The immunoregulatory role of CD1d-restricted natural killer T cells in disease

Clinical Immunology

Volumn 112, Issue 1, 2004, Pages 8-23

  Van Der Vliet, Hans J J ^a   Molling, Johan W ^a   Von Blomberg, B Mary E ^a   Nishi, Nobusuke ^b   Kölgen, Wendy ^a   Van Den Eertwegh, Alfons J M ^a   Pinedo, Herbert M ^a   Giaccone, Giuseppe ^a   Scheper, Rik J ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

Disease; Immunoregulatory; T cell

Indexed keywords

ALPHA GALACTOSYLCERAMIDE; CD1D ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 3; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 7; PHOSPHATIDYLINOSITOL; T LYMPHOCYTE RECEPTOR;

ALLERGIC ENCEPHALOMYELITIS; ALLERGY; ANTIGEN EXPRESSION; AUTOIMMUNE HEPATITIS; AUTOIMMUNITY; BACTERIAL INFECTION; CANCER INHIBITION; CELL FUNCTION; CELL MATURATION; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CLINICAL TRIAL; COLITIS; CYTOKINE RELEASE; DENDRITIC CELL; ENTERITIS; GRAFT REJECTION; HELPER CELL; HUMAN; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOREGULATION; IMMUNOTHERAPY; INSULIN DEPENDENT DIABETES MELLITUS; LUPUS VULGARIS; MICROBIAL IMMUNITY; MULTIPLE SCLEROSIS; MYCOSIS; NATURAL KILLER CELL; NEMATODIASIS; NONHUMAN; PRIORITY JOURNAL; PROTOZOAL INFECTION; REVIEW; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TH2 CELL; TISSUE DISTRIBUTION; TRANSPLANTATION; TUMOR IMMUNITY; VIRUS INHIBITION; VIRUS REPLICATION;

EID: 2942676755     PISSN: 15216616     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clim.2004.03.003     Document Type: Short Survey

References (193)

1. Fowlkes B.J., Kruisbeek A.M., Ton-That H., Weston M.A., Coligan J.E., Schwartz R.H., Pardoll D.M. A novel population of T-cell receptor ab-bearing thymocytes which predominantly expresses a single Vb gene family. Nature. 329:1987;251-254
2. + subset. J. Immunol. 145:1990;1039-1045
3. - T cells. J. Exp. Med. 186:1997;109-120
4. + T-cell antigen receptor α chain in mice. Proc. Natl. Acad. Sci. U. S. A. 88:1991;7518-7522
5. - T cells. J. Exp. Med. 180:1994;1171-1176
6. Benlagha K., Kyin T., Beavis A., Teyton L., Bendelac A. A thymic precursor to the NK T cell lineage. Science. 296:2002;553-555
7. + CD1d-dependent precursor stage. J. Exp. Med. 195:2002;835-844
8. MacDonald H.R. T before NK. Science. 296:2002;481-482
9. Gapin L., Matsuda J.L., Surh C.D., Kronenberg M. NKT cells derive from double-positive thymocytes that are positively selected by CD1d. Nat. Immunol. 2:2001;971-978
10. Mendiratta S.K., Martin W.D., Hong S., Boeseanu A., Joyce S., van Kaer L. CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4. Immunity. 6:1997;469-477
11. Chiu Y.H., Park S.H., Benlagha K., Forestier C., Jayawardena-Wolf J., Savage P.B., Teyton L., Bendelac A. Multiple defects of antigen presentation and T cell development in mice expressing tail-truncated CD1d. Nat. Immunol. 3:2002;55-60
12. Jayawardena-Wolf J., Benlagha K., Chiu Y.H., Mehr R., Bendelac A. CD1d endosomal trafficking is independently regulated by an intrinsic CD1d-encoded tyrosine motif and by the invariant chain. Immunity. 15:2001;897-908
13. van der Vliet H.J., Nishi N., de Gruijl T.D., von Blomberg B.M., van den Eertwegh A.J., Pinedo H.M., Giaccone G., Scheper R.J. Human natural killer T cells acquire a memory-activated phenotype before birth. Blood. 95:2000;2440-2442
14. + NKT cells in germ-free mice. Eur. J. Immunol. 30:2000;620-625
15. Zeng Z., Castano A.R., Segelke B.W., Stura E.A., Peterson P.A., Wilson I.A. Crystal structure of mouse CD1: an MHC-like fold with a large hydrophobic binding groove. Science. 277:1997;339-345
16. Brutkiewicz R.R., Sriram V. Natural killer T (NKT) cells and their role in antitumor immunity. Crit. Rev. Oncol. Hematol. 41:2002;287-298
17. Joyce S., Woods A.S., Yewdell J.W., Bennink J.R., De Silva A.D., Boesteanu A., Balk S.P., Cotter R.J., Brutkiewicz R.R. Natural ligand of mouse CD1d1: cellular glycosylphosphatidylinositol. Science. 279:1998;1541-1544
18. Joyce S. CD1d and natural T cells: how their properties jump-start the immune system. Cell. Mol. Life Sci. 58:2001;442-469
19. Gumperz J.E., Roy C., Makowska A., Lum D., Sugita M., Podrebarac T., Koezuka Y., Porcelli S.A., Cardell S., Brenner M.B., Behar S.M. Murine CD1d-restricted T cell recognition of cellular lipids. Immunity. 12:2000;211-221
20. Kawano T., Cui J., Koezuka Y., Toura I., Kaneko Y., Motoki K., Ueno H., Nakagawa R., Sato H., Kondo E., Koseki H., Taniguchi M. CD1d-restricted and TCR-mediated activation of Vα14 NKT cells by glycosylceramides. Science. 278:1997;1626-1629
21. Spada F.M., Koezuka Y., Porcelli S.A. CD1d-restricted recognition of synthetic glycolipid antigens by human natural killer T cells. J. Exp. Med. 188:1998;1529-1534
