Hierarchical interactions control CD4 gene expression during thymocyte development

Immunity

Volumn 18, Issue 2, 2003, Pages 173-184

  Adlam, Matthew ^b   Siu, Gerald ^a  

^a AMGEN INC   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN;

ANIMAL CELL; CELL LINEAGE; CELL MATURATION; CONTROLLED STUDY; ENHANCER REGION; GENE ACTIVITY; GENE EXPRESSION REGULATION; GENE LOCATION; GENE LOCUS; GENE SILENCING; GROWTH REGULATION; HEMATOPOIESIS; INTRON; MOUSE; NONHUMAN; POSITION EFFECT VARIEGATION; PRIORITY JOURNAL; REPORTER GENE; REVIEW; THYMOCYTE; TRANSGENE;

EID: 0037331666     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(03)00021-9     Document Type: Review

References (41)

1. Adlam M., Duncan D.D., Ng D.K., Siu G. Positive selection induces CD4 promoter and enhancer function. Int. Immunol. 9:1997;877-887.
2. Allen R.D., Bender T.P., Siu G. c-Myb is essential for early T cell development. Genes Dev. 13:1999;1073-1078.
3. Ansari-Lari M.A., Muzny D.M., Lu J., Lu F., Lilley C.E., Spanos S., Malley T., Gibbs R.A. A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13. Genome Res. 6:1996;314-326.
4. Boyer O., Zhao J.C., Cohen J.L., Depetris D., Yagello M., Lejeune L., Bruel S., Mattei M.G., Klatzmann D. Position-dependent variegation of a CD4 minigene with targeted expression to mature CD4+ T cells. J. Immunol. 159:1997;3383-3390.
5. Ceredig R., Rolink T. Opinion. a positive look at double-negative thymocytes Nat. Rev. Immunol. 2:2002;888-897.
6. Corbella P., Moskophidis D., Spanopoulou E., Mamalaki C., Tolaini M., Itano A., Lans D., Baltimore D., Robey E., Kioussis D. Functional commitment to helper T cell lineage precedes positive selection and is independent of T cell receptor MHC specificity. Immunity. 1:1994;269-276.
7. Duncan D.D., Adlam M., Siu G. Asymmetric redundancy in CD4 silencer function. Immunity. 4:1996;301-311.
8. Ellmeier W., Kioussis D. Chromatin and CD4, CD8A and CD8B gene expression during thymic differentiaion. Nat. Rev. Immunol. 2:2002;909-919.
9. Ellmeier W., Sawada S., Littman D.R. The regulation of CD4 and CD8 coreceptor gene expression during T cell development. Annu. Rev. Immunol. 17:1999;523-554.
10. Ellmeier W., Sunshine M.J., Maschek R., Littman D.R. Combined deletion of CD8 locus cis-regulatory elements affects initiation but not maintenance of CD8 expression. Immunity. 16:2002;623-634.
11. Festenstein R., Kioussis D. Locus control regions and epigenetic chromatin modifiers. Curr. Opin. Genet. Dev. 10:2000;199-203.
12. Fowlkes B.J., Pardoll D. Molecular and cellular events of T cell development. Adv. Immunol. 44:1989;207-264.
13. Frederickson G.G., Basch R.S. L3T4 antigen expression by hemopoietic precursor cells. J. Exp. Med. 169:1989;1473-1478.
14. Garefalaki A., Coles M., Hirschberg S., Mavria G., Norton T., Hostert A., Kioussis D. Variegated expression of CD8α resulting from in situ deletion of regulatory sequences. Immunity. 16:2002;635-647.
15. + T cells. Curr. Opin. Immunol. 8:1996;225-232.
16. + T cells and in macrophages of transgenic mice. Mol. Cell. Biol. 14:1994;1084-1094.
17. Hostert A., Tolaini M., Festenstein R., McNeill L., Malissen B., Williams O., Zamoyska R., Kioussis D. A CD8 genomic fragment that directs subset-specific expression of CD8 in transgenic mice. J. Immunol. 158:1997;4270-4281. a.
18. Hostert A., Tolaini M., Roderick K., Harker N., Norton T., Kioussis D. A region in the CD8 gene locus that directs expression to the mature CD8 T cell subset in transgenic mice. Immunity. 7:1997;525-536. b.
