Coreceptor reversal in the thymus: Signaled CD4+8+ thymocytes initially terminate CD8 transcription even when differentiating into CD8+ T cells

Immunity

Volumn 13, Issue 1, 2000, Pages 59-71

  Brugnera, Enrico ^a   Bhandoola, Avinash ^a   Cibotti, Ricardo ^a   Yu, Qing ^a   Guinter, Terry I ^a   Yamashita, Yoshio ^b   Sharrow, Susan O ^a   Singer, Alfred ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE RECEPTOR; INTERLEUKIN 7;

ANIMAL CELL; ARTICLE; CELL FATE; CELL LINEAGE; CELL MATURATION; CONTROLLED STUDY; FETUS; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROGENY; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; T LYMPHOCYTE; THYMOCYTE; THYMUS; TRANSCRIPTION TERMINATION;

EID: 0033696599     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)00008-X     Document Type: Article

References (37)

1. Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus
2. Molecular requirements for lineage commitment in the thymus - Antibody-mediated receptor engagements reveal a central role for Ick in lineage decisions
3. Development of cytolytic T lymphocyte precursors in organ-cultured mouse embryonic thymus rudiments
4. CD4/CD8 lineage commitment: Matching fate with competence
5. Changes in surface antigens of immature thymocytes under the influence of T-cell growth factor and thymic factors
6. Pulse labeling of heterogeneous nuclear RNA in isolated nuclei
7. Surface molecules that drive T cell development in vitro in the absence of thymic epithelium and in the absence of lineage-specific signals
8. Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes
9. Correlating notch signaling with thymocyte maturatior
10. The regulation of CD4 and CD8 coreceptor gene expression during T cell development
11. Studies of thymocytopoiesis in rats and mice. I. Kinetics of appearance of thymocytes using a direct intrathymic adoptive transfer assay for thymocyte precursors
12. T-cell fate
13. Interleukin-7: Physiological roles and mechanisms of action
14. T cell receptor antagonist peptides induce positive selection
15. Differential induction of helper and killer T cells from isolated CD4+CD8+ thymocytes in suspension culture
16. T-cell development. Accessories or coreceptors?
17. Cloning and overexpression of Moloney murine leukemia virus reverse transcriptase in Escherichia coli
18. Intermediate steps in positive selection: Differentiation of CD4+8int TCRint thymocytes into CD4-8+TCRhi thymocytes
19. Inhibition of gamma delta T cell development and early thymocyte maturation in IL7 -/- mice
20. Isolation and analysis of nuclear RNA
21. Functional cleavage of the common cytokine receptor gamma chain (gammac) by calpain
22. In vitro differentiation and commitment of CD4+ CD8+ thymocytes to the CD4 lineage, without TCR engagement
23. Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice
24. Selective events in T cell development
25. An activated form of Notch influences the choice between CD4 and CD8 T cell lineages
26. A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development
27. Role of self antigens in the selection of the developing T cell repertoire
28. Specificity of thymic selection and the role of self antigens
29. Signals involved in CD4/CD8 lineage commitment: Current concepts and potential mechanisms
30. A transcriptional silencer controls the developmental expression of the CD4 gene
31. Expression and function of the interleukin 7 receptor in murine lymphocytes
32. Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: A new perspective on thymic commitment and selection
33. Post-transcriptional regulation of early T cell development by T cell receptor signals
34. The T cell receptor repertoire of CD4-8+ thymocytes is altered by overexpression of the BCL-2 protooncogene in the thymus
35. CD4/CD8 lineage commitment: Back to instruction?
36. The earliest T lineage-committed cells depend on IL7 for Bcl-2 expression and normal cell cycle progression
37. Syndecan-4 is expressed by B lineage lymphocytes and can transmit a signal for formation of dendritic processes