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Volumn 5, Issue 5, 1996, Pages 461-477

Unexpectedly complex regulation of CD4/CD8 coreceptor expression supports a revised model for CD4+CD8+ thymocyte differentiation

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR;

EID: 0030293636     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80502-6     Document Type: Article
Times cited : (176)

References (67)
  • 1
    • 0028101913 scopus 로고
    • A human CD4 transgene rescues CD4-CD8+ cells in β2-microglobulin-deficient mice
    • Baron, A., Hafen, K., and von Boehmer, H. (1994). A human CD4 transgene rescues CD4-CD8+ cells in β2-microglobulin-deficient mice. Eur. J. Immunol. 24, 1933-1936.
    • (1994) Eur. J. Immunol. , vol.24 , pp. 1933-1936
    • Baron, A.1    Hafen, K.2    Von Boehmer, H.3
  • 2
    • 0024428184 scopus 로고
    • Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand
    • Berg, L.J., Pullen, A.M., Fazekas de St. Groth, B., Mathis, D., Benoist, C., and Davis, M.M. (1989). Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand. Cell 58, 1035-1046.
    • (1989) Cell , vol.58 , pp. 1035-1046
    • Berg, L.J.1    Pullen, A.M.2    Fazekas De St. Groth, B.3    Mathis, D.4    Benoist, C.5    Davis, M.M.6
  • 3
    • 0026078307 scopus 로고
    • Development of the CD4 and CD8 lineage of T cells: Instruction versus selection
    • Borgulya, P., Kishi, H., Mueller, V., Kirkberg, J., and von Boehmer, H. (1991). Development of the CD4 and CD8 lineage of T cells: instruction versus selection. EMBO J. 10, 913-918.
    • (1991) EMBO J. , vol.10 , pp. 913-918
    • Borgulya, P.1    Kishi, H.2    Mueller, V.3    Kirkberg, J.4    Von Boehmer, H.5
  • 4
    • 0027153897 scopus 로고
    • Another view of the selective model of thymocyte selection
    • Chan, S.H., Cosgrove, D., Waltzinger, C., Benoist, C., and Mathis, D. (1993a). Another view of the selective model of thymocyte selection. Cell 73, 225-236.
    • (1993) Cell , vol.73 , pp. 225-236
    • Chan, S.H.1    Cosgrove, D.2    Waltzinger, C.3    Benoist, C.4    Mathis, D.5
  • 5
    • 0027329981 scopus 로고
    • A challenge to the instructive model of positive selection
    • Chan, S.H., Benoist, C., and Mathis, D. (1993b). A challenge to the instructive model of positive selection. Immunol. Rev. 135, 119-131.
    • (1993) Immunol. Rev. , vol.135 , pp. 119-131
    • Chan, S.H.1    Benoist, C.2    Mathis, D.3
  • 6
    • 0028075391 scopus 로고
    • Role of coreceptors in positive selection and lineage commitment
    • Chan, S.H., Waltzinger, C., Baron, A., Benoist, C., and Mathis, D. (1994). Role of coreceptors in positive selection and lineage commitment. EMBO J. 13, 4482-4489.
    • (1994) EMBO J. , vol.13 , pp. 4482-4489
    • Chan, S.H.1    Waltzinger, C.2    Baron, A.3    Benoist, C.4    Mathis, D.5
  • 8
    • 0027515732 scopus 로고
    • Thymocyte development in major histocompatibility complex-deficient mice: Evidence for stochastic commitment to the CD4 and CD8 lineages
    • Crump, A.L., Grusby, M.J., Glimcher, L.H., and Cantor, H. (1993). Thymocyte development in major histocompatibility complex-deficient mice: evidence for stochastic commitment to the CD4 and CD8 lineages. Proc. Natl. Acad. Sci. USA 90, 10739-10743.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 10739-10743
    • Crump, A.L.1    Grusby, M.J.2    Glimcher, L.H.3    Cantor, H.4
  • 9
    • 0028354790 scopus 로고
    • Thymocyte lineage commitment: Is it instructed or stochastic?
