Signal strength in thymic selection and lineage commitment

Current Opinion in Immunology

Volumn 13, Issue 2, 2001, Pages 225-231

  Hogquist, K A ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR;

ANIMAL EXPERIMENT; CELL DIFFERENTIATION; LYMPHOPOIESIS; MOUSE; NONHUMAN; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE SUBPOPULATION; THYMUS;

EID: 0035313978     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(00)00208-9     Document Type: Review

References (58)

1. T-cell receptor affinity and thymocyte positive selection
2. A kinetic threshold between negative and positive selection based on the longevity of the T cell receptor-ligand complex
3. Selection of the T cell repertoire
4. Partial T cell signaling: Altered phospho-zeta and lack of zap70 recruitment in APL-induced T cell energy
5. Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists
6. The 21 and 23-kD forms of TCR zeta are generated by specific ITAM phosphorylation
7. Role of the multiple T cell receptor (TCR)-zeta chain signaling motifs in selection of the T cell repertoire
8. Crippling of CD3-zeta ITAMs does not impair T cell receptor signaling
9. Critical relationship between TCR signaling potential and TCR affinity during thymocyte selection
10. Regulation of TCR signal transduction in murine thymocytes by multiple TCR zeta-chain signaling motifs
11. Altered peptide ligands induce quantitatively but not qualitatively different intracellular signals in primary thymocytes
12. Divergent changes in the sensitivity of maturing T cells to structurally related ligands underlies formation of a useful T cell repertoire
13. Pre-selection thymocytes are more sensitive to TCR stimulation than mature T cells
14. Tec family kinases modulate thresholds for thymocyte development and selection
15. CD3 delta couples T-cell receptor signalling to ERK activation and thymocyte positive selection
16. A motif in the αβ T cell receptor controls positive selection by modulating the ERK pathway
17. CD3δ deficiency arrests development of the αβ but not the γδ T cell lineage
18. Positive selection through a motif in the alpha beta T cell receptor
19. Positive and negative selection invoke distinct signaling pathways
20. Differential roles of ERK and p38 MAP kinase pathways in positive and negative selection of T lymphocytes
21. The influence of the MAPK pathway on T cell lineage commitment
22. Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
23. Rap1 mediates sustained MAP kinase activation induced by nerve growth factor
24. Positive selection of thymocytes involves sustained interactions with the thymic microenvironment
25. Positive selection of T cells: Rescue from programmed cell death and differentiation require continual engagement of the T cell receptor
26. RasGRP is essential for mouse thymocyte differentiation and TCR signaling
27. Receptor editing in developing T cells
28. Thymocyte selection: Not by TCR alone
29. Negative selection of immature B cells by receptor editing or deletion is determined by site of antigen encounter
30. Signals involved in CD4/CD8 lineage commitment: Current concepts and potential mechanisms
31. Stochastic component to development of class I major histocompatibility complex-specific T cells
32. Highly efficient selection of CD4 and CD8 lineage thymocytes supports an instructive model of lineage commitment
33. MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent
34. The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells
35. Lck tyrosine kinase: Basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules
36. lck and cytoplasmic domains of CD4 and CD8 alpha in yeast
37. lck correlates with impaired function in vitro and lack of expression in vivo
38. The role of CD8 alpha′ in the CD4 versus CD8 lineage choice
39. Lck activity controls CD4/CD8 T cell lineage commitment
40. Commitment to the CD4 lineage mediated by extracellular signal-related kinase mitogen-activated protein kinase and Lck signaling
41. Lck transgene reveals a central role for Lck in the differentiation of CD4 SP thymocytes
42. + T-cell lineage fate
43. + T cells
44. Enhanced positive selection of a transgenic TCR by a restriction element that does not permit negative selection
45. Slow accumulation of active mitogen-activated protein kinase during thymocyte differentiation regulates the temporal pattern of transcription factor gene expression
46. Activation of the extracellular signal-related kinase/mitogen-activated protein kinase pathway discriminates CD4 versus CD8 lineage commitment in the thymus
47. Degree of ERK activation influences both positive and negative thymocyte selection
48. Selective requirement for MAP kinase activity in thymocyte differentiation
49. Defective thymocyte maturation in p44 MAP kinase (ERK 1) knockout mice
50. An activated form of Notch influences the choice between CD4 and CD8 T cell lineages
51. Correlating Notch signaling with thymocyte maturation
52. MHC recognition in thymic development: Distinct, parallel pathways for survival and lineage commitment
53. Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes
54. Constitutive activation of NF-kappa B and T-cell leukemia/lymphoma in Notch3 transgenic mice
55. Regulation of lineage commitment distinct from positive selection
56. Functional commitment to helper T cell lineage precedes positive selection and is independent of T cell receptor MHC specificity
57. The shaping of the T cell repertoire
58. Disruption of T cell signalling networks and development by Grb2 haploid insufficiency