The lineage decisions of helper T cells

Nature Reviews Immunology

Volumn 2, Issue 12, 2002, Pages 933-944

  Murphy, Kenneth M ^a   Reiner, Steven L ^b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DNA; GAMMA INTERFERON; HISTONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 12 RECEPTOR; INTERLEUKIN 18; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; STAT1 PROTEIN; STAT6 PROTEIN; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR NFAT; DNA BINDING PROTEIN; GATA3 PROTEIN, HUMAN; IMMUNOLOGICAL ADJUVANT; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; CHROMATIN; DENDRITIC CELL; DNA METHYLATION; EFFECTOR CELL; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HELPER CELL; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; ACTIVE IMMUNIZATION; ANIMAL; BIOSYNTHESIS; GENETICS; HUMAN; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; LYMPHOPOIESIS; PARASITOSIS; PHYSIOLOGY; SIGNAL TRANSDUCTION; TH1 CELL; TH2 CELL;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; CYTOKINES; DNA-BINDING PROTEINS; GATA3 TRANSCRIPTION FACTOR; HUMANS; IMMUNITY, ACTIVE; IMMUNOLOGIC MEMORY; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-4; LYMPHOPOIESIS; PARASITIC DISEASES; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, HELPER-INDUCER; TH1 CELLS; TH2 CELLS; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC;

EID: 0036885067     PISSN: 14741733     EISSN: None     Source Type: Journal    
DOI: 10.1038/nri954     Document Type: Review

References (122)

1. Abbas, A. K., Murphy, K. M. & Sher, A. Functional diversity of helper T lymphocytes. Nature 383, 787-793 (1996).
2. Ho, I. C. & Glimcher, L. H. Transcription: tantalizing times for T cells. Cell 109, S109-S120 (2002).
3. Mosmann, T. R., Cherwinski, H., Bond, M. W., Gledlin, M. A. & Coffman, R. L. Two types of murine helper T-cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136, 2348-2357 (1986).
4. H1-lineage commitment and IFN-γ production in CD4 and CD8 T cells. Science 295, 338-342 (2002).
5. H1)-lineage commitment.
6. H1 cells before IL-12-dependent selection. Science 292, 1907-1910 (2001).
7. H1 gene induction. Nature Immunol. 3, 652-658 (2002)
8. H2 development and commitment. Immunity 12, 27-37 (2000). This study showed that GATA3 might act independently of STAT6 and that GATA3 induces chromatin remodelling of the IL-4 locus.
9. H1 development mediated by GATA-3 through an IL-4-independent mechanism. Immunity 9, 745-755 (1998).
10. H2 cytokine gene expression in CD4 T cells. Cell 89, 587-596 (1997).
11. H2-cell-specific transcription factor.
12. H1 cells. J. Exp. Med. 192, 105-115 (2000).
13. Lee, G. R., Fields, P. E. & Flavell, R. A. Regulation of IL-4 gene expression by distal regulatory elements and GATA-3 at the chromatin level. Immunity 14, 447-459 (2001). This study defined the regulatory elements of the IL-4 locus that mediate GATA3-dependent chromatin induction.
14. H1 cells in addition to inducing IL-4 and IL-5 levels. Clin. Immunol. 91, 134-144 (1999).
15. Hsieh, C. S., Heimberger, A. B., Gold, J. S., O'Garra, A. & Murphy, K. M. Differential regulation of T helper phenotype development by interleukins 4 and 10 in an αβ T-cell-receptor transgenic system. Proc. Natl Acad. Sci. USA 89, 6065-6069 (1992).
16. + T cells from T-cell-receptor-transgenic mice. J. Exp. Med. 176, 1091-1098 (1992).
17. Le Gros, G., Ben-Sasson, S. Z., Seder, R., Finkelman, F. D. & Paul, W. E. Generation of interleukin-4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells. J. Exp. Med. 172, 921-929 (1990).
18. H2-like helper effectors. J. Immunol. 145, 3796-3806 (1990).
19. H2 cells. Immunity 4, 313-319 (1996).
20. H2 response and IgE class switching in mice with disrupted Stat6 gene. Nature 380, 630-633 (1996).
21. Takeda, K. et al. Essential role of Stat6 in IL-4 signalling. Nature 380, 627-630 (1996).
22. H2-cell-specific transcription factor.
23. H1 differentiation by both interleukin-4-dependent and -independent mechanisms J. Exp. Med. 188, 1859-1866 (1998).
24. H2 cytokines. Immunity 10, 745-751 (1999).
25. Hendriks, R. W. et al. Expression of the transcription factor GATA-3 is required for the development of the eadiest T-cell progenitors and correlates with stages of cellular proliferation in the thymus. Eur. J. Immunol. 29, 1912-1918 (1999).