    • Davis, C.B., and Littman, D.R. (1994). Thymocyte lineage commitment: is it instructed or stochastic? Curr. Opin. Immunol. 6, 266-272.
    • (1994) Curr. Opin. Immunol. , vol.6 , pp. 266-272
    • Davis, C.B.1    Littman, D.R.2
  • 10
    • 0029586349 scopus 로고
    • Disrupted development of thymocytes expressing a transgenic TCR upon CD4 overexpression
    • Davis, C.B., and Littman, D.R. (1995). Disrupted development of thymocytes expressing a transgenic TCR upon CD4 overexpression. Int. Immunol. 7, 1977-1986.
    • (1995) Int. Immunol. , vol.7 , pp. 1977-1986
    • Davis, C.B.1    Littman, D.R.2
  • 11
    • 0027266755 scopus 로고
    • Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes
    • Davis, C.B., Kileen, N., Casey Crooks, M.E., Raulet, D., and Littman, D.R. (1993). Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes. Cell 73, 237-247.
    • (1993) Cell , vol.73 , pp. 237-247
    • Davis, C.B.1    Kileen, N.2    Casey Crooks, M.E.3    Raulet, D.4    Littman, D.R.5
  • 12
    • 0023720148 scopus 로고
    • The T cell receptor genes and T cell recognition
    • Davis, M.M., and Bjorkman, P.J. (1988). The T cell receptor genes and T cell recognition. Nature 334, 395-398.
    • (1988) Nature , vol.334 , pp. 395-398
    • Davis, M.M.1    Bjorkman, P.J.2
  • 13
    • 0023521229 scopus 로고
    • Interaction between CD4 and class II MHC molecules mediates cell adhesion
    • Doyle, C., and Strominger, J.L. (1987). Interaction between CD4 and class II MHC molecules mediates cell adhesion. Nature 330, 256-259.
    • (1987) Nature , vol.330 , pp. 256-259
    • Doyle, C.1    Strominger, J.L.2
  • 14
    • 0022406411 scopus 로고
    • Early T lymphocytes: Differentiation in vivo of adult intrathymic precursor cells
    • Fowlkes, B.J., Edison, L., Mathieson, B.J., and Chused, T.M. (1985). Early T lymphocytes: differentiation in vivo of adult intrathymic precursor cells. J. Exp. Med. 162, 802-822.
    • (1985) J. Exp. Med. , vol.162 , pp. 802-822
    • Fowlkes, B.J.1    Edison, L.2    Mathieson, B.J.3    Chused, T.M.4
  • 15
    • 0025035509 scopus 로고
    • T cell receptor-mediated negative selection of autoreactive T lymphocytes precursors occurs after commitment to the CD4 or CD8 lineages
    • Guidos, C.J., Danska, J.S., Fathman, G.G., and Weissman, I.L. (1990). T cell receptor-mediated negative selection of autoreactive T lymphocytes precursors occurs after commitment to the CD4 or CD8 lineages. J. Exp. Med. 172, 835-845.
    • (1990) J. Exp. Med. , vol.172 , pp. 835-845
    • Guidos, C.J.1    Danska, J.S.2    Fathman, G.G.3    Weissman, I.L.4
  • 17
    • 0028053092 scopus 로고
    • Stochastic component to development of class I major histocompatibility complex-specific T cells
    • Itano, A., Kiousiss, D., and Robey, E. (1994). Stochastic component to development of class I major histocompatibility complex-specific T cells. Proc. Natl. Acad. Sci. USA 91, 220-224.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 220-224
    • Itano, A.1    Kiousiss, D.2    Robey, E.3
  • 18
    • 0030002882 scopus 로고    scopus 로고
    • The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells
    • Itano, A., Salmon, P., Kioussis, D., Tolaini, M., Corbella, P., and Robey, E. (1996). The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells. J. Exp. Med. 183, 731-741.
