NKT cells inhibit the onset of diabetes by impairing the development of pathogenic T cells specific for pancreatic β cells

Immunity

Volumn 17, Issue 6, 2002, Pages 725-736

  Beaudoin, Lucie ^a   Laloux, Véronique ^a,b   Novak, Jan ^a   Lucas, Bruno ^a,b   Lehuen, Agnès ^a,b  

^a Hopital Cochin Saint Vincent de Paul ^*  (France)

^b HÔPITAL NECKER ENFANTS MALADES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 2;

ANIMAL CELL; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DIABETES MELLITUS; EFFECTOR CELL; IN VIVO STUDY; MOUSE; NATURAL KILLER CELL; NONHUMAN; PANCREAS ISLET BETA CELL; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0036906618     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(02)00473-9     Document Type: Article

References (46)

1. Bach J.F. Insulin-dependent diabetes mellitus as an autoimmune disease. Endocr. Rev. 15:1994;516-542.
2. Bansal-Pakala P., Jember A.G., Croft M. Signaling through OX40 (CD134) breaks peripheral T-cell tolerance. Nat. Med. 7:2001;907-912.
3. Baxter A.G., Kinder S.J., Hammond K.J., Scollay R., Godfrey D.I. Association between alphabetaTCR+CD4-CD8- T-cell deficiency and IDDM in NOD/Lt mice. Diabetes. 46:1997;572-582.
4. Bendelac A., Rivera M.N., Park S.H., Roark J.H. Mouse CD1-specific NK1 T cells. development, specificity, and function Annu. Rev. Immunol. 15:1997;535-562.
5. Benlagha K., Kyin T., Beavis A., Teyton L., Bendelac A. A thymic precursor to the NK T cell lineage. Science. 296:2002;553-555.
6. Burdin N., Brossay L., Kronenberg M. Immunization with alpha-galactosylceramide polarizes CD1-reactive NK T cells towards Th2 cytokine synthesis. Eur. J. Immunol. 29:1999;2014-2025.
7. Carnaud C., Gombert J.M., Donnars O., Garchon H.J., Herbelin A. Protection against diabetes and improved NK/NKT cell performance in NOD.NK1.1 mice congenic at the NK complex. J. Immunol. 166:2001;2404-2411.
8. Cui J., Shin T., Kawano T., Sato H., Kondo E., Toura I., Kaneko Y., Koseki H., Kanno M., Taniguchi M. Requirement for Valpha14 NKT cells in IL-12-mediated rejection of tumors. Science. 278:1997;1623-1626.
9. Delovitch T.L., Singh B. The nonobese diabetic mouse as a model of autoimmune diabetes. immune dysregulation gets the NOD Immunity. 7:1997;727-738.
10. Denkers E.Y., Scharton-Kersten T., Barbieri S., Caspar P., Sher A. A role for CD4+ NK1.1+ T lymphocytes as major histocompatibility complex class II independent helper cells in the generation of CD8+ effector function against intracellular infection. J. Exp. Med. 184:1996;131-139.
11. Gombert J.M., Herbelin A., Tancrede-Bohin E., Dy M., Carnaud C., Bach J.F. Early quantitative and functional deficiency of NK1+-like thymocytes in the NOD mouse. Eur. J. Immunol. 26:1996;2989-2998.
12. Greenwald R.J., Boussiotis V.A., Lorsbach R.B., Abbas A.K., Sharpe A.H. CTLA-4 regulates induction of anergy in vivo. Immunity. 14:2001;145-155.
13. Gumperz J.E., Roy C., Makowska A., Lum D., Sugita M., Podrebarac T., Koezuka Y., Porcelli S.A., Cardell S., Brenner M.B., Behar S.M. Murine CD1d-restricted T cell recognition of cellular lipids. Immunity. 12:2000;211-221.
14. Hammond K.J.L., Poulton L.D., Palmisano L.J., Silveira P.A., Godfrey D.I., Baxter A.G. alpha/beta-T cell receptor (TCR)+CD4-CD8- (NKT) thymocytes prevent insulin-dependent diabetes mellitus in nonobese diabetic (NOD)/Lt mice by the influence of interleukin (IL)-4 and/or IL-10. J. Exp. Med. 187:1998;1047-1056.
