Circulating Vα24+ Vβ11+ NKT cell numbers are decreased in a wide variety of diseases that are characterized by autoreactive tissue damage

Clinical Immunology

Volumn 100, Issue 2, 2001, Pages 144-148

  Van Der Vliet, Hans J J ^a   Von Blomberg, B Mary E ^a   Nishi, Nobusuke ^a   Reijm, Martine ^a   Voskuyl, Alexandre E ^a   Van Bodegraven, Ad A ^a   Polman, Chris H ^a   Rustemeyer, Thomas ^a   Lips, Paul ^a   Van Den Eertwegh, Alfons J M ^a   Giaccone, Giuseppe ^a   Scheper, Rik J ^a   Pinedo, Herbert M ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

Autoimmune disease; CD1d; Regulatory cells; V 24+ V 11+ NKT cells

Indexed keywords

ADOLESCENT; ADULT; AGED; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CELIAC DISEASE; CELL COUNT; CELL POPULATION; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE COURSE; FEMALE; GRAVES DISEASE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; MALE; MYASTHENIA GRAVIS; NATURAL KILLER CELL; PRIORITY JOURNAL; REGULATORY MECHANISM; TISSUE INJURY; GENERAL ASPECTS OF DISEASE; IMMUNITY; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; LYMPHOCYTE COUNT;

CD1 ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR;

ANTIGENS, CD1; DISEASE; HUMANS; IMMUNITY; IMMUNOGLOBULIN VARIABLE REGION; KILLER CELLS, NATURAL; LYMPHOCYTE COUNT; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA;

EID: 0034742480     PISSN: 15216616     EISSN: None     Source Type: Journal    
DOI: 10.1006/clim.2001.5060     Document Type: Article

References (26)

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2. + T cells produce large amounts of IL-4 and IFN-γ upon activation by anti-CD3 or CD1
3. - T cells
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5. + like thymocytes in the NOD mouse
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7. + NK T cells associated with disease development in autoimmune-prone mice
8. Selective reduction of T cells bearing invariant Vα24JαQ antigen receptor in patients with systemic sclerosis
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14. - (NKT) thymocytes prevent insulin-dependent diabetes mellitus in nonobese diabetic (NOD)/Lt mice by the influence of interleukin (IL)-4 and/or IL-10
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26. Multiple differences in gene expression in regulatory Vα24JαQ T cells from identical twins discordant for type 1 diabetes