19. Hostert A., Garefalaki A., Mavria G., Tolaini M., Roderick K., Norton T., Mee P.J., Tybulewicz V.L., Coles M., Kioussis D. Hierarchical interactions of control elements determine CD8α gene expression in subsets of thymocytes and peripheral T cells. Immunity. 9:1998;497-508.
20. Hu M., Krause D., Greaves M., Sharkis S., Dexter M., Heyworth C., Enver T. Multilineage gene expression precedes commitment in the hemopoietic system. Genes Dev. 11:1997;774-785.
21. Igarashi H., Gregory S.C., Yokota T., Sakaguchi N., Kincade P.W. Transcription from the RAG1 locus marks the earliest lymphocyte progenitors in bone marrow. Immunity. 17:2002;117-130.
22. Kondo M., Weissman I.L., Akashi K. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell. 91:1997;661-672.
23. + thymocyte differentiation. Immunity. 5:1996;461-477.
24. MacDonald H.R., Radtke F., Wilson A. T cell fate specification and alphabeta/gammadelta lineage commitment. Curr. Opin. Immunol. 13:2001;219-224.
25. Merli C., Bergstrom D.E., Cygan J.A., Blackman R.K. Promoter specificity mediates the independent regulation of neighboring genes. Genes Dev. 10:1996;1260-1270.
26. Michie A.M., Carlyle J.R., Zuniga-Pflucker J.C. Early intrathymic precursor cells acquire a CD4(low) phenotype. J. Immunol. 160:1998;1735-1741.
27. Miyamoto T., Iwasaki H., Reizis B., Ye M., Graf T., Weissman I.L., Akashi K. Myeloid or lymphoid promiscuity as a critical step in hematopoietic lineage commitment. Dev. Cell. 3:2002;137-147.
28. Salmon P., Boyer O., Lores P., Jami J., Klatzmann D. Characterization of an intronless CD4 minigene expressed in mature CD4 and CD8 T cells, but not expressed in immature thymocytes. J. Immunol. 156:1996;1873-1879.
29. Sarafova S.D., Siu G. A potential role for Elf-1 in CD4 promoter function. J. Biol. Chem. 274:1999;16126-16134.
30. Sarafova S.D., Siu G. Precise orientation of factor-binding sites is required for CD4 promoter function. Nucleic Acids Res. 28:2000;2664-2671.
31. Sawada S., Scarborough J.D., Killeen N., Littman D.R. A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development. Cell. 77:1994;917-929.
32. Singer A. New perspectives on a developmental dilemma. the kinetic signaling model and the importance of signal duration for the CD4/CD8 lineage decision Curr. Opin. Immunol. 14:2002;207-215.
33. Siu G. Controlling CD4 gene expression during T cell lineage commitment. Semin. Immunol. 14:2002;441-451.
34. Siu G., Wurster A.L., Duncan D.D., Soliman T.M., Hedrick S.M. A transcriptional silencer controls the developmental expression of the CD4 gene. EMBO J. 13:1994;3570-3579.
35. + T cell lineages. a new perspective on thymic commitment and selection Immunity. 2:1995;413-425.
36. Takahama Y., Singer A. Post-transcriptional regulation of early T cell development by T cell receptor signals. Science. 258:1992;1456-1462.
37. Uematsu Y., Donda A., De Libero G. Thymocytes control the CD4 gene differently from mature T lymphocytes. Int. Immunol. 9:1997;179-187.
38. Vyas P., Vickers M.A., Simmons D.L., Ayyub H., Craddock C.F., Higgs D.R. Cis-acting sequences regulating expression of the human α-globin cluster lie within constitutively open chromatin. Cell. 69:1992;781-793.
39. Wineman J.P., Gilmore G.L., Gritzmacher C., Torbett B.E., Muller-Sieburg C.E. CD4 is expressed on murine pluripotent hematopoietic stem cells. Blood. 80:1992;1717-1724.
40. Wu L., Scollay R., Egerton M., Pearse M., Spangrude G.J., Shortman K. CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus. Nature. 349:1991;71-74.
41. Zuniga-Pflucker J.C., Di J., Lenardo M.J. Requirement for TNF-alpha and IL-1 alpha in fetal thymocyte commitment and differentiation. Science. 268:1995;1906-1909.