A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development

Immunity

Volumn 6, Issue 6, 1997, Pages 663-671

  Wiest, David L ^a,e   Ashe, Jennifer M ^a   Howcroft, T Kevin ^a   Lee, Hon Man ^b   Kemper, Debbie M ^b   Negishi, Izumi ^c   Singer, Dinah S ^a   Singer, Alfred ^a   Abe, Ryo ^b,d  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NAVAL MEDICAL RESEARCH INSTITUTE   (United States)

^c NIPPON ROCHE RESEARCH CENTER   (Japan)

^d TOKYO UNIVERSITY OF SCIENCE   (Japan)

^e FOX CHASE CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; CELL MATURATION; ENZYME ACTIVITY; GENE MUTATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; THYMOCYTE;

EID: 0030802186     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80442-2     Document Type: Article

References (45)

1. + thymic selection in humans lacking Zap-70. Cell 76, 947-958.
2. Asensi, V., Kimeno, K., Kawamura, I., and Sakumoto, M. (1989). Treatment of autoimmune MRL/lpr mice with anti-B220 monoclonal antibody reduces the level of anti-DNA antibodies and lymphadenopathies. Immunology 68, 204-208.
3. Bolen, J.B. (1995). Protein tyrosine kinases in the initiation of antigen receptor signaling. Curr. Opin. Immunol. 7, 306-311.
4. Burkhardt, A., Stealey, B., Rowley, R.B., Mahajan, S., Prendergast, M., Fargnoli, J., and Bolen, J.B. (1994). Temporal regulation of non-transmembrane protein tyrosine kinase enzyme activity following T cell antien receptor engagement. J. Biol. Chem. 269, 23642-23647.
5. Chan, A.C., Irving, B.A., Fraser, J.D., and Weiss, A. (1991). The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein. Proc. Natl. Acad. Sci. USA 88, 9166-9170.
6. Chan, A.C., Iwashima, M., Turck, C.W., and Weiss, A. (1992). ZAP-70: a 70 kD protein-tyrosine kinase that associates with the TCR zeta chain. Cell 71, 649-662.
7. Chan, A.C., Desai, D.M., and Weiss, A. (1994a). The role of protein-tyrosine kinases and protein-tyrosine phosphatases in T cell antigen receptor signal transduction. Annu. Rev. Immunol. 12, 555-592.
8. Chan, A.C., Kadlecek, T.A., Elder, M.E., Filipovich, A.M., Kuo, W.L., Iwashima, M., Parslow, T.G., and Weiss, A. (1994b). ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency. Science 264, 1599-1601.
9. Chan, A.C., Dalton, M., Johnson, R., Kong, G., Wang, T., Thoma, R., and Kurasaki, T. (1995). Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function. EMBO J. 14, 2499-2508.
10. Dialynas, D.P., Wilde, D.B., Marrack, P., Peirres, A., Wall, K.A., Havran, W., Otten, G., Loken, M.R., Pierres, M., Kappler, J., et al. (1983). Characterization of the murine antigenic determinant, designated L3T4a, recognized by monoclonal antibody GK1.5: expression of L3T4a by functional T cell clones appears to correlate primarily with class II MHC antigen-reactivity. Immunol. Rev. 74, 29-56.
11. Elder, M.E., Lin, D., Clever, J., Chan, A.C., Hope, T.J., Weiss, A., and Parslow, T.G. (1994). Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase. Science 264, 1596-1599.
12. Gelfand, E.W., Weinberg, K., Mazer, B.D., Kadlecek, T.A., and Weiss, A. (1995). Absence of ZAP-70 prevents signaling through the antigen receptor on peripheral blood T cells but not on thymocytes. J. Exp. Med. 182, 1057-1066.
13. Hanks, S.K., and Quinn, A.M. (1991). Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members. Meth. Enzymol. 200, 38-62.
14. Hashimoto, K., Sohn, S.J., Levin, S.D., Tada, T., Perlmutter, R.M., and Nakayama, T. (1996). Requirement for p56(lck) tyrosine kinase activation in T cell receptor-mediated thymic selection. J. Exp. Med. 184, 931-943.
15. Hubbard, S.R., Wei, L., Ellis, L., and Hendrickson, W.A. (1994). Crystal structure of the tyrosine kinase domain of the human insulin receptor. Nature 372, 746-754.
16. June, C.H., Fletcher, M.C., Ledbetter, J.A., Schieven, G.L., Siegel, J.N., Phillips, A.F., and Samelson, L.E. (1990). Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction. Proc. Natl. Acad. Sci. USA 87, 7722-7726.
17. Kolanus, W., Romeo, C., and Seed, B. (1993). T cell activation by clustered tyrosine kinases. Cell 74, 171-183.
18. Kong, G., Dalton, M., Wardenburg, J.B., Straus, D., Kurosaki, T., and Chan, A.C. (1996). Distinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor function. Mol. Cell Biol. 16, 5026-5035.
19. Kubo, R.T., Born, W., Kappler, J.W., Marrack, P., and Pigeon, M. (1989). Characterization of a monoclonal antibody which detects all murine αβ T cell receptors. J. Immunol. 142, 2736-2742.
