MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent

Immunity

Volumn 4, Issue 4, 1996, Pages 337-347

  Matechak, Errin O ^a   Killeen, Nigel ^b   Hedrick, Stephen M ^c   Fowlkes, B J ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; STEM CELL; T LYMPHOCYTE; THYMOCYTE; TRANSGENIC MOUSE;

EID: 0029988961     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80247-2     Document Type: Article

References (53)

1. Arnold, L.W., LoCascio, N.J., Lutz, P.M., Pennell, C.A., Klapper, D., and Haughton, G. (1983). Antigen-induced lymphomagenesis: identification of a murine B cell lymphoma with known antigen specificity. J. Immunol. 131, 2064-2068.
2. + cells in beta 2-microglobulin-deficient mice. Eur. J. Immunol. 24, 1933-1936.
3. Berg, L.J.,Fazekas de St. Groth, B., Pullen, A.M., and Davis, M.M. (1989a). Phenotypic differences between alpha beta versus beta T-cell receptor transgenic mice undergoing negative selection. Nature 340, 559-562.
4. Berg, L.J., Pullen, A.M., Fazekas de St. Groth, B., Mathis, D., Benoist, C., and Davis, M.M. (1989b). Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand. Cell 58, 1035-1046.
5. Bix, M., Liao, N.S., Zijlstra, M., Loring, J., Jaenisch, R., and Raulet, D. (1991). Rejection of class I MHC-deficient haematopoietic cells by irradiated MHC-matched mice. Nature 349, 329-331.
6. Brandle, D., Muller, S., Muller, C., Hengartner, H., and Pircher, H. (1994). Regulation of RAG-1 and CD69 expression in the thymus during positive and negative selection. Eur. J. Immunol. 24, 145-151.
7. Bruce, J., Symington, F.W., McKearn, T.J., and Sprent, J. (1981). A monoclonal antibody discriminating between subsets of T and B cells. J. Immunol. 127, 2496-2501.
8. Chan, S.H., Cosgrove, D., Waltzinger, C., Benoist, C., and Mathis, D. (1993). Another view of the selective model of thymocyte selection. Cell 73, 225-236.
9. Chan, S.H., Waltzinger, C., Baron, A., Benoist, C., and Mathis, D. (1994). Role of coreceptors in positive selection and lineage commitment. EMBO J. 13, 4482-4489.
10. Coligan, J.E., Kruisbeek, A.M., Margulies, D.H., Shevach, E.M., and Strober, W. (1995). Current Protocols in Immunology (New York: John Wiley and Sons, Incorporated).
11. Corbella, P., Moskophidis, D., Spanopoulou, E., Mamalaki, C., Tolaini, M., Itano, A., Lans, D., Baltimore, D., Robey, E., and Kioussis, D. (1994). Functional commitment to helper T cell lineage precedes positive selection and is independent of T cell receptor MHC specificity. Immunity 1, 269-276.
12. Crump, A.L., Grusby, M.J., Glimcher, L.H., and Cantor, H. (1993). Thymocyte development in major histocompatibility complex-deficient mice: evidence for stochastic commitment to the CD4 and CD8 lineages. Proc. Natl. Acad. Sci. USA 90, 10739-10743.
13. Davis, C.B., Killeen, N., Crooks, M.E., Raulet, D., and Littman, D.R. (1993). Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes. Cell 73, 237-247.
14. + thymocytes. J. Immunol. 152, 3254-3263.
15. Fowlkes, B.J. and Schweighoffer, E. (1995). Positive selection of T cells. Curr. Opin. Immunol 7, 188-195.
16. + T cells in major histocompatibility complex class II-deficient mice. Science 253, 1417-1420.
17. Grusby, M.J., Auchincloss, H., Jr., Lee, R., Johnson, R.S., Spencer, J.P., Zijlstra, M., Jaenisch, R., Papaioannou, V.E., and Glimcher, L.H. (1993). Mice lacking major histocompatibility complex class I and class II molecules. Proc. Natl. Acad. Sci. USA 90, 3913-3917.
18. Itano, A., Kioussis, D., and Robey, E. (1994). Stochastic component to development of class I major histocompatibility complex-specific T cells. Proc. Natl. Acad. Sci. USA 91, 220-224.
19. Itano, A., Salmon, P., Kioussis, D., Tolaini, M., Corbella, P., and Robey, E. (1996). The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells. J. Exp. Med. 183, 731-741.
20. Iwabuchi, K., Nakayama, K., McCoy, R.L., Wang, F., Nishimura, T., Habu, S., Murphy, K.M., and Loh, D.Y. (1992). Cellular and peptide requirements for in vitro clonal deletion of immature thymocytes. Proc. Natl. Acad. Sci. USA 89, 9000-9004.
21. + T cells in transgenic mice expressing a class II MHC-restricted antigen receptor. Nature 341, 746-749.
22. Kaye, J., Vasquez, N.J., and Hedrick, S.M. (1992). Involvement of the same region of the T cell antigen receptor in thymic selection and foreign peptide recognition. J. Immunol. 148, 3342-3353.
