Unravelling heterochromatin: Competition between positive and negative factors regulates accessibility

Trends in Genetics

Volumn 18, Issue 5, 2002, Pages 252-258

  Dillon, Niall ^a   Festenstein, Richard ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE; PROTEIN DERIVATIVE; PROTEIN HP 1; SATELLITE DNA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ACETYLATION; CELL FUNCTION; CELL NUCLEUS; CENTROMERE; CHROMATIN STRUCTURE; CYTOARCHITECTURE; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE SEQUENCE; GENE SILENCING; HETEROCHROMATIN; MARKER GENE; METHYLATION; MOLECULAR RECOGNITION; NONHUMAN; NUCLEOSOME; NUCLEOTIDE REPEAT; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; REVIEW;

ACETYLATION; ANIMALS; CENTROMERE; GENE EXPRESSION REGULATION; GENE SILENCING; HETEROCHROMATIN; HISTONES; HUMANS; MODELS, GENETIC;

EID: 0036574913     PISSN: 01689525     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-9525(02)02648-3     Document Type: Review

References (60)

1. Das heterochromatin der moose
2. Types of visible variations induced by X-rays in Drosophila
3. The phenomenon of position effect
4. Heterochromatin and gene expression in Drosophila
5. Molecular structure of a functional Drosophila centromere
6. The complete sequence of a heterochromatic island from a higher eukaryote
7. Repeats-induced gene silencing in mammals
8. Conspiracy of silence among repeated transgenes
9. Synthetic human beta-globin 5′HS2 constructs function as locus control regions only in multicopy constructs
10. Analysis of mice with single copies and multiple copies of transgenes reveals a novel arrangement for the l5-VpreB1 locus control region
11. Specific expression of a foreign beta-globin gene in erythroid cells of transgenic mice
12. Heterochromatic features of an 11-megabase transgene in brain cells
13. The beta-globin locus control region enhances transcription of but does not confer position-independent expression onto the lacZ gene in transgenic mice
14. Large scale chromatin structure and function
15. Position effect variegation in Drosophila is associated with an altered chromatin structure
16. Long-range nucleosome ordering is associated with gene silencing in Drosophila melanogaster pericentric heterochromatin
17. Distinctive higher-order chromatin structure at mammalian centromeres
18. Transcription factor dosage affects changes in higher-order chromatin structure associated with activation of a heterochromatic gene
19. The language of covalent histone modifications
20. Disruption of higher-order folding by core histone acetylation dramatically enhances transcription of nucleosomal arrays by RNA polymerase III
21. Reversible disruption of pericentric heterochromatin and centromere function by inhibiting deacetylases
22. Histone acetylation and an epigenetic code
23. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
24. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
25. Regulation of chromatin structure by site-specific histone H3 methyltransferases
26. Physical and functional association of SU(VAR)3-9 and HDAC1 in Drosophila
27. A histone H3 methyltransferase controls DNA methylation in Neurospora crassa
28. Transitions in distinct histone H3 methylation patterns at the heterochromatin domain boundaries
29. Methylation of histone H3 lysine 9 creates a binding site for Hp1 proteins
30. Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain
31. Heterochromatin formation in mammalian cells: Interaction between histones and HP1 proteins
32. Requirement of heterochromatin for cohesion at centromeres
33. Loss of the suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability
34. The centromere paradox: Stable inheritance with rapidly evolving DNA
35. Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin
36. Differentially methylated forms of histone H3 show unique association patterns with inactive human X chromosomes
37. Silencers, silencing, and heritable transcriptional states
38. Dosage-dependent modifiers of position effect variegation in Drosophila and a mass action model that explains their effect
39. Locus control region function and heterochromatin-induced position effect variegation
40. Heterochromatin effects on the frequency and duration of LCR-mediated gene transcription
41. Heterochromatin protein 1 modifies mammalian PEV in a dose and chromosomal context dependent manner
42. Activation of the beta globin locus by transcription factors and chromatin modifiers
43. Locus control regions and epigenetic chromatin modifiers
44. Human HMG box transcription factor HBP1: A role in hCD2 LCR function
45. Modulation of a transcription factor counteracts heterochromatic gene silencing in Drosophila
46. Silenced chromatin is permissive to activator binding and PIC recruitment
47. Position effect at S. cerevisiae telomeres: Reversible repression of Pol II transcription
48. Structure and function in the nucleus
49. Nuclear compartments and gene regulation
50. Genetic modification of heterochromatic association and nuclear organization in Drosophila
51. Perturbation of nuclear architecture by long-distance chromosome interactions
52. Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin
53. Dynamic repositioning of genes in the nucleus of cells preparing for cell division
54. A functional enhancer suppresses silencing of a transgene and prevents its localisation close to centromeric heterochromatin
55. Nuclear localisation and histone acetylation: A pathway for chromatin opening and transcriptional activation of the human β-globin locus
56. Binding of Ikaros to the λ5 promoter silences transcription through a mechanism that does not require heterochromatin formation
57. Down-regulation of TDT transcription in CD4+CD8+ thymocytes by Ikaros proteins in direct competition with an Ets activator
58. Correlation between histone lysine methylation and developmental changes at the chicken beta-globin locus
59. Rb targets histone H3 methylation and HP1 to promoters
60. Chromatin structure analysis of the mouse Xist locus