Hierarchical interactions of control elements determine CD8α gene expression in subsets of thymocytes and peripheral T cells

Immunity

Volumn 9, Issue 4, 1998, Pages 497-508

  Hostert, Arnd ^a   Garefalaki, Anna ^a   Mavria, Georgia ^a,b   Tolaini, Mauro ^a   Roderick, Kathleen ^a   Norton, Trisha ^a   Mee, P Joseph ^a   Tybulewicz, Victor L J ^a   Coles, Mark ^a   Kioussis, Dimitris ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; GENE EXPRESSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; THYMOCYTE; TRANSGENIC MOUSE;

EID: 0032192483     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80633-0     Document Type: Article

References (39)

1. Adlam, M., Duncan, D.D., Ng, D.K., and Siu, G. (1997). Positive selection induces CD4 promoter and enhancer function. Int. Immunol. 9, 877-887.
2. Blum, M.D., Wong, G.T., Higgins, K.M., Sunshine, M.J., and Lacy, E. (1993). Reconstitution of the subclass-specific expression of CD4 in thymocytes and peripheral T cells of transgenic mice: identification of a human CD4 enhancer. J. Exp. Med. 177, 1343-1358.
3. Correa, I., Bix, M., Liao, N.S., Zijlstra, M., Jaenisch, R., and Raulet, D. (1992). Most gamma delta T cells develop normally in beta 2-microglobulin-deficient mice. Proc. Natl. Acad. Sci. USA 89, 653-657.
4. Doetschman, T.C., Eistetter, H., Katz, M., Schmidt, W., and Kemler, R. (1985). The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium. J. Embryol. Exp. Morphol. 87, 27-45.
5. Duncan, D.D., Adlam, M., and Siu, G. (1996). Asymmetric redundancy in CD4 silencer function. Immunity 4, 301-311.
6. Ellmeier, W., Sunshine, M.J., Losos, K., Hatam, F., and Littman, D.R. (1997). An enhancer that directs lineage-specific expression of CD8 in positively selected thymocytes and mature T cells. Immunity 7, 537-547.
7. Fowlkes, B.J., and Pardoll, D.M. (1989). Molecular and cellular events of T cell development. Adv. Immunol. 44, 207-264.
8. + intraepithelial lymphocytes. Nature 333, 855-858.
9. Gorman, S.D., Sun, Y.H., Zamoyska, R., and Parnes, J.R. (1988). Molecular linkage of the Ly-3 and Ly-2 genes. Requirement of Ly-2 for Ly-3 surface expression. J. Immunol. 140, 3646-3653.
10. Greaves, D.R., Wilson, F.D., Lang, G., and Kioussis, D. (1989). Human CD2 3′-flanking sequences confer high-level, T cell-specific, position-independent gene expression in transgenic mice. Cell 56, 979-986.
11. Gu, J.J., and Gottlieb, P.D. (1992). Inducible functions in hybrids of a Lyt-2+ BW5147 transfectant and the 2C CTL line. Immunogenetics 36, 283-293.
12. Guy-Grand, D., Cerf-Bensussan, N., Malissen, B., Malassis-Seris, M., Briottet, C., and Vassalli, P. (1991). Two gut intraepithelial CD8+ lymphocyte populations with different T cell receptors: a role for the gut epithelium in Tcell differentiation. J. Exp. Med. 173, 471-481.
13. Hamerman, J.A., Page, S.T., and Pullen, A.M. (1997). Distinct methylation states of the CD8 beta gene in peripheral T cells and intraepithelial lymphocytes. J. Immunol. 159, 1240-1246.
14. Hostert, A., Tolaini, M., Festenstein, R., McNeill, L., Malissen, B., Williams, O., Zamoyska, R., and Kioussis, D. (1997a). A CD8 genomic fragment that directs subset-specific expression of CD8 in transgenic mice. J. Immunol. 158, 4270-4281.
15. Hostert, A., Tolaini, M., Roderick, K., Harker, N., Norton, T., and Kioussis, D. (1997b). A region in the CD8 gene locus that directs expression to the mature CD8 T cell subset in transgenic mice. Immunity 7, 525-536.
16. Hostert, A. (1998). Identification of regulatory elements in the CD8 gene locus. PhD thesis, University of London, London, United Kingdom.
17. Hwang, I., Gu, J.J., and Gottlieb, P.D. (1993). Differential susceptibility of mouse Lyt-2 and Lyt-3 genes to negative regulation. Immunogenetics 37, 129-134.
18. Jay, G., Palladino, M.A., Khoury, G., and Old, L.J. (1982). Mouse Lyt-2 antigen: evidence for two heterodimers with a common subunit. Proc. Natl. Acad. Sci. USA 79, 2654-2657.
19. Kieffer, L.J., Yan, L., Hanke, J.H., and Kavathas, P.B. (1997). Appropriate developmental expression of human CD8 beta in transgenic mice. J. Immunol. 159, 4907-4912.