    • (1996) J. Exp. Med. , vol.183 , pp. 731-741
    • Itano, A.1    Salmon, P.2    Kioussis, D.3    Tolaini, M.4    Corbella, P.5    Robey, E.6
  • 19
    • 0028238668 scopus 로고
    • Specificity and flexibility in thymic selection
    • Jameson, S.C., Hogquist, K.A., and Bevan, M.J. (1994). Specificity and flexibility in thymic selection. Nature 369, 750-752.
    • (1994) Nature , vol.369 , pp. 750-752
    • Jameson, S.C.1    Hogquist, K.A.2    Bevan, M.J.3
  • 20
    • 0028947844 scopus 로고
    • + thymocytes: Increased synthesis of TCR-α protein is an early response to TCR signaling that compensates for TCR-α instability, improves TCR assembly, and parallels other indicators of positive selection
    • + thymocytes: increased synthesis of TCR-α protein is an early response to TCR signaling that compensates for TCR-α instability, improves TCR assembly, and parallels other indicators of positive selection. J. Exp. Med. 181, 193-202.
    • (1995) J. Exp. Med. , vol.181 , pp. 193-202
    • Kearse, K.P.1    Takahama, Y.2    Punt, J.A.3    Sharrow, S.O.4    Singer, A.5
  • 21
    • 0028885198 scopus 로고
    • Role of TCR specificity in CD4 versus CD8 lineage commitment
    • Kersh, G.J., and Hedrick, S.M. (1995). Role of TCR specificity in CD4 versus CD8 lineage commitment. J. Immunol. 154, 1057-1068.
    • (1995) J. Immunol. , vol.154 , pp. 1057-1068
    • Kersh, G.J.1    Hedrick, S.M.2
  • 22
    • 0028911483 scopus 로고
    • Upregulation of surface markers on dying thymocytes
    • Kishimoto, H., Surh, C.D., and Sprent, J. (1995). Upregulation of surface markers on dying thymocytes. J. Exp. Med. 181, 649-655.
    • (1995) J. Exp. Med. , vol.181 , pp. 649-655
    • Kishimoto, H.1    Surh, C.D.2    Sprent, J.3
  • 23
    • 0025313515 scopus 로고
    • Normal development of mice deficient in β2m, MHC class I proteins, and CD8+ T cells
    • Koller, B.H., Marrack, P., Kappler, J.W., and Smithies, O. (1990). Normal development of mice deficient in β2m, MHC class I proteins, and CD8+ T cells. Science 248, 1227-1230.
    • (1990) Science , vol.248 , pp. 1227-1230
    • Koller, B.H.1    Marrack, P.2    Kappler, J.W.3    Smithies, O.4
  • 25
    • 0027421675 scopus 로고
    • Normal sequence of phenotypic transitions in one cohort of 5-bromo-2′-deoxyuridine-pulse-labeled thymocytes
    • Lucas, B., Vasseur, F., and Pénit, C. (1993). Normal sequence of phenotypic transitions in one cohort of 5-bromo-2′-deoxyuridine-pulse-labeled thymocytes. J. Immunol. 151, 4574-4582.
    • (1993) J. Immunol. , vol.151 , pp. 4574-4582
    • Lucas, B.1    Vasseur, F.2    Pénit, C.3
  • 26
    • 0028229558 scopus 로고
    • Production, selection, and maturation of thymocytes with high surface density of TcR
    • Lucas, B., Vasseur, F., and Pénit, C. (1994). Production, selection, and maturation of thymocytes with high surface density of TcR. J. Immunol. 153, 53-62.
