메뉴 건너뛰기




Volumn 14, Issue 4, 2001, Pages 483-494

Strength of signaling by CD4 and CD8 coreceptor tails determines the number but not the lineage direction of positively selected thymocytes

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

EID: 0035033216     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(01)00128-5     Document Type: Article
Times cited : (49)

References (46)
  • 1
    • 0141807008 scopus 로고
    • The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex
    • Barber E., Dasgupta J., Schlossman S., Trevillyan J., Rudd C. The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex. Proc. Natl. Acad. Sci. USA. 86:1989;3277-3281.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 3277-3281
    • Barber, E.1    Dasgupta, J.2    Schlossman, S.3    Trevillyan, J.4    Rudd, C.5
  • 2
    • 0032550367 scopus 로고    scopus 로고
    • CD3 ligation on immature thymocytes generates antagonist-like signals appropriate for CD8 lineage commitment, independently of T cell receptor specificity
    • Basson M.A., Bommhardt U., Cole M.S., Tso J.Y., Zamoyska R. CD3 ligation on immature thymocytes generates antagonist-like signals appropriate for CD8 lineage commitment, independently of T cell receptor specificity. J. Exp. Med. 187:1998;1249-1260.
    • (1998) J. Exp. Med. , vol.187 , pp. 1249-1260
    • Basson, M.A.1    Bommhardt, U.2    Cole, M.S.3    Tso, J.Y.4    Zamoyska, R.5
  • 3
    • 0033571795 scopus 로고    scopus 로고
    • Association of the adaptor molecule LAT with CD4 and CD8 coreceptors identifies a new coreceptor function in T cell receptor signal transduction
    • Bosselut R., Zhang W., Ashe J., Kopacz J., Samelson L., Singer A. Association of the adaptor molecule LAT with CD4 and CD8 coreceptors identifies a new coreceptor function in T cell receptor signal transduction. J. Exp. Med. 190:1999;1517-1526.
    • (1999) J. Exp. Med. , vol.190 , pp. 1517-1526
    • Bosselut, R.1    Zhang, W.2    Ashe, J.3    Kopacz, J.4    Samelson, L.5    Singer, A.6
  • 4
    • 0033625405 scopus 로고    scopus 로고
    • Role of CD8beta domains in CD8 coreceptor function: Importance for MHC I binding, signaling, and positive selection of CD8+ T cells in the thymus
    • Bosselut R., Kubo S., Guinter T., Kopacz J., Altman J., Feigenbaum L., Singer A. Role of CD8beta domains in CD8 coreceptor function. importance for MHC I binding, signaling, and positive selection of CD8+ T cells in the thymus Immunity. 12:2000;409-418.
    • (2000) Immunity , vol.12 , pp. 409-418
    • Bosselut, R.1    Kubo, S.2    Guinter, T.3    Kopacz, J.4    Altman, J.5    Feigenbaum, L.6    Singer, A.7
  • 5
    • 0033696599 scopus 로고    scopus 로고
    • Coreceptor reversal in the thymus: Signaled CD4+8+ thymocytes initially terminate CD8 transcription even when differentiating into CD8+ T cells
    • Brugnera E., Bhandoola A., Cibotti R., Yu Q., Guinter T., Yamashita Y., Sharrow S., Singer A. Coreceptor reversal in the thymus. signaled CD4+8+ thymocytes initially terminate CD8 transcription even when differentiating into CD8+ T cells Immunity. 13:2000;59-71.
    • (2000) Immunity , vol.13 , pp. 59-71
    • Brugnera, E.1    Bhandoola, A.2    Cibotti, R.3    Yu, Q.4    Guinter, T.5    Yamashita, Y.6    Sharrow, S.7    Singer, A.8
  • 6
    • 0027153897 scopus 로고
    • Another view of the selective model of thymocyte selection
    • Chan S., Cosgrove D., Waltzinger C., Benoist C., Mathis D. Another view of the selective model of thymocyte selection. Cell. 73:1993;225-236.
    • (1993) Cell , vol.73 , pp. 225-236
    • Chan, S.1    Cosgrove, D.2    Waltzinger, C.3    Benoist, C.4    Mathis, D.5
  • 7
    • 0028075391 scopus 로고
    • Role of coreceptors in positive selection and lineage commitment
    • Chan S., Waltzinger C., Baron A., Benoist C., Mathis D. Role of coreceptors in positive selection and lineage commitment. EMBO J. 13:1994;4482-4489.
