Subsets of transgenic T cells that recognize CD1 induce or prevent murine lupus: Role of cytokines

Journal of Experimental Medicine

Volumn 187, Issue 4, 1998, Pages 525-536

  Zeng, Defu ^a   Dick, Michael ^a   Cheng, Lirong ^a   Amano, Masahiko ^a   Dejbakhsh Jones, Sussan ^a   Huie, Philip ^a   Sibley, Richard ^a   Strober, Samuel ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD1 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; DNA ANTIBODY; DOUBLE STRANDED DNA; GAMMA INTERFERON; IMMUNOGLOBULIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERLEUKIN 10; INTERLEUKIN 4; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASCITES; B LYMPHOCYTE; BONE MARROW; CONTROLLED STUDY; IMMUNE COMPLEX NEPHRITIS; IMMUNOGLOBULIN PRODUCTION; LUPUS ERYTHEMATOSUS; MALE; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROTEINURIA; T LYMPHOCYTE RECEPTOR GENE; T LYMPHOCYTE SUBPOPULATION; TRANSGENE; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, CD1; BONE MARROW CELLS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CYTOKINES; DISEASE MODELS, ANIMAL; INTERFERON TYPE II; INTERLEUKIN-4; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE; MICE, INBRED BALB C; MICE, NUDE; MICE, TRANSGENIC; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA;

EID: 0032536445     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.187.4.525     Document Type: Article

References (48)