22. Hammond K.J., Pellicci D.G., Poulton L.D., Naidenko O.V., Scalzo A.A., Baxter A.G., Godfrey D.I. CD1d-restricted NKT cells: an interstrain comparison. J. Immunol. 167:2001;1164-1173
23. +NKT cells. J. Immunol. 162:1999;5094-5098
24. Matsuda J.L., Naidenko O.V., Gapin L., Nakayama T., Taniguchi M., Wang C.R., Koezuka Y., Kronenberg M. Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramers. J. Exp. Med. 192:2000;741-754
25. Davodeau F., Peyrat M.-A., Necker A., Dominici R., Blanchard F., Leget C., Gaschet J., Costa P., Jacques Y., Godard A., Vie H., Poggi A., Romagne F., Bonneville M. Close phenotypic and functional similarities between human and murine αβ T cells expressing invariant TCR α-chains. J. Immunol. 158:1997;5603-5611
26. + T cells. Immunology. 98:1999;557-563
27. Prussin C., Foster B. TCR Vα24 and Vα11 coexpression defines a human NK1 T cell analog containing a unique Th0 subpopulation. J. Immunol. 159:1997;5862-5870
28. + T cells preferentially accumulate in human liver. Eur. J. Immunol. 29:1999;2406-2413
29. pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J. Exp. Med. 179:1994;1285-1295
30. Godfrey D.I., Hammond K.J., Poulton L.D., Smyth M.J., Baxter A.G. NKT cells: facts, functions and fallacies. Immunol. Today. 21:2000;573-583
31. Chen Y.H., Chiu N.M., Mandal M., Wang N., Wang C.R. Impaired NK1+ T cell development and early IL-4 production in CD1-deficient mice. Immunity. 6:1997;459-467
32. H2 response and in immunoglobulin E production. Science. 270:1995;1845-1847
33. Smiley S.T., Kaplan M.H., Grusby M.J. Immunoglobulin E production in the absence of interleukin-4-secreting CD1-dependent cells. Science. 275:1997;977-979
34. -T cell deficiency and IDDM in NOD/Lt mice. Diabetes. 46:1997;572-582
35. +-like thymocytes in the NOD mouse. Eur. J. Immunol. 26:1996;2989-2998
36. Iwakoshi N.N., Greiner D.L., Rossini A.A., Mordes J.P. Diabetes prone BB rats are severely deficient in natural killer T cells. Autoimmunity. 31:1999;1-14
37. Frey A.B., Rao T.D. NKT cell cytokine imbalance in murine diabetes mellitus. Autoimmunity. 29:1999;201-214
38. Wang B., Geng Y.B., Wang C.R. CD1-restricted NK T cells protect nonobese diabetic mice from developing diabetes. J. Exp. Med. 194:2001;313-320
39. Shi F.D., Flodstrom M., Balasa B., Kim S.H., van Gunst K., Strominger J.L., Wilson S.B., Sarvetnick N. Germ line deletion of the CD1 locus exacerbates diabetes in the NOD mouse. Proc. Natl. Acad. Sci. U. S. A. 98:2001;6777-6782
40. Mueller R., Krahl T., Sarvetnick N. Pancreatic expression of interleukin-4 abrogates insulitis and autoimmune diabetes in nonobese diabetic (NOD) mice. J. Exp. Med. 184:1996;1093-1099
41. Sharif S., Arreaza G.A., Zucker P., Mi Q.S., Sondhi J., Naidenko O.V., Kronenberg M., Koezuka Y., Delovitch T.L., Gombert J.M., Leite-de-Moraes M., Gouarin C., Zhu R., Hameg A., Nakayama T., Taniguchi M., Lepault F., Lehuen A., Bach J.F., Herbelin A. Activation of natural killer T cells by α-galactosylceramide treatment prevents the onset and recurrence of autoimmune type 1 diabetes. Nat. Med. 7:2001;1057-1062
42. Wilson S.B., Kent S.C., Patton K.T., Orban T., Jackson R.A., Exley M., Porcelli S., Schatz D.A., Atkinson M.A., Balk S.P., Strominger J.L., Hafler D.A. Extreme Th1 bias of invariant Vα24JαQ T cells in type 1 diabetes. Nature. 391:1998;177-181
43. Wilson S.B., Kent S.C., Horton H.F., Hill A.A., Bollyky P.L., Hafler D.A., Strominger J.L., Byrne M.C. Multiple differences in gene expression in regulatory Vα24JαQ T cells from identical twins discordant for type I diabetes. Proc. Natl. Acad. Sci. U. S. A. 197:2000;7411-7416
44. -(NKT) thymocytes prevent insulin-dependent diabetes mellitus in nonobese diabetic (NOD/Lt) mice by the influence of interleukin (IL)-4 and/or IL-10. J. Exp. Med. 187:1998;1047-1056
45. Lehuen A., Lantz O., Beaudoin L., Laloux V., Carnaud C., Bendelac A., Bach J.F., Monteiro R.C. Overexpression of natural killer T cells protects Vα14Jα281 transgenic nonobese diabetic mice against diabetes. J. Exp. Med. 188:1998;1831-1839
46. Laloux V., Beaudoin L., Jeske D., Carnaud C., Lehuen A. NK T cell-induced protection against diabetes in Vα14-Jα281 transgenic nonobese diabetic mice is associated with a Th2 shift circumscribed regionally to the islets and functionally to islet autoantigen. J. Immunol. 166:2001;3749-3756
47. Beaudoin L., Laloux V., Novak J., Lucas B., Lehuen A. NKT cells inhibit the onset of diabetes by impairing the development of pathogenic T cells specific for pancreatic β cells. Immunity. 17:2002;725-736
48. Burdin N., Brossay L., Kronenberg M. Immunization with β-galactosylceramide polarizes CD1-reactive NK T cells towards Th2 cytokine synthesis. Eur. J. Immunol. 29:1999;2014-2025
