Severe and selective deficiency of interferon-γ-producing invariant natural killer T cells in patients with myelodysplastic syndromes

British Journal of Haematology

Volumn 122, Issue 4, 2003, Pages 617-622

  Fujii, Shin Ichiro ^a   Shimizu, Kanako ^a   Klimek, Virginia ^b   Geller, Matthew D ^a   Nimer, Stephen D ^a   Dhodapkar, Madhav V ^a,b  

^a ROCKEFELLER UNIVERSITY   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

CD1d; Glycolipids; Innate immunity; Myelodysplastic syndromes; Natural killer T cells

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ERYTHROPOIETIN; GALACTOSYLCERAMIDE; GAMMA INTERFERON; GRANULOCYTE COLONY STIMULATING FACTOR; PREDNISONE; T LYMPHOCYTE RECEPTOR;

ADULT; AGED; ANTIGEN PRESENTATION; ANTIGEN SPECIFICITY; ARTICLE; BLOOD SAMPLING; BONE MARROW CELL; CELL COUNT; CELL POPULATION; CLINICAL ARTICLE; CONTROLLED STUDY; EFFECTOR CELL; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOREGULATION; LYMPHOCYTE COUNT; LYMPHOCYTE FUNCTION; MALE; MONONUCLEAR CELL; MYELODYSPLASTIC SYNDROME; NATURAL KILLER CELL; NATURAL KILLER T CELL; PRIORITY JOURNAL; T LYMPHOCYTE;

ADULT; AGED; AGED, 80 AND OVER; BONE MARROW CELLS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; HUMANS; IMMUNITY, CELLULAR; INTERFERON TYPE II; KILLER CELLS, NATURAL; LEUKOCYTE COUNT; MALE; MIDDLE AGED; MYELODYSPLASTIC SYNDROMES; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTE SUBSETS;

EID: 0043163751     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2003.04465.x     Document Type: Article

References (12)

1. Dhodapkar, M.V., Geller, M.D., Chang, D., Shimizu, K., Fujii, S.I., Dhodapkar, K. & Krasovsky, J. (2003) A reversible defect in natural killer T cell function characterizes the progression of premalignant to malignant multiple myeloma. Journal of Experimental Medicine, 197, 1667-1676.
2. Exley, M.A., Tahir, S.M., Cheng, O., Shaulov, A., Joyce, R., Avigan, D., Sackstein, R. & Balk, S.P. (2001) A major fraction of human bone marrow lymphocytes are Th2-like CD1d-reactive T cells that can suppress mixed lymphocyte responses. Journal of Immunology, 167, 5531-5534.
3. Fujii, S.I., Shimuzu, K., Kronenberg, M. & Steinman, R.M. (2002) Prolonged interferon-γ producing NKT responses induced with α-galactosyl ceramide loaded dendritic cells. Nature Immunology, 3, 867-874.
4. Fujii, S.I., Shimizu, K., Steinman, R.M. & Dhodapkar, M.V. (2003) Detection and activation of human V alpha 24+ natural killer T cells using alpha galactosyl ceramide pulsed dendritic cells. Journal of Immunological Methods, 272, 147-159.
5. Godfrey, D.I., Hammond, K.J., Poulton, L.D., Smyth, M.J. & Baxter. A.G. (2000) NKT cells: facts, functions and fallacies. Immunological Today, 21, 573-583.
6. Hamblin, T.J. (2002) Immunology aspects of the myelodysplastic syndromes. In: The Myelodysplastic Syndromes: Pathobiology and Clinical Management (ed. by J.M. Bennett), pp. 65-88. Marcel Dekker, New York.
7. Inui, T., Nakagawa, R., Ohkura, S., Habu, Y., Koike, Y., Motoki, K., Kuranaga, N., Fukasawa, M., Shinomiya, N. & Seki, S. (2002) Age-associated augmentation of the synthetic ligand-mediated function of mouse NK1.1 ag(+) T cells: their cytokine production and hepatotoxicity in vivo and in vitro. Journal of Immunology. 169, 6127-6132.
8. Karadimitris, A., Gadola, S., Altamirano, M., Brown, D., Woolfson, A., Klenerman, P., Chen, J.L., Koezuka, Y., Roberts, I.A., Price, D.A., Dusheiko, G., Milstein, C., Fersht, A., Luzzatto, L. & Cerundolo, V. (2001) Human CD1d-glycolipid tetramers generated by in vitro oxidative refolding chromatography. Proceedings of the National Academy of Sciences of the United States of America, 98, 3294-3298.
9. Lee, P.T., Putnam, A., Benlagha, K., Teyton, L., Gottlieb, P.A. & Bendelac, A. (2002) Testing the NKT cell hypothesis of human IDDM pathogenesis. Journal of Clinical Investigations, 110, 793-800.
10. Milner, J.D., Kent, S.C., Ashley, T.A., Wilson, S.B., Strominger, J.L. & Hafler, D.A. (1999) Differential responses of invariant V alpha 24J alpha Q T cells and MHC class II-restricted CD4+ T cells to dexamethasone. Journal of Immunology, 163, 2522-2529.
11. Tahir, S.M., Cheng, O., Shaulov, A., Koezuka, Y., Bubley, G.J., Wilson, S.B., Balk, S.P. & Exley, M.A. (2001) Loss of IFN-gamma production by invariant NK T cells in advanced cancer. Journal of Immunology, 167, 4046-4050.
12. Zeng, W., Maciejewski, J.P., Chen, G., Risitano, A.M., Kirby, M., Kajigaya, S. & Young, N.S. (2002) Selective reduction of natural killer T cells in the bone marrow of aplastic anaemia. British Journal of Haematology, 119, 803-809.