23. Kersh, G.J. and Hedrick, S.M. (1995). Role of TCR specificity in CD4 versus CD8 lineage commitment. J. Immunol. 154, 1057-1068.
24. Killeen, N. and Littman, D. R. (1993). Helper T-cell development in the absence of CD4-p56lck association. Nature 364, 729-732.
25. Killeen, N., Sawada, S., and Littman, D.R. (1993). Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4. EMBO J. 12, 1547-1553.
26. + single positive cells with a class II major histocompatibility complex-restricted receptor. J. Exp. Med. 180, 25-34.
27. Kisielow, P., and Miazek, A. (1995). Positive selection of T cells: rescue from programmed cell death and differentiation require continual engagement of the T cell receptor. J. Exp. Med. 181, 1975-1984.
28. + thymocytes. Nature 333, 742-746.
29. Kisielow, P., Teh, H.S., Bluthmann, H., and von Boehmer, H. (1988b). Positive selection of antigen-specific T-cells in thymus by restricting MHC molecules. Nature 335, 730-733.
30. + T cells. Science 248, 1227-1230.
31. Koo, G.C., Dumont, F.J., Tutt, M., Hackett, J., Jr., and Kumar, V. (1986). The NK-1.1(-) mouse: a model to study differentiation of murine NK cells. J. Immunol. 137, 3742-3747.
32. Locksley, R.M., Reiner, S.L., Hatam, F., Littman, D.R., and Killeen, N. (1993). Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice. Science 261, 1448-1451.
33. hi thymocytes. J. Exp. Med. 181, 1643-1651.
34. Mark, C., Figueroa, F., Nagy, Z.A., and Klein, J. (1982). Cytotoxic monoclonal antibody specific for the Lyt-1.2 antigen. Immunogenetics 16, 95-97.
35. Mombaerts, P., Clarke, A.R., Rudnicki, M.A., Iacomini, J., Itohara, S., Lafaille, J.J., Wang, L., Ichikawa, Y., Jaenisch, R., Hooper, M.L., and Tonegawa, S. (1992). Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages. Nature 360, 225-231.
36. lo thymocytes in vivo. Science 250, 1720-1723.
37. Paterson, R.K., Burkly, L.C., Kurahara, D.K., Dunlap, A., Flavell, R.A., and Finkel, T.H. (1994). Thymic development in human CD4 transgenic mice: positive selection occurs after commitment to the CD8 lineage. J. Immunol. 153, 3491-3503.
38. Pircher, H., Burki, K., Lang, R., Hengartner, H., and Zinkernagel, R.M. (1989). Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen. Nature 342, 559-561.
39. Rahemtulla, A., Kundig, T.M., Narendran, A., Bachmann, M.F., Julius, M., Paige, C.J., Ohashi, P.S., Zinkernagel, R.M., and Mak, T.W. (1994). Class II major histocompatibility complex-restricted T cell function in CD4-deficient mice. Eur. J. Immunol. 24, 2213-2228.
40. - thymocytes are functionally immature. J. Immunol. 147, 1779-1785.
41. Ravichandran, K.S., and Burakoff, S.J. (1994). Evidence for differential intracellular signaling via CD4 and CD8 molecules. J. Exp. Med. 179, 727-732.
42. Robey, E., and Fowlkes, B.J. (1994). Selective events in T cell development. Annu. Rev. Immunol. 12, 675-705.
43. Robey, E.A., Fowlkes, B.J.,Gordon, J.W., Kioussis, D.,von Boehmer, H., Ramsdell, F., and Axel, R. (1991). Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage. Cell 64, 99-107.
44. + helper T cells in class II major histocompatibility complex mutant mice. J. Exp. Med. 179, 1997-2004.
45. Sha, W.C., Nelson, C.A., Newberry, R.D., Kranz, D.M., Russell, J.H., and Loh, D.Y. (1988a). Positive and negative selection of an antigen receptor on T cells in transgenic mice. Nature 336, 73-76.
46. Sha, W.C., Nelson, C.A., Newberry, R.D., Kranz, D.M., Russell, J.H., and Loh, D.Y. (1988b). Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice. Nature 335, 271-274.
47. Shinkai, Y., Rathbun, G., Lam, K.P., Oltz, E.M., Stewart, V., Mendelsohn, M., Charron, J., Datta, M., Young, F., Stall, A.M., and Alt, F.W. (1992). RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 68, 855-867.
48. + T cell lineages: a new perspective on thymic commitment and selection. Immunity 2, 413-425.
49. + thymocytes: selection rather than instruction? Science 261, 911-915.
50. lck. Cell 55, 301-308.
51. von Boehmer, H. (1986). The selection of the alpha-beta heterodimeric T-cell receptor for antigen. Immunol. Today 7, 333-336.
52. + thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules. J. Exp. Med. 178, 1701-1712.
53. Yague, J., Blackman, M., Born, W., Marrack, P., Kappler, J., and Palmer, E. (1988). The structure of Vα and Jα segments in the mouse. Nucl. Acids Res. 16, 11355-11364.