49. Hong S., Wilson M.T., Serizawa I., Wu L., Singh N., Naidenko O.V., Miura T., Haba T., Scherer D.C., Wei J., Kronenberg M., Koezuka Y., van Kaer L. The natural killer T-cell ligand α-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice. Nat. Med. 7:2001;1052-1056
50. Naumov Y.N., Bahjat K.S., Gausling R., Abraham R., Exley M.A., Koezuka Y., Balk S.P., Strominger J.L., Clare-Salzer M., Wilson S.B. Activation of CD1d-restricted T cells protects NOD mice from developing diabetes by regulating dendritic cell subsets. Proc. Natl. Acad. Sci. U. S. A. 98:2001;13838-13843
51. Kukreja A., Cost G., Marker J., Zhang C., Sun Z., Lin-Su K., Ten S., Sanz M., Exley M., Wilson B., Porcelli S., Maclaren N. Multiple immuno-regulatory defects in type-1 diabetes. J. Clin. Invest. 109:2002;131-140
52. Steinman L. Assessment of animal models for MS and demyelinating disease in the design of rational therapy. Neuron. 24:1999;511-514
53. + T cells that promptly produce interleukin-4. Proc. Natl. Acad. Sci. U. S. A. 92:1995;11931-11934
54. Singh A.K., Wilson M.T., Hong S., Olivares-Villagomez D., Du C., Stanic A.K., Joyce S., Sriram S., Koezuka Y., van Kaer L. Natural killer T cell activation protects mice against experimental autoimmune encephalomyelitis. J. Exp. Med. 194:2001;1801-1811
55. Mars L.T., Laloux V., Goude K., Desbois S., Saoudi A., van Kaer L., Lassmann H., Herbelin A., Lehuen A., Liblau R.S. Cutting edge: Vα14-Jα281 NKT cells naturally regulate experimental autoimmune encephalomyelitis in nonobese diabetic mice. J. Immunol. 168:2002;6007-6011
56. Jahng A.W., Maricic I., Pederson B., Burdin N., Naidenko O., Kronenberg M., Koezuka Y., Kumar V. Activation of natural killer T cells potentiates or prevents experimental autoimmune encephalomyelitis. J. Exp. Med. 194:2001;1789-1799
57. Pal E., Tabira T., Kawano T., Taniguchi M., Miyake S., Yamamura T. Costimulation-dependent modulation of experimental autoimmune encephalomyelitis by ligand stimulation of Vα14 NK T cells. J. Immunol. 166:2001;662-668
58. Miyamoto K., Miyake S., Yamamura T. A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing Th2 bias of natural killer T cells. Nature. 413:2001;531-534
59. Illes Z., Kondo T., Newcombe J., Oka N., Tabira T., Yamamura T. Differential expression of NK T cell Vα24JαQ invariant TCR chain in the lesions of multiple sclerosis and chronic inflammatory demyelinating polyneuropathy. J. Immunol. 164:2000;4375-4381
60. + NKT cell numbers are decreased in a wide variety of disorders that are characterized by autoreactive tissue damage. Clin. Immunol. 100:2001;144-148
61. -Vα24JαQ T cells in peripheral blood of patients with relapsing-remitting multiple sclerosis. Clin. Immunol. 98:2001;11-17
62. Canchis P.W., Bhan A.K., Landau S.B., Yang L., Balk S.P., Blumberg R.S. Tissue distribution of the non-polymorphic major histocompatibility complex class I-like molecule CD1d. Immunology. 80:1993;561-565
63. Saubermann L.J., Beck P., de Jong Y.P., Pitman R.S., Ryan M.S., Kim H.S., Exley M., Snapper S., Balk S.P., Hagen S.J., Kanauchi O., Motoki K., Sakai T., Terhorst C., Koezuka Y., Podolsky D.K., Blumberg R.S. Activation of natural killer T cells by α-galactosylceramide in the presence of CD1d provides protection against colitis in mice. Gastroenterology. 119:2000;119-128
64. Colgan S.P., Hershberg R.M., Furata G.T., Blumberg R.S. Ligation of intestinal epithelial CD1d induces bioactive IL-10; critical role of the cytoplasmic tail in autocrine signaling. Proc. Natl. Acad. Sci. U. S. A. 96:1999;13938-13943
65. Heller F., Fuss I.J., Nieuwenhuis E.E., Blumberg R.S., Strober W. Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells. Immunity. 17:2002;629-638
66. + NKT cells associated with disease development in autoimmune-prone mice. J. Immunol. 156:1996;4035-4040
67. Takeda K., Dennert G. The development of autoimmunity in C57BL/6 lpr mice correlates with the disappearance of natural killer type-1 positive cells: evidence for their suppressive action on bone marrow stem cell proliferation, B cell immunoglobulin secretion, and autoimmune symptoms. J. Exp. Med. 177:1993;155-164
68. Zeng D., Lee M.-K., Tung J., Brendolan A., Strober S. Cutting edge: a role for CD1 in the pathogenesis of lupus in NZB/NZW mice. J. Immunol. 164:2000;5000-5004
69. Zeng D., Dick M., Cheng L., Amano M., Dejbakhsh-Jones S., Huie P., Sibley R., Strober S. Subsets of transgenic T cells that recognize CD1 induce or prevent murine lupus: role of cytokines. J. Exp. Med. 187:1998;525-536
70. lpr mice: an example of disease regulation at the organ level. J. Immunol. 167:2001;2985-2990
71. Yang J.-Q., Singh A.K., Wilson M.T., Satoh M., Stanic A.K., Park J.-J., Hong S., Gadola S.D., Mizutani A., Kakumanu S.R., Reeves W.H., Cerundolo V., Joyce S., van Kaer L., Singh R.R. Immunoregulatory role of CD1d in the hydrocarbon oil-induced model of lupus nephritis. J. Immunol. 171:2003;2142-2153
