.5
  • 98
    • 0035879115 scopus 로고    scopus 로고
    • H2-committed T cell compartment in vivo
    • H2-committed T cell compartment in vivo. J. Immunol. 167, 724-732 (2001).
    • (2001) J. Immunol. , vol.167 , pp. 724-732
    • Nawijn, M.C.1
  • 99
    • 0026737664 scopus 로고
    • Studies on T cell maturation on defined thymic stromal cell populations in vitro
    • Jenkinson, E. J., Anderson, G. & Owen, J. J. Studies on T cell maturation on defined thymic stromal cell populations in vitro. J. Exp. Med. 176, 845-853 (1992).
    • (1992) J. Exp. Med. , vol.176 , pp. 845-853
    • Jenkinson, E.J.1    Anderson, G.2    Owen, J.J.3
  • 100
    • 0035879288 scopus 로고    scopus 로고
    • Enforced expression of GATA-3 during T cell development inhibits maturation of CD8 single-positive cells and induces thymic lymphoma in transgenic mice
    • Nawijn, M. C. et al. Enforced expression of GATA-3 during T cell development inhibits maturation of CD8 single-positive cells and induces thymic lymphoma in transgenic mice. J. Immunol. 167, 715-723 (2001).
    • (2001) J. Immunol. , vol.167 , pp. 715-723
    • Nawijn, M.C.1
  • 101
    • 0348110327 scopus 로고    scopus 로고
    • Critical roles for transcription factor GATA-3 in thymocyte development
    • + T-cell differentiation.
    • (2003) Immunity , vol.19 , pp. 863-875
    • Pai, S.Y.1
  • 102
    • 0035313978 scopus 로고    scopus 로고
    • Signal strength in thymic selection and lineage commitment
    • Hogquist, K. A. Signal strength in thymic selection and lineage commitment. Curr. Opin. Immunol. 13, 225-231 (2001).
    • (2001) Curr. Opin. Immunol. , vol.13 , pp. 225-231
    • Hogquist, K.A.1
  • 103
    • 0141807008 scopus 로고
    • The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex
    • Barber, E. K., Dasgupta, J. D., Schlossman, S. F., Trevillyan, J. M. & Rudd, C. E. The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex. Proc. Natl Acad. Sci. USA 86, 3277-3281 (1989).
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 3277-3281
    • Barber, E.K.1    Dasgupta, J.D.2    Schlossman, S.F.3    Trevillyan, J.M.4    Rudd, C.E.5
  • 104
    • 0023737931 scopus 로고
    • The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck
    • Veillette, A., Bookman, M. A., Horak, E. M. & Bolen, J. B. The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck, Cell 55, 301-308 (1988).
    • (1988) Cell , vol.55 , pp. 301-308
    • Veillette, A.1    Bookman, M.A.2    Horak, E.M.3    Bolen, J.B.4
  • 105
    • 0028141681 scopus 로고
    • Involvement of the protein tyrosine kinase p56lck in T cell signaling and thymocyte development
    • Anderson, S. J., Levin, S. D. & Perlmutter, R. M. Involvement of the protein tyrosine kinase p56lck in T cell signaling and thymocyte development. Adv. Immunol. 56, 151-178 (1994).
    • (1994) Adv. Immunol. , vol.56 , pp. 151-178
    • Anderson, S.J.1    Levin, S.D.2    Perlmutter, R.M.3
  • 106
    • 0027379699 scopus 로고
    • + thymocytes by p56lck tyrosine kinase: Basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules
    • + thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules. J. Exp. Med. 178, 1701-1712 (1993).
    • (1993) J. Exp. Med. , vol.178 , pp. 1701-1712
    • Wiest, D.L.1
  • 107
    • 0026522260 scopus 로고
    • Signal for T-cell differentiation to a CD4 cell lineage is delivered by CD4 transmembrane region and/or cytoplasmic tail
    • Seong, R. H., Chamberlain, J. W. & Parnes, J. R. Signal for T-cell differentiation to a CD4 cell lineage is delivered by CD4 transmembrane region and/or cytoplasmic tail. Nature 356, 718-720 (1992).
