Thymocytes control the CD4 gene differently from mature T lymphocytes

International Immunology

Volumn 9, Issue 1, 1997, Pages 179-187

  Uematsu, Yasushi ^a   Donda, Alena ^a   De Libero, Gennaro ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

Enhancer; Gene regulation; Silencer; Thymic development; Transgenic mouse

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENHANCER REGION; GENE CONTROL; IMMUNOFLUORESCENCE; IMMUNOGENETICS; INTRON; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; THYMOCYTE; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, CD4; CELL DIFFERENTIATION; ENHANCER ELEMENTS (GENETICS); GENE EXPRESSION REGULATION; HUMANS; MICE; MICE, TRANSGENIC; PROMOTER REGIONS (GENETICS); REPRESSOR PROTEINS; T-LYMPHOCYTES; THYMUS GLAND; TRANS-ACTIVATORS; TRANSGENES;

EID: 0031058251     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/9.1.179     Document Type: Article

References (29)

1. Schwartz, R. H. 1985. T-lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex. Annu. Rev. Immunol. 3:237.
2. lck. Cell 55:301.
3. Kisielow, P. and von Boehmer, H. 1995. Development and selection of T cells facts and puzzles. Adv. Immunol. 58:87.
4. von Boehmer, H. 1994. Positive selection of lymphocytes. Cell 76:219.
5. + T cells acquire specific lymphokine secretion potentials during thymic maturation. Nature 353:68.
6. Nossal, G. J. 1994. Negative selection of lymphocytes. Cell 76:229.
7. Sawada, S. and Littman, D. R. 1991. Identification and characterization of a T-cell-specific enhancer adjacent to the murine CD4 gene. Mol. Cell. Biol. 11:5506.
8. Siu, G., Wurster, A. L., Lipsick, J. S. and Hedrick, S. M. 1992. Expression of the CD4 gene requires a Myb transcription factor. Mol. Cell. Biol. 12:1592.
9. Sawada, S. and Littman, D. R. 1993. A heterodimer of HEB and an E12-related protein interacts with the CD4 enhancer and regulates its activity in T-cell lines. Mol. Cell. Biol. 13:5620.
10. Salmon, P., Giovane, A., Wasylyk, B. and Klatzmann, D. 1993. Characterization of the human CD4 gene promoter: transcription from the CD4 gene core promoter is tissue-specific and is activated by Ets proteins, Proc. Natl Acad. Sci. USA 90:7739.
11. Donda, A., Schulz, M., Bürki, K., De Libero, G. and Uematsu, Y. 1996. Identification and characterization of a human CD4 silencer. Eur. J. Immunol. 26:493.
12. Sawada, S., Scarborough, J. D., Killeen, N. and Littman, D. R. 1994. A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development. Cell 77:917.
13. Siu, G., Wurster, A. L., Duncan, D. D., Soliman, T. M. and Hedrick, S. M. 1994. A transcriptional silencer controls the developmental expression of the CD4 gene. EMBO J. 13:3570.
14. + thymocytes. Eur. J. Immunol. 23:739.
15. Salmon, P., Boyer, O., Lorès, P., Jami, J. and Klatzmann, D. 1996. Characterization of an intronless CD4 minigene expressed in mature CD4 and CDS T cells, but not expressed in immature thymocytes. J. Immunol. 156:1873.
16. Cosgrove, D., Gray, D., Dierich, A., Kaufman, J., Lemeur, M., Benoist, C. and Mathis, D. 1991. Mice lacking MHC class II molecules. Cell 66:1051.
17. Marodon, G. and Rocha, B. 1994. Generation of mature T cell populations in the thymus: CD4 or CD8 down-regulation occurs at different stages of thymocyte differentiation. Eur. J. Immunol. 24:196.
18. hi thymocytes. J. Exp. Med. 181:1643.
19. + T cell lineages: a new perspective on thymic commitment and selection. Immunity 2:413.
20. Benveniste, P., Knowles, G. and Cohen, A, 1996. CD8/CD4 lineage commitment occurs by an instructional/default process followed by positive selection. Eur. J. Immunol. 26:461.
21. Lefranc, M. P. and Alexandre, D. 1995. γδ lineage-specific transcription of human T cell receptor y genes by a combination of a non-lineage-specific enhancer and silencers. Eur. J. Immunol. 25:617.
22. Shi, Y., Seto, E., Chang, L. S. and Shenk, T. 1991. Transcriptional repression by YY1, a human GLI-Krüppel-related protein, and relief of repression by adenovirus E1A protein. Cell 67:377.
23. Natesan, S. and Gilman, M. 1995. YY1 facilitates the association of serum response factor with the c-fos serum response element. Mol. Cell. Biol. 15:5975.
24. Bauknecht, T., Jundt, F., Herr, I., Oehler, T., Delius, H., Shi, Y., Angel, P. and Zur-Hausen. H. 1995. A switch region determines the cell type-specific positive or negative action of YY1 on the activity of the human papillomavirus type 18 promoter. J. Virol. 69:1.
25. Gstaiger, M., Knoepfel, L., Georgiev, O., Schaffner, W. and Hovens, C. M. 1995. A B-cell coactivator of octamer-binding transcription factors. Nature 373:360.
26. Strubin, M., Newell, J. W. and Matthias, P. 1995. OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins. Cell 80:497.
27. + T cells and in macrophages of transgenic mice. Mol. Cell. Biol. 14:1084.
28. Blum, M. D., Wong, G. T., Higgins, K. M., Sunshine, M. J. and Lacy, E. 1993. Reconstitution of the subclass-specific expression of CD4 in thymocytes and peripheral T cells of transgenic mice: identification of a human CD4 enhancer. J. Exp. Med. 177:1343.
29. Killeen, N., Sawada, S. and Littman, D. R. 1993. Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4. EMBO J. 12:1547.