72. 1 mice. Eur. J. Immunol. 32:2002;2551-2561
73. Takeda K., Hayakawa Y., van Kaer L., Matsuda H., Yagita H., Okumura K. Critical contribution of liver natural killer T cells to a murine model of hepatitis. Proc. Natl. Acad. Sci. U. S. A. 97:2000;5498-5503
74. Kaneko Y., Harada M., Kawano T., Yamashita M., Shibata Y., Gejyo F., Nakayama T., Taniguchi M. Augmentation of Vα14 NKT cell-mediated cytotoxicity by interleukin 4 in an autocrine mechanism resulting in the development of concanavalin A-induced hepatitis. J. Exp. Med. 191:2000;105-114
75. Louis H., Le Moine A., Flamand V., Nagy N., Quertinmont E., Paulart F., Abramowicz D., Le Moine O., Goldman M., Deviere J. Critical role of interleukin 5 and eosinophils in concanavalin A-induced hepatitis in mice. Gastroenterology. 122:2002;2001-2010
76. Sumida T., Sakamoto A., Murata H., Makino Y., Takahashi H., Yoshida S., Nishioka K., Iwamoto I., Taniguchi M. Selective reduction of T cells bearing invariant Vα24JαQ antigen receptor in patients with systemic sclerosis. J. Exp. Med. 182:1995;1163-1168
77. Kojo S., Adachi Y., Keino H., Taniguchi M., Sumida T. Dysfunction of T cell receptor AV24AJ18+, BV11+ double-negative regulatory natural killer T cells in autoimmune diseases. Arthritis Rheum. 44:2001;1127-1138
78. Kita H., Naidenko O.V., Kronenberg M., Ansari A.A., Rogers P., He X.-S., Koning F., Mikayama T., van de Water J., Coppel R.L., Kaplan M., Gerswin M.E. Quantitation and phenotypic analysis of natural killer T cells in primary biliary cirrhosis using a human CD1d tetramer. Gastroenterology. 123:2002;1031-1043
79. + double-negative T cells in rheumatoid synovium. Rheumatology. 38:1999;186-188
80. Reinhardt C., Melms A. Elevated frequencies of natural killer T lymphocytes in myasthenia gravis. Neurology. 52:1999;1485-1487
81. Tori M., Ito T., Kitagawa-Sakakida S., Nozawa M., Matsuda H., Shirakura R. Importance of donor-derived lymphocytes in the protection of pancreaticoduodenal or islet grafts from recurrent autoimmunity: a role for RT6+NKR-P1+ T cells. Transplantation. 70:2000;32-38
82. + T cells reciprocally regulate acute graft versus host disease. J. Exp. Med. 189:1999;1073-1081
83. Sharif S., Arreaza G.A., Zucker P., Mi Q.-S., Delovitch T.L. Regulation of autoimmune disease by natural killer T cells. J. Mol. Med. 80:2002;290-300
84. Ohkawa A., Ito T., Yumiba T., Maeda A., Tori M., Sawai T., Kiyomoto T., Akamaru Y., Matsuda H. Immunological characteristics of intragraft NKR-P1+ TCR αβ+T (NKT) cells in rat hepatic allografts. Transplant. Proc. 31:1999;2699-2700
85. Seino K.I., Fukao K., Muramoto K., Yanagisawa K., Takeda Y., Kakuta S., Iwakura Y., van Kaer L., Takeda K., Nakayama T., Taniguchi M., Bashuda H., Yagita H., Okumura K. Requirement for natural killer T (NKT) cells in the induction of allograft tolerance. Proc. Natl. Acad. Sci. U. S. A. 98:2001;2577-2581
86. Konieczny B.T., Dai Z., Elwood E.T., Saleem S., Linsley P.S., Baddoura F.K., Larsen C.P., Pearson T.C., Lakkis F.G. IFN-γ is critical for long-term allograft survival induced by blocking the CD28 and CD40 ligand T cell costimulation pathways. J. Immunol. 160:1998;2059-2064
87. + natural killer T cells are essential for acceptance of rat islet xenografts in mice. J. Clin. Invest. 105:2000;1761-1767
88. Sonoda K.H., Exley M., Snapper S., Balk S.P., Stein-Streilein J. CD1-reactive natural killer T cells are required for development of systemic tolerance through an immune-privileged site. J. Exp. Med. 190:1999;1215-1226
89. Faunce D.E., Sonoda K.H., Stein-Streinlein J. MIP-2 recruits NKT cells to the spleen during tolerance induction. J. Immunol. 166:2001;313-321
90. + T cells to the spleen during the generation of regulatory T cells in tolerance. J. Immunol. 169:2002;31-38
91. Sonoda K.H., Faunce D.E., Taniguchi M., Exley M., Balk S., Stein-Streinlein J. NK T cell-derived IL-10 is essential for the differentiation of antigen-specific T regulatory cells in systemic tolerance. J. Immunol. 166:2001;42-50
92. Sonoda K.H., Stein-Streinlein J. CD1d on antigen-transporting APC and splenic marginal zone B cells promotes NKT cell-dependent tolerance. Eur. J. Immunol. 32:2002;848-857
93. Sonoda K.H., Taniguchi M., Stein-Streinlein J. Long-term survival of corneal allografts is dependent on intact CD1d-reactive NKT cells. J. Immunol. 168:2002;2028-2034
94. Ito K., Karasawa M., Kawano T., Akasaka T., Koseki H., Akutsu Y., Kondo E., Sekiya S., Sekikawa K., Harada M., Yamashita M., Nakayama T., Taniguchi M. Involvement of decidual Vα14 NKT cells in abortion. Proc. Natl. Acad. Sci. U. S. A. 97:2000;740-744