26. Pandolfi, P. P. et al. Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal-liver haematopoiesis. Nature Genet. 11, 40-44 (1995).
27. Ting, C. N., Olson, M. C., Barton, K. P. & Leiden, J. M. Transcription factor GATA-3 is required for development of the T-cell lineage. Nature 384, 474-478 (1996).
28. Ranganath, S. et al. GATA-3-dependent enhancer activity in IL-4 gene regulation. J. Immunol. 161, 3822-3826 (1998).
29. H2-specific cytokine gene cluster. J. Immunol. 165, 6687-6691 (2000).
30. Zhang, D. H. et al. Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3. Immunity 11, 473-482 (1999).
31. Finotto, S. et al. Treatment of allergic airway inflammation and hyperresponsiveness by antisense-induced local blockade of GATA-3 expression. J. Exp. Med. 193, 1247-1260 (2001).
32. H2-cell differentiation by mel-18, a mammalian polycomb-group gene. Immunity 15, 275-287 (2001).
33. Francis, N. J. & Kingston, R. E. Mechanisms of transcriptional memory. Nature Rev. Mol. Cell. Biol. 2, 409-421 (2001).
34. + T cells. J. Exp. Med. 194, 1461-1471 (2001).
35. H2-cell development. J. Immunol. 168, 4538-4545 (2002).
36. Miaw, S. C., Choi, A., Yu, E., Kishikawa, H. & Ho, I. C. ROG, repressor of GATA, regulates the expression of cytokine genes. Immunity 12, 323-333 (2000).
37. + T cells. Nature Immunol. 3, 549-557 (2002).
38. Finotto, S. et al. Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science 295, 336-338 (2002).
39. Hentsch, B. et al. Hlx homeobox gene is essential for an inductive tissue interaction that drives expansion of embryonic liver and gut. Genes Dev. 10, 70-79 (1996).
40. Lighvani, A. A. et al. T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells. Proc. Natl Acad. Sci. USA 98, 15137-15142 (2001).
41. Peng, S. L., Gerth, A. J., Ranger, A. M. & Glimcher, L. H. NFATc1 and NFATc2 together control both T- and B-cell activation and differentiation. Immunity 14, 13-20 (2001).
42. H1 development but synergizes with IL-12 for interferon-γ production and activates IRAK and NF-κB. Immunity 7, 571-581 (1997).
43. + T cells: evidence for two distinct pathways for promoter activation. Eur. J. Immunol. 29, 548-555 (1999).
44. Neighbors, M. et al. A critical role for interleukin-18 in primary and memory effector responses to Listeria monocytogenes that extends beyond its effects on interferon-γ production. J. Exp. Med. 194, 343-354 (2001).
45. H1 response in IL-18-deficient mice. Immunity 8, 383-390 (1998).
46. Yang, J., Zhu, H., Murphy, T. L., Ouyang, W. & Murphy, K. M. IL-18-stimulated GADD45β required in cytokine-induced, but not TCR-induced, IFN-γ production. Nature Immunol. 2, 157-164 (2001).
47. H1 cells. Immunity 14, 583-590 (2001).
48. H1 effector T cells mediated by the p38 MAP kinase signaling pathway. EMBO J. 17, 2817-2829 (1998).
49. Dong, C., Davis, R. J. & Flavell, R. A. MAP kinases in the immune response. Annu. Rev. Immunol. 20, 55-72 (2002).
50. + T cells contributes to the rapid production of IFN-γ in response to bacterial pathogens. J. Immunol. 166, 1097-1105 (2001).
51. Yap, G., Pesin, M. & Sher, A. Cutting edge: IL-12 is required for the maintenance of IFN-γ production in T cells mediating chronic resistance to the intracellular pathogen. Toxoplasma gondii. J. Immunol. 165, 628-631 (2000).
52. H1 response during Leishmania major infection. J. Immunol. 165, 896-902 (2000).
53. H1 cells sufficient to mediate protection to an infectious parasite challenge. Proc. Natl Acad. Sci. USA 97, 8427-8432 (2000).
54. H1 response and host defense against infection by Mycobacterium tuberculosis: a comparative study with IL-12 p40. J. Immunol. 169, 323-329 (2002).
55. Oppmann, B. et al. Novel p19 protein engages IL-12 p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13, 715-725 (2000).
56. Parham, C. et al. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rβ1 and a novel cytokine receptor subunit, IL-23R. J. Immunol. 168, 5699-5708 (2002).