1. Theofilopoulous, A.N., R. Kofler, P.A. Singer, and F.J. Dixon. 1989. Molecular genetics of murine lupus models. Adv. Immunol. 46:61-109.
2. Yoshida, S., J.J. Castles, and M.E. Gershwin. 1990. The pathogenesis of autoimmunity in New Zealand mice. Semin. Arthritis. Rheum. 19:224-242.
3. Hahn, B.H. 1993. Animal models of systemic lupus erythematosus. In Dubois Lupus Erythematosus. 4th ed. D.J. Wallace and B.H. Hahn, editors. Philadelphia, PA: Lea and Febiger, Philadelphia. 157-177.
4. Tsao, B.P., F.M. Ebling, C. Roman, N. Panosian-Sahadian, K. Calame, and B.H. Hahn. 1990. Structural characteristics of the variable regions of immunoglobulin genes encoding a pathogenic autoantibody in murine lupus. J. Clin. Invest. 85: 530-540.
5. O'Keefe, T.L., S.K. Datta, and T. Imanishi-Kari. 1992. Cationic residues in pathogenic anti-DNA autoantibodies arise by mutations of a germline gene that belongs to a large VH gene subfamily. Eur. J. Immunol. 22:619-624.
6. Datta, S.K., H. Patel, and D. Berry. 1987. Induction of a cationic shift in IgG anti-DNA autoantibodies. Role of T helper cells with classical and novel phenotypes in three murine models of lupus nephritis. J. Exp. Med. 165:1252-1268.
7. 1 murine SLE model. J. Immunol. 138:3185-3190.
8. Hardin, J.A., and J.O. Thomas. 1983. Antibodies to histones in systemic lupus erythematosus. Localization of prominent autoantigens on histone H1 and H2B. Proc. Natl. Acad. Sci. USA. 80:7410-7414.
9. Mohan, C., S. Adams, V. Stanik, and S.K. Datta. 1993. Nucleosome: a major immunogen for pathogenic autoantibody-inducing T cells of lupus. J. Exp. Med. 177:1367-1381.
10. Ebling, F.M., B.P. Tsao, R.R. Singh, E.E. Sercarz, and B.H. Hahn. 1993. A peptide derived from an autoantibody can stimulate T cells in the (NZB/NZW) F1 mouse model of systemic lupus erythematosus. Arthritis Rheum. 36:355-364.
11. Singh, R.R., V. Kumar, F.M. Ebling, S. Southwood, A. Sette, E.E. Sercarz, and B.H. Hahn. 1995. T cell determinants from autoantibodies to DNA can upregulate autoimmunity in murine systemic lupus erythematosus. J. Exp. Med. 181:2017-2027.
12. + T lymphocytes. Science. 268:863-865.
13. + cells: new clues to their origin, specificity, and function. J. Exp. Med. 182:633-638.
14. + T cells. Nature. 372:691-694.
15. Sieling, P.A., D. Chatterjee, S.A. Porcelli, T.I. Prigozy, R.J. Mazzaccaro, T. Soriano, B.R. Bloom, M.B. Brenner, M. Kronenberg, and P.J. Brennan. 1995. CD1-restricted T cell recognition of microbial lipoglycan antigens. Science. 269: 227-230.
16. Cheng, L., S. Dejbakhsh-Jones, R. Liblau, D. Zeng, and S. Strober. 1996. Different patterns of TCR transgene expression in single-positive and double-negative T cells. J. Immunol. 156:3591-3601.
17. - surface phenotype and the α, β heterodimer of the T cell antigen receptor. J. Immunol. 143:1118-1122.
18. 1 can be activated by LPS to secrete IgM. J. Immunol. 125:976-980.
19. Kim K.J., G.B. Nero, R. Laskov, R.M. Merwin, W.J. Logan, and R. Asofsky. 1979. Establishment and characterization of BALB/c lymphoma lines with B cell properties. J. Immunol. 122:549-554.
20. Dejbakhsh-Jones, S., H. Okazaki, and S. Strober. 1993. Similar rates of production of T and B lymphocytes in the bone marrow. J. Exp. Med. 181:2201-2211.
21. Bleicher, P.A., S.P. Balk, S.J. Hagen, R.S. Blumberg, T.J. Flotte, and C. Terhorst. 1990. Expression of murine CD1 on gastrointestinal epithelium. Science. 250:679-682.
22. 1 pre-B mice. J. Exp. Med. 176: 1343-1353.
23. 1 leukemia by transplantation of low density fractions of allogeneic bone marrow and spleen cells. J. Immunol. 148:3319-3326.
24. Striker, L.J., J.L. Olson, and Gary E. Striker. 1990. Handling and preparation of specimens. In The Renal Biopsy. J.L. Bennington, consulting editor. W.B. Saunders Company, Philadelphia. 39-49.
25. Mosmann, T.R., and R.L. Coffman. 1989. Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7:145-173.
26. Powrie, F., and R.L. Coffman. 1993. Cytokine regulation of T cell function: potential for therapeutic intervention. Immunol. Today. 14:270-274.
27. Drake, C.G., S.J. Rozzo, T.J. Vyse, E. Palmer, and B.L. Kotzin. 1995. Genetic contributions to lupus-like disease in (NZB × NZW) F1 mice. Immunol. Rev. 144:51-74.
28. - T cells in mice and humans. J. Exp. Med. 180:1097-1106.
29. Bendelac, A., R.D. Hunziker, and O. Lantz. 1996. Increased interleukin 4 and immunoglobulin E production in transgenic mice overexpressing NK1 T cells. J. Exp. Med. 184: 1285-1293.
30. Mackall, C.L., C.V. Bare, L.A. Granger, S.O. Sharrow, J.A. Titus, and R.E. Gress. 1996. Thymic-independent T cell regeneration occurs via antigen-driven expansion of peripheral T cells resulting in a repertoire that is limited in diversity and prone to skewing. J. Immunol. 156:4609-4616.
31. Slack, J.H., L. Hang, J. Barkley, R.J. Fulton, L. D'Hoostelaere, A. Robinson, and F.J. Dixon. 1984. Isotypes of spontaneous and mitogen-induced autoantibodies in SLE-prone mice. J. Immunol. 132:1271-1275.
32. Racke, M.K., S. Dhib-Jalbut, B. Cannella, P.S. Albert, C.S. Raine, and D.E. McFarlin. 1991. Prevention and treatment of chronic relapsing experimental allergic encephalomyelitis by transferring growth factor beta-1. J. Immunol. 146:3012-3017.
33. + T cells. Immunity. 1:553-562.
34. Inobe, J.I., Y. Chen, and H.L. Weiner. 1996. In vivo administration of IL-4 induces TGF-beta-producing cells and protects animals from experimental autoimmune encephalamyelitis. Ann. NY Acad. Sci. 778:390-392.
35. Steinman, L. 1996. A few autoreactive cells in an autoimmune infiltrate control a vast population of nonspecific cells: a tale of smart bombs and infantry. Proc. Natl. Acad. Sci. USA. 93:2253-2256.
36. Shaw, M.K., J.B. Lorens, A. Dhawan, R. Dalcanto, H.Y. Tse, A.B. Tran, C. Bonpane, S.L. Eswaran, S. Brocke, and N. Sarvetnick. 1997. Local delivery of interleukin-4 by retrovirus-transduced T lymphocytes ameliorates experimental autoimmune encephalomyelitis. J. Exp. Med. 185:1711-1714.
37. Mueller, R., T. Krahl, and N. Sarvetnick. 1996. Pancreatic expression of interleukin-4 abrogates insulitis and autoimmune diabetes in non-obese (NOD) mice. J. Exp. Med. 184: 1093-1099.
38. Santiago, M.L., L. Fossati, C. Jacquet, W. Muller, S. Izui, and L. Reininger. 1997. Interleukin-4 protects against a genetically linked lupus-like autoimmune syndrome. J. Exp. Med. 185:65-70.
39. 1 mice. J. Exp. Med. 179:305-310.
40. 1 hybrid mice with Mycobacterium bovis strain BCG or type II interferon preparations accelerates autoimmune disease. Arthritis Rheum. 24:1396-1402.
41. 1 lupus-like nephritis with monoclonal antibody to γ interferon. J. Exp. Med. 166: 798-803.
42. Strober, S., V. Palathumpat, R. Schwadron, and B. Hertel-Wulff. 1987. Cloned natural suppressor cells prevent lethal graft versus host disease. J. Immunol. 138:699-703.
43. Palathumpat, V. S. Dejbakhsh-Jones, B. Holm, and S. Strober. 1992. Different subsets of T cells in the adult mouse bone marrow and spleen induce or suppress acute graft versus host disease. J. Immunol. 149:808-817.
44. Grewal, I.S., and R.A. Flavell. 1996. The role of CD40 ligand in co-stimulation and T-cell activation. Immunol. Rev. 153:85-106.
45. Van Gool, S.W., P. Vandenberghe, M. de Doer, and J.L. Ceuppens. 1996. CD80, CD86 and CD40 provide accessory signals in a multiple-step T-cell activation model. Immunol. Rev. 153:47-83.
46. 2-microglobulin-dependence of the lupus-like autoimmune syndrome of MLR-lpr mice. J. Immunol. 156:4932-4939.
47. Mozes, E., L.D. Kohn, F. Hakim, and D.S. Singer. 1993. Resistance of MHC class I-deficient mice to experimental systemic lupus erythematosus. Science. 261:91-93.
48. + NK T cells associated with disease development in autoimmune-prone mice. J. Immunol. 156:4035-4040.