    • (1994) EMBO J. , vol.13 , pp. 4482-4489
    • Chan, S.1    Waltzinger, C.2    Baron, A.3    Benoist, C.4    Mathis, D.5
  • 8
    • 0028467946 scopus 로고
    • Disruption of T lymphocyte positive and negative selection in mice lacking the CD8β chain
    • Crooks M., Littman D. Disruption of T lymphocyte positive and negative selection in mice lacking the CD8β chain. Immunity. 1:1994;277-285.
    • (1994) Immunity , vol.1 , pp. 277-285
    • Crooks, M.1    Littman, D.2
  • 9
    • 0027266755 scopus 로고
    • Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes
    • Davis C., Killeen N., Crooks M., Raulet D., Littman D. Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes. Cell. 73:1993;237-247.
    • (1993) Cell , vol.73 , pp. 237-247
    • Davis, C.1    Killeen, N.2    Crooks, M.3    Raulet, D.4    Littman, D.5
  • 10
    • 0023521229 scopus 로고
    • Interaction between CD4 and class II MHC molecules mediates cell adhesion
    • Doyle C., Strominger J. Interaction between CD4 and class II MHC molecules mediates cell adhesion. Nature. 330:1987;256-259.
    • (1987) Nature , vol.330 , pp. 256-259
    • Doyle, C.1    Strominger, J.2
  • 11
    • 0028930772 scopus 로고
    • Distinct differentiative stages of CD4+CD8+ thymocyte development defined by the lack of coreceptor binding in positive selection
    • Dutz J.P., Ong C.J., Marth J., Teh H.S. Distinct differentiative stages of CD4+CD8+ thymocyte development defined by the lack of coreceptor binding in positive selection. J. Immunol. 154:1995;2588-2599.
    • (1995) J. Immunol. , vol.154 , pp. 2588-2599
    • Dutz, J.P.1    Ong, C.J.2    Marth, J.3    Teh, H.S.4
  • 12
    • 0027366168 scopus 로고
    • The lack of CD8 alpha cytoplasmic domain resulted in a dramatic decrease in efficiency in thymic maturation but only a moderate reduction in cytotoxic function of CD8+ T lymphocytes
    • Fung-Leung W., Louie M., Limmer A., Ohashi P., Ngo K., Chen L., Kawai K., Lacy E., Loh D., Mak T. The lack of CD8 alpha cytoplasmic domain resulted in a dramatic decrease in efficiency in thymic maturation but only a moderate reduction in cytotoxic function of CD8+ T lymphocytes. Eur. J. Immunol. 23:1993;2834-2840.
    • (1993) Eur. J. Immunol. , vol.23 , pp. 2834-2840
    • Fung-Leung, W.1    Louie, M.2    Limmer, A.3    Ohashi, P.4    Ngo, K.5    Chen, L.6    Kawai, K.7    Lacy, E.8    Loh, D.9    Mak, T.10
  • 14
    • 0024558096 scopus 로고
    • Human CD2 3′-flanking sequences confer high-level, T cell-specific, position-independent gene expression in transgenic mice
    • Greaves D., Wilson F., Lang G., Kioussis D. Human CD2 3′-flanking sequences confer high-level, T cell-specific, position-independent gene expression in transgenic mice. Cell. 56:1989;979-986.
    • (1989) Cell , vol.56 , pp. 979-986
    • Greaves, D.1    Wilson, F.2    Lang, G.3    Kioussis, D.4
  • 16
    • 0025933951 scopus 로고
    • Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice
    • Huesmann M., Scott B., Kisielow P., von Boehmer H. Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice. Cell. 66:1991;533-540.
    • (1991) Cell , vol.66 , pp. 533-540
    • Huesmann, M.1    Scott, B.2    Kisielow, P.3    Von Boehmer, H.4
  • 17
    • 0028986357 scopus 로고
    • CD8 beta chain influences CD8 alpha chain-associated Lck kinase activity
    • Irie H.Y., Ravichandran K.S., Burakoff S.J. CD8 beta chain influences CD8 alpha chain-associated Lck kinase activity. J. Exp. Med. 181:1995;1267-1273.