57. Belladonna, M. L. et al. IL-23 and IL-12 have overlapping, but distinct, effects on murine dendritic cells. J. Immunol. 168, 5445-5454 (2002).
58. - T cells. Immunity 16, 779-790 (2002).
59. Devergne, O. et al. A novel intedeukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes. J. Virol. 70, 1143-1153 (1996).
60. H1-type immune responses requires the type I cytokine receptor TCCR. Nature 407, 916-920 (2000).
61. H1 responses and resistance to L. major infection. Immunity 15, 569-578 (2001).
62. H1 development. Immunity 16, 755-758 (2002).
63. Huang, H. & Paul, W. E. Impaired intedeukin-4 signaling in T helper type 1 cells. J. Exp. Med. 187, 1305-1313 (1998).
64. H2 cells. J. Exp. Med. 185, 817-824 (1997).
65. H1 cells. Immunity 11, 677-688 (1999).
66. H2 cells selectively.
67. H2) development mediated by GATA-3. J. Exp. Med. 193, 643-650 (2001).
68. Finkelman, F. D. et al. Stat6 regulation of in vivo IL-4 responses. J. Immunol. 164, 2303-2310 (2000).
69. H2 cytokine profile. J. Immunol. 164, 3047-3055 (2000).
70. Rodnguez-Palmero, M., Hara, T., Thumbs, A. & Hunig, T. Ttriggering of T-cell proliferation through CD28 induces GATA-3 and promotes T helper type 2 differentiation in vitro and in vivo. Eur. J. Immunol. 29, 3914-3924 (1999).
71. H2 differentiation in allergic airway inflammation. Nature Immunol. 2, 45-50 (2001).
72. Ghosh, P., Tan, T. H., Rice, N. R., Sica, A. & Young, H. A. The interleukin-2 CD28-responsive complex contains at least three members of the NF-κB family: c-Rel, p50 and p65. Proc. Natl Acad. Sci. USA 90, 1696-1700 (1993).
73. Rissoan, M. C. et al. Reciprocal control of T-helper-cell and denddtic-cell differentiation. Science 283, 1183-1186 (1999).
74. Liu, Y. J., Kanzler, H., Soumelis, V. & Gilliet, M. Dendritic-cell lineage, plasticity and cross-regulation. Nature Immunol. 2, 585-589 (2001).
75. Greenwald, R. J., Latchman, Y. E. & Sharpe, A. H. Negative co-receptors on lymphocytes. Curr. Opin. Immunol. 14, 391-396 (2002).
76. H2 cytokine production. J. Immunol. 161, 5136-5142 (1998).
77. Camacho, S. A. et al. A key role for ICAM-1 in generating effector cells mediating inflammatory responses. Nature Immunol. 2, 523-529 (2001).
78. Luksch, C. R. et al. Intercellular adhesion molecule-1 inhibits interleukin-4 production by naive T cells. Proc. Natl Acad. Sci. USA 96, 3023-3028 (1999).
79. H1 development. J Immunol. 168, 1710-1716 (2002).
80. Ben-Sasson, S. Z., Gerstel, R., Hu-Li, J. & Paul, W. E. Cell division is not a 'clock' measuring acquisition of competence to produce IFN-γ or IL-4. J. Immunol. 166, 112-120 (2001).
81. H-cell differentiation.
82. Mullen, A. C. et al. Cell cycle controlling the silencing and functioning of mammalian activators. Curr. Biol. 11, 1695-1699 (2001).
83. Richter, A., Lohning, M. & Radbruch, A. Instruction for cytokine expression in T helper lymphocytes in relation to proliferation and cell-cycle progression. J. Exp. Med. 190, 1439-1450 (1999).
84. + T-cell proliferation and effector function in vivo. Immunity 13, 291-301 (2000).
85. H2 cytokine secretion phenotype. J. Immunol. 153, 3514-3522 (1994).
86. H2 cells does not affect the production of IL-4 or induce the production of IFN-γ. J. Immunol. 164, 2861-2865 (2000).
87. H1 differentiation and proliferation that is independent of its role in the maintenance of IL-12Rβ2 chain expression and signaling. J. Immunol. 169, 4388-4398 (2002).
88. Mohrs, M., Shinkai, K., Mohrs, K. & Locksley, R. M. Analysis of type-2 immunity in vivo with a bicistronic IL-4 reporter. Immunity 15, 303-311 (2001).
89. Doyle, A. M. et al. Induction of cytotoxic T lymphocyte antigen 4 (CTLA-4) restncts clonal expansion of helper T cells. J. Exp. Med 194, 893-902 (2001).