    • (1992) Nature , vol.356 , pp. 718-720
    • Seong, R.H.1    Chamberlain, J.W.2    Parnes, J.R.3
  • 108
    • 0030002882 scopus 로고    scopus 로고
    • The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells
    • Itano, A. et al. The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells. J. Exp. Med. 183, 731-741 (1996).
    • (1996) J. Exp. Med. , vol.183 , pp. 731-741
    • Itano, A.1
  • 109
    • 0029988961 scopus 로고    scopus 로고
    • MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent
    • Matechak, E. O., Killeen, N., Hedrick, S. M. & Fowlkes, B. J. MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent. Immunity 4, 337-347 (1996). References 108 and 109 report the observations that gave rise to the strength-of-signal hypothesis.
    • (1996) Immunity , vol.4 , pp. 337-347
    • Matechak, E.O.1    Killeen, N.2    Hedrick, S.M.3    Fowlkes, B.J.4
  • 110
    • 1242343668 scopus 로고    scopus 로고
    • The CD8 population in CD4-deficient mice is heavily contaminated with MHC class II-restricted T cells
    • Tyznik, A. J., Sun, J. C. & Bevan, M. J. The CD8 population in CD4-deficient mice is heavily contaminated with MHC class II-restricted T cells. J. Exp. Med. 199, 559-565 (2004).
    • (2004) J. Exp. Med. , vol.199 , pp. 559-565
    • Tyznik, A.J.1    Sun, J.C.2    Bevan, M.J.3
  • 111
    • 0033696201 scopus 로고    scopus 로고
    • Lck activity controls CD4/CD8 T cell lineage commitment
    • Hernandez-Hoyos, G., Sohn, S. J., Rothenberg, E. V. & Alberola-Ila, J. Lck activity controls CD4/CD8 T cell lineage commitment. Immunity 12, 313-322 (2000). This paper documents that interfering with LCK activity redirects thymocytes into the 'wrong' lineage: transgenic LCK molecules with constitutive or disrupted catalytic activity promote CD4- or CD8-lineage differentiation, respectively.
    • (2000) Immunity , vol.12 , pp. 313-322
    • Hernandez-Hoyos, G.1    Sohn, S.J.2    Rothenberg, E.V.3    Alberola-Ila, J.4
  • 112
    • 0030989595 scopus 로고    scopus 로고
    • Signals through CD8 or CD4 can induce commitment to the CD4 lineage in the thymus
    • Bommhardt, U., Cole, M. S., Tso, J. Y. & Zamoyska, R. Signals through CD8 or CD4 can induce commitment to the CD4 lineage in the thymus. Eur. J. Immunol. 27, 1152-1163 (1997).
    • (1997) Eur. J. Immunol. , vol.27 , pp. 1152-1163
    • Bommhardt, U.1    Cole, M.S.2    Tso, J.Y.3    Zamoyska, R.4
  • 113
  • 114
    • 0034544509 scopus 로고    scopus 로고
    • The quantity of TCR signal determines positive selection and lineage commitment of T cells
    • Watanabe, N., Arase, H., Onodera, M., Ohashi, P. S. & Saito, T. The quantity of TCR signal determines positive selection and lineage commitment of T cells. J. Immunol. 165, 6252-6261 (2000).
    • (2000) J. Immunol. , vol.165 , pp. 6252-6261
    • Watanabe, N.1    Arase, H.2    Onodera, M.3    Ohashi, P.S.4    Saito, T.5
  • 115
    • 0028051551 scopus 로고
    • Role of TCR ζ chain in T cell development and selection
    • Shores, E. W. et al. Role of TCR ζ chain in T cell development and selection. Science 266, 1047-1050 (1994).
    • (1994) Science , vol.266 , pp. 1047-1050
    • Shores, E.W.1
  • 116
    • 0028904413 scopus 로고
    • + thymocytes
    • + thymocytes. Nature 374, 474-477 (1995).
