LIME: A New Membrane Raft-associated Adaptor Protein Involved in CD4 and CD8 Coreceptor Signaling

Journal of Experimental Medicine

Volumn 198, Issue 10, 2003, Pages 1453-1462

  Brdičková, Naděžda ^a   Brdička, Tomáš ^a   Angelisová, Pavla ^a   Horváth, Ondrej ^a   Špička, Jiří ^a   Hilgert, Ivan ^a   Pačes, Jan ^a   Simeoni, Luca ^b   Kliche, Stefanie ^b   Merten, Camilla ^b   Schraven, Burkhart ^b   Hořejší, Václav ^a  

^a INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

^b OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

Csk; Lck; Membrane microdomains; Phosphorylation; Signal transduction

Indexed keywords

ADAPTOR PROTEIN; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; MEMBRANE PROTEIN; PROTEIN TYROSINE KINASE; TYROSINE;

ARTICLE; CONTROLLED STUDY; CROSS LINKING; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; AMINO ACID SEQUENCE; ANTIGENS, CD4; ANTIGENS, CD8; DATABASES, PROTEIN; DNA, COMPLEMENTARY; HUMANS; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MEMBRANE MICRODOMAINS; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES;

EID: 10744225431     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20031484     Document Type: Article

References (46)

1. Harder, T. 2001. Raft membrane domains and immunoreceptor functions. Adv. Immunol. 77:45-92.
2. Cherukuri, A., M. Dykstra, and S.K. Pierce. 2001. Floating the raft hypothesis: lipid rafts play a role in immune cell activation. Immunity. 14:657-660.
3. Horejsi, V. 2003. The roles of membrane microdomains (rafts) in T cell activation. Immunol. Rev. 191:148-164.
4. Saint-Ruf, C., M. Panigada, O. Azogui, P. Debey, H. von Boehmer, and F. Grassi. 2000. Different initiation of pre-TCR and γδTCR signalling. Nature. 406:524-527.
5. Fragoso, R., D. Ren, X. Zhang, M.W. Su, S.J. Burakoff, and Y.J. Jin. 2003. Lipid raft distribution of CD4 depends on its palmitoylation and association with Lck, and evidence for CD4-induced lipid raft aggregation as an additional mechanism to enhance CD3 Signaling. J. Immunol. 170:913-921.
6. Arcaro, A., C. Gregoire, N. Boucheron, S. Stotz, E. Palmer, B. Malissen, and I.F. Luescher. 2000. Essential role of CD8 palmitoylation in CD8 coreceptor function. J. Immunol. 165:2068-2076.
7. Brdicka, T., J. Cerny, and V. Horejsi. 1998. T cell receptor signalling results in rapid tyrosine phosphorylation of the linker protein LAT present in detergent-resistant membrane microdomains. Biochem. Biophys. Res. Commun. 248:356-360.
8. Zhang, W., R.P. Trible, and L.E. Samelson. 1998. LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation. Immunity. 9:239-246.
9. Brdicka, T., D. Pavlistova, A. Leo, E. Bruyns, V. Korinek, P. Angelisova, J. Scherer, A. Shevchenko, I. Hilgert, J. Cerny, et al. 2000. Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase Csk and is involved in regulation of T cell activation. J. Exp. Med. 191:1591-1604.
10. Kawabuchi, M., Y. Satomi, T. Takao, Y. Shimonishi, S. Nada, K. Nagai, A. Tarakhovsky, and M. Okada. 2000. Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases. Nature. 404:999-1003.
11. Brdicka, T., M. Imrich, P. Angelisova, N. Brdickova, O. Horvath, J. Spicka, I. Hilgert, P. Luskova, P. Draber, P. Novak, et al. 2002. Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling. J. Exp. Med. 196:1617-1626.
12. Janssen, E., M. Zhu, W. Zhang, and S. Koonpaew. 2003. LAB: A new membrane-associated adaptor molecule in B cell activation. Nat. Immunol. 4:117-123.