90. H2 and nonpoladzed T cells. Nature Immunol. 1, 311-316 (2000).
91. Sallusto, F., Lenig, D., Forster, R., Lipp, M. & Lanzavecchia, A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401, 708-712 (1999).
92. Gorelik, L., Constant, S. & Flavell, R. A. Mechanism of transforming growth factor β-induced inhibition of T helper type 1 differentiation. J. Exp. Med. 195, 1499-1505 (2002).
93. H-type 2 development through inhibition of GATA-3 expression. J. Immunol. 165, 4773-4777 (2000).
94. H2 development and results in decreased IL-4-induced STAT6 activation and GATA-3 expression. Eur. J. Immunol. 30, 2639-2649 (2000).
95. Neurath, M. F. et al. The transcription factor T-bet regulates mucosal T-cell activation in experimental colitis and Crohn's disease. J. Exp. Med. 195, 1129-1143 (2002).
96. H-cell differentiation.
97. Kamogawa, Y., Minasi, L. A., Carding, S. R., Bottomly, K. & Flavell, R. A. The relationship of IL-4- and IFN-γ-producing T cells studied by lineage ablation of IL-4-producing cells. Cell 75, 985-995 (1993).
98. H-cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes. Nature Immunol. 3, 643-651 (2002).
99. H2 differentiation. J. Immunol. 169, 647-650 (2002).
100. Hutchins, A. S. et al. Gene silencing quantitatively controls the function of a developmental trans-activator. Mol. Cell 10, 81-91 (2002).
101. Agarwal, S. & Rao, A. Modulation of chromatin structure regulates cytokine gene expression during T-cell differentiation. Immunity 9, 765-775 (1998).
102. Agarwal, S., Avni, O. & Rao, A. Cell-type-restricted binding of the transcription factor NFAT to a distal IL-4 enhancer in vivo. Immunity 12, 643-652 (2000).
103. Richards, E. J. & Elgin, S. C. R. Epigenetic codes for heterochromatin formation and silencing: rounding up the usual suspects. Cell 108, 489-500 (2002).
104. Ng, H. H. et al. MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex. Nature Genet. 23, 58-61 (1999).
105. Nan, X. et al. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393, 386-389 (1998).
106. Jones, P. L. et al. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nature Genet. 19, 187-191 (1998).
107. Jackson, J. P., Lindroth, A. M., Cao, X. & Jacobsen, S. E. Control of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferase. Nature 416, 556-560 (2002).
108. Jeddeloh, J. A., Stokes, T. L. & Richards, E. J. Maintenance of genomic methylation requires a SW12/SNF2-like protein. Nature Genet. 22, 94-97 (1999).
109. Dennis, K., Fan, T, Geiman, T., Yan, Q. & Muegge, K. Lsh, a member of the SNF2 family, is required for genome-wide methylation. Genes Dev. 15, 2940-2944 (2001).
110. Jenuwein, T. & Allis, C. D. Translating the histone code. Science 293, 1074-1080 (2001).
111. H2-lineage commitment and efficient IL-4 production involves extended demethylation of the IL-4 gene. Immunity 16, 649-660 (2002).
112. Lee, P. P. et al. A critical role for Dnmt1 and DNA methylation in T-cell development, function and survival. Immunity 15, 763-774 (2001).
113. Loots, G. G. et al. Identifieation of a coordinate regulator of interleukins 4, 13 and 5 by cross-species sequence comparisons. Science 288, 136-140 (2000).
114. Mohrs, M. et al. Deletion of coordinate regulator of type-2 cytokine expression in mice. Nature Immunol. 2, 842-847 (2001).
115. H2 cells and mast cells. Immunity 17, 41-50 (2002)
116. Cirillo, L. A. et al. Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4. Mol. Cell 9, 279-289 (2002).
117. Zhang, D. H., Yang, L. & Ray, A. Differential responsiveness of the IL-5 and IL-4 genes to transcription factor GATA-3. J. Immunol. 161, 3817-3821 (1998).
118. H2 development. J. Immunol. 169, 4103-4107 (2002).
119. Bird, A. DNA methylation patterns and epigenetic memory. Genes Dev. 16, 6-21 (2002).
120. + T cells through IL-12 produced by Listeria-induced macrophages. Science 260, 547-549 (1993).
121. Murphy, K. M. et al. Signaling and transcription in T-helper development. Annu. Rev. Immunol. 18, 451-494 (2000).
122. Stetson, D. B., Mohrs, M., Mallet-Designe, V., Teyton, L. & Locksley, R. M. Rapid expansion and IL-4 expression by Leishmania-specific naive helper T cells in vivo. Immunity 17, 191-200 (2002).