    • (1995) Nature , vol.374 , pp. 474-477
    • Fischer, K.D.1
  • 117
    • 0028956337 scopus 로고
    • Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav
    • Tarakhovsky, A. et al. Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav. Nature 374, 467-470 (1995).
    • (1995) Nature , vol.374 , pp. 467-470
    • Tarakhovsky, A.1
  • 118
    • 0028915948 scopus 로고
    • Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene
    • Zhang, R., Alt, F. W., Davidson, L., Orkin, S. H. & Swat, W. Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene. Nature 374, 470-473 (1995).
    • (1995) Nature , vol.374 , pp. 470-473
    • Zhang, R.1    Alt, F.W.2    Davidson, L.3    Orkin, S.H.4    Swat, W.5
  • 119
    • 0029658305 scopus 로고    scopus 로고
    • Requirement for p56lck tyrosine kinase activation in T cell receptor-mediated thymic selection
    • Hashimoto, K. et al. Requirement for p56lck tyrosine kinase activation in T cell receptor-mediated thymic selection. J. Exp. Med. 184, 931-943 (1996).
    • (1996) J. Exp. Med. , vol.184 , pp. 931-943
    • Hashimoto, K.1
  • 120
    • 0030719389 scopus 로고    scopus 로고
    • A requirement for the Rho-family GTP exchange factor Vav in positive and negative selection of thymocytes
    • Turner, M. et al. A requirement for the Rho-family GTP exchange factor Vav in positive and negative selection of thymocytes. Immunity 7, 451-460 (1997).
    • (1997) Immunity , vol.7 , pp. 451-460
    • Turner, M.1
  • 121
    • 17144458301 scopus 로고    scopus 로고
    • Defective thymocyte maturation in p44 MAP kinase (Erk1) knockout mice
    • Pages, G. et al. Defective thymocyte maturation in p44 MAP kinase (Erk1) knockout mice. Science 266, 1374-1377 (1999).
    • (1999) Science , vol.266 , pp. 1374-1377
    • Pages, G.1
  • 122
    • 0035033216 scopus 로고    scopus 로고
    • Strength of signaling by CD4 and CD8 coreceptor tails determines the number but not the lineage direction of positively selected thymocytes
    • Bosselut, R., Feigenbaum, L., Sharrow, S. O. & Singer, A. Strength of signaling by CD4 and CD8 coreceptor tails determines the number but not the lineage direction of positively selected thymocytes. Immunity 14, 483-494 (2001). This paper compared the efficiency of the CD4 and CD8 cytoplasmic tails in promoting CD4- and CD8-lineage differentiation. The results indicate that, when fused to the CD8 molecule, the CD4 tail promotes equally the differentiation of MHC class-I-restricted thymocytes into CD4- and CD8-lineage T cells.
    • (2001) Immunity , vol.14 , pp. 483-494
    • Bosselut, R.1    Feigenbaum, L.2    Sharrow, S.O.3    Singer, A.4
  • 123
    • 0034732334 scopus 로고    scopus 로고
    • + T-cell lineage fate
    • + T-cell lineage fate. Nature 404, 506-510 (2000). An in vitro study using an original two-step culture system to propose a role for TCR-signal duration in lineage differentiation. Unlike the kinetic signalling model, lineage choice in this system seems to occur before any change in co-receptor gene expression.
    • (2000) Nature , vol.404 , pp. 506-510
    • Yasutomo, K.1    Doyle, C.2    Miele, L.3    Fuchs, C.4    Germain, R.N.5
  • 124
    • 0028340167 scopus 로고
    • ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency
    • Chan, A. C. et al. ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency. Science 264, 1599-1601 (1994).
    • (1994) Science , vol.264 , pp. 1599-1601
    • Chan, A.C.1
  • 125
    • 0028292001 scopus 로고
    • Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase
    • Elder, M. E. et al. Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase. Science 264, 1596-1599 (1994).
    • (1994) Science , vol.264 , pp. 1596-1599
    • Elder, M.E.1
  • 126
    • 0029133646 scopus 로고
    • Essential role for ZAP-70 in both positive and negative selection of thymocytes
    • Negishi, I. et al. Essential role for ZAP-70 in both positive and negative selection of thymocytes. Nature 376, 435-438 (1995).