13. Zhang, W., J. Sloan-Lancaster, J. Kitchen, R.P. Trible, and L.E. Samelson. 1998. LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell. 92:83-92.
14. Cinek, T., and V. Horejsi. 1992. The nature of large noncovalent complexes containing glycosyl-phosphatidylinositol-anchored membrane glycoproteins and protein tyrosine kinases. J. Immunol. 149:2262-2270.
15. Kirchgessner, H., J. Dietrich, J. Scherer, P. Isomaki, V. Korinek, I. Hilgert, E. Bruyns, A. Leo, A.P. Cope, and B. Schraven. 2001. The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR ζ chain. J. Exp. Med. 193:1269-1284.
16. Hobbs, S., S. Jitrapakdee, and J.C. Wallace. 1998. Development of a bicistronic vector driven by the human polypeptide chain elongation factor 1α promoter for creation of stable mammalian cell lines that express very high levels of recombinant proteins. Biochem. Biophys. Res. Commun. 252:368-372.
17. c-src by overexpression of a protein tyrosine phosphatase. Nature. 359:336-339.
18. lck and mediates T cell activation. J. Exp. Med. 198:1463-1473.
19. Yaffe, M.B., G.G. Leparc, J. Lai, T. Obata, S. Volinia, and L.C. Cantley. 2001. A motif-based profile scanning approach for genome-wide prediction of signaling pathways. Nat. Biotechnol. 19:348-353.
20. Bruyns, E., A. Marie-Cardine, H. Kirchgessner, K. Sagolla, A. Shevchenko, M. Mann, F. Autschbach, A. Bensussan, S. Meuer, and B. Schraven. 1998. T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-ζ complex, recruits intracellular signaling proteins to the plasma membrane. J. Exp. Med. 188:561-575.
21. Marie-Cardine, A., H. Kirchgessner, E. Bruyns, A. Shevchenko, M. Mann, F. Autschbach, S. Ratnofsky, S. Meuer, and B. Schraven. 1999. SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T cell activation. J. Exp. Med. 189:1181-1194.
22. Zhu, M., E. Janssen, K. Leung, and W. Zhang. 2002. Molecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signaling. J. Biol. Chem. 277:46151-46158.
23. Samelson, L.E. 2002. Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins. Annu. Rev. Immunol. 20:371-394.
24. Baumgartner, M., P. Angelisova, N. Setterblad, N. Mooney, D. Werling, V. Horejsi, and G. Langsley. 2003. Constitutive exclusion of Csk from Hck-positive membrane microdomains permits Src kinase-dependent proliferation of Theileria-transformed B-lymphocytes. Blood. 101:1874-1881.
25. Ohtake, H., N. Ichikawa, M. Okada, and T. Yamashita. 2002. Cutting Edge: Transmembrane phosphoprotein Csk-binding protein/phosphoprotein associated with glycosphingolipid-enriched microdomains as a negative feedback regulator of mast cell signaling through the FcεRI. J. Immunol. 168:2087-2090.
26. Torgersen, K.M., T. Vang, H. Abrahamsen, S. Yaqub, V. Horejsi, B. Schraven, B. Rolstad, T. Mustelin, and K. Tasken. 2001. Release from tonic inhibition of T cell activation through transient displacement of C-terminal Src kinase (Csk) from lipid rafts. J. Biol. Chem. 276:29313-29318.
27. Owens, T., B. Fazekas de St Groth, and J.F. Miller. 1987. Coaggregation of the T-cell receptor with CD4 and other T-cell surface molecules enhances T-cell activation. Proc. Natl. Acad. Sci. USA. 84:9209-9213.
28. Eichmann, K., J.I. Jonsson, I. Falk, and F. Emmrich. 1987. Effective activation of resting mouse T lymphocytes by cross-linking submitogenic concentrations of the T cell antigen receptor with either Lyt-2 or L3T4. Eur. J. Immunol. 17:643-650.
