The natural killer T (NKT) cell ligand α-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells

Journal of Experimental Medicine

Volumn 189, Issue 7, 1999, Pages 1121-1127

  Kitamura, Hidemitsu ^a,c   Iwakabe, Kenji ^b   Yahata, Takashi ^b   Nishimura, Shin Ichiro ^c   Ohta, Akio ^a   Ohmi, Yasushi ^a   Sato, Marimo ^a   Takeda, Kazuyoshi ^d   Okumura, Ko ^d   Van Kaer, Luc ^e   Kawano, Tetsu ^f   Taniguchi, Masaru ^f   Nishimura, Takashi ^a,b  

^a Section of Genetic Engineering   (Japan)

^b TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c HOKKAIDO UNIVERSITY   (Japan)

^d JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

galactosylceramide; Dendritic cells; Interleukin 12; Interleukin 12 receptor; Natural killer T cells

Indexed keywords

GALACTOSYLCERAMIDE; INTERLEUKIN 12; INTERLEUKIN RECEPTOR;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL INTERACTION; CELL KILLING; CELL POPULATION; CYTOTOXICITY; DENDRITIC CELL; IMMUNOPOTENTIATION; KILLER CELL; LIGAND BINDING; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; TARGET CELL; TUMOR IMMUNITY;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; CYTOTOXICITY, IMMUNOLOGIC; DENDRITIC CELLS; DRUG SYNERGISM; GALACTOSYLCERAMIDES; GENE EXPRESSION REGULATION; IMMUNITY, CELLULAR; INTERFERON TYPE II; INTERLEUKIN-12; KILLER CELLS, NATURAL; LIGANDS; LYMPHOCYTE ACTIVATION; LYMPHOCYTE SUBSETS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-12; UP-REGULATION;

EID: 0033526066     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.189.7.1121     Document Type: Article

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