Csk controls antigen receptor-mediated development and selection of T- lineage cells

Nature

Volumn 394, Issue 6696, 1998, Pages 901-904

  Schmedt, Christian ^a   Saijo, Kaoru ^a   Niidome, Tetsuhiro ^b,c   Kühn, Ralf ^a   Aizawa, Shinichi ^b   Tarakhovsky, Alexander ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

^b KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

^c Tsukuba Research Laboratories   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANTIGEN SPECIFICITY; ARTICLE; CELL LINEAGE; CELL SELECTION; CELL SPECIFICITY; GROWTH REGULATION; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; THYMOCYTE;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL LINEAGE; CELLS, CULTURED; HISTOCOMPATIBILITY ANTIGENS CLASS II; LEUKOPOIESIS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; PROTEIN-TYROSINE KINASES; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; T-LYMPHOCYTES;

EID: 0032572720     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/29802     Document Type: Article

References (29)

1. von Boehmer, H. & Fehling, H. J. Structure and function of the pre-T cell receptor. Annu. Rev. Immunol. 15, 432-452 (1997).
2. Mombaerts, P. Lymphocyte development and function in T-cell receptor and RAG-1 mutant mice. Int. Rev. Immunol. 13, 43-63 (1995).
3. Alberola-Ila, J., Takaki, S., Kerner, J. D. & Perlmutter, R. M. Differential signaling by lymphocyte antigen receptors. Annu. Rev. Immunol. 15, 125-154 (1997).
4. Weiss, A. & Littman, D. R. Signal transduction by lymphocyte antigen receptors. Cell 76, 263-274 (1994).
5. c-src. Nature 351, 69-72 (1991).
6. Jameson, S. C., Hogquist, K. A. & Bevan, M. J. Positive selection of thymocytes. Annu. Rev. Immunol. 13, 93-126 (1995).
7. Groves, T. et al. Fyn can partially substitute for Lck in T lymphocyte development. Immunity 5, 417-428 (1996).
8. van Oers, N. S., Lowin-Kropf, B., Finlay, D., Connolly, K. & Weiss, A. αβ T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases. Immunity 5, 429-436 (1996).
9. Mombaerts, P., Anderson, S. J., Perlmutter, R. M., Mak, T. W. & Tonegawa, S. An activated lck transgene promotes thymocyte development in RAG-1 mutant mice. Immunity 1, 261-267 (1994).
10. Nada, S. et al. Constitutive activation of Src family kinases in mouse embryos that lack Csk. Cell 73, 1125-1135 (1993).
11. Imamoto, A. & Soriano, P. Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice. Cell 73, 1117-1124 (1993).
12. Hanks, S. K. & Hunter, T. Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. FASEB J. 9, 576-596 (1995).
13. Kühn, R., Schwenk, F., Aguet, M. & Rajewsky, K. Inducible gene targeting in mice. Science 269, 1427-1429 (1995).
14. -/- mice. J. Immunol. 157, 2366-2373 (1996).
15. Mombaerts, P. et al. Mutations in T-cell antigen receptor genes α and β and block thymocyte development at different stages. Nature 360, 225-231 (1992).
16. - thymocytes lacking the heat-stable antigen. Cell Immunol. 117, 312-326 (1988).
17. + thymocytes. Eur. J. Immunol. 23, 739-746 (1993).
18. Sprent, J. & Tough, D. F. Lymphocyte life-span and memory. Science 265, 1395-1400 (1994).
19. lck. Cell 55, 301-308 (1988).
20. Norment, A. M., Forbush, K. A., Nguyen, N., Malissen, M. & Perlmutter, R. M. Replacement of pre-T cell recpetor signaling functions by the CD4 coreceptor. J. Exp. Med. 185, 121-130 (1997).
21. Köntgen, F., Suss, G., Stewart, C., Steinmetz, M. & Bluethmann, H. Targeted disruption of the MHC class II Aα gene in C57BL/6 mice. Int. Immunol. 5, 957-964 (1993).
22. + T cells in major histocompatlbility complex class II-deficient mice. Science 253, 1417-1420 (1991).
23. Gosgrove, D. et al. Mice lacking MHC class II molecules. Cell 66, 1051-1066 (1991).
24. Torres, R. & Kühn, R. Laboratory Protocols for Conditional Gene Targeting (Oxford Univ. Press 1997).
25. Ledbetter, J. A. & Herzenberg, L. A. Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens. Immunol. Rev. 47, 63-90 (1979).
26. lck. EMBO J. 11, 4877-4886 (1992).
27. Krotkova, A., von Boehmer, H. & Fehling, H. J. Allelic exclusion in pTα-deficient mice: no evidence for cell surface expression of two T cell receptor (TCR)-β chains but less efficient inhibition of endogenous Vβ → (D)Jβ rearrangements in the presence of a functional TCR-β transgene. J. Exp. Med. 186, 767-775 (1997).
28. Saijo, K., Park, S. Y., Ishida, Y., Arase, H. & Saito, T. Crucial role of Jak3 in negative selection of self-reactive T cells. J. Exp. Med. 185, 351-356 (1997).
29. Murphy, E. et al. Reversibility of T helper 1 and 2 populations is lost after long-term stimulation. J. Exp. Med. 183, 901-913 (1996).