Human NKT cells mediate antitumor cytotoxicity directly by recognizing target cell CD1d with bound ligand or indirectly by producing IL-2 to activate NK cells

Journal of Immunology

Volumn 167, Issue 6, 2001, Pages 3114-3122

  Metelitsa, L S ^a   Naidenko, O V ^a   Kant, A ^a   Wu, H W ^a   Loza, M J ^a   Perussia, B ^a   Kronenberg, M ^a   Seeger, R C ^a  

^a CHILDREN S HOSPITAL LOS ANGELES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD1 ANTIGEN; GALACTOSYLCERAMIDE; INTERLEUKIN 2; LIGAND;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; LEUKEMIA CELL LINE; NATURAL KILLER CELL; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; NEUROBLASTOMA CELL; NORMAL HUMAN; PRIORITY JOURNAL; TARGET CELL; TUMOR CELL LINE;

EID: 0035884974     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.6.3114     Document Type: Article

References (66)

1. - T cells
2. CD161 (NKRP1A) costimulation of CD1d-dependent activation of human T cells expressing invariant Vα24 JαQ T cell receptor α chains
3. CD1d-restricted recognition of synthetic glycolipid antigens by human natural killer T cells
4. CD1d on myeloid dendritic cells stimulates cytokine secretion from and cytolytic activity of Vα24JαQ T cells: A feedback mechanism for immune regulation
5. NK T cell-derived IL-10 is essential for the differentiation of antigen-specific T regulatory cells in systemic tolerance
6. NKT cells: Facts, functions and fallacies
7. Differential tumor surveillance by natural killer (NK) and NKT cells
8. NKT cell-mediated repression of tumor immunosurveillance by IL-13 and the IL-4R-STAT6 pathway
9. Structure-activity relationship of α-galactosylceramides against B 16-bearing mice
10. Treatment of hepatic metastasis of the colon26 adenocarcinoma with an α-galactosylceramide, KRN7000
11. Cutting edge: Inhibition of experimental tumor metastasis by dendritic cells pulsed with α-galactosylceramide
12. Antitumor activity of α-galactosylceramide, KRN7000, in mice with the melanoma B 16 hepatic metastasis and immunohistulogical study of tumor infiltrating cells
13. Antitumor cytotoxicity mediated by ligand-activated human Vα24 NKT cells
14. + natural killer T cells activated by α-galactosylceramide (KRN7000) have cytotoxic anti-tumor activity through mechanisms distinct from T cells and natural killer cells
15. + NKT cells activated by α-glycosylceramide-pulsed monucyte-derived dendritic cells
16. CD1d-mediated recognition of an α-galactosylceramide by natural killer T cells is highly conserved through mammalian evolution
17. Requirement for Vα14 NKT cells in IL-12-mediated rejection of tumors
18. Natural killer-like nonspecific tumor cell lysis mediated by specific ligand-activated Vα14 NKT cells
19. + NK cells in vitro
20. Diverse CD1d-restricted reactivity patterns of human T cells bearing "invariant" AV24BV11 TCR
21. Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramers
22. Selective induction of NK cell proliferation and cytotoxicity by activated NKT cells
23. Cutting edge: Cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells
24. A novel recognition motif of human NKT antigen receptor for a glycolipid ligand
25. Morphology, growth chromosomal pattern, and fibrinolytic activity of two new human neuroblastoma cell lines
26. + Jurkat cells facilitates CD3-T cell receptor-mediated IL-2 production
27. Drug resistance patterns of human neuroblastoma cell lines derived from patients at different phases of therapy
28. Activation-induced expression of CD1d antigen on mature T cells
29. A human β-actin expression vector system directs high-level accumulation of antisense transcripts
30. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector
31. Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo
32. A high-titer lentiviral production system mediates efficient transduction of differentiated cells including beating cardiac myocytes
33. 2-microglobulin antibody and its use in the genetic and biochemical analysis of major histocompatibility antigens
34. 2-microglobulin binding antigen encoded by the human CD1D gene
35. Neutrophils are cytotoxic and growth-inhibiting for neuroblastoma cells with an anti-GD2 antibody but, without cytotoxicity, can be growth-stimulating
36. A fluorescence digital image microscopy system for quantifying relative cell numbers in tissue culture plates
37. Simultaneous quantitation of 15 cytokines using a multiplexed flow cytometric assay
38. T-lymphocyte functionality assessed by analysis of cytokine receptor expression, intracellular cytokine expression, and femtomolar detection of cytokine secretion by quantitative flow cytometry
39. Flow microsphere immunoassay for the quantitative and simultaneous detection of multiple soluble analytes
40. Simultaneous quantification of six human cytokines in a single sample using microparticle-based flow cytometric technology
41. Multiple color immunofluorescence for cytokine detection at the single cell level
42. Human neuroblastoma cell lines are susceptible to lysis by natural killer cells but not by cytotoxic T lymphocytes
43. In vitro induction of lymphokine-activated killer (LAK) activity in patients with neuroblastoma
44. + NK T lymphocytes
45. Antigen-presenting function of mouse CD1: One molecule with two different kinds of antigenic ligands
46. + DN T cells
47. +Vα24 NKT cells induces in vitro and in vivo apoptosis of human acute myeloid leukemia cells
48. The CD1 system: Antigen-presenting molecules for T cell recognition of lipids and glycolipids
49. Antigen-specific regulation of CD1 expression in humans
50. Low expression level but potent antigen presenting function of CD1d on monocyte lineage cells
51. Mouse CD1-specific NK1 T cells: Development, specificity, and function
52. Human NKR-P1A: A disulfide-linked homodimer of the C-type lectin superfamily expressed by a subset of NK and T lymphocytes
53. lck via cysteine residues
54. Structural requirements for galactosylceramide recognition by CD1-restricted NK T cells
55. Expression of a nonpolymorphic MHC class I-like molecule, CD1D, by human intestinal epithelial cells
56. Overexpression of CD1d by keratinocytes in psoriasis and CD1d-dependent IFN-γ production by NK-T cells
57. Trafficking and activation of murine natural killer cells: Differing roles for IFN-γ and IL-2
58. Regulation of human natural killer cell activity by interferon-γ: Lack of a role in interleukin 2-mediated augmentation
59. Lysis of fresh and cultured autologous tumor by human lymphocytes cultured in T-cell growth factor
60. Lymphokine-activated killer cells: Lysis of fresh syngeneic natural killer-resistant murine tumor cells by lymphocytes cultured in interleukin 2
61. Recombinant interferons or interleukin-2 increase cytotoxicity by human monocytes and NK cells
62. Long-term growth of lymphokine-activated killer (LAK) cells: Role of anti-CD3. β-IL-I, interferon-γ, and -β
63. Antitumor activity of α-galactosylceramide, KRN7000, in mice with EL-4 hepatic metastasis and its cytokine production
64. The natural killer T (NKT) cell ligand α-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells
65. Perforin-dependent NK cell cytotoxicity is sufficient for anti-metastatic effect of IL-12
66. Adenovirus-interleukin-12-mediated tumor regression in a murine hepatocellular carcinoma model is not dependent on CD1-restricted natural killer T cells