    • (1995) Nature , vol.376 , pp. 435-438
    • Negishi, I.1
  • 127
    • 0037415559 scopus 로고    scopus 로고
    • + thymocytes reveals a T cell receptor-dependent proofreading mechanism controlling the completion of positive selection
    • + thymocytes reveals a T cell receptor-dependent proofreading mechanism controlling the completion of positive selection. J. Exp. Med. 197, 363-373 (2003).
    • (2003) J. Exp. Med. , vol.197 , pp. 363-373
    • Liu, X.1
  • 128
    • 0030916961 scopus 로고    scopus 로고
    • Peptide-induced positive selection of TCR transgenic thymocytes in a coreceptor-independent manner
    • Sebzda, E., Choi, M., Fung-Leung, W. P., Mak, T. W. & Ohashi, P. S. Peptide-induced positive selection of TCR transgenic thymocytes in a coreceptor-independent manner. Immunity 6, 643-653 (1997).
    • (1997) Immunity , vol.6 , pp. 643-653
    • Sebzda, E.1    Choi, M.2    Fung-Leung, W.P.3    Mak, T.W.4    Ohashi, P.S.5
  • 130
    • 0036533386 scopus 로고    scopus 로고
    • New perspectives on a developmental dilemma: The kinetic signaling model and the importance of signal duration for the CD4/CD8 lineage decision
    • Singer, A. New perspectives on a developmental dilemma: the kinetic signaling model and the importance of signal duration for the CD4/CD8 lineage decision. Curr. Opin. Immunol. 14, 207-215 (2002).
    • (2002) Curr. Opin. Immunol. , vol.14 , pp. 207-215
    • Singer, A.1
  • 131
    • 0030990038 scopus 로고    scopus 로고
    • CD8 lineage commitment in the absence of CD8
    • Goldrath, A. W., Hogquist, K. A. & Bevan, M. J. CD8 lineage commitment in the absence of CD8. Immunity 6, 633-642 (1997).
    • (1997) Immunity , vol.6 , pp. 633-642
    • Goldrath, A.W.1    Hogquist, K.A.2    Bevan, M.J.3
  • 132
    • 0032572720 scopus 로고    scopus 로고
    • Csk controls antigen receptor-mediated development and selection of T-lineage cells
    • Schmedt, C. et al. Csk controls antigen receptor-mediated development and selection of T-lineage cells. Nature 394, 901-904 (1998).
    • (1998) Nature , vol.394 , pp. 901-904
    • Schmedt, C.1
  • 133
    • 0035864352 scopus 로고    scopus 로고
    • Activated p56lck directs maturation of both CD4 and CD8 single-positive thymocytes
    • Sohn, S. J., Forbush, K. A., Pan, X. C. & Perlmutter, R. M. Activated p56lck directs maturation of both CD4 and CD8 single-positive thymocytes. J. Immunol. 166, 2209-2217 (2001).
    • (2001) J. Immunol. , vol.166 , pp. 2209-2217
    • Sohn, S.J.1    Forbush, K.A.2    Pan, X.C.3    Perlmutter, R.M.4
  • 134
    • 15844374279 scopus 로고    scopus 로고
    • H2 response and IgE class switching in mice with disrupted Stat6 gene
    • H2 response and IgE class switching in mice with disrupted Stat6 gene. Nature 380, 630-633 (1996).
    • (1996) Nature , vol.380 , pp. 630-633
    • Shimoda, K.1
  • 135
    • 15844404509 scopus 로고    scopus 로고
    • Essential role of Stat6 in IL-4 signalling
    • Takeda, K. et al. Essential role of Stat6 in IL-4 signalling. Nature 380, 627-630 (1996).
    • (1996) Nature , vol.380 , pp. 627-630
    • Takeda, K.1
  • 136
    • 0033973582 scopus 로고    scopus 로고
    • H2 development and commitment
    • H2 development and commitment. Immunity 12, 27-37 (2000).