15. Hayakawa Y., Takeda K., Yagita H., Kakuta S., Iwakura Y., Van Kaer L., Saiki I., Okumura K. Critical contribution of IFN-gamma and NK cells, but not perforin- mediated cytotoxicity, to anti-metastatic effect of alpha-galactosylceramide. Eur. J. Immunol. 31:2001;1720-1727.
16. Hoglund P., Mintern J., Waltzinger C., Heath W., Benoist C., Mathis D. Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodes. J. Exp. Med. 189:1999;331-339.
17. Hong S., Wilson M.T., Serizawa I., Wu L., Singh N., Naidenko O.V., Miura T., Haba T., Scherer D.C., Wei J.et al. The natural killer T-cell ligand alpha-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice. Nat. Med. 7:2001;1052-1056.
18. Judkowski V., Pinilla C., Schroder K., Tucker L., Sarvetnick N., Wilson D.B. Identification of MHC class II-restricted peptide ligands, including a glutamic acid decarboxylase 65 sequence, that stimulate diabetogenic T cells from transgenic BDC2.5 nonobese diabetic mice. J. Immunol. 166:2001;908-917.
19. Kaneko Y., Harada M., Kawano T., Yamashita M., Shibata Y., Gejyo F., Nakayama T., Taniguchi M. Augmentation of Valpha14 NKT cell-mediated cytotoxicity by interleukin 4 in an autocrine mechanism resulting in the development of concanavalin A-induced hepatitis. J. Exp. Med. 191:2000;105-114.
20. Katz J.D., Wang B., Haskins K., Benoist C., Mathis D. Following a diabetogenic T cell from genesis through pathogenesis. Cell. 74:1993;1089-1100.
21. Kawano T., Cui J., Koezuka Y., Toura I., Kaneko Y., Motoki K., Ueno H., Nakagawa R., Sato H., Kondo E.et al. CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides. Science. 278:1997;1626-1629.
22. Laloux V., Beaudoin L., Jeske D., Carnaud C., Lehuen A. NK T Cell-induced protection against diabetes in Valpha14-Jalpha281 transgenic nonobese diabetic mice is associated with a Th2 shift circumscribed regionally to the islets and functionally to islet autoantigen. J. Immunol. 166:2001;3749-3756.
23. Laloux V., Beaudoin L., Ronet C., Lehuen A. Phenotypic and functional differences between NKT cells colonizing splanchnic and peripheral lymph nodes. J. Immunol. 168:2002;3251-3258.
24. Lanoue A., Bona C., von Boehmer H., Sarukhan A. Conditions that induce tolerance in mature CD4+ T cells. J. Exp. Med. 185:1997;405-414.
25. Lantz O., Bendelac A. An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in mice and humans. J. Exp. Med. 180:1994;1097-1106.
26. Lehuen A., Lantz O., Beaudoin L., Laloux V., Carnaud C., Bendelac A., Bach J.F., Monteiro R.C. Overexpression of natural killer T cells protects Valpha14- Jalpha281 transgenic nonobese diabetic mice against diabetes. J. Exp. Med. 188:1998;1831-1839.
27. Lenschow D.J., Ho S.C., Sattar H., Rhee L., Gray G., Nabavi N., Herold K.C., Bluestone J.A. Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse. J. Exp. Med. 181:1995;1145-1155.
28. Luhder F., Chambers C., Allison J.P., Benoist C., Mathis D. Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells. Proc. Natl. Acad. Sci. USA. 97:2000;12204-12209.
29. Lyons A.B., Parish C.R. Determination of lymphocyte division by flow cytometry. J. Immunol. Methods. 171:1994;131-137.
30. Mars L.T., Laloux V., Goude K., Desbois S., Saoudi A., Van Kaer L., Lassmann H., Herbelin A., Lehuen A., Liblau R.S. Cutting edge. V alpha 14-J alpha 281 NKT cells naturally regulate experimental autoimmune encephalomyelitis in nonobese diabetic mice J. Immunol. 168:2002;6007-6011.
