Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage

Nature Genetics

Volumn 29, Issue 3, 2001, Pages 332-336

  Zou, Yong Rui ^a,b   Sunshine, Mary Jean ^a   Taniuchi, Ichiro ^a   Hatam, Farah ^a   Killeen, Nigel ^c   Littman, Dan R ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b The New York Presbyterian Hospital   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL LINEAGE; CELL MATURATION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DEACETYLATION; DNA METHYLATION; GENE DELETION; GENE EXPRESSION; GENE LOCUS; GENE SILENCING; GENETIC STABILITY; INHERITANCE; INTRON; MITOSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SILENCER GENE; THYMOCYTE;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL LINEAGE; CYTOTOXICITY, IMMUNOLOGIC; DNA METHYLATION; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENE SILENCING; MICE; MICE, TRANSGENIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; T-LYMPHOCYTES, CYTOTOXIC; TRANSCRIPTION, GENETIC;

ANIMALIA;

EID: 0035190986     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng750     Document Type: Article

References (33)

1. T-cell lineage fate: Instructed by receptor signals?
2. Molecular determinants of TCR expression and selection
3. Development and selection of T cells: Facts and puzzles
4. The regulation of CD4 and CD8 coreceptor gene expression during T cell development
5. A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development
6. A transcriptional silencer controls the developmental expression of the CD4 gene
7. Signal transduction by lymphocyte antigen receptors
8. The CD4/CD8 lineage decision: Integration of signalling pathways
9. Positive selection of thymocytes bearing αβ T cell receptors
10. Repression: Targeting the heart of the matter
11. The Drosophila Fab-7 chromosomal element conveys epigenetic inheritance during mitosis and meiosis
12. Yeast heterochromatin: Regulation of its assembly and inheritance by histones
13. Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8T cell development
14. An enhancer that directs lineage-specific expression of CD8 in positively selected thymocytes and mature T cells
15. + T cell lineages: A new perspective on thymic commitment and selection
16. Epigenetics: Regulation through repression
17. Methylation-induced repression-belts, braces, and chromatin
18. Histone acetylation in chromatin structure and transcription
19. Methylation of a CTCF-dependent boundary controls imprinted expression of the lgf2 gene
20. CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/lgf2 locus
21. RNA and the epigenetic regulation of X chromosome inactivation
22. Genetics. Reprogramming X inactivation
23. Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer
24. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
25. Synergism of Xist RNA, DNA methylation, and histone hypoacetylation in maintaining X chromosome inactivation
26. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
27. Enzymatic activities of Sir2 and chromatin silencing
28. Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting
29. 1 Regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors
30. Episomal vectors rapidly and stably produce high-titer recombinant retrovirus
31. Uncoupling IL·2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death
32. The JAM test. A simple assay for DNA fragmentation and cell death
33. High sensitivity mapping of methylated cytosines