20. Landry, D.B., Engel, J.D., and Sen, R. (1993). Functional GATA-3 binding sites within murine CDS alpha upstream regulatory sequences. J. Exp. Med. 178, 941-949.
21. Ledbetter, J.A., and Seaman, W.E. (1982). The Lyt-2, Lyt-3 macromolecules: structural and functional studies. Immunol. Rev. 68, 197-218.
22. Ledbetter, J.A., Seaman, W.E., Tsu, T.T., and Herzenberg, L.A. (1981). Lyt-2 and lyt-3 antigens are on two different polypeptide subunits linked by disulfide bonds. Relationship of subunits to T cell cytolytic activity. J. Exp. Med. 153, 1503-1516.
23. Lee, W.H., Banan, M., Harriss, J.V., Hwang, I., Woodward, E., Youn, H.J., and Gottlieb, P.D. (1994). Cis-acting DNA elements and cell type-specific nuclear proteins which may play a role in regulation of mouse CD8 alpha (Lyt-2) gene transcription. Int. Immunol. 6, 1307-1321.
24. Maloy, K.J., Mowat, A.M., Zamoyska, R., and Crispe, I.N. (1991). Phenotypic heterogeneity of intraepithelial T lymphocytes from mouse small intestine. Immunology 72, 555-562.
25. Mamalaki, C., Elliott, J., Norton, T., Yannoutsos, N., Townsend, A.R., Chandler, P., Simpson, E., and Kioussis, D. (1993). Positive and negative selection in transgenic mice expressing a T-cell receptor specific for influenza nucleoprotein and endogenous superantigen. Dev. Immunol. 3, 159-174.
26. Mamalaki, C., Norton, T., Tanaka, Y., Townsend, A.R., Chandler, P., Simpson, E., and Kioussis, D. (1992). Thymic depletion and peripheral activation of class I major histocompatibility complex-restricted T cells by soluble peptide in T-cell receptor transgenic mice. Proc. Natl. Acad. Sci. USA 89, 11342-11346.
27. Mansour, S.L., Thomas, K.R., and Capecchi, M.R. (1988). Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. Nature 336, 348-352.
28. Poussier, P., and Julius, M. (1994). Thymus independent T cell development and selection in the intestinal epithelium. Annu. Rev. Immunol. 12, 521-553.
29. Robey, E., Chang, D., Itano, A., Cado, D., Alexander, H., Lans, D., Weinmaster, G., and Salmon, P. (1996). An activated form of Notch influences the choice between CD4 and CD8 T cell lineages. Cell 87, 483-492.
30. Rocha, B., Vassalli, P., and Guy-Grand, D. (1992). The extrathymic T-cell development pathway. Immunol. Today 13, 449-454.
31. Saito, H., Kanamori, Y., Takemori, T., Nariuchi, H., Kubota, E., Takahashi, I.H., Iwanaga, T., and Ishikawa, H. (1998). Generation of intestinal T cells from progenitors residing in gut cryptopatches. Science 280, 275-278.
32. Salmon, P., Boyer, O., Lores, P., Jami, J., and Klatzmann, D. (1996). Characterization of an intronless CD4 minigene expressed in mature CD4 and CD8 T cells, but not expressed in immature thymocytes. J. Immunol. 156, 1873-1879.
33. Sawada, S., and Littman, D.R. (1991). Identification and characterization of a T-cell-specific enhancer adjacent to the murine CD4 gene. Mol. Cell Biol. 11, 5506-5515.
34. Sawada, S., Scarborough, J.D., Killeen, N., and Littman, D.R. (1994). A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development. Cell 77, 917-929.
35. Siu, G., Wurster, A.L., Duncan, D.D., Soliman, T.M., and Hedrick, S.M. (1994). A transcriptional silencer controls the developmental expression of the CD4 gene. EMBO J. 13, 3570-3579.
36. Spanopoulou, E., Roman, C.A., Corcoran, L.M., Schlissel, M.S., Silver, D.P., Nemazee, D., Nussenzweig, M.C., Shinton, S.A., Hardy, R.R., and Baltimore, D. (1994). Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice. Genes Dev. 8, 1030-1042.
37. Tybulewicz, V.L., Crawford, C.E., Jackson, P.K., Bronson, R.T., and Mulligan, R.C. (1991). Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell 65, 1153-1163.
38. Uematsu, Y., Donda, A., and De Libero, G. (1997). Thymocytes control the CD4 gene differently from mature T lymphocytes. Int. Immunol. 9, 179-187.
39. Washburn, T., Schweighoffer, E., Gridley, T., Chang, D., Fowlkes, B.J., Cado, D., and Robey, E. (1997). Notch activity influences the αβ versus γδ T cell lineage decision. Cell 88, 833-843.