95. Boyson J.E., Rybalov B., Koopman L.A., Exley M., Balk S.P., Racke F.K., Schatz F., Masch R., Wilson S.B., Strominger J.L. CD1d and invariant NKT cells at the human maternal-fetal interface. Proc. Natl. Acad. Sci. U. S. A. 99:2002;13741-13746
96. Akbari O., Stock P., Meyer E., Kronenberg M., Sidobre S., Nakayama T., Taniguchi M., Grusby M.J., DeKruyff R.H., Umetsu D.T. Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity. Nat. Med. 9:2003;582-588
97. Lisbonne M., Diem S., de Castro Keller A., Lefort J., Araujo L.M., Hachem P., Fourneau J.-M., Sidobre S., Kronenberg M., Taniguchi M., Van Endert P., Dy M., Askenase P., Russo M., Vargaftig B.B., Herbelin A., Leite-de-Moraes M.C. Cutting edge: invariant Vα14 NKT cells are required for allergen-induced airway inflammation and hyperreactivity in an experimental asthma model. J. Immunol. 171:2003;1637-1641
98. Terabe M., Matsui S., Noben-Trauth N., Chen H., Watson C., Donaldson D.D., Carbone D.P., Paul W.E., Berzofsky J.A. NKT cell-mediated repression of tumor immunosurveillance by IL-13 and the IL-4-STAT6 pathway. Nat. Immunol. 1:2000;515-520
99. Moodycliffe A.M., Nghiem D., Clydesdale G., Ullrich S.E. Immune suppression and skin cancer development: regulation by NKT cells. Nat. Immunol. 1:2000;521-525
100. Fuji N., Ueda Y., Fujiwara H., Toh T., Yoshimura T., Yamagishi H. Antitumor effect of α-galactosylceramide (KRN7000) on spontaneous hepatic metastases requires endogenous interleukin-12 in the liver. Clin. Cancer Res. 6:2000;3380-3387
101. Nakui M., Ohta A., Sekimoto M., Sato M., Iwakabe K., Yahata T., Kitamura H., Koda T., Kawano T., Makuuchi H., Taniguchi M., Nishimura T. Potentiation of antitumor effects of NKT cell ligand, α-galactosylceramide by combination with IL-12 on lung metastasis of malignant melanoma cells. Clin. Exp. Metastasis. 18:2000;147-153
102. Kawano T., Cui J., Koezuka Y., Toura I., Kaneko Y., Sato H., Kondo E., Harada M., Koseki H., Nakayama T., Tanaka Y., Taniguchi M. Natural killer-like nonspecific tumor cell lysis mediated by specific ligand-activated Vα14 NKT cells. Proc. Natl. Acad. Sci. U. S. A. 95:1998;5690-5693
103. Nakagawa R., Motoki K., Ueno H., Iijima R., Nakamura H., Kobayashi E., Shimosaka A., Koezuka Y. Treatment of hepatic metastasis of the colon 26 adenocarcinoma with an alpha-galactosylceramide, KRN7000. Cancer Res. 58:1998;1202-1207
104. Nakagawa R., Serizawa I., Motoki K., Sato M., Ueno H., Iijima R., Nakamura H., Shimosaka A., Koezuka Y. Antitumor activity of α- galactosylceramide, KRN7000, in mice with the melanoma B16 hepatic metastasis and immunohistological study of tumor infiltrating cells. Oncol. Res. 12:2000;51-58
105. Kobayashi E., Motoki K., Uchida T., Fukushima H., Koezuka Y. KRN7000, a novel immunomodulator, and its antitumor activities. Oncol. Res. 7:1995;529-534
106. Nakui M., Iwakabe K., Ohta A., Sekimoto M., Sato M., Makuuchi H., Kawano T., Taniguchi M., Nishimura T. Natural killer T cell ligand α- galactosylceramide inhibited lymph node metastasis of highly metastatic melanoma cells. Jpn. J. Cancer Res. 90:1999;801-804
107. Akutsu Y., Nakayama T., Harada M., Kawano T., Motohashi S., Shimizu E., Ito T., Kamada N., Saito T., Matsubara H., Miyazawa Y., Ochiai T., Taniguchi M. Expansion of lung Vα14 NKT cells by administration of α- galactosylceramide pulsed dendritic cells. Jpn. J. Cancer Res. 93:2002;397-403
108. Eberl G., MacDonald H.R. Selective induction of NK cell proliferation and cytotoxicity by activated NKT cells. Eur. J. Immunol. 39:2000;985-992
109. Kakimi K., Guidotti L.G., Koezuka Y., Chisari F.V. Natural killer T cell activation inhibits hepatitis B virus replication in vivo. J. Exp. Med. 192:2000;921-930
110. Osman Y., Kawamura T., Naito T., Takeda K., van Kaer L., Okumura K., Abo T. Activation of hepatic NKT cells and subsequent liver injury following administration of α-galactolsylceramide. Eur. J. Immunol. 30:2000;1919-1928
111. + NKT cells. Cancer Res. 59:1999;5102-5105
112. van der Vliet H.J., Pinedo H.M., von Blomberg B.M., van den Eertwegh A.J., Scheper R.J., Giaccone G. Natural Killer T cells. Lancet Oncol. 3:2002;574
113. + natural killer T cells activated by α-galactosylceramide (KRN7000) have cytotoxic anti-tumour activity through mechanisms distinct from T cells and natural killer cells. Immunology. 99:2000;229-234
114. + NKT cells activated by α-glycosylceramide-pulsed monocyte-derived dendritic cells. J. Immunol. 164:2000;4458-4464
115. Metelitsa L.S., Naidenko O.V., Kant A., Wu H.W., Loza M.J., Perussia B., Kronenberg M., Seeger R.C. Human NKT cells mediate antitumor cytotoxicity directly by recognizing target cell CD1d with bound ligand or indirectly by producing IL-2 to activate NK cells. J. Immunol. 167:2001;3114-3122
