Association of the adaptor molecule LAT with CD4 and CD8 coreceptors identifies a new coreceptor function in T cell receptor signal transduction

Journal of Experimental Medicine

Volumn 190, Issue 10, 1999, Pages 1517-1525

  Bosselut, Rémy ^a   Zhang, Weiguo ^a   Ashe, Jennifer M ^a   Kopacz, Jeffrey L ^a   Samelson, Lawrence E ^a   Singer, Alfred ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Development; Phosphorylation; Signaling; T cell receptor; Thymus

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR AFFINITY; RECEPTOR BINDING; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; THYMOCYTE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIGENS, CD4; ANTIGENS, CD8; CARRIER PROTEINS; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; PHOSPHOPROTEINS; PHOSPHORYLATION; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS;

EID: 0033571795     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.190.10.1517     Document Type: Article

References (44)

1. Marth, J.D., R. Peet, E.G. Krebs, and R.M. Perlmutter. 1985. A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA. Cell. 43:393-404.
2. Cooke, M.P., and R.M. Perlmutter. 1989. Expression of a novel form of the fyn proto-oncogene in hematopoietic cells. New Biol. 1:66-74.
3. Weiss, A., and D.R. Littman. 1994. Signal transduction by lymphocyte antigen receptors. Cell. 76:263-274.
4. Wange, R.L., and L.E. Samelson. 1996. Complex complexes: signaling at the TCR. Immunity. 5:197-205.
5. Kolanus, W., C. Romeo, and B. Seed. 1993. T cell activation by clustered tyrosine kinases. Cell. 74:171-183.
6. Wange, R.L., S.N. Malek, S. Desiderio, and L.E. Samelson. 1993. Tandem SH2 domains of ZAP-70 bind to T cell antigen receptor zeta and CD3 epsilon from activated Jurkat T cells. J. Biol. Chem. 268:19797-19801.
7. Iwashima, M., B.A. Irving, N.S. van Oers, A.C. Chan, and A. Weiss. 1994. Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases. Science. 263:1136-1139.
8. Watts, J.D., M. Affolter, D.L. Krebs, R.L. Wange, L.E. Samelson, and R. Aebersold. 1994. Identification by electrospray ionization mass spectrometry of the sites of tyrosine phosphorylation induced in activated Jurkat T cells on the protein tyrosine kinase ZAP-70. J. Biol. Chem. 269:29520-29529.
9. Chan, A.C., M. Dalton, R. Johnson, G.H. Kong, T. Wang, R. Thonia, and T. Kurosaki. 1995. Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function. EMBO (Eur. Mol. Biol. Organ.) J. 14:2499-2508.
10. Wange, R.L., R. Guitian, N. Isakov, J.D. Watts, R. Aebersold, and L.E. Samelson. 1995. Activating and inhibitory mutations in adjacent tyrosines in the kinase domain of ZAP-70. J. Biol. Chem. 270:18730-18733.
11. Barber, E.K., J.D. Dasgupta, S.F. Schlossman, J.M. Trevillyan, and C.E. Rudd. 1989. The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex. Prof. Natl. Acad. Sci. USA. 86:3277-3281.
12. Veillette, A., M.A. Bookman, E.M. Horak, L.E. Samelson, and J.B. Bolen. 1989. Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck. Nature. 338:257-259.
13. Wiest, D.L., J.M. Ashe, R. Abe, J.B. Bolen, and A. Singer. 1996. TCR activation of ZAP70 is impaired in CD4+ CD8+ thymocytes as a consequence of intrathymic interactions that diminish available p56lck. Immunity. 4:495-504.
14. Zhang, W., J. Sloan-Lancaster, J. Kitchen, R.P. Trible, and L.E. Samelson. 1998. LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell. 92:83-92.
15. Weber, J.R., S. Orstavik, K.M. Torgersen, N.C. Danbolt, S.F. Berg, J.C. Ryan, K. Tasken, J.B. Imboden, and J.T. Vaage. 1998. Molecular cloning of the cDNA encoding pp36, a tyrosine-phosphorylated adaptor protein selectively expressed by T cells and natural killer cells. J. Exp. Med. 187:1157-1161.
16. Finco, T.S., T. Kadlecek, W. Zhang, L.E. Samelson, and A. Weiss. 1998. LAT is required for TCR-mediated activation of PLCγ1 and the Ras pathway. Immunity. 9:617-626.
17. Nakayama, T., A. Singer, E.D. Hsi, and L.E. Samelson. 1989. Intrathymic signalling in immature CD4+CD8+ thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta chain. Nature. 341:651-654.
18. Kubo, R.T., W. Born, J.W. Kappler, P. Marrack, and M. Pigeon. 1989. Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors. J. Immunol. 142:2736-2742.
19. Sarmiento, M., A.L. Glasebrook, and F.W. Fitch. 1980. IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt 2 antigen block T cell-mediated cytolysis in the absence of complement. J. Immunol. 125:2665-2672.