    • (2000) Immunity , vol.12 , pp. 27-37
    • Ouyang, W.1
  • 137
    • 0035222187 scopus 로고    scopus 로고
    • H2 differentiation in allergic airway inflammation
    • H2 differentiation in allergic airway inflammation. Nature Immunol. 2, 45-50 (2001).
    • (2001) Nature Immunol. , vol.2 , pp. 45-50
    • Das, J.1
  • 138
    • 0041488620 scopus 로고    scopus 로고
    • The influence of the thymic environment on the CD4-versus-CD8 T lineage decision
    • Canelles, M., Park, M. L., Schwartz, O. M. & Fowlkes, B. J. The influence of the thymic environment on the CD4-versus-CD8 T lineage decision. Nature Immunol. 4, 756-764 (2003).
    • (2003) Nature Immunol. , vol.4 , pp. 756-764
    • Canelles, M.1    Park, M.L.2    Schwartz, O.M.3    Fowlkes, B.J.4
  • 139
    • 2442597781 scopus 로고    scopus 로고
    • TOX provides a link between calcineurin activation and CD8 lineage commitment
    • Aliahmad, P. et al. TOX provides a link between calcineurin activation and CD8 lineage commitment. J. Exp. Med. 199, 1089-1099 (2004).
    • (2004) J. Exp. Med. , vol.199 , pp. 1089-1099
    • Aliahmad, P.1
  • 140
    • 0037815268 scopus 로고    scopus 로고
    • H2 lineage by repressing GATA3 expression
    • H2 lineage by repressing GATA3 expression. J. Exp. Med. 198, 51-61 (2003).
    • (2003) J. Exp. Med. , vol.198 , pp. 51-61
    • Komine, O.1
  • 141
    • 0033527615 scopus 로고    scopus 로고
    • Regulation of lineage commitment distinct from positive selection
    • Keefe, R., Dave, V., Allman, D., Wiest, D. & Kappes, D. J. Regulation of lineage commitment distinct from positive selection. Science 266, 1149-1153 (1999).
    • (1999) Science , vol.266 , pp. 1149-1153
    • Keefe, R.1    Dave, V.2    Allman, D.3    Wiest, D.4    Kappes, D.J.5
  • 142
    • 0036636857 scopus 로고    scopus 로고
    • Core-binding factors in haematopoiesis and leukaemia
    • Speck, N. A. & Gilliland, D. G. Core-binding factors in haematopoiesis and leukaemia. Nature Rev. Cancer 2, 502-513 (2002).
    • (2002) Nature Rev. Cancer , vol.2 , pp. 502-513
    • Speck, N.A.1    Gilliland, D.G.2
  • 143
    • 0034486564 scopus 로고    scopus 로고
    • Mechanisms of transcriptional regulation by Runt domain proteins
    • Wheeler, J. C., Shigesada, K., Gergen, J. P. & Ito, Y. Mechanisms of transcriptional regulation by Runt domain proteins. Semin. Cell. Dev. Biol. 11, 369-375 (2000).
    • (2000) Semin. Cell. Dev. Biol. , vol.11 , pp. 369-375
    • Wheeler, J.C.1    Shigesada, K.2    Gergen, J.P.3    Ito, Y.4
  • 144
    • 0033916901 scopus 로고    scopus 로고
    • Groucho/TLE/R-esp proteins associate with the nuclear matrix and repress RUNX (CBFα/AML/PEBP2α) dependent activation of tissue-specific gene transcription
    • Javed, A. et al. Groucho/TLE/R-esp proteins associate with the nuclear matrix and repress RUNX (CBFα/AML/PEBP2α) dependent activation of tissue-specific gene transcription. J. Cell Sci. 113, 2221-2231 (2000).
    • (2000) J. Cell Sci. , vol.113 , pp. 2221-2231
    • Javed, A.1
  • 145
    • 0028131194 scopus 로고
    • Elf-1 binds to a critical element in a second CD4 enhancer
    • Wurster, A. L., Siu, G., Leiden, J. M. & Hedrick, S. M. Elf-1 binds to a critical element in a second CD4 enhancer. Mol. Cell. Biol. 14, 6452-6463 (1994).