116. Carnaud C., Lee D., Donnars O., Park S.H., Beavis A., Koezuka Y., Bendelac A. Cutting edge: cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells. J. Immunol. 163:1999;4647-4650
117. Gansuvd B., Hagihara M., Yu Y., Inoue H., Ueda Y., Tsuchiya T., Masui A., Ando K., Nakamura Y., Munkhtuvshin N., Kato S., Thomas J.M., Hotta T. Human umbilical cord blood NK T cells kill tumors by multiple cytotoxic mechanisms. Hum. Immunol. 63:2002;164-175
118. +Vα24NKT cells induces in vitro and in vivo apoptosis of human myeloid leukemia cells. Blood. 97:2001;2067-2074
119. Cui J., Shin T., Kawano T., Sato H., Kondo E., Toura I., Kaneko Y., Koseki H., Kanno M., Taniguchi M. Requirement for Vα14 NKT cells in IL-12-mediated rejection of tumors. Science. 278:1997;1623-1626
120. Takeda K., Hayakawa Y., Atsuta M., Hong S., van Kaer L., Kobayashi K., Ito M., Yagita H., Okumura K. Relative contribution of NK and NKT cells to the anti-metastatic activities of IL-12. Int. Immunol. 12:2000;909-914
121. Smyth M.J., Taniguchi M., Street S.E. The anti-tumor activity of IL-12: mechanisms of innate immunity that are model and dose dependent. J. Immunol. 165:2000;2665-2670
122. Shin T., Nakayama T., Akutsu Y., Mtohashi S., Shibata Y., Harada M., Kamada N., Shimizu C., Shimizu E., Saito T., Ochiai T., Taniguchi M. Inhibition of tumor metastasis by adoptive transfer of IL-12-activated Vα14 NKT cells. Int. J. Cancer. 91:2001;523-528
123. Smyth M.J., Thia K.Y., Street S.E., Cretney E., Trapani J.A., Taniguchi M., Kawano T., Pelikan S.B., Crowe N.Y., Godfrey D.I. Differential tumor surveillance by natural killer (NK) and NKT cells. J. Exp. Med. 191:2000;661-668
124. + T cells in IL-12-induced immune responses in vivo. J. Immunol. 160:1998;16-19
125. + NKT cells: stimulation of IL-12 production by antigen-presenting cells in the innate immune system. J. Immunol. 163:1999;93-101
126. Kitamura H., Iwakabe K., Yahata T., Nishimura S.-I., Ohta A., Ohmi Y., Sato M., Takeda K., Okumura K., van Kaer L., Kawano T., Taniguchi M., Nishimura T. The natural killer T (NKT) cell ligand α-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells. J. Exp. Med. 189:1999;1121-1128
127. Matsumoto G., Omi Y., Lee U., Nishimura T., Shindo J., Penninger J.M. Adhesion mediated by LFA-1 is required for efficient IL-12-induced NK and NKT cell cytotoxicity. Eur. J. Immunol. 30:2000;3723-3731
128. Leite-de-Moraes M.C., Hameg A., Arnould A., Machavoine F., Koezuka Y., Schneider E., Herbelin A., Dy M. A distinct IL-18-induced pathway to fully activate NKT lymphocytes independently from TCR engagement. J. Immunol. 163:1999;5871-5876
129. + NKT cells and antigen-presenting cells. Int. Immunol. 12:2000;1669-1675
130. Nishimura T., Kitamura H., Iwakabe K., Yahata T., Ohta A., Sato M., Takeda K., Okumura K., van Kaer L., Kawano T., Taniguchi M., Nakui M., Sekimoto M., Koda T. The interface between innate and acquired immunity: glycolipid antigen presentation by CD1d-expressing dendritic cells to NKT cells induces the differentiation of antigen-specific cytotoxic T lymphocytes. Int. Immunol. 12:2000;987-994
131. + T cells upon NKT or T cell activation. J. Immunol. 165:2000;4305-4311
132. Hayakawa Y., Takeda K., Yagita H., Kakuta S., Iwakura Y., van Kaer L., Saiki I., Okumura K. Critical contribution of IFN-gamma and NK cells, but not perforin-mediated cytotoxicity, to anti-metastatic effect of alpha-galactosylceramide. Eur. J. Immunol. 31:2001;1720-1727
133. Smyth M.J., Crowe N.Y., Pellicci D.G., Kyparissoudis K., Kelly J.M., Takeda K., Yagita H., Godfrey D.I. Sequential production of IFN-γ by NKT cells and NK cells is essential for the anti-metastatic effect of α-galactosylceramide. Blood. 99:2002;1259-1266
134. Nakagawa R., Nagafune I., Tazunoki Y., Ehara H., Tomura H., Iijima R., Motoki K., Kamishohara M., Seki S. Mechanisms of the antimetastatic effect in the liver and of the hepatocyte injury induced by alpha-galactosylceramide in mice. J. Immunol. 166:2001;6578-6584
135. Smyth M.J., Cretney E., Takeda K., Wiltrout R.H., Sedger L.M., Kayagaki N., Yagita H., Okumura K. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) contributes to interferon γ-dependent natural killer cell protection from tumor metastasis. J. Exp. Med. 193:2001;661-670
136. Karnbach C., Daws M.R., Niemi E.C., Nakamura M.C. Immune rejection of a large sarcoma following cyclophosphamide and IL-12 treatment requires both NK and NK T cells and is associated with the induction of a novel NK T cell population. J. Immunol. 167:2001;2569-2576
137. Toura I., Kawano T., Akutsu Y., Nakayama T., Ochiai T., Taniguchi M. Inhibition of experimental tumor metastasis by dendritic cells pulsed with α-galactosylceramide. J. Immunol. 163:1999;2387-2391