20. Zamoyska, R., P. Derham, S.D. Gorman, P. von Hoegen, J.B. Bolen, A. Veillette, and J.R. Parnes. 1989. Inability of CD8 alpha′ polypeptides to associate with p56lck correlates with impaired function in vitro and lack of expression in vivo. Nature. 342:278-281.
21. Landt, O., H.P. Grunert, and U. Hahn. 1990. A general method for rapid site-directed mutagenesis using the polymerase chain reaction. Gene. 96:125-128.
22. Zhang, W., R.P. Trible, and L.E. Samelson. 1998. LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation. Immunity. 9:239-246.
23. Graham, F.L., and A.J. van der Eb. 1973. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology. 52:456-467.
24. Veillette, A., J.C. Zuniga-Pflucker, J.B. Bolen, and A.M. Kruisbeek. 1989. Engagement of CD4 and CD8 expressed on immature thymocytes induces activation of intracellular tyrosine phosphorylation pathways. J. Exp. Med. 170:1671-1680.
25. + thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules. J. Exp. Med. 178:1701-1712.
26. Simons, K., and E. Ikonen. 1997. Functional rafts in cell membranes. Nature. 387:569-572.
27. Cerny, J., H. Stockinger, and V. Horejsi. 1996. Noncovalent associations of T lymphocyte surface proteins. Eur. J. Immunol. 26:2335-2343.
28. Brown, D.A., and J.K. Rose. 1992. Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. Cell. 68:533-544.
29. Thomas, P.M., and L.E. Samelson. 1992. The glycophosphatidylinositol-anchored Thy-1 molecule interacts with the p60fyn protein tyrosine kinase in T cells. J. Biol. Chem. 267: 12317-12322.
30. Crooks, M.E., and D.R. Littman. 1994. Disruption of T lymphocyte positive and negative selection in mice lacking the CD8 beta chain. Immunity. 1:277-285.
31. + T cells in CD8β gene-targeted mice. J. Exp. Med. 180:959-967.
32. Irie, H.Y., K.S. Ravichandran, and S.J. Burakoff. 1995. CD8 β chain influences CDS α chain-associated Lck kinase activity. J. Exp. Med. 181:1267-1273.
33. Irie, H.Y., M.S. Mong, A. Itano, M.E. Crooks, D.R. Littman, S.J. BurakofF, and E. Robey. 1998. The cytoplasmic domain of CD8 beta regulates Lck kinase activation and CD8 T cell development. J. Immunol. 161:183-191.
34. Shaw, A.S., J. Chalupny, J.A. Whitney, C. Hammond, K.E. Amrein, P. Kavathas, B.M. Sefton, and J.K. Rose. 1990. Short related sequences in the cytoplasmic domains of CD4 and CD8 mediate binding to the amino-terminal domain of the p56lck tyrosine protein kinase. Mol. Cell. Biol. 10:1853-1862.
35. Turner, J.M., M.H. Brodsky, B.A. Irving, S.D. Levin, R.M. Perlmutter, and D.R. Littman. 1990. Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs. Cell. 60:755-765.
36. Secrist, J.P., L.A. Burns, L. Karnitz, G.A. Koretzky, and R.T. Abraham. 1993. Stimulatory effects of the protein tyrosine phosphatase inhibitor, pervanadate, on T-cell activation events. J. Biol. Chem. 268:5886-5893.
37. Zhang, W., C.L. Sommers, D.N. Burshtyn, C.C. Stebbins, J.B. DeJarnette, R.P. Trible, A. Grinberg, H.C. Tsay, H.M. Jacobs, C.M. Kessler, et al. 1999. Essential role of LAT in T cell development. Immunity. 10:323-332.
38. Lin, R.S., C. Rodriguez, A. Veillette, and H.F. Lodish. 1998. Zinc is essential for binding of p56(lck) to CD4 and CD8alpha. J. Biol. Chem. 273:32878-32882.
39. Montixi, C., C. Langlet, A.M. Bernard, J. Thimonier, C. Dubois, M.A. Wurbel, J.P. Chauvin, M. Pierres, and H.T. He. 1998. Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains. EMBO (Eur. Mol. Biol. Organ.) J. 17:5334-5348.
40. Xavier, R., T. Brennan, Q. Li, C. McCormack, and B. Seed. 1998. Membrane compartmentation is required for efficient T cell activation. Immunity. 8:723-732.
41. Deckert, M., S. Tartare-Deckert, J. Hernandez, R. Rottapel, and A. Altman. 1998. Adaptor function for the Syk kinases-interacting protein 3BP2 in IL-2 gene activation. Immunity. 9:595-605.
42. Gibbins, J.M., S. Briddon, A. Shutes, M.J. van Vugt, J.G. van de Winkel, T. Saito, and S.P. Watson. 1998. The p85 subunit of phosphatidylinositol 3-kinase associates with the Fc receptor gamma-chain and linker for activator of T cells (LAT) in platelets stimulated by collagen and convulxin. J. biol. Chem. 273:34437-34443.
43. Williams, B.L., B.J. Irvin, S.L. Sutor, C.C. Chini, E. Yacyshyn, J. Bubeck Wardenburg, M. Dalton, A.C. Chan, and R.T. Abraham. 1999. Phosphorylation of Tyr319 in ZAP-70 is required for T-cell antigen receptor-dependent phospholipase C-gamma1 and Ras activation. EMBO (Eur. Mol. Biol. Organ.) J. 18:1832-1844.
44. Tourvieille, B., S.D. Gorman, E.H. Field, T. Hunkapiller, and J.R. Parnes. 1986. Isolation and sequence of L3T4 complementary DNA clones: expression in T cells and brain. Science. 234:610-614.