    • (1995) J. Exp. Med. , vol.181 , pp. 1267-1273
    • Irie, H.Y.1    Ravichandran, K.S.2    Burakoff, S.J.3
  • 18
  • 19
    • 0028053092 scopus 로고
    • Stochastic component to development of class I major histocompatibility complex-specific T cells
    • Itano A., Kioussis D., Robey E. Stochastic component to development of class I major histocompatibility complex-specific T cells. Proc. Natl. Acad. Sci. USA. 91:1994;220-224.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 220-224
    • Itano, A.1    Kioussis, D.2    Robey, E.3
  • 20
    • 0030002882 scopus 로고    scopus 로고
    • The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells
    • Itano A., Salmon P., Kioussis D., Tolaini M., Corbella P., Robey E. The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells. J. Exp. Med. 183:1996;731-741.
    • (1996) J. Exp. Med. , vol.183 , pp. 731-741
    • Itano, A.1    Salmon, P.2    Kioussis, D.3    Tolaini, M.4    Corbella, P.5    Robey, E.6
  • 21
    • 0024288672 scopus 로고
    • T-cell development. Accessories or coreceptors?
    • Janeway C.A. Jr. T-cell development. Accessories or coreceptors? Nature. 335:1988;208-210.
    • (1988) Nature , vol.335 , pp. 208-210
    • Janeway C.A., Jr.1
  • 22
    • 0024444304 scopus 로고
    • Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor
    • Kaye J., Hsu M., Sauron M., Jameson S., Gascoigne N., Hedrick S. Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor. Nature. 341:1989;746-749.
    • (1989) Nature , vol.341 , pp. 746-749
    • Kaye, J.1    Hsu, M.2    Sauron, M.3    Jameson, S.4    Gascoigne, N.5    Hedrick, S.6
  • 24
    • 0028300349 scopus 로고
    • Differential effects of zeta and eta transgenes on early alpha/beta T cell development
    • Love P., Shores E., Lee E., Grinberg A., Munitz T., Westphal H., Singer A. Differential effects of zeta and eta transgenes on early alpha/beta T cell development. J. Exp. Med. 179:1994;1485-1494.
    • (1994) J. Exp. Med. , vol.179 , pp. 1485-1494
    • Love, P.1    Shores, E.2    Lee, E.3    Grinberg, A.4    Munitz, T.5    Westphal, H.6    Singer, A.7
  • 25
    • 0022262848 scopus 로고
    • Automated identification of subpopulations in flow cytometric list mode data using cluster analysis
    • Murphy R.F. Automated identification of subpopulations in flow cytometric list mode data using cluster analysis. Cytometry. 6:1985;302-309.
    • (1985) Cytometry , vol.6 , pp. 302-309
    • Murphy, R.F.1
  • 26
    • 0024446403 scopus 로고
    • Intrathymic signalling in immature CD4+CD8+ thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta chain
    • Nakayama T., Singer A., Hsi E.D., Samelson L.E. Intrathymic signalling in immature CD4+CD8+ thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta chain. Nature. 341:1989;651-654.
    • (1989) Nature , vol.341 , pp. 651-654
    • Nakayama, T.1    Singer, A.2    Hsi, E.D.3    Samelson, L.E.4
  • 27
    • 0023796326 scopus 로고
    • Cell-cell adhesion mediated by CD8 and MHC class I molecules
    • Norment A., Salter R., Parham P., Engelhard V., Littman D. Cell-cell adhesion mediated by CD8 and MHC class I molecules. Nature. 336:1988;79-81.
    • (1988) Nature , vol.336 , pp. 79-81
    • Norment, A.1    Salter, R.2    Parham, P.3    Engelhard, V.4    Littman, D.5
  • 28
    • 0024595609 scopus 로고
    • Substitution at residue 227 of H-2 class I molecules abrogates recognition by CD8-dependent, but not CD8-independent, cytotoxic T lymphocytes
    • Potter T., Rajan T., Dick R., Bluestone J. Substitution at residue 227 of H-2 class I molecules abrogates recognition by CD8-dependent, but not CD8-independent, cytotoxic T lymphocytes. Nature. 337:1989;73-75.