20. Ledbetter, J.A., Rouse, R.V., Micklem, H.S., and Herzenberg, L.A. (1980). T cell subsets defined by expression of Lyt-1,2,3 and Thy-1 antigens. Two-parameter immunofluorescence and cytotoxicity analysis with monoclonal antibodies modifies current views. J. Exp. Med. 152, 280-295.
21. Littman, D.R., Davis, C.B., Killeen, N., and Xu, H. (1994). Signal transduction during T cell development. Adv. Exp. Med. Biol. 365, 63-71.
22. lo thymocytes in vivo. Science 250, 1720-1723.
23. + cells by CD4. Science 249, 1558-1561.
24. + thymocytes results in tyrosine phosphorylation of the T cell receptor ζ chain. Nature 341, 651-654.
25. Negishi, I., Motoyama, N., Nakayama, K., Nakayama, K., Senju, S., Hatakeyama, S., Zhang, Q., Chan, A.C., and Loh, D.Y. (1995). Essential role for ZAP-70 in both positive and negative selection of thymocytes. Nature 376, 435-438.
26. Neumeister, E.N., Zhu, Y., Richard, S., Terhorst, C., Chan, A.C., and Shaw, A.S. (1995). Binding of ZAP-70 to phosphorylated T-cell receptor zeta and eta enhances its autophosphorylation and generates specific binding sites for SH2 domain-containing proteins. Mol. Cell Biol. 15, 3171-3178.
27. O'Shea, J.J., McVicar, D.W., Bailey, T.L., Burns, C., and Smyth, M.J. (1992). Activation of human peripheral blood T lymphocytes by pharmacological induction of protein-tyrosine phosphorylation. Proc. Natl. Acad. Sci. USA 89, 10306-10310.
28. + thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28. J. Exp. Med. 179, 709-713.
29. Qian, D., Mollenauer, M.N., and Weiss, A. (1996). Dominant-negative zeta-associated protein 70 inhibits T cell antigen receptor signaling. J. Exp. Med. 183, 611-620.
30. Robey, E., and Fowlkes, B.J. (1994). Selective events in T cell development. Annu. Rev. Immunol. 12, 675-705.
31. Sambrook, J., Fritsch, E.F., and Maniatis, T. (1989). Molecular Cloning: A Laboratory Manual (Plainview, NY: Cold Spring Harbor Laboratory Press).
32. Samelson, L.E., Phillips, A.F., Luong, E.T., and Klausner, R.D. (1990). Association of fyn protein-tyrosine kinase with the T-cell antigen receptor. Proc. Natl. Acad. Sci. USA 87, 4358-4362.
33. Secrist, J.P., Karnitz, L., and Abraham, R.T. (1991). T-cell antigen receptor ligation induces tyrosine phosphorylation of phospholipase Cγ1. J. Biol. Chem. 266, 12135-12139.
34. Secrist, J.P., Burns, L.A., Karnitz, L., Koretzky, G.A., and Abraham, R.T. (1993). Stimulatory effects of the protein tyrosine phosphatase inhibitor, pervanadate, on T-cell activation events. J. Biol. Chem. 268, 5886-5893.
35. Shahinian, A., Pfeffer, K., Lee, K.P., Kundig, T.M., Kishihara, K., Wakeham, A., Kawai, K., Ohashi, P.S., Thompson, C.B., and Mak, T.W. (1993). Differential T cell co-stimulatory requirements in CD28-deficient mice. Science 261, 609-612.
36. lck. Cell 55, 301-308.
37. Wange, R.L., Isakov, N., Burke, T.R., Otaka, A., Roller, P.P., Watts, J.D., Aebersold, R., and Samelson, L.E. (1995a). F2(Pmp)2-TAM zeta 3, a novel competative inhibitor of the binding of ZAP-70 to the T cell antigen receptor, blocks early T cell signaling. J. Biol. Chem. 270, 944-948.
38. Wange, R.L., Guitian, R., Isakov, N., Watts, J.D., Aebersold, R., and Samelson, L.E. (1995b). Activating and inhibitory mutations in adjacent tyrosines in the kinase domain of ZAP-70. J. Biol. Chem. 270, 18730-18733.
39. Wardenburg, J.B., Fu, C., Jackman, J.K., Flotow, H., Wilkinson, S.E., Williams, D.H., Johnson, R., Kong, G., Chan, A.C., and Findell, P.R. (1996). Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function. J. Biol. Chem. 271, 19641-19644.
40. Watts, J.D., Affolter, M., Krebs, D.L., Wange, R.L., Samelson, L.E., and Aebersold, R. (1994). Identification by electrospray ionization mass spectrometry of the sites of tyrosine phosphorylation induced in activated Jurkat T cells on the protein tyrosine kinase ZAP-70. J. Biol. Chem. 269, 29520-29529.
41. Weiss, A., Koretzky, G., Schatzman, R., and Kadlecek, T. (1991). Stimulation of the T cell antigen receptor induces tyrosine phosphorylation of phospholipase C-γ1. Proc. Natl. Acad. Sci. USA 88, 5484-5488.
42. Weiss, A., and Liftman, D. (1994). Signal transduction by lymphocyte antigen receptors. Cell 76, 263-274.
43. lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules. J. Exp. Med. 178, 1701-1712.
44. Wiest, D.L., Burgess, W., McKean, D., Kearse, K.P., and Singer, A. (1995). The molecular chaperone calnexin is expressed on the surface of immature thymocytes in association with clonotype-independent CD3 complexes. EMBO J. 14, 3425-3433.
45. lck. Immunity 4, 495-504.