    • (1994) J. Immunol. , vol.153 , pp. 53-62
    • Lucas, B.1    Vasseur, F.2    Pénit, C.3
  • 27
    • 0028947581 scopus 로고
    • Stochastic coreceptor shut-off is restricted to the CD4 lineage maturation pathway
    • Lucas, B., Vasseur, F., and Pénit, C. (1995). Stochastic coreceptor shut-off is restricted to the CD4 lineage maturation pathway. J. Exp. Med. 181, 1623-1633.
    • (1995) J. Exp. Med. , vol.181 , pp. 1623-1633
    • Lucas, B.1    Vasseur, F.2    Pénit, C.3
  • 28
    • 0029671456 scopus 로고    scopus 로고
    • intthymocytes do not belong to the CD8 lineage maturation pathway
    • intthymocytes do not belong to the CD8 lineage maturation pathway. J. Immunol. 156, 1743-1747.
    • (1996) J. Immunol. , vol.156 , pp. 1743-1747
    • Lucas, B.1    Marodon, G.2    Pénit, C.3
  • 29
    • 0028354215 scopus 로고
    • Small cortical thymocytes are subject to positive selection
    • Lundberg, K., and Shortman, K. (1994). Small cortical thymocytes are subject to positive selection. J. Exp. Med. 179, 1475-1483.
    • (1994) J. Exp. Med. , vol.179 , pp. 1475-1483
    • Lundberg, K.1    Shortman, K.2
  • 31
    • 0028902752 scopus 로고
    • ζ Phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists
    • Madrenas, J., Wange, R.L., Wang, J.L., Isakov, N., Samelson, L.E., and Germain, R.N. (1995).ζ Phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists. Science 267, 515-518.
    • (1995) Science , vol.267 , pp. 515-518
    • Madrenas, J.1    Wange, R.L.2    Wang, J.L.3    Isakov, N.4    Samelson, L.E.5    Germain, R.N.6
  • 32
    • 0028945329 scopus 로고
    • Autologous rat myelin basic protein is a partial agonist that is converted into a full antagonist upon blockade of CD4: Evidence for the integration of efficacious and nonefficacious signals during T cell antigen recognition
    • Mannie, M.D., Rosser, J.M., and White, G.A. (1995). Autologous rat myelin basic protein is a partial agonist that is converted into a full antagonist upon blockade of CD4: evidence for the integration of efficacious and nonefficacious signals during T cell antigen recognition. J Immunol. 154, 2642-2654.
    • (1995) J Immunol. , vol.154 , pp. 2642-2654
    • Mannie, M.D.1    Rosser, J.M.2    White, G.A.3
  • 33
    • 0028057579 scopus 로고
    • Generation of mature T cells in the thymus: CD4 or CD8 down-regulation occurs at different stages of thymocyte development
    • Marodon, G., and Rocha, B. (1994). Generation of mature T cells in the thymus: CD4 or CD8 down-regulation occurs at different stages of thymocyte development. Eur. J. Immunol. 24, 196-204.
    • (1994) Eur. J. Immunol. , vol.24 , pp. 196-204
    • Marodon, G.1    Rocha, B.2
  • 34
    • 0029988961 scopus 로고    scopus 로고
    • MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent
    • Matechak, E.O., Killeen, N., Hedrick, S.M., and Fowlkes, B.J. (1996). MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent. Immunity 4, 337-347.
    • (1996) Immunity , vol.4 , pp. 337-347
    • Matechak, E.O.1    Killeen, N.2    Hedrick, S.M.3    Fowlkes, B.J.4
  • 38
    • 0028973001 scopus 로고
    • Comparison of p56lck and p59fyn protein expression in thymocyte subsets, peripheral T cells, NK cells, and lymphoid cell lines
    • Olszowy, M.W., Leuchtmann, P.L., Veillette, A., and Shaw, A.S. (1995). Comparison of p56lck and p59fyn protein expression in thymocyte subsets, peripheral T cells, NK cells, and lymphoid cell lines. J. Immunol. 155, 4236-4240.