    • (1989) Nature , vol.337 , pp. 73-75
    • Potter, T.1    Rajan, T.2    Dick, R.3    Bluestone, J.4
  • 29
    • 0030469751 scopus 로고    scopus 로고
    • Lineage commitment in the thymus: Only the most differentiated (TCRhibcl-2hi) subset of CD4+CD8+ thymocytes has selectively terminated CD4 or CD8 synthesis
    • Punt J., Suzuki H., Granger L., Sharrow S., Singer A. Lineage commitment in the thymus. only the most differentiated (TCRhibcl-2hi) subset of CD4+CD8+ thymocytes has selectively terminated CD4 or CD8 synthesis J. Exp. Med. 184:1996;2091-2099.
    • (1996) J. Exp. Med. , vol.184 , pp. 2091-2099
    • Punt, J.1    Suzuki, H.2    Granger, L.3    Sharrow, S.4    Singer, A.5
  • 30
    • 0028201339 scopus 로고
    • Selective events in T cell development
    • Robey E., Fowlkes B.J. Selective events in T cell development. Annu. Rev. Immunol. 12:1994;675-705.
    • (1994) Annu. Rev. Immunol. , vol.12 , pp. 675-705
    • Robey, E.1    Fowlkes, B.J.2
  • 31
    • 0026034155 scopus 로고
    • Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage
    • Robey E., Fowlkes B., Gordon J., Kioussis D., von Boehmer H., Ramsdell F., Axel R. Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage. Cell. 64:1991;99-107.
    • (1991) Cell , vol.64 , pp. 99-107
    • Robey, E.1    Fowlkes, B.2    Gordon, J.3    Kioussis, D.4    Von Boehmer, H.5    Ramsdell, F.6    Axel, R.7
  • 33
    • 0019218668 scopus 로고
    • IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt 2 antigen block T cell-mediated cytolysis in the absence of complement
    • Sarmiento M., Glasebrook A., Fitch F. IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt 2 antigen block T cell-mediated cytolysis in the absence of complement. J. Immunol. 125:1980;2665-2672.
    • (1980) J. Immunol. , vol.125 , pp. 2665-2672
    • Sarmiento, M.1    Glasebrook, A.2    Fitch, F.3
  • 34
    • 0026522260 scopus 로고
    • Signal for T-cell differentiation to a CD4 cell lineage is delivered by CD4 transmembrane region and/or cytoplasmic tail
    • Seong R., Chamberlain J., Parnes J. Signal for T-cell differentiation to a CD4 cell lineage is delivered by CD4 transmembrane region and/or cytoplasmic tail. Nature. 356:1992;718-720.
    • (1992) Nature , vol.356 , pp. 718-720
    • Seong, R.1    Chamberlain, J.2    Parnes, J.3
  • 35
    • 0023785318 scopus 로고
    • Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice
    • Sha W., Nelson C., Newberry R., Kranz D., Russell J., Loh D. Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice. Nature. 335:1988;271-274.
    • (1988) Nature , vol.335 , pp. 271-274
    • Sha, W.1    Nelson, C.2    Newberry, R.3    Kranz, D.4    Russell, J.5    Loh, D.6
  • 36
    • 0028051551 scopus 로고
    • Role of TCR zeta chain in T cell development and selection
    • Shores E., Huang K., Tran T., Lee E., Grinberg A., Love P. Role of TCR zeta chain in T cell development and selection. Science. 266:1994;1047-1050.
    • (1994) Science , vol.266 , pp. 1047-1050
    • Shores, E.1    Huang, K.2    Tran, T.3    Lee, E.4    Grinberg, A.5    Love, P.6
  • 37
    • 0033178645 scopus 로고    scopus 로고
    • Signals involved in CD4/CD8 lineage commitment: Current concepts and potential mechanisms
    • Singer A., Bosselut R., Bhandoola A. Signals involved in CD4/CD8 lineage commitment. current concepts and potential mechanisms Semin. Immunol. 11:1999;273-281.
    • (1999) Semin. Immunol. , vol.11 , pp. 273-281
    • Singer, A.1    Bosselut, R.2    Bhandoola, A.3
  • 38
    • 0023813094 scopus 로고
    • Thymic major histocompatibility complex antigens and the alpha beta T-cell receptor determine the CD4/CD8 phenotype of T cells
    • Teh H., Kisielow P., Scott B., Kishi H., Uematsu Y., Bluthmann H., von Boehmer H. Thymic major histocompatibility complex antigens and the alpha beta T-cell receptor determine the CD4/CD8 phenotype of T cells. Nature. 335:1988;229-233.
