Mechanisms of transcriptional regulation by Runt domain proteins

Seminars in Cell and Developmental Biology

Volumn 11, Issue 5, 2000, Pages 369-375

  Wheeler, John C ^a   Shigesada, Katsuya ^b   Peter Gergen, J ^a   Ito, Yoshiaki ^b  

^a STONY BROOK UNIVERSITY   (United States)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Activation; Brother; CBFb; Drosophila; Ets; Groucho; Mouse; Repression; RUNX; SMAD

Indexed keywords

DNA; PROTEIN RUNT; REGULATOR PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

BONE DEVELOPMENT; DEVELOPMENTAL BIOLOGY; DIMERIZATION; DNA BINDING; EMBRYO DEVELOPMENT; GENE EXPRESSION REGULATION; HEMATOPOIESIS; HUMAN; MODEL; MOLECULAR BIOLOGY; NONHUMAN; PROTEIN ANALYSIS; REVIEW; SEX DETERMINATION; TRANSCRIPTION REGULATION;

ANIMALIA; DROSOPHILA; DROSOPHILA MELANOGASTER; EUKARYOTA; MAMMALIA; RAPHIA FRATER;

EID: 0034486564     PISSN: 10849521     EISSN: None     Source Type: Journal    
DOI: 10.1006/scdb.2000.0184     Document Type: Article

References (57)

1. A simple screening for mutant DNA binding proteins: Application to murine transcription factor PEBP2alpha subunit, a founding member of the Runt domain protein family
2. Groucho-dependent and -independent repression activities of Runt domain proteins
3. An AML-1 consensus sequence binds an osteoblast-specific complex and transcriptionally activates the osteocalcin gene
4. Core binding factor cannot synergistically activate the myeloperoxidase proximal enhancer in immature myeloid cells without c-Myb
5. ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function
6. The enhanceosome and transcriptional synergy
7. The Drosophila sex determination signal: How do flies count to two?
8. SpRunt-1, a new member of the runt domain family of transcription factors, is a positive regulator of the aboral ectoderm-specific CyIIIA gene in sea urchin embryos
9. Patterning of cells in the Drosophila eye by Lozenge, which shares homologous domains with AML1
10. Expression patterns of hairy, even-skipped and runt in the spider Cupiennius salei imply that these genes were segmentation genes in a basal arthropod
11. Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene
12. Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation
13. The Drosophila segmentation gene runt acts as a position-specific numerator element necessary for the uniform expression of the sex-determining gene Sex-lethal
14. Leukemogenesis by CBF oncoproteins
15. Isolation and characterization of the distal promoter region of mouse Cbfa1
16. A PEBP2 alpha/AML-1-related factor increases osteocalcin promoter activity through its binding to an osteoblast-specific cis-acting element
17. Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions
18. Auto-inhibition of Ets-1 is counteracted by DNA binding cooperativity with core-binding factor alpha2
19. Alignment of U3 region sequences of mammalian type C viruses: Identification of highly conserved motifs and implications for enhancer design
20. Drosophila homologs of the proto-oncogene product PEBP2/CBF beta regulate the DNA-binding properties of Runt
21. Auto-inhibition and partner proteins, core-binding factor beta (CBFbeta) and Ets-1, modulate DNA binding by CBFalpha2 (AML1)
22. Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter
23. Regulation of the T-cell receptor delta enhancer by functional cooperation between c-Myb and core-binding factors
24. The runt protein and its companion PEBP2: A close link between this transcription factor and AML
25. In vivo interactions of the Drosophila Hairy and Runt transcriptional repressors with target promoters
26. Characterization of the cooperative function of inhibitory sequences in Ets-1
27. The Runt domain identifies a new family of heteromeric transcriptional regulators
28. Intrinsic transcriptional activation-inhibition domains of the polyomavirus enhancer binding protein 2/core binding factor alpha subunit revealed in the presence of the beta subunit
29. The genetic transformation of bone biology
30. Mutual activation of Ets-1 and AML1 DNA binding by direct interaction of their autoinhibitory domains
31. Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation
32. Direct activation of Sex-lethal transcription by the Drosophila runt protein
33. Functional domains of the t(8;21) fusion protein, AML-1/ETO
34. Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors
35. Functional differences in the requirements for interactions of the Runt protein with the Brother proteins and DNA
36. Differential interactions between Brother proteins and Runt domain proteins in the Drosophila embryo and eye
37. DNA binding by c-Ets-1, but not v-Ets, is repressed by an intramolecular mechanism
38. A mechanism of repression by Acute Myeloid Leukemia-1, the target of multiple chromosomal translocations in acute leukemia
39. Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation
40. Control of segmental asymmetry in Drosophila embryos
41. PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2 beta/CBF beta proto-oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells
42. Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2alpha
43. Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2alphaB gene associated with myeloblastic leukemias
44. Multiple functional domains of AML1: PU.1 and C/EBPalpha synergize with different regions of AML1
45. Transcription-coupled translation control of AML1/RUNX1 is mediated by cap- and internal ribosome entry site-dependent mechanisms
46. Virus induction of human IFN beta gene expression requires the assembly of an enhanceosome
47. A Xenopus homologue and aml-1 reveals unexpected patterning mechanism leading to the formation of embryonic blood
48. Quantitative analysis of gene function in the Drosophila embryo
49. Gap gene properties of the pair-rule gene runt during Drosophila segmentation
50. Pair-rule expression of the Drosophila fushi tarazu gene: A nuclear receptor response element mediates the opposing regulatory effects of runt and hairy
51. Pair-rule gene unit restricts orthodenticle expression to the presumptive head of the Drosophila embryo
52. Runt domains take the lead in hematopoiesis and osteogenesis
53. Cooperative binding of Ets-1 and core binding factor to DNA
54. Regulation of Smad activity
55. Transcriptional activation of a retrovirus enhancer by CBF (AML1) requires a second factor: Evidence for cooperativity with c-Myb
56. CBF, Myb, and Ets binding sites are important for activity of the core I element of the murine retrovirus SL3-3 in T lymphocytes
57. Identification of a region which directs the monocytic activity of the colony-stimulating factor 1 (macrophage colony-stimulating factor) receptor promoter and binds PEBP2/CBF (AML1)