    • (1995) J. Immunol. , vol.155 , pp. 4236-4240
    • Olszowy, M.W.1    Leuchtmann, P.L.2    Veillette, A.3    Shaw, A.S.4
  • 40
    • 0022529559 scopus 로고
    • In vivo thymocyte maturation: BUdr labeling of cycling thymocytes and phenotypic analysis of their progeny support the single lineage model
    • Pénit, C. (1986). In vivo thymocyte maturation: BUdr labeling of cycling thymocytes and phenotypic analysis of their progeny support the single lineage model. J. Immunol. 137, 2115-2121.
    • (1986) J. Immunol. , vol.137 , pp. 2115-2121
    • Pénit, C.1
  • 41
    • 0024319834 scopus 로고
    • Cell proliferation and differentiation in the fetal and early postnatal mouse thymus
    • Pénit, C., and Vasseur, F. (1989). Cell proliferation and differentiation in the fetal and early postnatal mouse thymus. J. Immunol. 142, 3369-3377.
    • (1989) J. Immunol. , vol.142 , pp. 3369-3377
    • Pénit, C.1    Vasseur, F.2
  • 42
    • 0029072262 scopus 로고
    • Cell expansion and growth arrest phases during the transition from precursor (CD4-8-) to immature (CD4+8+) thymocytes in normal and genetically modified mice
    • Pénit, C., Lucas, B., and Vasseur, F. (1995). Cell expansion and growth arrest phases during the transition from precursor (CD4-8-) to immature (CD4+8+) thymocytes in normal and genetically modified mice. J. Immunol. 154, 5103-5113.
    • (1995) J. Immunol. , vol.154 , pp. 5103-5113
    • Pénit, C.1    Lucas, B.2    Vasseur, F.3
  • 43
    • 0027317031 scopus 로고
    • CD4+CD8- and CD4-CD8+ mature thymocytes require different post-selection processing for final development
    • Petrie, H.T., Strasser, A., Harris, A.W., Hugo, P., and Shortman, K. (1993). CD4+CD8- and CD4-CD8+ mature thymocytes require different post-selection processing for final development. J. Immunol. 151, 1273-1279.
    • (1993) J. Immunol. , vol.151 , pp. 1273-1279
    • Petrie, H.T.1    Strasser, A.2    Harris, A.W.3    Hugo, P.4    Shortman, K.5
  • 44
    • 0028125972 scopus 로고
    • Evidence for differential intracellular signaling via CD4 and CD8 molecules
    • Ravichandran, K.S., and Burakoff, S.J. (1994). Evidence for differential intracellular signaling via CD4 and CD8 molecules. J. Exp. Med. 179, 727-732.
    • (1994) J. Exp. Med. , vol.179 , pp. 727-732
    • Ravichandran, K.S.1    Burakoff, S.J.2
  • 45
    • 0028201339 scopus 로고
    • Selective events in T cell development
    • Robey, E., and Fowlkes, B.J. (1994). Selective events in T cell development. Annu. Rev. Immunol. 12, 675-705.
    • (1994) Annu. Rev. Immunol. , vol.12 , pp. 675-705
    • Robey, E.1    Fowlkes, B.J.2
  • 46
    • 0026034155 scopus 로고
    • Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage
    • Robey, E.A., Fowlkes, B.J., Gordon, J.W., Kioussiss, D., von Boehmer, H., Ramsdell, F., and Axel, R. (1991). Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage. Cell 64, 99-107.
    • (1991) Cell , vol.64 , pp. 99-107
    • Robey, E.A.1    Fowlkes, B.J.2    Gordon, J.W.3    Kioussiss, D.4    Von Boehmer, H.5    Ramsdell, F.6    Axel, R.7
  • 47
    • 0028308197 scopus 로고
    • Constitutive CD8 expression allows inefficient maturation of CD4+ helper T cells in class II major histocompatibility complex mutant mice
    • Robey, E., Itano, A., Fanslow, W.C., and Fowlkes, B.J. (1994). Constitutive CD8 expression allows inefficient maturation of CD4+ helper T cells in class II major histocompatibility complex mutant mice. J. Exp. Med. 179, 1997-2004.