31. Matsuda J.L., Naidenko O.V., Gapin L., Nakayama T., Taniguchi M., Wang C.R., Koezuka Y., Kronenberg M. Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramers. J. Exp. Med. 192:2000;741-754.
32. Miyamoto K., Miyake S., Yamamura T. A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cells. Nature. 413:2001;531-534.
33. Pellicci D.G., Hammond K.J., Uldrich A.P., Baxter A.G., Smyth M.J., Godfrey D.I. A natural killer T (NKT) cell developmental pathway involving a thymus-dependent NK1.1(-)CD4(+) CD1d-dependent precursor stage. J. Exp. Med. 195:2002;835-844.
34. Penit C., Vasseur F. Phenotype analysis of cycling and postcycling thymocytes. evaluation of detection methods for BrdUrd and surface proteins Cytometry. 14:1993;757-763.
35. Pied S., Roland J., Louise A., Voegtle D., Soulard V., Mazier D., Cazenave P.A. Liver CD4-CD8- NK1.1+ TCR alpha beta intermediate cells increase during experimental malaria infection and are able to exhibit inhibitory activity against the parasite liver stage in vitro. J. Immunol. 164:2000;1463-1469.
36. Schwartz R.H. Models of T cell anergy. is there a common molecular mechanism? J. Exp. Med. 184:1996;1-8.
37. Sharif S., Arreaza G.A., Zucker P., Mi Q.S., Sondhi J., Naidenko O.V., Kronenberg M., Koezuka Y., Delovitch T.L., Gombert J.M.et al. Activation of natural killer T cells by alpha-galactosylceramide treatment prevents the onset and recurrence of autoimmune Type 1 diabetes. Nat. Med. 7:2001;1057-1062.
38. Singh N., Hong S., Scherer D.C., Serizawa I., Burdin N., Kronenberg M., Koezuka Y., Van Kaer L. Cutting edge. activation of NK T cells by CD1d and alpha-galactosylceramide directs conventional T cells to the acquisition of a Th2 phenotype J. Immunol. 163:1999;2373-2377.
39. Tamada K., Harada M., Ito O., Takenoyama M., Mori T., Matsuzaki G., Nomoto K. The emergence of non-cytolytic NK1.1+ T cells in the long-term culture of murine tumour-infiltrating lymphocytes. a possible role of transforming growth factor-beta Immunology. 89:1996;627-635.
40. + T cell function during in vivo memory or tolerance induction. Immunity. 8:1998;581-590.
41. Tanchot C., Barber D.L., Chiodetti L., Schwartz R.H. Adaptive tolerance of cd4(+) t cells in vivo. multiple thresholds in response to a constant level of antigen presentation J. Immunol. 167:2001;2030-2039.
42. Terabe M., Matsui S., Noben-Trauth N., Chen H.Z., Watson C., Donaldson D.D., Carbone D., Paul W., Berzofsky J. NKT cell-mediated repression of tumor immunosurveillance by IL-13 and the IL-4R-STAT6 pathway. Nat. Immunol. 1:2000;515-520.
43. Tony H.P., Parker D.C. Major histocompatibility complex-restricted, polyclonal B cell responses resulting from helper T cell recognition of antiimmunoglobulin presented by small B lymphocytes. J. Exp. Med. 161:1985;223-241.
44. Wang B., Geng Y.B., Wang C.R. CD1-restricted NK T cells protect nonobese diabetic mice from developing diabetes. J. Exp. Med. 194:2001;313-320.
45. Wilson S.B., Kent S.C., Patton K.T., Orban T., Jackson R.A., Exley M., Porcelli S., Schatz D.A., Atkinson M.A., Balk S.P.et al. Extreme Th1 bias of invariant Valpha24JalphaQ T cells in type 1 diabetes. Nature. 391:1998;177-181.
46. Zeng D., Lewis D., Dejbakhsh-Jones S., Lan F., Garcia-Ojeda M., Sibley R., Strober S. Bone marrow NK1.1(-) and NK1.1(+) T cells reciprocally regulate acute graft versus host disease. J. Exp. Med. 189:1999;1073-1081.