메뉴 건너뛰기




Volumn 109, Issue 1, 2002, Pages 131-140

Multiple immuno-regulatory defects in type-1 diabetes

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ANTIGENICITY; ARTICLE; AUTOIMMUNITY; CLINICAL ARTICLE; FEMALE; FLOW CYTOMETRY; GENETIC DISORDER; GENETIC SUSCEPTIBILITY; HUMAN; IMMUNOREGULATION; INSULIN DEPENDENT DIABETES MELLITUS; MALE; NATURAL KILLER CELL; PANCREAS ISLET BETA CELL; PATHOGENESIS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE ACTIVATION;

EID: 0036141438     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI0213605     Document Type: Article
Times cited : (635)

References (69)
  • 4
    • 0000197275 scopus 로고
    • Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM. Therapeutic intervention by immunosumulation?
    • (1994) Diabetes , vol.44 , pp. 859-862
    • Rabinovitch, A.1
  • 5
    • 0031573072 scopus 로고    scopus 로고
    • IL-4 prevents insulitis and insulin-dependent diabetes mellitus in nonobese diabetic mice by potentiation of regulatory T helper-2 cell function
    • (1997) J. Immunol. , vol.159 , pp. 4686-4692
    • Cameron, M.J.1
  • 7
    • 0029036567 scopus 로고
    • Interferon expression in the pancreases of patients with type 1 diabetes
    • (1995) Diabetes , vol.44 , pp. 658-664
    • Huang, X.1
  • 12
    • 0031912361 scopus 로고    scopus 로고
    • Resistance of T-cells to apoptosis in autoimmune diabetic (NOD) mice is increased early in life and is associated with dysregulated expression of Bcl-x
    • (1998) Diabetologia , vol.41 , pp. 178-184
    • Lamhamedi-Cherradi, S.E.1
  • 13
    • 8544274482 scopus 로고    scopus 로고
    • Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups
    • (1997) Hum. Mol. Genet. , vol.6 , pp. 1275-1282
    • Marron, M.P.1
  • 14
    • 0029966335 scopus 로고    scopus 로고
    • Liver NK1.1+ CD4+ alpha beta T cells activated by IL-12 as a major effector in inhibition of experimental tumor metastasis
    • (1996) J. Immunol. , vol.16 , pp. 3366-3373
    • Takeda, K.1
  • 15
    • 0030613856 scopus 로고    scopus 로고
    • Requirement for Valphal4 NKT cells in IL-12-mediated rejection of tumors
    • (1997) Science , vol.278 , pp. 1623-1626
    • Cui, J.1
  • 17
    • 0031570534 scopus 로고    scopus 로고
    • Close phenotypic and functional similarities between human and murine alphabeta T cells expressing invariant TCR alpba-chains
    • (1997) J. Immunol. , vol.158 , pp. 5603-5611
    • Davodeau, F.1
  • 19
    • 0027178514 scopus 로고
    • Analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8-[alpha]/[beta] T cells demonstrates preferential use of several V[beta] genes and an invariant TCR [alpha] chain
    • (1993) J. Exp. Med. , vol.178 , pp. 1-16
    • Porcelli, S.1    Yockey, C.2    Brenner, M.3    Balk, S.4
  • 20
    • 0028025074 scopus 로고
    • An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in mice and humans
    • (1994) J. Exp. Med. , vol.180 , pp. 1097-1106
    • Lantz, O.1    Bendelac, A.2
  • 22
    • 9244225599 scopus 로고    scopus 로고
    • Selective reduction of V alpha 14+ NK T cells associated with disease development in autoimmune-prone mice
    • (1996) J. Immunol. , vol.156 , pp. 4035-4040
    • Mieza, M.A.1
  • 25
    • 0032538904 scopus 로고    scopus 로고
    • Overexpression of natural killer T cells protects Valpha14- Jalpha281 transgenic nonobese diabetic mice against diabetes
    • (1998) J. Exp. Med. , vol.188 , pp. 1831-1839
    • Lehuen, A.1
  • 27
    • 0029121325 scopus 로고
    • Selective reduction of T cells bearing invariant V alpha 24J alpha Q antigen receptor in patients with systemic sclerosis
    • (1995) J. Exp. Med. , vol.182 , pp. 1163-1168
    • Sumida, T.1
  • 29
    • 0343618469 scopus 로고    scopus 로고
    • Differential expression of NK T cell V[alpha]24J[alpha]Q invariant TCR chain in the lesions of multiple sclerosis and chronic inflammatory demyelinating polyneuropathy
    • (2000) J. Immunol. , vol.164 , pp. 4375-4381
    • Illes, Z.1
  • 31
    • 0033853625 scopus 로고    scopus 로고
    • Naturally anergic and suppressive CD25(+)CD4(+) T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulation
    • (2000) Int. Immunol. , vol.12 , pp. 1145-1155
    • Kuniyasu, Y.1
  • 32
    • 0031821875 scopus 로고    scopus 로고
    • CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
    • (1998) J. Exp. Med. , vol.188 , pp. 287-296
    • Thornton, A.M.1    Shevach, E.M.2
  • 36