138. Smyth M.J., Crowe N.Y., Hayakawa Y., Takeda K., Yagita H., Godfrey D.I.
139. Crowe N.Y., Smyth M.J., Godfrey D.I. A critical role for natural killer T cells in immunosurveillance of methylcholanthrene-induced sarcomas. J. Exp. Med. 196:2002;119-127
140. Hayakawa Y., Takeda K., Yagita H., Smyth M.J., van Kaer L., Okumura K., Saiki I. IFN-γ-mediated inhibition of tumor angiogenesis by natural killer T-cell ligand, α-galactosylceramide. Blood. 100:2002;1728-1733
141. Tahir S.M., Cheng O., Shaulov A., Koezuka Y., Bubley G.J., Wilson S.B., Balk S.P., Exley M.A. Loss of IFN-γ production by invariant NK T cells in advanced cancer. J. Immunol. 167:2001;4046-4050
142. Fujii S.-I., Shimizu K., Klimek V., Geller M.D., Nimer S.D., Dhodapkar M.V. Severe and selective deficiency of interferon-γ-producing invariant natural killer T cells in patients with myelodysplastic syndromes. Br. J. Haematol. 122:2003;617-622
143. Dhodapkar M.V., Geller M.D., Chang D.H., Shimizu K., Fujii S.-I., Dhodapkar K.M., Krasovsky J. A reversible defect in natural killer T cell function characterizes the progression of premalignant to malignant multiple myeloma. J. Exp. Med. 197:2003;1667-1676
144. Giaccone G., Punt C.J., Ando Y., Ruijter R., Nishi N., Peters M., von Blomberg B.M., Scheper R.J., van der Vliet H.J., van den Eertwegh A.J., Roelvink M., Beijnen J., Zwierzina H., Pinedo H.M. for the EORTC Biological Therapeutics Development Group A Phase I study on the NKT cell ligand α- galactosylceramide (KRN7000) in patients with solid tumors. Clin. Cancer Res. 8:2002;3702-3709
145. Exley M.A., Bigley N.J., Cheng O., Tahir S.M., Smiley S.T., Carter Q.L., Stills H.F., Grusby M.J., Koezuka Y., Taniguchi M., Balk S.P. CD1d-reactive T-cell activation leads to amelioration of disease caused by diabetogenic encephalomyocarditis virus. J. Leukocyte Biol. 69:2001;713-718
146. Grubor-Bauk B., Simmons A., Mayrhofer G., Speck P.G. Impaired clearance of herpes simplex virus type 1 from mice lacking CD1d or NKT cells expressing the semivariant Vα14-Jα281 TCR. J. Immunol. 170:2003;1430-1434
147. van Dommelen S.L., Tabarias H.A., Smyth M.J., Degli-Esposti M.A. Activation of natural killer (NK) T cells during murine cytomegalovirus infection enhances the antiviral response mediated by NK cells. J. Virol. 77:2003;1877-1884
148. + T cells and amplification of antiviral immune responses to respiratory syncytial virus. J. Virol. 76:2002;4294-4303
149. Biron C.A., Brossay L. NK and NKT cells in innate defense against viral infections. Curr. Opin. Immunol. 13:2001;458-464
150. Hobbs J.A., Cho S., Roberts T.J., Sriram V., Zhang J., Xu M., Brutkiewicz R.R. Selective loss of natural killer T cells by apoptosis following infection with lymphocytic choriomeningitis virus. J. Virol. 75:2001;10746-10754
151. + NKT cells during HIV type 1 infection. J. Immunol. 168:2002;1490-1495
152. Motsinger A., Haas D.W., Stanic A.K., van Kaer L., Joyce S., Unutmaz D. CD1d-restricted human natural killer T cells are highly susceptible to human immunodeficiency virus 1 infection. J. Exp. Med. 195:2002;869-879
153. Karadimitris A., Gadola S., Altamirano M., Brown D., Woolfson A., Klenerman P., Chen J.-L., Koezuka Y., Roberts I.A., Price D.A., Dusheiko G., Milstein C., Fersht A., Luzzatto L., Cerundolo V. Human CD1d-glycolipid tetramers generated by in vitro oxidative refolding chromatography. Proc. Natl. Acad. Sci. U. S. A. 98:2001;3294-3298
154. Schofield L., McConville M.J., Hansen D., Campbell A.S., Fraser-Reid B., Grusby M.J., Tachado S.D. CD1d-restricted immunoglobulin G formation to GPI-anchored antigens mediated by NKT cells. Science. 283:1999;225-229
155. + TCRαβ intermediate cells increase during experimental malaria infection and are able to exhibit inhibitory activity against the parasite liver stage in vitro. J. Immunol. 164:2000;1463-1469
156. Gonzalez-Aseguinolaza G., de Oliveira C., Tomaska M., Hong S., Bruna-Romero O., Nakayama T., Taniguchi M., Bendelac A., van Kaer L., Koezuka Y., Tsuji M. α-Galactosylceramide-activated Vα14 natural killer T cells mediate protection against murine malaria. Proc. Natl. Acad. Sci. U. S. A. 97:2000;8461-8466
157. Gonzalez-Aseguinolaza G., van Kaer L., Bergmann C.C., Wilson J.M., Schmieg J., Kronenberg M., Nakayama T., Taniguchi M., Koezuka Y., Tsuji M. Natural killer T cell ligand α-galactosylceramide enhances protective immunity induced by malaria vaccines. J. Exp. Med. 195:2002;617-624
158. Duthie M.S., Wleklinski-Lee M., Smith S., Nakayama T., Taniguchi M., Kahn S.J. During Trypanosoma cruzi infection CD1d-restricted NK T cells limit parasitemia and augment the antibody response to a glycophosphoinositol-modified surface protein. Infect. Immun. 70:2002;36-48
159. Duthie M.S., Kahn S.J. Treatment with α-galactosylceramide before Trypanosoma cruzi infection provides protection or induces failure to thrive. J. Immunol. 168:2002;5778-5785
160. + effector function against intracellular infection. J. Exp. Med. 184:1996;131-139
161. Nakano Y., Hiseada H., Sakai T., Ishikawa H., Zhang M., Maekawa Y., Zhang T., Takashima M., Nishitani M., Good R.A., Himeno K. Roles of NKT cells in resistance against infection with Toxoplasma gondii and in expression of heat shock protein 65 in the host macrophages. Microb. Infect. 4:2002;1-11
162. Nakano Y., Hiseada H., Sakai T., Zhang T., Maekawa M., Himeno K. Role of innate immune cells in protection against Toxoplasma gondii at inflamed site. J. Med. Invest. 48:2001;73-80
163. + Vα14 NKT cells play a crucial role in an early stage of protective immunity against infection with Leishmania major. Int. Immunol. 12:2000;1267-1274
164. Cui J., Watanabe N., Kawano T., Yamashita M., Kamata T., Shimizu C., Kimura M., Shimizu E., Koike J., Koseki H., Tanaka Y., Taniguchi M., Nakayama T. Inhibition of T helper cell type 2 cell differentiation and immunoglobulin E response by ligand-activated Vα14 natural killer T cells. J. Exp. Med. 190:1999;783-792