    • (1994) J. Exp. Med. , vol.179 , pp. 1997-2004
    • Robey, E.1    Itano, A.2    Fanslow, W.C.3    Fowlkes, B.J.4
  • 48
    • 0028988659 scopus 로고
    • Thymic emigration: Conveyor belts or lucky dips?
    • Scollay, R., and Godfrey, D.I. (1995). Thymic emigration: conveyor belts or lucky dips? Immunol. Today 16, 268-273.
    • (1995) Immunol. Today , vol.16 , pp. 268-273
    • Scollay, R.1    Godfrey, D.I.2
  • 49
    • 0027967385 scopus 로고
    • Partial T cell signaling: Altered phospho-ζ and lack of ZAP-70 recruitment in APL-induced T cell anergy
    • Sloan-Lancaster, J., Shaw, A.S., Rothbard, J.B., and Allen, P.M. (1994). Partial T cell signaling: altered phospho-ζ and lack of ZAP-70 recruitment in APL-induced T cell anergy. Cell 79, 913-922.
    • (1994) Cell , vol.79 , pp. 913-922
    • Sloan-Lancaster, J.1    Shaw, A.S.2    Rothbard, J.B.3    Allen, P.M.4
  • 50
    • 0028281677 scopus 로고
    • A peptide antigen antagonist prevents the differentiation of T cell receptor transgenic thymocytes
    • Spain, L.M., Jorgensen, J.L., Davis, M.M., and Berg, L.J. (1994). A peptide antigen antagonist prevents the differentiation of T cell receptor transgenic thymocytes. J Immunol. 152, 1709-1717.
    • (1994) J Immunol. , vol.152 , pp. 1709-1717
    • Spain, L.M.1    Jorgensen, J.L.2    Davis, M.M.3    Berg, L.J.4
  • 51
    • 0028904213 scopus 로고
    • + T cell lineages: A new perspective on thymic commitment and selection
    • + T cell lineages: a new perspective on thymic commitment and selection. Immunity 2, 413-425.
    • (1995) Immunity , vol.2 , pp. 413-425
    • Suzuki, H.1    Punt, J.A.2    Granger, L.G.3    Singer, A.4
  • 52
    • 0025806588 scopus 로고
    • Clonal deletion of immature CD4+CD8+ thymocytes in suspension culture by extrathymic antigen-presenting cells
    • Swat, O., Ignatowitcz, L., von Boehmer, H., and Kisielow, P. (1991). Clonal deletion of immature CD4+CD8+ thymocytes in suspension culture by extrathymic antigen-presenting cells. Nature 351, 150-153.
    • (1991) Nature , vol.351 , pp. 150-153
    • Swat, O.1    Ignatowitcz, L.2    Von Boehmer, H.3    Kisielow, P.4
  • 53
    • 0023813094 scopus 로고
    • Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/ CD8 phenotype of T cells
    • Teh, H.S., Kisielow, P., Scott, B., Kishi, H., Uematsu, Y., Blüthmann, H., and von Boehmer, H. (1988). Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/ CD8 phenotype of T cells. Nature 335, 229-233.
    • (1988) Nature , vol.335 , pp. 229-233
    • Teh, H.S.1    Kisielow, P.2    Scott, B.3    Kishi, H.4    Uematsu, Y.5    Blüthmann, H.6    Von Boehmer, H.7
  • 54
    • 0027164960 scopus 로고
    • Development of mature CD8+ thymocytes: Selection rather than instruction
    • van Meerwijk, J.P.M., and Germain, R.N. (1993). Development of mature CD8+ thymocytes: selection rather than instruction. Science 261, 911-915.