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 6452-6463
    • Wurster, A.L.1    Siu, G.2    Leiden, J.M.3    Hedrick, S.M.4
  • 146
    • 0030022783 scopus 로고    scopus 로고
    • Characterization of an intronless CD4 minigene expressed in mature CD4 and CD8 T cells, but not expressed in immature thymocytes
    • Salmon, P., Boyer, O., Lores, P., Jami, J. & Klatzmann, D. Characterization of an intronless CD4 minigene expressed in mature CD4 and CD8 T cells, but not expressed in immature thymocytes. J. Immunol. 156, 1873-1879 (1996).
    • (1996) J. Immunol. , vol.156 , pp. 1873-1879
    • Salmon, P.1    Boyer, O.2    Lores, P.3    Jami, J.4    Klatzmann, D.5
  • 147
    • 0031058251 scopus 로고    scopus 로고
    • Thymocytes control the CD4 gene differently from mature T lymphocytes
    • Uematsu, Y., Donda, A. & De, L. G. Thymocytes control the CD4 gene differently from mature T lymphocytes. Int. Immunol. 9, 179-187 (1997).
    • (1997) Int. Immunol. , vol.9 , pp. 179-187
    • Uematsu, Y.1    Donda, A.2    De, L.G.3
  • 148
    • 0037331666 scopus 로고    scopus 로고
    • Hierarchical interactions control CD4 gene expression during thymocyte development
    • Adlam, M. & Siu, G. Hierarchical interactions control CD4 gene expression during thymocyte development. Immunity 18, 173-184 (2003).
    • (2003) Immunity , vol.18 , pp. 173-184
    • Adlam, M.1    Siu, G.2
  • 149
    • 0030059620 scopus 로고    scopus 로고
    • Identification and characterization of a human CD4 silencer
    • Donda, A., Schulz, M., Burki, K., De, L. G. & Uematsu, Y. Identification and characterization of a human CD4 silencer. Eur. J. Immunol. 26, 493-500 (1996).
    • (1996) Eur. J. Immunol. , vol.26 , pp. 493-500
    • Donda, A.1    Schulz, M.2    Burki, K.3    De, L.G.4    Uematsu, Y.5
  • 150
    • 0035052917 scopus 로고    scopus 로고
    • Negative regulation of CD4 gene expression by a HES-1-c-Myb complex
    • Allen, R. D., Kim, H. K., Sarafova, S. D. & Siu, G. Negative regulation of CD4 gene expression by a HES-1-c-Myb complex. Mol. Cell. Biol. 21, 3071-3082 (2001).
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 3071-3082
    • Allen, R.D.1    Kim, H.K.2    Sarafova, S.D.3    Siu, G.4
  • 151
    • 0033103765 scopus 로고    scopus 로고
    • Positive selection as a developmental progression initiated by αβ TCR signals that fix TCR specificity prior to lineage commitment
    • Bhandoola, A. et al. Positive selection as a developmental progression initiated by αβ TCR signals that fix TCR specificity prior to lineage commitment. Immunity 10, 301-311 (1999).
    • (1999) Immunity , vol.10 , pp. 301-311
    • Bhandoola, A.1
  • 154
    • 0035202314 scopus 로고    scopus 로고
    • Deletion of the CD4 silencer element supports a stochastic mechanism of thymocyte lineage commitment
    • Leung, R. K. et al. Deletion of the CD4 silencer element supports a stochastic mechanism of thymocyte lineage commitment. Nature Immunol. 2, 1167-1173 (2001).
    • (2001) Nature Immunol. , vol.2 , pp. 1167-1173
    • Leung, R.K.1
  • 155
    • 2442522357 scopus 로고    scopus 로고
    • Regulation of αβ/γδ T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling
    • Tanigaki, K. et al. Regulation of αβ/γδ T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling. Immunity 20, 611-622 (2004).
    • (2004) Immunity , vol.20 , pp. 611-622
    • Tanigaki, K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.