Inhibition of tumor metastasis by adoptive transfer of IL-12-activated Vα14 NKT cells

International Journal of Cancer

Volumn 91, Issue 4, 2001, Pages 523-528

  Shin, Tahiro ^a,b   Nakayama, Toshinori ^b   Akutsu, Yasunori ^a   Motohashi, Shinichiro ^b   Shibata, Youichi ^a   Harada, Michishige ^a   Kamada, Noriaki ^a   Shimizu, Chiori ^a   Shimizu, Eiko ^a   Saito, Tsuyoshi ^a   Ochiai, Takenori ^a   Taniguchi, Masaru ^b  

^a JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^b CHIBA UNIVERSITY   (Japan)

Author keywords

Adoptive transfer; IL 12; Liver metastasis; Melanoma; NKT cell

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 4;

ADOPTIVE TRANSFER; ALLERGIC REACTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; IMMUNE RESPONSE; IMMUNITY; LIVER METASTASIS; LYMPHOID CELL; MELANOMA B16; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; VALPHA14 NKT CELL;

ADOPTIVE TRANSFER; ANIMALS; CELL LINE; CHROMIUM RADIOISOTOPES; ENZYME-LINKED IMMUNOSORBENT ASSAY; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-2; INTERLEUKIN-4; KILLER CELLS, NATURAL; LIVER; LIVER NEOPLASMS; LYMPHOCYTES; MELANOMA, EXPERIMENTAL; MICE; MICE, TRANSGENIC; NEOPLASM METASTASIS; NEOPLASM TRANSPLANTATION; NEOPLASMS; RECOMBINANT PROTEINS; SPLEEN; TIME FACTORS;

EID: 0035866037     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0215(20010215)91:4<523::AID-IJC1087>3.0.CO;2-L     Document Type: Article

References (44)

1. - T cells in mice and humans
2. + T cell populations
3. β gene family
4. Developmentally regulated expression of T cell receptor β chain variable domains in immature thymocytes
5. + subset
6. + cells
7. + thymocytes
8. Requirement for Vα14 NKT cells in IL-12-mediated rejection of tumors
9. Essential requirement of an invariant Vα14 T cell antigen receptor expression in the development of natural killer T cells
10. + NK T cells: A novel lymphoid cell lineage with regulatory function
11. The development of autoimmunity in C57BL/6 lpr mice correlates with the disappearance of natural killer type 1-positive cells: Evidence for their suppressive action on bone marrow stem cell proliferation, B cell immunoglobulin secretion, and autoimmune symptoms
12. Selective reduction of T cells bearing invariant Vα24JαQ antigen receptor in patients with systemic sclerosis
13. + NK T cells associated with disease development in autoimmune-prone mice
14. CD1d-restricted and TCR-mediated activation of Vα14 NKT cells by glycosylceramides
15. pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3
16. + T cells upon NKR-P1 cross-linking
17. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes
18. Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor)
19. Cloning and expression of murine IL-12
20. Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells
21. Natural killer-like nonspecific tumor cell lysis mediated by specific ligand-activated Vα14 NKT cells
22. + thymocytes undergoing thymic selection: Requirement of calcineurin activation for thymic positive selection but not negative selection
23. Recombinant interleukin 2 or 5, but not 3 or 4, induces maturation of resting mouse B lymphocytes and propagates proliferation of activated B cell blasts
24. Systemic administration of rIL-12 induces complete tumor regression and protective immunity: Response is correlated with a striking reversal of suppressed IFN-γ production by anti-tumor T cells
25. Multiple roles of interferon-γ, in the mediation of interleukin 12-induced tumor regression
26. Response of human natural killer (NK) cells to NK cell stimulatory factor (NKSF): Cytolytic activity and proliferation of NK cells are differentially regulated by NKSF
27. Antitumor and antimetastatic activity of interleukin 12 against murine tumors
28. + αβ T cells with intermediate TCR induced in the liver of mice by IL-12
29. + αβ T cells with potent cytotoxicity in the liver of mice via production of IL-12 from kupffer cells
30. Perforin-dependent NK cell cytotoxicity is sufficient for anti-metastatic effect of IL-12
31. Cutting edge: Cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells
32. Immune suppression by recombinant interleukin (rIL)-12 involves interferon γ induction of nitric oxide synthase 2 (iNOS) activity: Inhibitors of no generation reveal the extent of rIL-12 vaccine adjuvant effect
33. Molecular mechanisms underlying IFN-γ-mediated tumor growth inhibition induced during tumor immunotherapy with rIL-12
34. The cell envelope structure of the lipopolysaccharide-lacking gram-negative bacterium sphingomonas paucimobilis
35. α-L-fucopyranosylceramide, a novel glycolipid accumulated in some of the human colon tumors
36. Transfection of interleukin-12 cDNAs into tumor cells induces cytotoxic immune responses against native tumor: Implications for tumor vaccination
37. Role of endogenous production of interleukin 12 in immunotherapy
38. The natural killer T (NKT) cell ligand α-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)- 12 production by dendritic cells and IL-12 receptor expression on NKT cells
39. +NKT cells: Stimulation of IL-12 production by antigen-presenting cells in the innate immune system
40. Differential tumor surveillance by natural killer (NK) and NKT cells
41. Recombinant IL-12 administration induces tumor regression in association with IFN-γ production
42. Cytokine gene therapy of cancer using interleukin-12: Murine and clinical trials
43. Interleukin-12: A cytokine at the interface of inflammation and immunity
44. Antitumor cytotoxicity mediated by ligand-activated human Vα24 NKT cells