    • (1988) Nature , vol.335 , pp. 229-233
    • Teh, H.1    Kisielow, P.2    Scott, B.3    Kishi, H.4    Uematsu, Y.5    Bluthmann, H.6    Von Boehmer, H.7
  • 39
    • 0024505883 scopus 로고
    • Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules
    • Teh H.S., Kishi H., Scott B., Von Boehmer H. Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules. J. Exp. Med. 169:1989;795-806.
    • (1989) J. Exp. Med. , vol.169 , pp. 795-806
    • Teh, H.S.1    Kishi, H.2    Scott, B.3    Von Boehmer, H.4
  • 40
    • 0028535120 scopus 로고
    • ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR zeta in murine thymocytes and lymph node T cells
    • van Oers N.S., Killeen N., Weiss A. ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR zeta in murine thymocytes and lymph node T cells. Immunity. 1:1994;675-685.
    • (1994) Immunity , vol.1 , pp. 675-685
    • Van Oers, N.S.1    Killeen, N.2    Weiss, A.3
  • 41
    • 0023737931 scopus 로고
    • The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck
    • Veillette A., Bookman M., Horak E., Bolen J. The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck. Cell. 55:1988;301-308.
    • (1988) Cell , vol.55 , pp. 301-308
    • Veillette, A.1    Bookman, M.2    Horak, E.3    Bolen, J.4
  • 42
    • 0024807506 scopus 로고
    • Engagement of CD4 and CD8 expressed on immature thymocytes induces activation of intracellular tyrosine phosphorylation pathways
    • Veillette A., Zuniga-Pflucker J., Bolen J., Kruisbeek A. Engagement of CD4 and CD8 expressed on immature thymocytes induces activation of intracellular tyrosine phosphorylation pathways. J. Exp. Med. 170:1989;1671-1680.
    • (1989) J. Exp. Med. , vol.170 , pp. 1671-1680
    • Veillette, A.1    Zuniga-Pflucker, J.2    Bolen, J.3    Kruisbeek, A.4
  • 43
    • 0027379699 scopus 로고
    • Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: Basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules
    • Wiest D., Yuan L., Jefferson J., Benveniste P., Tsokos M., Klausner R., Glimcher L., Samelson L., Singer A. Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase. basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules J. Exp. Med. 178:1993;1701-1712.
    • (1993) J. Exp. Med. , vol.178 , pp. 1701-1712
    • Wiest, D.1    Yuan, L.2    Jefferson, J.3    Benveniste, P.4    Tsokos, M.5    Klausner, R.6    Glimcher, L.7    Samelson, L.8    Singer, A.9
  • 44
    • 0030152354 scopus 로고    scopus 로고
    • TCR activation of ZAP70 is impaired in CD4+CD8+ thymocytes as a consequence of intrathymic interactions that diminish available p56lck
    • Wiest D., Ashe J., Abe R., Bolen J., Singer A. TCR activation of ZAP70 is impaired in CD4+CD8+ thymocytes as a consequence of intrathymic interactions that diminish available p56lck. Immunity. 4:1996;495-504.
    • (1996) Immunity , vol.4 , pp. 495-504
    • Wiest, D.1    Ashe, J.2    Abe, R.3    Bolen, J.4    Singer, A.5
  • 45
    • 0034732334 scopus 로고    scopus 로고
    • The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate
    • Yasutomo K., Doyle C., Miele L., Germain R. The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate. Nature. 404:2000;506c-5510.
    • (2000) Nature , vol.404
    • Yasutomo, K.1    Doyle, C.2    Miele, L.3    Germain, R.4
  • 46
    • 0024451745 scopus 로고
    • Inability of CD8 alpha' polypeptides to associate with p56lck correlates with impaired function in vitro and lack of expression in vivo
    • Zamoyska R., Derham P., Gorman S., von Hoegen P., Bolen J., Veillette A., Parnes J. Inability of CD8 alpha' polypeptides to associate with p56lck correlates with impaired function in vitro and lack of expression in vivo. Nature. 342:1989;278-281.
    • (1989) Nature , vol.342 , pp. 278-281
    • Zamoyska, R.1    Derham, P.2    Gorman, S.3    Von Hoegen, P.4    Bolen, J.5    Veillette, A.6    Parnes, J.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.