29. Bank, I., and L. Chess. 1985. Perturbation of the T4 molecule transmits a negative signal to T cells. J. Exp. Med. 162:1294-1303.
30. Harding, S., P. Lipp, and D.R. Alexander. 2002. A therapeutic CD4 monoclonal antibody inhibits TCR-ζ chain phosphorylation, ζ-associated protein of 70-kDa Tyr319 phosphorylation, and TCR internalization in primary human T cells. J. Immunol. 169:230-238.
31. Benjamin, R.J., and H. Waldmann. 1986. Induction of tolerance by monoclonal antibody therapy. Nature. 320:449-451.
32. + advanced transgenic mouse model. J. Immunol. 169:2947-2955.
33. Mazerolles, F., C. Barbat, M. Trucy, W. Kolanus, and A. Fischer. 2002. Molecular events associated with CD4-mediated down-regulation of LFA-1-dependent adhesion. J. Biol. Chem. 277:1276-1283.
34. Milia, E., M.M. Di Somma, M.B. Majolini, C. Ulivieri, F. Somma, E. Piccolella, J.L. Telford, and C.T. Baldari. 1997. Gene activating and proapoptotic potential are independent properties of different CD4 epitopes. Mol. Immunol. 34:287-296.
35. Ulivieri, C., S. Pacini, S. Bartalini, S. Valensin, J.L. Telford, and C.T. Baldari. 1999. Obligatory cross-talk with the tyrosine kinases assembled with the TCR/CD3 complex in CD4 signal transduction. Eur. J. Immunol. 29:2625-2635.
36. Newell, M.K., L.J. Haughn, C.R. Maroun, and M.H. Julius. 1990. Death of mature T cells by separate ligation of CD4 and the T-cell receptor for antigen. Nature. 347:286-289.
37. Tuosto, L., B. Marinari, and E. Piccolella. 2002. CD4-Lck through TCR and in the absence of Vav exchange factor induces Bax increase and mitochondrial damage. J. Immunol. 168:6106-6112.
38. Filipp, D., J. Zhang, B.L. Leung, A. Shaw, S.D. Levin, A. Veillette, and M. Julius. 2003. Regulation of Fyn through translocation of activated Lck into lipid rafts. J. Exp. Med. 197:1221-1227.
39. FAK-dependent tyrosine phosphorylation of paxillin creates a high-affinity binding site for Crk. Mol. Cell. Biol. 15:2635-2645.
40. Cao, H., W.E. Courchesne, and C.C. Mastick. 2002. A phosphotyrosine-dependent protein interaction screen reveals a role for phosphorylation of caveolin-1 on tyrosine 14: recruitment of C-terminal Src kinase. J. Biol. Chem. 277:8771-8774.
41. Wang, B., S. Lemay, S. Tsai, and A. Veillette. 2001. SH2 domain-mediated interaction of inhibitory protein tyrosine kinase Csk with protein ryrosine phosphatase-HSCF. Mol. Cell. Biol. 21:1077-1088.
42. Arbet-Engels, C., S. Tartare-Deckert, and W. Eckhart. 1999. C-terminal Src kinase associates with ligand-stimulated insulin-like growth factor-I receptor. J. Biol. Chem. 274:5422-5428.
43. Shah, K., and K.M. Shokat. 2002. A chemical genetic screen for direct v-Src substrates reveals ordered assembly of a retrograde signaling pathway. Chem. Biol. 9:35-47.
44. Pfrepper, K.I., A. Marie-Cardine, L. Simeoni, Y. Kuramitsu, A. Leo, J. Spicka, I. Hilgert, J. Scherer, and B. Schraven. 2001. Structural and functional dissection of the cytoplasmic domain of the transmembrane adaptor protein SIT (SHP2-interacting transmembrane adaptor protein). Eur. J. Immunol. 31:1825-1836.
45. Ishino, M., H. Aoto, H. Sasaski, R. Suzuki, and T. Sasaki. 2000. Phosphorylation of Hic-5 at tyrosine 60 by CAKβ and Fyn. FEBS Lett. 474:179-183.
46. Songyang, Z., S.E. Shoelson, J. McGlade, P. Olivier, T. Pawson, X.R. Bustelo, M. Barbacid, H. Sabe, H. Hanafusa, T. Yi, et al. 1994. Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav. Mol. Cell. Biol. 14:2777-2785.