165. Kawakami K., Kinjo Y., Uezu K., Yara S., Miyagi K., Koguchi Y., Nakayama T., Taniguchi M., Saito A. Monocyte chemoattractant protein-1-dependent increase of Vα14 NKT cells in lungs and their roles in Th1 response and host defense in cryptococcal infection. J. Immunol. 167:2001;6525-6532
166. + natural killer T cells by α-galactosylceramide results in development of Th1 response and local host resistance in mice infected with Cryptococcus neoformans. Infect. Immun. 69:2001;213-220
167. Apostolou I., Takahama L., Belmant C., Kawano T., Huerre M., Marchal G., Cui J., Taniguchi M., Nakauchi H., Fournie J.J., Kourilsky P., Gachelin G. Murine natural killer T (NKT) cells contribute to the granulomatous reaction caused by mycobacterial cell walls. Proc. Natl. Acad. Sci. U. S. A. 96:1999;5141-5146
168. Guinet F., Ronet C., Mempel M., Huerre M., Carniel E., Gachelin G. NKT cells-containing inflammatory lesions induced by Yersinia pseudotuberculosis glycolipids. Immunol. Lett. 80:2002;113-118
169. Mempel M., Ronet C., Suarez F., Gilleron M., Puzo G., van Kaer L., Lehuen A., Kourilsky P., Gachelin G. Natural killer T cells restricted by the monomorphic MHC class 1b CD1d1 molecules behave like inflammatory cells. J. Immunol. 168:2002;365-371
170. + NKT cell subsets with distinct cytokine-producing capacity. Blood. 100:2002;11-16
171. Behar S.M., Dascher C.C., Grusby M.J., Wang C.R., Brenner M.B. Susceptibility of mice deficient in CD1D or TAP1 to infection with Mycobacterium tuberculosis. J. Exp. Med. 189:1999;1973-1980
172. Schaible U.E., Kaufmann S.H. CD1 molecules and CD1-dependent T cells in bacterial infections: a link from innate and acquired immunity? Semin. Immunol. 12:2000;527-535
173. + T cells for liver injury induced by Salmonella infection in mice. Hepatology. 29:1999;1799-1808
174. Sousa A.O., Mazzaccaro R.J., Russell R.G., Lee F.K., Turner O.C., Hong S., van Kaer L., Bloom B.R. Relative contributions of distinct MHC class I-dependent cell populations in protection to tuberculosis infection in mice. Proc. Natl. Acad. Sci. U. S. A. 97:2000;4204-4208
175. + αβ T cells in IL-12 protection during Salmonella infection. J. Immunol. 163:1999;2057-2063
176. Chackerian A., Alt J., Perera V., Behar S.M. Activation of NKT cells protects mice from tuberculosis. Infect. Immun. 70:2002;6302-6309
177. Kumar H., Belperron A., Barthold S.W., Bockenstedt L.K. CD1d deficiency impairs murine host defense against the spirochete, Borrelia burgdorferi. J. Immunol. 165:2000;4797-4801
178. Nieuwenhuis E.E., Matsumoto T., Exley M., Schleipman R.A., Glickman J., Bailey D.T., Corazza N., Colgan S.P., Onderdonk A.B., Blumberg R.S. CD1d-dependent macrophage-mediated clearance of Pseudomonas aeruginosa from lung. Nat. Med. 8:2002;588-593
179. Kumar V., Bhardwaj V., Soares L., Alexander J., Sette A., Sercarz E. Major histocompatibility complex binding affinity of an antigenic determinant is crucial for the differential secretion of interleukin 4/5 or interferon γ by T cells. Proc. Natl. Acad. Sci. U. S. A. 92:1995;9510-9514
180. Leite-de-Moraes M.C., Herbelin A., Gouarin C., Koezuka Y., Schneider E., Dy M. Fas/Fas Ligand interactions promote activation-induced cell death of NK T lymphocytes. J. Immunol. 165:2000;4367-4371
181. Hayakawa Y., Takeda K., Yagita H., van Kaer L., Saiki I., Okumura K. Differential regulation of Th1 and Th2 functions of NKT cells by CD28 and CD40 costimulatory pathways. J. Immunol. 166:2001;6012-6018
182. + T cells upon NKR-P1 cross-linking. J. Exp. Med. 183:1996;2391-2396
183. Leite-de-Moraes M.C., Hameg A., Pacilio M., Koezuka Y., Taniguchi M., van Kaer L., Schneider E., Dy M., Herbelin A. IL-18 enhances IL-4 production by ligand-activated NKT lymphocytes: a pro-Th2 effect of IL-18 exerted through NKT cells. J. Immunol. 166:2001;945-951
184. + T cells. J. Immunol. 162:1999;7067-7074
185. Kadowaki N., Antonenko S., Ho S., Rissoan M.C., Soumelis V., Porcelli S.A., Lanier L.L., Liu Y.J. Distinct cytokine profiles of neonatal natural killer T cells after expansion with subsets of dendritic cells. J. Exp. Med. 192:2001;823-833
186. Leite-de-Moraes M.C., Moreau G., Arnould A., Machavoine F., Garcia C., Papiernik M., Dy M. IL-4-producing NK T cells are biased towards IFN-γ production by IL-12. Influence of the microenvironment on the functional capacities of NK T cells. Eur. J. Immunol. 28:1998;1507-1515
187. + NKT cells of healthy volunteers and cancer patients using α- galactosylceramide-loaded and environmentally instructed dendritic cells. Cancer Res. 63:2003;4101-4106
188. Fujii S., Shimizu K., Kronenberg M., Steinman R. Prolonged IFN-γ-producing NKT response induced with α-galactosylceramide- loaded DCs. Nat. Immunol. 3:2002;867-874
189. van der Vliet H.J., Nishi N., Koezuka Y., von Blomberg B.M., van den Eertwegh A.J., Porcelli S.A., Pinedo H.M., Scheper R.J., Giaccone G. Potent expansion of human natural killer T cells using α-galactosylceramide (KRN7000)-loaded monocyte-derived dendritic cells, cultured in the presence of IL-7 and IL-15. J. Immunol. Methods. 247:2001;61-72
190. Langenkamp A., Messi M., Lanzavacchia A., Sallusto F. Kinetics of dendritic cell activation: impact on priming of Th1, Th2 and nonpolarized T cells. Nat. Immunol. 1:2000;311-316
191. Lee P.T., Benlagha K., Teyton L., Bendelac A. Distinct functional lineages of human Vα24 natural killer T cells. J. Exp. Med. 195:2002;637-641
192. Gumperz J.E., Miyake S., Yamamura T., Brenner M.B. Functionally distinct subsets of CD1d-restricted natural killer T cells revealed by CD1d tetramer staining. J. Exp. Med. 195:2002;625-636
193. + NKT cells activated by α-galactosylceramide-pulsed monocyte-derived dendritic cells. J. Immunol. 168:2002;3140-3144