    • 0033020127 scopus 로고    scopus 로고
    • Only multiple autoantibodies to islet cells (ICA), insulin, GAD65, JA-2 and IA-2beta predict immune-mediated (type 1) diabetes in relatives
    • (1999) J. Autoimmun. , vol.12 , pp. 279-287
    • Maclaren, N.1
  • 37
    • 0033682056 scopus 로고    scopus 로고
    • B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatoty T cells that control autoimmune diabetes
    • (2000) Immunity , vol.12 , pp. 431-440
    • Salomon, B.1
  • 38
    • 0032495536 scopus 로고    scopus 로고
    • Extreme Th1 bias of invariant Valpha24JalphaQ T cells in type 1 diabetes
    • (1998) Nature , vol.391 , pp. 177-181
    • Wilson, S.B.1
  • 40
    • 0034691205 scopus 로고    scopus 로고
    • Multiple differences in gene expression in regulatoty Valpha24JalphaQT cells from identical twins discordant for type 1 diabetes
    • (2000) Proc. Natl. Acad. Sci. USA , vol.197 , pp. 7411-7416
    • Wilson, S.B.1
  • 41
    • 0031227762 scopus 로고    scopus 로고
    • Cultured NK1.1+ CD4+ T cells produce large amounts of IL-4 and IFN-gamma upon activation by anti-CD3 or CD1
    • (1997) J. Immunol. , vol.159 , pp. 2240-2249
    • Chen, H.1    Paul, W.E.2
  • 43
    • 0028863822 scopus 로고
    • Positive selection of mouse NK1+ T cells by CD1-expressing cortical thymocytes
    • (1995) J. Exp. Med. , vol.182 , pp. 2091-2096
    • Bendelac, A.1
  • 47
    • 0023710685 scopus 로고
    • Autoimmune thyroiditis induced in mice depleted of particular T cell subsets. I. Requirement of Lyt-1 dull L3T4 bright normal T cells for the induction of thyroiditis
    • (1988) J. Immunol. , vol.141 , pp. 105-113
    • Sugihara, S.1
  • 49
    • 0023161556 scopus 로고
    • Transfusions enriched for W3/25+ helper/inducer T lymphocytes prevent spontaneous diabetes in the BB/W rat
    • (1987) Diabetologia , vol.30 , pp. 22-26
    • Mordes, J.P.1
  • 52
    • 0033794297 scopus 로고    scopus 로고
    • T lymphopenia in genetically obese-diabetic Wistar fatty rats: Effects of body weight reduction on T cells
    • (2000) Metabolism , vol.49 , pp. 1261-1266
    • Tanaka, S.1
  • 53
    • 18744435491 scopus 로고    scopus 로고
    • T lymphopenia in obese diabetic (db/db) mice is non-selective and thymus independent
    • (1998) Life Science , vol.62 , pp. 1243-1250
    • Kimura, M.1
  • 55
    • 0026817153 scopus 로고
    • Influence of blood glucose levels on peripheral lymphocytes in patients with diabetes mellitus
    • (1992) Am. J. Clin. Pathol. , vol.19 , pp. 77-80
    • Bouter, K.P.1
  • 60
    • 0035863721 scopus 로고    scopus 로고
    • Th1 to Th2 cytokine shifts in non obese diabetic mice: Sometimes an outcome, rather than the cause of diabetes resistance elicited by immunostimulation
    • (2001) J. Immunol. , vol.166 , pp. 1352-1359
    • Serreze, D.V.1
  • 61
    • 0024243585 scopus 로고
    • Dissociated production of interleukin-2 and immune gamma-interferon by phytohaemoagglutinin stimulated peripheral mononuclear cells in type 1 (insulin-dependent) diabetes
    • (1988) J. Clin. Lab. Immunol. , vol.27 , pp. 73-76
    • Giordano, C.1
  • 62
    • 0022472851 scopus 로고
    • Acquired defect in IL-2 production in patients with type 1 diabetes mellitus
    • (1986) N. Engl. J. Med. , vol.315 , pp. 920-924
    • Kaye, W.A.1
  • 63
    • 0024565494 scopus 로고
    • Interleukin 2 and soluble interleukin 2 receptor secretion defect in vitro in newly diagnosed type 1 diabetic patients
    • (1989) Diabetes , vol.38 , pp. 310-315
    • Giordano, C.1
  • 65
    • 0034668381 scopus 로고    scopus 로고
    • Specific deficiency, of p56[lck] expression in T lymphocytes form type 1 diabetic patients
    • (2000) J. Immunol. , vol.165 , pp. 5874-5883
    • Nervi, S.1
  • 66
    • 0035073058 scopus 로고    scopus 로고
    • A defect in bone marrow derived dendritic cell maturation in the nonobese diabetic mouse
    • (2001) Clin. Exp. Immunol. , vol.123 , pp. 375-381
    • Strid, J.1
  • 68
    • 0034799397 scopus 로고    scopus 로고
    • Activation of NKT cells by α-galactosylceramide treatment prevents the onset and reoccurrence of autoimmune type 1 diabetes
    • (2001) Nat. Med. , vol.7 , pp. 1057-1062
    • Sharif, S.1
  • 69
    • 0034786013 scopus 로고    scopus 로고
    • The natural killer T-cell ligand α-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice
    • (2001) Nat. Med. , vol.7 , pp. 1052-1056
    • Hong, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.