    • (1993) Science , vol.261 , pp. 911-915
    • Van Meerwijk, J.P.M.1    Germain, R.N.2
  • 55
    • 0028490925 scopus 로고
    • The different roles of MHC class recognition in thymocyte CD4 versus CD8 lineage commitment and positive selection
    • van Meerwijk, J.P.M., and Germain, R.N. (1994). The different roles of MHC class recognition in thymocyte CD4 versus CD8 lineage commitment and positive selection. Semin. Immunol. 6, 231-239.
    • (1994) Semin. Immunol. , vol.6 , pp. 231-239
    • Van Meerwijk, J.P.M.1    Germain, R.N.2
  • 56
    • 0029033757 scopus 로고
    • Evidence for lineage commitment and initiation of positive selection by thymocytes with intermediate surface phenotypes
    • van Meerwijk, J.P.M., O'Connel, E.M., and Germain, R.N. (1995). Evidence for lineage commitment and initiation of positive selection by thymocytes with intermediate surface phenotypes. J. Immunol. 154, 6314-6323.
    • (1995) J. Immunol. , vol.154 , pp. 6314-6323
    • Van Meerwijk, J.P.M.1    O'Connel, E.M.2    Germain, R.N.3
  • 57
    • 0026551703 scopus 로고
    • In vivo and in vitro clonal deletion of double-positive thymocytes
    • Vasquez, N.J., Kaye, J., and Hedrick, S.M. (1992). In vivo and in vitro clonal deletion of double-positive thymocytes. J. Exp. Med. 175, 1307-1316.
    • (1992) J. Exp. Med. , vol.175 , pp. 1307-1316
    • Vasquez, N.J.1    Kaye, J.2    Hedrick, S.M.3
  • 59
    • 0027199233 scopus 로고
    • Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes
    • Veis, D.J., Sentman, L., Bach, E.A., and Korsmeyer, S.J. (1993). Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes. J. Immunol. 151, 2546-2554.
    • (1993) J. Immunol. , vol.151 , pp. 2546-2554
    • Veis, D.J.1    Sentman, L.2    Bach, E.A.3    Korsmeyer, S.J.4
  • 60
    • 0022869073 scopus 로고
    • The selection of the αβ heterodimeric T cell receptor for antigen
    • von Boehmer, H. (1986). The selection of the αβ heterodimeric T cell receptor for antigen, Immunol. Today 7, 333-336.
    • (1986) Immunol. Today , vol.7 , pp. 333-336
    • Von Boehmer, H.1
  • 62
    • 0024502409 scopus 로고
    • The thymus selects the useful, neglects the useless and destroys the harmful
    • von Boehmer, H., Teh, H., and Kisielow, P. (1989). The thymus selects the useful, neglects the useless and destroys the harmful. Immunol. Today 10, 57-61.
    • (1989) Immunol. Today , vol.10 , pp. 57-61
    • Von Boehmer, H.1    Teh, H.2    Kisielow, P.3
  • 64
    • 0029897674 scopus 로고    scopus 로고
    • Inhibition of thymocyte negative selection by T cell receptor antagonist peptides
    • Williams, O., Tanaka, Y., Bix, M., Murdjeva, M., Littman, D.R., and Kioussis, D. (1996). Inhibition of thymocyte negative selection by T cell receptor antagonist peptides. Eur. J. Immunol. 26, 532-538.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 532-538
    • Williams, O.1    Tanaka, Y.2    Bix, M.3    Murdjeva, M.4    Littman, D.R.5    Kioussis, D.6
  • 66
    • 0024505586 scopus 로고
    • Positive selection of CD4-CD8+ cells in the thymus of normal mice
    • Zúñiga-Pflücker, J.-C., Longo, D.L., and Kruisbeek, A.M. (1989). Positive selection of CD4-CD8+ cells in the thymus of normal mice. Nature 338, 76-78.
    • (1989) Nature , vol.338 , pp. 76-78
    • Zúñiga-Pflücker, J.-C.1    Longo, D.L.2    Kruisbeek, A.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.