Characterization of an intronless CD4 minigene expressed in mature CD4 and CD8 T cells, but not expressed in immature thymocytes

Journal of Immunology

Volumn 156, Issue 5, 1996, Pages 1873-1879

  Salmon, Patrick ^a,c   Boyer, Olivier ^a   Lorès, Patrick ^b   Jami, Jacques ^b   Klatzmann, David ^a  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^b INSTITUT COCHIN   (France)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; COMPLEMENTARY DNA; MONOCLONAL ANTIBODY; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; DEVELOPMENTAL GENETICS; ENHANCER REGION; GENE EXPRESSION REGULATION; IMMUNOGENETICS; LYMPHOCYTE DIFFERENTIATION; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; SILENCER GENE; T LYMPHOCYTE; THYMOCYTE; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, CD4; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; ENHANCER ELEMENTS (GENETICS); GENE EXPRESSION REGULATION; INTRONS; LYMPH NODES; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, TRANSGENIC; PROMOTER REGIONS (GENETICS); SPLEEN; THYMUS GLAND;

EID: 0030022783     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Doyle, C., and J L. Strominger 1987. Interaction between CD4 and class II MHC molecules mediates cell adhesion. Nature 330:256.
2. Norment, A. M., R. D. Salter, P. Parham, V. H. Engelhard, and D R. Littman. 1988. Cell-cell adhesion mediated by CD8 and MHC class I molecules. Nature 336:79.
3. Parnes, J. R. 1989 Molecular biology and function of CD4 and CD8 Adv. Immunol. 44:265.
4. lck. Cell 55.301.
5. Robey, E., and B. J Fowlkes 1994. Selective events in T cell development. Annu. Rev. Immunol. 12:675.
6. + T cells in transgenic mice expressing a class II MHC-restricted antigen receptor. Nature 341.746.
7. Sha, W. C , C. A Nelson, R. D. Newberry, D. M. Kranz, J. H. Russell, and D. Y Loh. 1988. Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice Nature 335:271.
8. Salmon, P., A. Giovane, B. Wasylyk, and D Klatzmann. 1993. Characterization of the human CD4 gene promoter: transcription from the CD4 gene core promoter is tissue-specific and is activated by Ets proteins. Proc. Natl Acad. Sci USA 90, 7739.
9. Siu, G., A. L. Wurster, J. S. Lipsick, and S. M. Hedrick. 1992. Expression of the CD4 gene requires a Myb transcription factor. Mol Cell. Biol. 12:1592.
10. + T cells and in macrophages of transgenic mice. Mol. Cell Biol. 14:1084.
11. Littman, D. R., and S. N. Gettner. 1987. Unusual intron in the immunoglobulin domain of the newly isolated murine CD4 (L3T4) gene. Nature 325:453.
12. Tourvieille, B., S. D. Gorman, E. H Field, T Hunkapiller, and J R. Parnes. 1986. Isolation and sequence of L3T4 complementary DNA clones: expression in T cells and brain. Science 234:610.
13. Killeen, N., S. Sawada, and D. R. Littman. 1993. Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4. EMBO J. 12:1547.
14. Sawada, S., and D. R Littman 1991. Identification and characterization of a T-cell-specific enhancer adjacent to the murine CD4 gene. Mol Cell. Biol 11: 5506.
15. Blum, M. D., G. T. Wong, K. M Higgins, M. J. Sunshine, and E. Lacy. 1993. Reconstitution of the subclass-specific expression of CD4 in thymocytes and peripheral T cells of transgenic mice. identification of a human CD4 enhancer. J. Exp. Med. 177:1343.
16. Siu, G., A L. Wurster, D. D. Duncan, T. M. Soliman, and S. M Hedrick. 1994. A transcriptional silencer controls the developmental expression of the CD4 gene. EMBO J. 13:3570
17. Sawada, S., J. D. Scarborough, N. Killeen, and D. R. Littman. 1994 A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development. Cell 77 917.
18. Gillespie, F. P., L Doros, J. Vitale, C. Blackwell, J. Gosselin, B. W. Snyder, and S. C. Wadsworth 1993. Tissue-specific expression of human CD4 in transgenic mice Mol. Cell Biol. 13.2952.
19. Wurster, A. L , G. Siu, J. M Leiden, and S. M Hedrick. 1994. Elf-1 binds to a critical element in a second CD4 enhancer. Mol Cell. Biol. 14:6452.
20. Maddon, P. J., D. R Littman, M. Godfrey, D. E. Maddon, L. Chess, and R Axel. 1985. The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4 a new member of the immunoglobulin gene family. Cell 42:93.
21. Hogan, B., F. Costantini, and E Lacy 1986. Manipulating the Mouse Embryo: A Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
22. Paterson, R. K., L. C. Burkly, D. K Kurahara, A. Dunlap, R A. Flavell, and T H. Finkel 1994. Thymic development in human CD4 transgenic mice: positive selection occurs after commitment to the CD8 lineage. J. Immunol. 153:3491.
23. (-) mouse: a model to study differentiation of murine NK cells J. Immunol. 137:3742.
24. Sentman, C L., J. J. Hackett, V. Kumar, and M. Bennett. 1989. Identification of a subset of murine natural killer cells that mediates rejection of Hh-1d but not Hh-1b bone marrow grafts. J. Exp Med. 170.191
25. Alterman, L A., I. N. Crispe, and C. Kinnon. 1990. Characterization of the murine heat-stable antigen: an hematolymphoid differentiation antigen defined by the J11d, M1/69 and B2A2 antibodies. Eur. J. Immunol. 20:1597.
26. Fowlkes, B. J., and D M. Pardoll. 1989. Molecular and cellular events of T cell development Adv Immunol. 44:207.